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Serotonin uptake rates in platelets from angiotensin II-induced hypertensive mice

Health 2013年第4期5卷 31-39页

作者： Preeti Singh terry w. fletcher Yicong Li Nancy J. Rusch Fusun Kilic Department of Biochemistry and Molecular Biology College of Medicine The University of Arkansas for Medical Sciences Little Rock USA Department of Pharmacology and Toxicology College of Medicine The University of Arkansas for Medical Sciences Little Rock USA

Angiotensin II (Ang II) is a critical component of the reninangiotensin system that contributes to hypertension. Although platelets in blood from hypertensive subjects have an abnormal biological profile, it is unclear if circulating Ang II influences platelet aggregation or thrombus formation. One of the abnormalities presented to the platelets during hypertension is an elevated plasma concentration of serotonin (5-HT) caused by reduced 5-HT uptake secondary to loss of the 5-HT transporter (SERT) on the platelet plasma membrane. In the current study, w. evaluated in vivo platelet function after 7 days of subcutaneous Ang II infusion to establish hypertension in mice and additionally assessed the biology of isolated platelets exposed to Ang II in vitro. The administration of Ang II elevated systolic blood pressure, but markers of platelet activation including P-selectin and PEJon/A staining w.re not changed. How.ver, the aggregation response to collagen w.s reduced in isolated platelets from Ang II-infused mice, w.ich also show.d reduced 5-HT uptake by SERT. In vitro exposure of isolated platelets to Ang II also resulted in a loss of surface SERT associated w.th a reduced aggregation response to collagen. These abnormalities w.re reversed by increasing concentra tions of the Ang II receptor antagonist, valsartan. Interestingly, SERT KO mice failed to fully develop hypertension in response to Ang II infusion and isolated platelets from these animals w.re insensitive to the anti-aggregatory influence of Ang II. Thus, Ang II blunts the aggregation responses of platelets and the mechanism underlying this action may involve a loss of SERT on the platelet plasma membrane. The latter event depletes intracellular 5-HT in platelets, an event that is associated w.th reduced aggregation. The w.despread use of antihypertensive drugs that target the renin-angiotensin system suggest the potential clinical utility of our findings and emphasize the importance of understanding the i

关键词： Serotonin Angiotensin Platelet Hypertension

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Real Time Thermal Image Based Machine Learning Approach for Early Collision Avoidance System of Snow.low.

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Journal of Intelligent Learning Systems and Applications 2024年第2期16卷 107-142页

作者： fletcher w.dsw.rth Suresh S. Muknahallipatna Khaled Ksaibati Department of Electrical Engineering and Computer Science University of Wyoming Laramie WY USA Department of Civil and Architectural Engineering University of Wyoming Laramie WY USA

In an effort to reduce vehicle collisions w.th snow.low. in poor w.ather conditions, this paper details the development of a real time thermal image based machine learning approach to an early collision avoidance system for snow.low., w.ich intends to detect and estimate the distance of trailing vehicles. Due to the operational conditions of snow.low., w.ich include heavy-blow.ng snow. traditional optical sensors like LiDAR and visible spectrum cameras have reduced effectiveness in detecting objects in such environments. Thus, w. propose using a thermal infrared camera as the primary sensor along w.th machine learning algorithms. First, w. curate a large dataset of thermal images of vehicles in heavy snow.conditions. Using the curated dataset, tw. machine-learning models based on the modified ResNet architectures w.re trained to detect and estimate the trailing vehicle distance using real-time thermal images. The trained detection netw.rk w.s capable of detecting trailing vehicles 99.0% of the time at 1500.0 ft distance from the snow.low. The trained trailing distance netw.rk w.s capable of estimating distance w.th an average estimation error of 10.70 ft. The inference performance of the trained models is discussed, along w.th the interpretation of the performance.

关键词： Convolutional Neural Netw.rks Residual Netw.rks Object Detection Image Processing Thermal Imaging

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网络安全事件管理和响应指南

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中国教育网络 2024年第2期 76-77页

作者： Christine w.alley Matt Kenslea Asha Ramachandra Steve fletcher 董明(译) 不详

确保整个团队了解要采取什么行动,可以对机构如何以及多快地从一个安全事件中恢复产生重要影响事件管理和响应是任何网络安全计划的关键要素。每一个事件都提供了教训和改进的机会,高等教育领导者永远不应该假设类似的事件不会再次发生... 详细信息

确保整个团队了解要采取什么行动,可以对机构如何以及多快地从一个安全事件中恢复产生重要影响事件管理和响应是任何网络安全计划的关键要素。每一个事件都提供了教训和改进的机会,高等教育领导者永远不应该假设类似的事件不会再次发生。本指南涵盖了在事件发生之前、期间和之后应该做些什么,以确保机构通过有效的响应、恢复和持续改进保持更好的弹性。事件发生前制定事件响应计划:制定详细的事件响应计划,概述检测过程、报告和响应安全事件的程序。

关键词：事件响应安全事件检测过程高等教育持续改进关键要素指南网络安全计划

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Isotopic Ages of the Penglai Group in the Jiaobei Belt and Their Geotectonic Implications

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Acta Geologica Sinica(English Edition) 1994年第4期68卷 417-433页

作者： w.R.Fitches C.J.N.fletcher Institute of Earth Studies University College of WalesAberystwythSY23 3D B U KBritish Geological SurveyAberystwythSY 23 4BYU K

The Penglai Group in the Jiaobei Belt is the only remaining cover of the Archaean to Early Proterozoic crystalline basement in eastern Shandong. The ages of deposition of the Penglai Group and of its deformation and metamorphism have long been a subject of speculation. w.ole-rock Rb-Sr ages, illite-w.ole-rock pair Rb-Sr ages and illite K-Ar ages recently obtained from the Penglai Group slates are reported and interpreted in this paper. On the basis of structural and metamorphic studies coupled w.th analyses of illite crystallinity, XRD and SEM , a w.ole-rock age of 473±32 Ma (Ordovician) is interpreted as the time of termination of burial metamorphism experienced by the Penglai Group. Therefore, the age of the Penghai Group is older than Ordovician. The first-phase folding and syntectonic low.greenschist facies metamorphism in the Penglai Group, i.e. the Penglai Movement, took place before 299±4 Ma B.P., i.e in the Late Carboniferous. The Penglai Movement that occurred in the Jiaobei Belt on the southern margin of the North China Plate is attributed to collision betw.en the North China and Yangtze plates along the Jiaonan Collision Belt. This demonstrates that the continent-continent collision betw.en the North China and Yangtze plates east of the Tan-Lu Fault Zone took place in the Late Carboniferous. The collision caused N-S compression and deformation in the southern margin belt of the North China Plate north of the Qinling-Dabieshan-Jiaonan Collision Belt.

关键词： illite age Jiaobei Belt North China Plate Yangtze Plate plate collision

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Mantle plumes,triple junctions and transforms:A reinterpretation of Pacific Cretaceous-Tertiary LIPs and the Laramide connection

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Geoscience Frontiers 2020年第4期11卷 1133-1144页

作者： Michael fletcher Derek A.w.man Sabin Zahirovic EarthByte Group School of GeosciencesUniversity of SydneySydneyNew South Wales2006Australia

The Shatsky and Hess Rises,the Mid-Pacific Mountains and the Line Islands large igneous provinces(LIPs) present different challenges to conventional plume *** the genesis of these LIPs is important not only for a more complete understanding of mantle plumes and plume-generated magmatism,but also for establishing the role of subducted LIP conjugates in the evolution of the Laramide orogeny and other circum-Pacific orogenic events,w.ich are related to the development of large porphyry *** past difficulties in developing consistent geodynamic models for these LIPs,it is useful to consider w.ether viable alternative geodynamic scenarios may be provided by recent concepts such as melt channel netw.rks and channel-associated lineaments,along w.th the "tw. mode"model of melt generation,w.ere a deeply-sourced channel netw.rk is superimposed on the plume,evolving and adapting over millions of years.A plume may also interact w.th transform faults in close proximity to a mid ocean ridge,w.th the resultant bathymetric character strongly affected by the relative age difference of lithosphere across the *** results suggest that the new.tw.-mode melt models resolve key persistent issues associated w.th the Shatsky Rise and other LIPs and provide evidence for the existence of a conduit system w.thin plumes that feed deeply-sourced material to the plume head,w.th flow.maintained over considerable *** conduit system eventually breaks dow. during plume-ridge separation and may do so prior to the plume head being freed from the triple junction or spreading *** is evidence for not only plume head capture by a triple junction but also for substantial deformation of the plume stem as the distance betw.en the stem and anchored plume head *** evidence suggests that young transforms can serve as pathw.ys for plume material migration,at least in certain plume head-transform configurations.A fortuitous similarity betw.en the path of the

关键词： Mantle plume Shatsky rise Hess rise Mid-pacific mountains Laramide orogeny

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用艺术超越文化与民族的界限——加拿大艺术家傅文笛作品欣赏

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国际人才交流 2024年第5期 40-43页

作者：李彦(文/译) 傅文笛(图) 不详

傅文笛是加拿大艺术家,从事油画创作长达20多年。同时,她也担任滑铁卢大学瑞纳森学院的校长。文笛的画作曾在中国、德国和加拿大等地展出,并被中国、加拿大、美国、英国及其他欧洲国家的高校、政府机构以及私人收藏。当她还是个年轻姑娘... 详细信息

傅文笛是加拿大艺术家,从事油画创作长达20多年。同时,她也担任滑铁卢大学瑞纳森学院的校长。文笛的画作曾在中国、德国和加拿大等地展出,并被中国、加拿大、美国、英国及其他欧洲国家的高校、政府机构以及私人收藏。当她还是个年轻姑娘时,艺术和中国一样,就已深深嵌入了文笛的心怀。1987年,还在攻读博士学位时,她首次踏上了华夏大地。深受中国文化和历史之美感染的同时,她也从遇到的中国学者和学生身上感受到千丝万缕的紧密相连的纽带。步入中年时,她重新拾起对艺术的热忱,也接续上了早年与中华大地的联系。

关键词：滑铁卢大学私人收藏博士学位艺术超越华夏大地作品欣赏油画创作加拿大

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Optimal control and energy storage for DC electric train systems using evolutionary algorithms

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Railw.y Engineering Science 2021年第4期29卷 327-335页

作者： Sam Nallaperuma David fletcher Robert Harrison University of Cambridge CambridgeUK University of Sheffield SheffieldUK

Electrified railw.ys are becoming a popular transport medium and these consume a large amount of electrical *** concerns demand reduction in energy use and peak pow.r demand of railw.y ***,high transmission losses in DC railw.y systems make local storage of energy an increasingly attractive *** optimisation framew.rk based on genetic algorithms is developed to optimise a DC electric rail netw.rk in terms of a comprehensive set of decision variables including storage size,charge/discharge pow.r limits,timetable and train driving style/trajectory to maximise benefits of energy storage in reducing railw.y peak pow.r and energy *** results for the considered real-w.rld netw.rks show.a reduction of energy consumption in the range 15%–30%depending on the train driving style,and reduced pow.r peaks.

关键词： Autonomous control Intelligent transport systems Energy optimisation DC railw.y systems Energy regeneration

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Urban heat mitigation by green and blue infrastructure:Drivers,effectiveness,and future needs

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The Innovation 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.Debele Soheila Khalili Christos H.Halios Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep Bhui Nerea Calvillo Shi-Jie Cao Frederic Coulon Jill L.Edmondson David fletcher Edmilson Dias de Freitas Hai Guo Matthew.C.Hort Madhusudan Katti Thomas Rodding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Moraw.ka Rajan Parajuli Christopher D.F.Rogers Runming Yao Fang w.ng Jannis w.nk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Environment University of ReadingWhiteknightsReading RG66BUUK School Design and the Built Environment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences Department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK Department of Psychiatry and Nuffield Department of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield University School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina Department of Forestry and Environmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA Departments of Architecture&Civil Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA Department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global w.rming leads to urban overheating and compounds the frequency and intensity of extreme heat events due to climate ***,the risk of urban overheating can be mitigated by urban green-blue-grey infrastructure(GBGI),such as parks,w.tlands,and engineered greening,w.ich have the potential to effectively reduce summer air *** many review.,the evidence bases on quantified GBGI cooling benefits remains partial and the practical recommendations for implementation are *** systematic literature review.synthesizes the evidence base for heat mitigation and related co-benefits,identifies know.edge gaps,and proposes recommendations for their implementation to maximize their *** screening 27,486 papers,202 w.re review.d,based on 51 GBGI types categorized under 10 main *** GBGI(green w.lls,parks,street trees)have been w.ll researched for their urban cooling ***,several other GBGI have received negligible(zoological garden,golf course,estuary)or minimal(private garden,allotment)*** most efficient air cooling w.s observed in botanical gardens(5.0±3.5℃),w.tlands(4.9±3.2℃),green w.lls(4.1±4.2℃),street trees(3.8±3.1℃),and vegetated balconies(3.8±2.7℃).Under changing climate conditions(2070–2100)w.th consideration of RCP8.5,there is a shift in climate subtypes,either w.thin the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental w.rm-summer humid]to BSk[dry,cold semi-arid]and Cw.[temperate]to Am[tropical]).These shifts may result in low.r efficiency for the current GBGI in the *** the importance of multiple services,it is crucial to balance their functionality,cooling performance,and other related co-benefits w.en planning for the future *** global GBGI heat mitigation inventory can assist policymakers and urban planners in prioritizing effective interventions to reduce the risk of urban overheating,fi

关键词： estuary w.lls extreme

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Novel ecosystems created by coal mines in central Queensland’s Bow.n Basin

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Ecological Processes 2013年第1期2卷 368-379页

作者： Peter D Erskine Andrew.T fletcher Centre for Mined Land Rehabilitation The University of QueenslandBrisbane QLD 4072Australia

Introduction:Open-cut coal mining began in central Queensland’s Bow.n Basin approximately 50 years *** this period of time,mine rehabilitators have used a variety of tree,shrub,and groundcover species to create‘novel ecosystems’to stabilise soils and provide vegetative cover for pre-supposed final end-land *** examine post-mining rehabilitation from multiple soil and vegetation monitoring activities in the Bow.n Basin to assess the similarity of landforms,plant composition,and trends in plant diversity compared to unmined reference ***:Rehabilitated spoil dumps and reference sites w.re assessed using soil and vegetation data contained in compliance monitoring reports from Goonyella Riverside,Moura,Oaky Creek,Rolleston,and Blackw.ter ***,soil chemistry,and plant species mixes of rehabilitation aged from 2 to 22 years w.re compared to selected reference ***:Mines in this region have generally proposed one of tw. post-rehabilitation end-land uses:either pasture for cattle grazing or reconstructed native communities w.ich potentially provide native fauna *** data from a selection of these mine sites suggest that w.en their rehabilitation w.s compared to nearby reference sites median slope values w.re betw.en 2.5 and 7 times steeper and soil pH,electrical conductivity,and phosphorus levels w.re significantly *** steeply sloped landforms,poor soil characteristics,depauperate native species pool,and uniform presence of exotic pasture grasses in the rehabilitation indicate that most of these new.y created ecosystems should not be used for cattle grazing and also have few.natural ***:Legislative and community expectations have changed progressively over time and,although much of the rehabilitation is currently dominated by an assemblage of exotic buffel grass(Cenchrus ciliaris)and Acacia spp.,recent environmental authorities suggest these‘novel ecosystems’w.ll be judged against native refere

关键词： Coal mining Completion criteria Environmental conditions Novel ecosystems

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LARGE SIGNALS OF CLIMATIC VARIATION OVER THE OCEAN IN THE ASIAN MONSOON REGION

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Advances in Atmospheric Sciences 1988年第4期5卷 389-404页

作者：符淙斌 ,J. fletcher National Ocean and Atmospheric Administration U.S.A.

The aim of this paper is to identify and delineate large signals of climatic variation in the Asian monsoon region and try to understand the nature of transformation from one climate regime to *** is found that the summer monsoon over the Indian and w.stern Pacific oceans show. distinct climatic regimes w.th changes occurring in the years around 1875, 1900, 1940 and 1960. The change of about 1900 is the largest one, w.ich occurs in step w.th the variation of global oceanic climate pointed out by fletcher, et al.(1982).The main characteristics of the transformation from one regime to another is an alternation of meridio-nality of monsoon current. The transformation occurs most strongly in the w.stern Pacific convergence zone, w.ere monsoon has strong interaction w.th the trade w.nd *** variability of monsoon rainfall over India and East China also exhibits some large signals w.ich are synchronous w.th those of w.nd field over the ocean: the monsoon rainfall increases (decreases) during the

关键词： In Bay LARGE SIGNALS OF CLIMATIC VARIATION OVER THE OCEAN IN THE ASIAN MONSOON REGION

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