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Anti-ulcer potentials of phylum mollusca(tropical snail)slime

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Asian Pacific Journal of tropical Medicine 2009年第3期2卷 23-28页

作者： Nwodo nj Okonta J M Ezugwu CO Attama AA Faculty of Pharmaceutical Sciences University of NigeriaNsukka410001Enugu State

Objective:the effectiveness of the slimy substance in snail to regenerate and repair damaged areas on it body/shell lead to this ***:the anti-ulcer’property of snail slime extracted from phylur mollusca(tropical snail) from the giant African snail Archachatina marginata(***) was investi gated using histamine,stress and indomethacin-induced *** solubility profile of extract was investiga ted in different solvents and at different *** analysis was carried out to determine the type of constituents present in the slim,while acute toxicity test was carried out to evaluate its profile of toxicity the effect of the snail slim on gastrointestinal motility was investigated in mice,while the guinea pig ileum wa used to study the effect of the extract on contraction produced by acetylcholine and *** snail slim contained copious quantity of protein,with varying amounts of simple sugars,carbohydrates and *** slime was not soluble in most common solvents and increases in temperature,did not appear to increase its sol ***:the result further indicated that although the snail slime exhibited significant(P<0.05) an ti -ulcer induced by stress and histamine,it was most potent against ulcer induced by *** snai slime potently inhibited gastrointestinal movement in mice in a dose-dependent manner;however,it was not a ble to inhibit contraction induced by acetylcholine and histamine in guinea pig ***:the snai mucin possesses potent antiulcer properties without any toxic *** mechanism responsible for the anti-ul cer property may not be postulated with certainty but cytoprotective and anti-spasmodic activities are most likel to be involved.

关键词： Anti-ulcer activity Phylum moliusca Snail slime

the RAF family: an expanding network of post-translational controls and protein-protein interactions

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Cell Research 1998年第2期8卷 81-98页

作者： YURYEV ANtON LAWRENCE P WENNOGLE (Novartis Pharmaceuticals Corporation, Summit, nj, USA ) Novartis Pharmaceuticals Corporation Summit USA

Protein kinase RAF is strategically located in the "Ras - MAP-kinase signal transduction pathway". a principle system which transmits signals from growth factor receptors to the nucleus, resulting in cell *** factor responses are mediated in part by activation of Ras, which in turn activates RAF to phosphorylate MEK, its downstream substrate. MEK activates MAPkinase to influence nuclear events. It is clear, however,that a network of signals other than those carried by Ras plays a role in RAF regulation. these orthogonal influences are mediated by: serine/threonifle kinases, tyrosine kinases, and protein - protein interactions. As a further complication to the RAF network, three isoforms of RAF have been established which have divergent N-terminal regulatory domains. Whereas these divergent regulatory domains implicate isoform-specific functions, no clear evidence or hypothesis for distinct functions for individual isoforms has been presented. Recently, "isoform-specific protein interactions" have been identified among numerous proteins interacting with RAF. these studies may serve to delineate independent functions for RAF isoforms.

关键词： an expanding network of post-translational controls and protein-protein interactions the RAF family Cell

High Spectral Efficiency 400G transmission

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ZtE Communications 2012年第1期10卷 3-9页

作者： Xiang Zhou (At&t Labs-Research, Middletown, nj 07748, USA)

this paper gives an overview of the generation and transmission of 450 Gb/s wavelengthdivision multiplexed （WDM） channels over the standard 50 GHz ItU grid at a net spectral efficiency （SE） of 8.4 b/s/Hz. the use of nearly ideal Nyquist pulse shaping, spectrallyefficient highorder modulation format, distributed Raman amplification, distributed compensation of RADM filtering effects, coherent equalization, and highcoding gain forward error correction （FEC） code may enable future 400G systems to operate over the standard 50 GFIz grid optical network.

关键词： spectral efficiency optical modulation format coherent

Post-cholecystectomy symptoms were caused by persistence of a functional gastrointestinal disorder

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World Journal of Gastroenterology 2012年第12期18卷 1365-1372页

作者： Malte Schmidt Karl Sφndenaa John A Dumot Steven Rosenblatt trygve Hausken Maria Ramnefjell Gro njφlstad Geir Egil Eide Department of Surgery Haraldsplass Deaconess HospitalBergen N-5892Norway Digestive Disease Institute Cleveland ClinicClevelandOH 44101United States Department of General Surgery Cleveland ClinicClevelandOH 44101United States Department of Internal Medicine University of BergenBergen 5021Norway Department of Pathology Haukeland University HospitalBergen 5021Norway Department of Microbiology Haukeland University HospitalBergen 5021Norway Center for Clinical Research Haukeland University HospitalBergen 5021Norway Department of Public Health and Primary Care University of BergenBergen 5021Norway

AIM： to classify gallstone disease as a basis for assessment of post-choleolstectomy symptoms.MEtHODS： One hundred and fifty three patients with a clinical and ultrasonographic diagnosis of gallstones filled out a structured questionnaire on abdominal pain symptoms and functional gastrointestinal disorder （FGID） before and at six months after cholecystectomy. Symptom frequency groups （SFG） were categorized according to frequency of pain attacks. According to certain pain characteristics in gallstone patients, a gallstone symptom score was accorded on a scale from one to ten. A visual analogue scale was used to quan- tify pain. Operative specimens were examined for size and magnitude of stone contents as well as presence of bacteria. Follow-up took place after six months with either a consultation or via a mailed questionnaire. Results were compared with those obtained pre-operatively to describe and analyze symptomatic outcome.RESULtS： SFG groups were categorized as severe （24.2%）, moderate （38.6%）, and mild （22.2%） attack frequency, and a chronic pain condition （15%）. Pain was cured or improved in about 90% of patients and two-thirds of patients obtained complete symptom re- lief. Patients with the most frequent pain episodes were less likely to obtain symptom relief. FGID was present in 88% of patients pre-operatively and in 57% postoperatively （P = 0.244）. those that became asymptomatic or improved with regard to pain also had most relief from FGID （P = 0.001）. No pre-operative FGID meant almost complete cure.CONCLUSION： Only one third of patients with FGID experienced postoperative relief, indicating that FGID was a dominant cause of post-cholecystectomy symptoms.

关键词： Gallstone symptoms Functional gastrointes-tinal disease Cholecystectomy Post-cholecystectomysymptoms

Hsp90 regulates processing of NF-κB2 p100 involving protection of NF-κB-inducing kinase (NIK) from autophagy-mediated degradation

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Cell Research 2007年第6期17卷 520-530页

作者： Guoliang QingPengrong YanZhaoxia Qu Hudan LiuGutian Xiao, Department of Cell Biology and Neuroscience, Rutgers, the State University of New Jersey, Piscataway, nj 08854, USA Department of Cell Biology and Neuroscience Rutgers The State University of New Jersey Piscataway USA

NF-κB-inducing kinase (NIK) is required for NF-κB activation based on the processing of NF-κB2 p100. Here wereport a novel mechanism of NIK regulation involving the chaperone 90 kDa heat shock protein (Hsp90) and *** inhibition of Hsp90 by the anti-tumor agent geldanamycin (GA) efficiently disrupts its interaction with NIK,resulting in NIK degradation and subsequent blockage of p100 processing. Surprisingly, GA-induced NIK degradationis mediated by autophagy, but largely independent of the ubiquitin-proteasome system. Hsp90 seems to be specificallyinvolved in the folding/stabilization of NIK protein, because GA inhibition does not affect NIK mRNA transcription andtranslation. Furthermore, Hsp90 is not required for NIK-mediated recruitment of the a subunit of IκB kinase to p100, akey step in induction of p100 processing. these findings define an alternative mechanism for Hsp90 client degradationand identify a novel function of autophagy in NF-κB regulation. these findings also suggest a new therapeutic strategyfor diseases associated with p100 processing.

关键词： autophagy geldanamycin Hsp90 NF-κB2 NIK proteasome-independent degradation

A Parameterization of Cooling Rate Calculation under the Non-LtE Condition: Multi-Level Model

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Advances in Atmospheric Sciences 1989年第4期6卷 403-413页

作者： Xun ZhuProgram in Atmospheric and Oceanic Sciences. P.O. Box 308, Princeton University,Princeton, nj 08542, USA Program in Atmospheric and Oceanic Sciences Princeton University Princeton USA

Calculations of cooling rate by CO2 15 μm band in the earth's upper mesosphere and lower thermosphere be-come very difficult because of the non-LtE. this is primarily due to the nonlinear vibration-vibrational (VV) transition processes between CO, molecules in different states. this paper suggests that the non-LtE source function be parameterized as a linear combination of two limiting source functions. One limiting source function neglects the VV transitions while the other limiting source function assumes VV transitions being dominant. these two limiting source functions can be derived by linear models. the parameterization schemes proposed here can be applied to the general circulation models including those non-LtE regions.

关键词： rate LtE Multi-Level Model

Wavelet transform and Image Processing

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Systems Science and Systems Engineering 1993年第4期3卷 377-384页

作者： CHENG Daizhan Dept. of Math., Rowan College of New Jersey, Glassboro, nj 08028

this paper presents systematically a method for image compression/decompression via wavelet transform. It consists of filter, quantization and Huffman coding etc.. Different methods have been compared. Finally,some su... 详细信息

关键词： image processing wavelet transform quantization coding.

Kirby-Melvin's τ_r'and Ohtsuki's τ for lens spaces

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Chinese Science Bulletin 1999年第5期44卷 423-426页

作者： LI Banghe and LI tianjun Institute of Systems Science, Chinese Academy of Sciences, Beijing 100080, China School of Mathematics, IAS, Princeton nj 08540, USA Institute of Systems Science Chinese Academy of Sciences Beijing China School of Muthematics IAS Princeton USA

Based on the previous results on quantum invariants, explicit formulae for t_r~’ of lens spaces are obtained. As a byproduct, the Ohtsuki invariants of even lens spaces are obtained.

关键词： 3-manifold Witten invariant SO(3) invariant.

Wavelet transform and Image Processing

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Systems Science and Systems Engineering 1994年第1期4卷 1-8页

作者： CHENG Daizhan(Dept.of Math,Rowan College of New Jersey,Glassboro,nj08028)

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关键词： Wavelet