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Urothelial bladder cancer progression: lessons learned from the bench

Journal of Cancer Metastasis and Treatment 2015年第1期1卷 57-66页

作者： Julieta P.Afonso Rui Freitas Francisco Lobo António Morais Jorge Oliveira teresina amaro Rui M.Reis Fátima M.Baltazar Adhemar Longatto-Filho Lúcio L.Santos Life and Health Sciences Research Institute(ICVS) School of Health SciencesUniversity of MinhoCampus de Gualtar4710-057 BragaPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal Department of Urology Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal Experimental Pathology and Therapeutics Research Center Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal Molecular Oncology Research Center Barretos Cancer HospitalCEP 14784-400 BarretosSão PauloBrazil Laboratory of Medical Investigation(LIM 14) Faculty of MedicineSão Paulo State UniversityCEP 01246-000São PauloBrazil Department of Surgical Oncology Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal Faculty of Health Sciences University Fernando PessoaRua Carlos da Maia4200-150 PortoPortugal.

Urothelial bladder carcinoma(UBC)is an intricate malignancy with a variable natural history and clinical *** developments in diagnosis/prognosis refi nement and treatment modalities,the recurrence rate is high,and progression from non-muscle to muscle invasive UBC commonly leads to ***,patients with muscle-invasive or extra-vesical disease often fail the standard chemotherapy treatment,and overall survival rates are ***,UBC remains a challenge in the oncology fi eld,representing an ideal candidate for research on biomarkers that could identify patients at increased risk of recurrence,progression,and ***,progress toward personalized medicine has been hampered by the unique genetic complexity of *** genome-wide expression and sequencing studies have brought new insights into its molecular features,pathogenesis and clinical diversity,revealing a landscape where classical pathology is intersected by the novel and heterogeneous molecular ***,it seems plausible to postulate that only an integrated signature of prognostic/predictive biomarkers inherent in different cancer hallmarks will reach clinical *** this review,we have summarized ours and others’research into novel putative biomarkers of progression and chemoresistance that encompass several hallmarks of cancer:tumor neovascularization,invasion and metastasis,and energy metabolism reprogramming of the tumor microenvironment.

关键词： CD147 lymphovascular invasion mammalian target of rapamycin monocarboxylate transporters progression Raf kinase inhibitor protein scoring system urothelial bladder cancer

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