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Preimplantation genetic testing for embryos predisposed to hereditary cancer:Possibilities and challenges

Cancer Pathogenesis and Therapy 2024年第1期2卷 1-14页

作者： Mohammed H.Albujja Maher Al-Ghedan Lakshmidevi Dakshnamoorthy Josep pla Victori Department of Forensic Sciences Naif Arab University for Security SciencesRiyadh 11452Saudi Arabia Genetics Laboratory Thuriah Medical CenterRiyadh 11523Saudi Arabia Department of Genetic Counselling VI-RMA GlobalValencia 46004Spain

Preimplantation genetic testing(PGT),which was developed as an alternative to prenatal genetic testing,allows couples to avoid pregnancies with abnormal chromosomes and the subsequent termination of the affected *** used for early onset monogenic conditions,PGT is now used to prevent various types of inherited cancer conditions based on the development of PGT technology,assisted reproductive techniques(ARTs),and in vitro fertilization(IVF).This review provides insights into the potential benefits and challenges associated with the application of PGT for hereditary cancer and provides an overview of the existing literature on this test,with a particular focus on the current challenges related to laws,ethics,counseling,and ***,this review predicts the future potential applications of this *** PGT may be utilized to predict and prevent hereditary cancer,each case should be comprehensively *** motives of couples must be assessed to prevent the misuse of this technique for eugenic purposes,and non-pathogenic phenotypes must be carefully *** cases that require this technology should also be carefully considered based on legal and ethical *** may be the preferred treatment for hereditary cancer cases;however,such cases require careful case-by-case ***,this study concludes that multidisciplinary counseling and support for patients and their families are essential to ensure that PGT is a viable option that meets all legal and ethical concerns.

关键词： Preimplantation genetic testing Hereditary cancer Late-onset diseases Ethics Legal restrictions

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Optimal heat release shaping in a reactivity controlled compression ignition （RCCI） engine

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Control Theory and Technology 2017年第2期15卷 117-128页

作者： Carlos GUARDIOLA Benjamin pla Antonio GARCiA Vicente BORONAT CMT-Motores Termicos Universitat Politecnica de Valencia Valencia Spain

The present paper addresses the optimal heat release （HR） law in a single cylinder engine operated under reactivity controlled compression ignition （RCCl） combustion mode to minimise the indicated specific fuel consumption （ISFC） subject to different constraints including pressure related limits （maximum cylinder pressure and maximum cylinder pressure gradient）. With this aim, a 0-dimensional （OD） engine combustion model has been identified with experimental data. Then, the optimal control problem of minimising the ISFC of the engine at different operating conditions of the engine operating map has been stated and analytically solved. To evaluate the method viability a data-driven model is developed to obtain the control actions （gasoline fraction） leading to the calculated optimal HR, more precisely to the optimal ratio between premixed and diffusive combustion. The experimental results obtained with such controls and the differences with the optimal HR are finally explained and discussed.

关键词： Diesel engine RCCI combustion analysis optimal control

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Innovative strategies and nutritional perspectives for fortifying pumpkin tissue and other vegetable matrices with iron

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Food Science and Human Wellness 2020年第2期9卷 103-111页

作者： Marina F.de Escalada pla Silvia k.Flores Carolina E.Genevois Universidad de Buenos Aires Facultad de Ciencias Exactas y NaturalesDepartamento de IndustriasBuenos AiresArgentina CONICET-Universidad de Buenos Aires Instituto de Tecnologia de Alimentos y Procesos Quimicos(ITAPROQ)Buenos AiresArgentina Universidad Nacional de Entre Rios(UNER) Facultad de BromatologiaGualeguaychuEntre RiosArgentina CONICET Buenos AiresArgentina

The present review article focuses on different technological strategies and nutritional perspectives having added advantage to human health in fortifying vegetables matrices with *** introduction to the main aspects related to iron deficiency consequences is resumed in order to understand the importance of developing new strategies for improving iron *** this sense,the tendencies and alternatives will also be *** technologies like impregnation or dry infusion are presented as sustainable options for obtaining structured fortified vegetables.A review about the usefulness of edible covers for stabilizing micronutrients and/or probiotic microorganisms in fortified matrices is also *** iron deficiency still continue to be a worldwide health issue,innovating in food fortification remains a challenge for researchers and food manufactures.

关键词： Vegetables Iron Ascorbic acid Probiotics Edible covers

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Advances in the prognosis of soil sodicity under dryland and irrigated conditions

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International Soil and Water Conservation Research 2014年第4期2卷 50-63页

作者： Ildefonso pla Sentís Universitat de Lleida LleidaSpain

Salt-affected soils,both saline and sodic,may develop under both dryland and irrigated conditions,affecting the physical and chemical soil properties,with negative consequences in the environment,in crop production and in animal and human *** the development processes of salt-affected soils,the processes of sodification have generally received less attention and are less understood than the development of saline *** in both,hydrological processes are involved in their development,in the case of sodic soils we have to consider some additional chemical and physicochemical reactions,making more difficult their modeling and *** is especially true where we have to consider the effects of the groundwater level and *** this contribution there are presented three case studies:one related to the development of sodic soils in the lowlands of the Argentina Pampas,under dry-land conditions with sub-humid temperate climate and pastures for cattle production;the second deals with the development of sodic soils in the Colombia Cauca Valley,under irrigated conditions and tropical sub-humid climate,in lands used for sugarcane cropping dedicated to sugar and ethanol production;and the last one related to the sodification of soils in the Western plains of Venezuela,under irrigated conditions,sub-humid tropical climate and continuous cropping of rice under *** development of sodicity in the surface soil is partially related to the composition and level of the ground-water,mainly affected in the Argentina case by drainage conditions,in the case of Colombia to the inefficient irrigation and inadequate drainage,and in the case of Venezuela to the soil management and irrigation *** is shown how the model SALSODIMAR,developed by the author,based on the balance of water and soluble components of both irrigation water and ground-water,under different water and land management conditions,may be successfully adapted for the diagnosis

关键词： Sodicitiy Models Hydrology Ground water

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Improved thromboresistance and analytical performance of intravascular amperometric glucose sensors using optimized nitric oxide release coatings

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Chinese Chemical Letters 2015年第4期26卷 464-468页

作者： Alexander k.Wolf Yu Qin terry C.Major Mark E.Meyerhoff Department of Chemistry University of Michigan Department of Chemistry Nanjing University Department of Surgery University of Michigan

In this work, nitric oxide （NO） release coatings designed for intravenous amperometric glucose sensors are optimized through the use ofa polylactic acid （pla） layer doped with a lipophilic diazeniumdiolated species that releases NO through a proton-driven mechanism. An Elast-Eon E2As polyurethane coating is used to both moderate NO release from the sensor surface and increase the sensor＇s linear detection range toward glucose. These sensors were evaluated for thromboresistance and in vivo glucose performance through implantation in rabbit veins. By maintaining NO flux on a similar scale to endogenous endothelial cells, implanted glucose sensors exhibited reduced surface clot formation which enables more accurate quantitative glucose measurements continuously. An in vivo time trace of implanted venous sensors demonstrated glucose values that correlated well with the discrete measurements of blood samples on a benchtop point-of-care sensor-based instrument. The raw measured currents from the implanted glucose sensors over 7 h time periods were converted to glucose concentration through use of both a one-point in vivo calibration and a calibration curve obtained in vitro within a bovine serum solution. Control sensors, assembled without NO release functionality, exhibit distinctive surface clotting over the 7 h in vivo implantation period.

关键词： Nitric oxide release coatingsGlucose sensorsPolylactic acid layerQuantitative glucose measurements

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New development of biliary surgery in China

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World Journal of Gastroenterology 2000年第2期6卷 187-192页

作者： Zhi Qiang Huang The Research Institute of General Surgery,The General Hospital of pla,Beijing 100853,China 解放军总医院北京

CHARACTERISTICS OF BILIARY CALCULOUSDISEASES IN CHINA:THE CHANGING SCOPEDiseases of the biliary tract in China is complicatedwith the prevalence of primary infection of the bileduct *** the middle of the 20th century,biliary infection,biliary parasitic infestation,andbiliary stones made up the three chief componentsof biliary diseases in *** to the

关键词： biliary surgery cholelithiasis intrahepatic stones carcinoma gallbladder carcinoma bile duct

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The effects of anisodamine and dobutamine on gut mucosal blood flow during gut ischemia/reperfusion

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World Journal of Gastroenterology 2002年第3期8卷 555-557页

作者： Sen Hu Zhi-Yong Sheng,Burns Institute,304th Hospital of pla,Beijing 100037,China Burns Institute 304th Hospital of PLA 51 Fu Cheng Road Beijing 100037 China.

AIM: To determine if anisodamine is able to augment mucosal perfusion during gut I/R ischemia-reperfusion. METHODS: A jejunal sac was formed in Sprague Dawley rat. A Laser Doppler probe and a tonometer were inserted into the sac which was filled with saline. The superior mesenteric artery was occluded (SMAO)for 60 minutes followed by 90 minutes of reperfusion. At the end of 60 minutes of SMAO, either 0.2 mg/kg of anisodmine or dobutamine was injected into the jejunal sac. Laser Doppler mucosal blood flow and regional PCO2 (PrCO2)measurements were made. RESULTS: Mucosal blood flow was significantly increased at 30,60 and 90 minutes of reperfusion (R30, R60, R90) when intraluminal anisodamine or dobutamine was present compared to intraluminal saline only(44+/-3.3% or 48+/-4.1% vs 37+/-2.6% at R30, 57+/-5.0% or 56+/-4.7% vs 45+/-2.7% at R60, 64+/-3.3% or 56+/-4.2% vs 48+/-3.4% at R90,respectively Pplanchnic hypoperfusion following traumatic or burn shock.

关键词： Animals Carbon Dioxide Dobutamine Intestinal Mucosa Ischemia Jejunum Male Rats Rats, Sprague-Dawley Regional Blood Flow Reperfusion Injury Research Support, Non-U.S. Gov't Solanaceous Alkaloids

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Discussion　on　Reinforcing　and　Reducing　Manipulation　of　Yin　and　Yang　in　Acupuncture

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中国针灸 1995年第S2期15卷 351-352页

作者： Zhang Changzhi(Cerebral Institute,52935 Unit of the pla)Zhao Xhuancha Wang Junhong,(Outpatient Department,52935 Unit of the pla)

ＤｉｓｃｕｓｓｉｏｎｏｎＲｅｉｎｆｏｒｃｉｎｇａｎｄＲｅｄｕｃｉｎｇＭａｎｉｐｕｌａｔｉｏｎｏｆＹｉｎａｎｄＹａｎｇｉｎＡｃｕｐｕｎｃｔｕｒｅ￥ＺｈａｎｇＣｈａｎｇｚｈｉ（ＣｅｒｅｂｒａｌＩｎｓｔｉｔｕｔｅ，５２９３... 详细信息

ＤｉｓｃｕｓｓｉｏｎｏｎＲｅｉｎｆｏｒｃｉｎｇａｎｄＲｅｄｕｃｉｎｇＭａｎｉｐｕｌａｔｉｏｎｏｆＹｉｎａｎｄＹａｎｇｉｎＡｃｕｐｕｎｃｔｕｒｅ￥ＺｈａｎｇＣｈａｎｇｚｈｉ（ＣｅｒｅｂｒａｌＩｎｓｔｉｔｕｔｅ，５２９３５ＵｎｉｔｏｆｔｈｅＰＬＡ）Ｚｈａ...

关键词： Acupuncture Discussion Yin Reducing Reinforcing Yang Manipulation and of

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Military Transparency and Mutual Trust between China and the United States

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和平与发展 2008年第2期 76-80页

作者： Xu Jia Chief Professor of the pla University of Foreign Languages

I. Essence of the Military Transparency The concept of military transparency, which bears the official significance and is regarded as a standard of measuring national conducts, originated from the United Nations Resolution 35/142B entitled Reduction of Military Budgets adopted on 12 December, 1980 and other relevant UN resolutions which provided the basis for formulating the military transparency system. Over the past few years, the United States often has repeatedly asked China to meet its demands on the issue of military transparency. However,

关键词： Military Transparency and Mutual Trust between China and the United States than view UN

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Changing patterns of traumatic bile duct injuries:a review of forty years experience

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World Journal of Gastroenterology 2002年第1期8卷 5-12页

作者： Zhi-Qiang Huang Xiao-Qiang Huang Research Institute of General Surgery,The General Hospital of Chinese pla,Beijing 100853,China Research Institute of General Surgery The General Hospital of Chinese PLA Beijing 100853China. zhiqianghuang2000@***

AIM:To summarize the experiences of treating bile ductinjuries in 40 years of clinical ***:Based on the experience of more than 40 yearsof clinical work,122 cases including a series of 61 bile ductinjuries of the Southwest Hospital,Chongqing,and 42cases(1989-1997)and 19 cases(1998-2001)of the GeneralHospital of pla,Beijing,cases were reviewed with specialreference to the pattern of injury.A series of cases of theliver and the biliary tract injuries following interventionaltherapy for hepatic tumors,most often hemangioma of theliver,were *** medical literature from 1995 to1999 dealing with 2742 traumatic bile duct strictures ***:There was a changing pattern of the bile *** most of the cases of bile duct injuriesresulted from open *** types of traumasuch as laparoscopic cholecysiectomy(LC)and hepaticsurgery were increased in recent ***,serioushepato-biliary injuries following HAE using sclerotic agentssuch as sodium morrhuate and absolute ethanol for thetreatment of hepatic hemangiomas were encountered inrecent *** in how to avoid bile duct injuryand to treat traumatic biliary strictures were ***:Traumatic bile duct stricture is one of theserious complications of hepato-biliary surgery,itsprevalence seemed to be increased in recent *** of bile duct injury was also changed and has becomemore *** therapy with sclerosingagents may cause serious hepatobiliary complications andshould be avoided.

关键词：创伤性胆管损伤临床分析胆管外科并发症医源性损伤

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