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Lassa Fever: Patients Profile and Treatment Outcomes at Benue State University Teaching Hospital Makurdi, North-Central Nigeria

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Advances in Infectious Diseases 2023年第4期13卷 722-734页

作者： Tsavyange Peter Mbaave Onyilo Ogbu Patrick O. Echekwube terrumun Zaiyol swende Igba Terhile Igbah Department of Medicine Benue State University and Teaching Hospital Makurdi Nigeria Department of Paediatrics Benue State University and Teaching Hospital Makurdi Nigeria Department of Obstetrics and Gynaecology Benue State University and Teaching Hospital Makurdi Nigeria

Lassa fever is a viral haemorrhagic fever found mostly in West Africa where it is endemic but generates periodic outbreaks in the dry seasons. The virus is spread by the rat species named mastomys natalensis. While the illness is minor in most cases, the mortality is significant in hospitalized patients. Few completely equipped treatment centers existed in Nigeria previous to current increase in frequency requiring demand for new treatment centers without the full complement of essential capabilities. Aim: To analyze the profile and treatment outcome in patients hospitalized in one of such new resource-constrained centers at the Benue State University Teaching Hospital Makurdi, Nigeria. Methodology: This was a retrospective, descriptive hospital-based research encompassing January 2020 to March 2023. Medical records of those admitted to the isolation center were reviewed. The relevant data was coded and analyzed using IBM SPSS version 23. Results: One hundred and ten (110) individuals were hospitalized for probable or suspected Lassa fever throughout the research period. A total of 35 confirmed patients satisfied the inclusion criteria and were included as the study subjects. There were 23 (65.7%) men and 12 (34.3%) females. Their mean age was 35.36 ± 12.21 years (range 15-61 years). The treatment outcome showed that 24 (75%) survived and were discharged, 5 (15.6%) were referred out of the facility for dialysis and 3 died, providing a mortality of 8.6%. The causes of mortality in study patients were acute kidney injury and encephalopathy. Conclusion: Lassa fever is endemic in Benue state with all types of individuals afflicted. The outcome of treatment was good despite resource difficulties. Lassa fever can be successfully managed even in resource-challenged situations typically encountered in developing countries.

关键词： Lassa Fever Treatment Outcome Benue State Nigeria

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Prevalence and Predictors of High-Risk HPV in Nigeria

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Advances in Infectious Diseases 2022年第4期12卷 745-757页

作者： Aigbe Gregory Ohihoin Patrick Azuka Okwuraiwe Adesola Zaidat Musa Gbenga Olorunfemi Chika Kingsley Onwuamah Fehintola Ige Olufemi Samuel Amoo Rosemary Audu Felix Okogbo Babafemi Daniyan terrumun swende Geoffrey Chukwubuike Onyemelukwe Haruna Daru Hadiza Usman Oladapo Shittu Jonah Musa Oliver Chukwujekwu Ezechi Innocent Achanya Ujah Nigerian Institute of Medical Research (NIMR) Lagos Nigeria School of Public Health University of Witwatersrand Johannesburg South Africa College of Medicine Ambrose Alli University Edo State Nigeria National Obstetric Fistula Center Abakaliki Ebonyi State Nigeria Benue State University Benue State Nigeria Ahmadu Bello University Zaria Kaduna State Nigeria University of Jos Jos Nigeria University of Maiduguri Borno State Nigeria

Introduction: Cervical cancer remains a major cause of morbidity and mortality among the female population in sub-Saharan Africa. Vaccination against human papillomavirus (HPV), the main causative agent, has the potential to eradicate cervical cancer. In-country evidence of sub-types of HPV associated with cervical cancer is scanty, thus necessitating this study. Methods: A cross-sectional study was performed using a multistage sampling technique. A molecular technique using the Cobas 4800 machine was used for genotyping. Results: 570 participants were recruited for the study. The mean age of the participants was 32.4 ± 5.2 years. The age of sexual debut ranged from 15 - 24 years with a median of 19 years. 194 participants were positive for high-risk HPV giving a prevalence of 34%. 3% (n = 17) were positive for HPV, 16. 4% (23) had a positive result for HPV, 18. 27% (n = 154) had a positive result for other high-risk groups (OHR) other than HPV 16 or 18. Positive status for high-risk HPV is associated with the presence of genital warts (OR = 7.5), a Positive HIV status (OR = 3.48), abnormal vaginal discharge (OR = 2.20), multiple sexual partners (OR = 2.30), and obesity (OR = 2.70). The prevalence of HIV in the study population was 6.84% (n = 39). Conclusion: Another High-risk HPV other than 16 and 18 appears to be the predominant form of HPV infection in Nigerian women. The risk of being positive for high-risk HPV is associated with the presence of genital warts, abnormal vaginal discharge, a positive HIV status, multiple sexual partners and Obesity. It is therefore necessary to disaggregate and study these high-risk sub-types.

关键词： HPV Cervical Cancer Prevalence Predictors Nigeria

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Lassa Fever: Patients Profile and Treatment Outcomes at Benue State University Teaching Hospital Makurdi, North-Central Nigeria

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Advances in Infectious Diseases（传染病进展） 2023年第4期

作者： Tsavyange Peter Mbaave Onyilo Ogbu Patrick O.Echekwube terrumun Zaiyol swende Igba Terhile Igbah

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Prevalence and Predictors of High-Risk HPV in Nigeria

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Advances in Infectious Diseases 2022年第4期

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Determinants of Male Coital Difficulties among Attendees of the Gynae Clinic at a Tertiary Health Center in North-Central Nigeria

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Open Journal of Obstetrics and Gynecology 2017年第7期7卷 719-724页

作者： A. O. Ojabo O. Audu A. G. Adesiyun S. K. Hembah-Hilekaan T. Z. swende Sulayman-Umar Hajaratu M. T. Maanongun P. O. Eka Department of Obstetrics and Gynaecology College of Health Sciences Benue State University Makurdi Nigeria Department of Community Medicine and Epidemiology College of Health Sciences Benue State University Makurdi Nigeria Department of Obstetrics and Gynaecology Ahmadu Bello University Zaria Nigeria

Background: Male sexual or coital difficulties are among the factors contributing to infertility in couples seeking fertility as this may result in low coital frequency. Aims/Objectives: To evaluate the causes of male sexual or coital difficulties among couples attending the infertility clinic at BSUTH, Makurdi over a 2 year period. Methodology: This was a cross-sectional study involving all males attending the infertility clinic at Benue State University Teaching Hospital (BSUTH) who consent to participate in the study. A pretested structured questionnaire was administered and analyzed with statistical package for social sciences (version 23.0) and the results were presented in simple proportions. Results: There were several factors responsible for male coital difficulties. The most common was male erectile dysfunction 33 (32.4%), vaginismus 11 (10.8%), penile pain 14 (13.7%), poor response from the female partner 8 (7.8%) and severe dyspareunia 18 (17.1%). Conclusion: Coital difficulties resulting to low frequency of sexual exposure constitutes a major cause of infertility among males attending the infertility clinic at BSUTH, Makurdi. Therefore efforts should be made to evaluate these factors while assessing infertility couples in order to mitigate the effect.

关键词： Coital Difficulties Erectile Dysfunction Aphrodisiacs Dyspareunia Vaginismus

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