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Modulation of faecal metagenome in Crohn's disease:Role of microRNAs as biomarkers

World Journal of Gastroenterology 2018年第46期24卷 5223-5233页

作者： María Rojas-Feria teresa romero-garcía Jose Angel Fernández Caballero-Rico Helena Pastor Ramírez Marta Avilés-Recio Manuel Castro-Fernandez Natalia Chueca Porcuna Manuel romero-Gomez Federico garcía Lourdes Grande JoséA Del Campo Department of Digestive Diseases Valme University HospitalUGC Digestive Disease and CIBERehdServicio Andaluz de SaludSeville E-41014Spain Complejo Hospitalario Universitario de Granada MicrobiologyGranada E-18016Spain Institute of Biomedicine of Seville Digestive DiseasesHospital Universitario Virgen del Rocío and CIBERehdSeville E-41013Spain Facultad de ciencias de la salud.Universidad Europea Miguel de Cervantes Madrid E-28280Spain

BACKGROUND The gut microbiota plays a key role in the maintenance of intestinal homeostasis and the development and activation of the host immune system. It has been shown that commensal bacterial species can regulate the expression of host genes. 16 S rRNA gene sequencing has shown that the microbiota in inflammatory bowel disease(IBD) is abnormal and characterized by reduced diversity. Micro RNAs(miRNAs) have been explored as biomarkers and therapeutic targets, since they are able to regulate specific genes associated with Crohn's disease(CD). In this work, we aim to investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut *** To investigate the composition of gut microbiota of active treatment-na?ve adult CD patients, with miRNA profile from gut *** Patients attending the outpatient clinics at Valme University Hospital without relevant co-morbidities were matched according to age and gender. Faecal samples of newonset CD patients, free of treatment, and healthy controls were collected. Faecal samples were homogenized, and DNA was amplified by PCR using primers directed to the 16 S bacterial rRNA gene. Pyrosequencing was performed using GS-Junior platform. For sequence analysis, MGRAST server with the database Ribosomal Project was used. MiRNA profile and their relative abundance were analyzed by quantitative *** Microbial community was characterized using 16 S rRNA gene sequencing in 29 samples(n = 13 CD patients, and n = 16 healthy controls). The mean Shannon diversity was higher in the healthy control population compared to CD group(5.5 vs 3.7). A reduction in Firmicutes and an increase in Bacteroidetes were found. Clostridia class was also significantly reduced in CD. Principal components analysis showed a grouping pattern, identified in most of the subjects in both groups, showing a marked difference between control and CD groups. A functional metabolic study showe

关键词： Crohn’s disease Dysbiosis microRNAs Firmicutes Bacteroidetes

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Sex-specific participation in inter-group conflicts within a multilevel society:the first evidence at the individual level

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Integrative Zoology 2013年第4期8卷 441-454页

作者： Dapeng ZHAO Zhuoyue CHEN Baoguo LI teresa romero Tianjin Key Laboratory of Animal and Plant Resistance College of Life SciencesTianjin Normal UniversityTianjinChina College of Life Sciences Northwest UniversityXi’anChina Institute of Zoology Shaanxi Academy of SciencesXi’anChina Department of Cognitive and Behavioral Science Graduate School of Arts and SciencesUniversity of TokyoTokyoJapan Japan Society for the Promotion of Science ChiyodaTokyoJapan

Inter-group conflicts are common among many group-living animals and involve potentially complex motivations and *** living in multilevel societies offer a good opportunity to study inter-group *** study is the first to explore the function of sex-specific participation during inter-group conflicts within a multilevel society at the individual *** Sichuan snub-nosed monkey(Rhinopithecus roxellana)is an endangered seasonal breeding species living in a multilevel *** Sep 2007 to May 2008 we recorded 290 inter-group conflicts of a free-ranging provisioned band of *** in the Qinling Mountains of China to investigate the function of individual aggression during inter-group *** findings show that adult males were the main participants in inter-group conflicts,while females took part in them only *** male participation rate during the mating season,when adult females were estrous,was significantly higher than that during the non-mating ***,males directed their aggression to other males,and directed more intense aggression towards bachelor males than towards other resident *** both sexes,the participation rate as initiators was higher in the winter than that in the spring;and there was a significant positive correlation between group size and the participation rate as *** results suggest that inter-group aggression in Sichuan snub-nosed monkeys is linked to both mate defense and resource defense.

关键词： inter-group conflict mate defense multilevel society resource defense Rhinopithecus roxellana

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Severe Acute Hepatitis of Unknown Origin in Children: What Do We Know Today?

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Journal of Clinical and Translational Hepatology 2022年第4期10卷 711-717页

作者： María teresa Pérez-Gracia Antonio Tarín-Pelló Beatriz Suay-garcía Área de Microbiología.Departamento de Farmacia Universidad Cardenal Herrera-CEU.CEU UniversitiesAlfara del Patri-arca(Valencia)Spain ESI International Chair@CEU-UCH Departamento de MatemáticasFísica y Ciencias TecnológicasUniversidad Cardenal Herrera-CEUCEU UniversitiesAlfara del Patriarca(Valencia)Spain

In May 2022, the UK International Health Regulations National Focal Point notified World Health Organization of 176 cases of severe acute hepatitis of unknown etiology in children under 10 years of age. From that moment on, cases of severe acute hepatitis of unknown origin in children began to be reported in several countries. As of June 17, 2022, a total of 991 cases had been reported in 35 countries worldwide, 50 children needed a liver transplant and 28 patients died. According to information published by ECDC, 449 cases have been detected in 21 EU countries. The children were between 1 month and 16 years of age. Adenovirus was detected in 62.2% of the analyzed samples. So far, the cause of these cases is unknown and many hypotheses remain open, but hepatitis A-E viruses and COVID-19 vaccines have been ruled out. A possible hypothesis has been published to explain the cause of these cases of severe hepatitis, according to which it could be a consequence of adenovirus infection in the intestine in healthy children previously infected with SARS-CoV-2. No other clear epidemiological risk factors have been identified to date. Thus, at this time, the etiology of the current cases of hepatitis remains under active investigation.

关键词： Hepatitis Children Unknown origin SARS-CoV-2 Adenovirus

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On the effect of pitch and yaw angles in oblique impacts of smallcaliber projectiles

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Defence Technology（防务技术） 2024年第1期31卷 73-94页

作者： teresa Fras French-German Research Institute of Saint-Louis(ISL) Saint-LouisFrance

A terminal ballistic analysis of the effects of 7.62 mm × 51 AP P80 rounds on inclined high-strength armor steel plates is the focus of the presented *** findings of an instrumented ballistic testing combined with 3D advanced numerical simulations performed using the IMPETUS Afea? software yielded the *** experimental verification proved that slight differences in the pitch-andyaw angles of a projectile upon an impact caused different damage types to the projectile’s *** residual velocities predicted numerically were close to the experimental values and the calculated core deviations were in satisfactory agreement with the experimental *** extended matrix of the core deviation angles with combinations of pitch-and-yaw upon impact angles was subsequently built on the basis of the numerical *** presented experimental and numerical investigation examined thoroughly the influence of the initial pitch and yaw angles on the after-perforation projectile’s performance.

关键词： Ballistic impact Small-caliber projectile Pitch and yaw impact angles Shadowgraphy IMPETUS Afea Numerical simulations

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Kinetic study and kinetic parameters of lipase-catalyzed glycerolysis of sardine oil in a homogeneous medium

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Chinese Journal of Catalysis 2016年第4期37卷 596-606页

作者： Angela garcía Solaesa María teresa Sanz Sagrario Beltrán Rodrigo Melgosa 布尔戈斯大学生物技术与食品科学系(化学工程部) 西班牙布尔戈斯09001

The production of polyunsaturated fatty acids （PUFAs） concentrates by enzymatic catalysis has gained interest due to their stereospecificity and the milder conditions employed compared to the use of inorganic catalysts. The enzymatic glycerolysis of sardine oil by Lipozymeò435 to get PUFA concentrates in the forms of di‐and monoacylglycerols （DAGs, MAGs） in an optimized amount of tert‐butanol as the organic solvent was studied. First, mass transfer limitation of the reaction sys‐tem was analyzed. The effects of different operating variables such as lipase loading, temperature and feed composition were investigated. A semi‐empirical kinetic model based on the reversible elementary reactions of glycerolysis and hydrolysis of the glycerides was employed to correlate the experimental kinetic data. A molar ratio glycerol：oil of 3：1 was the optimum, which produced more than 84 wt%of MAG at 323 K. A comparison with other glycerolysis systems was performed using MAG yield, reaction rate and significance of kinetic parameters.

关键词： Lipase Glycerolysis Tert-butanol Mass transfer Kinetic model

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-Calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism:WLB-73502,an analgesic with improved efficacy and safety profile compared to strong opioids

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Acta Pharmaceutica Sinica B 2023年第1期13卷 82-99页

作者： Alba Vidal-Torres Begoña Fernández-Pastor Mónica garcía Eva Ayet Anna Cabot Javier Burgueño Xavier Monroy Bertrand Aubel Xavier Codony Luz romero Rosalía Pascual Maria teresa Serafini Gregorio Encina Carmen Almansa Daniel Zamanillo Manuel Merlos JoséMiguel Vela WeLab Barcelona Parc Cientific de BarcelonaBarcelona 08028Spain

Opioids are the most effective painkillers,but their benefit-risk balance often hinder their therapeutic ***-73502 is a dual,bispecific compound that binds sigma-1(S1R)and mu-opioid(MOR)***-73502 is an antagonist at the *** behaved as a partial MOR agonist at the G-protein pathway and produced no/unsignificantβ-arrestin-2 recruitment,thus demonstrating low intrinsic efficacy on MOR at both signalling *** its partial MOR agonism,WLB-73502exerted full antinociceptive efficacy,with potency superior to morphine and similar to oxycodone against nociceptive,inflammatory and osteoarthritis pain,and superior to both morphine and oxycodone against neuropathic ***-73502 crosses the blood-brain barrier and binds brain S1R and MOR to an extent consistent with its antinociceptive *** to morphine and oxycodone,tolerance to its antinociceptive effect did not develop after repeated 4-week ***,contrary to opioid comparators,WLB-73502 did not inhibit gastrointestinal transit or respiratory function in rats at doses inducing full efficacy,and it was devoid of proemetic effect(retching and vomiting)in ferrets at potentially effective ***-73502 benefits from its bivalent S1R antagonist and partial MOR agonist nature to provide an improved antinociceptive and safety profile respect to strong opioid therapy.

关键词： WLB-73502 Sigma-1 receptor Mu-opioid receptor Biased agonist Analgesic activity Chronic pain Neuropathic pain Safety

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Residual activity of cetrimide and chlorhexidine on Enterococcus faecalis-infected root canals

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International Journal of Oral Science 2014年第1期6卷 46-49页

作者： Carmen María Ferrer-Luque María teresa Arias-Moliz Matilde Ruíz-Linares María Elena Martínez garcía Pilar Baca Department of Stomatology School of Dentistry University of Granada Department of Microbiology School of Dentistry University of Granada

Effective final irrigation regimen is an important step in order to achieve better disinfection and ensure residual antimicrobial effects after root canal preparation. The aim of this study was to compare the residual antimicrobial activity of 0.2% cetrimide, and 0.2% and 2% chlorhexidine in root canals infected with Enterococcus faecalis. Biofilms of E. faecalis were grown on uniradicular roots for 4 weeks. After root canal preparation, root canals were irrigated with 17% ethylenediaminetetraacetic acid （EDTA） to remove the smear layer. The roots were randomly divided into three experimental groups （n=26） according to the final irrigating solution： Group I, 5 mL 0.2% cetrimide; Group II, 5 mL 0.2% chlorhexidine; and Group III, 5 mL 2% chlorhexidine. Samples were collected for 50 days to denote the presence of bacterial growth. The proportion of ungrown specimens over 50 days was evaluated using the nonparametric Kaplan-Meier survival analysis. Differences among groups were tested using the log-rank test and the level of statistical significance was set at P〈0.05. The highest survival value was found with 2% chlorhexidine, showing statistically significant differences from the other two groups. At 50 days, E. faecalisgrowth was detected in 69.23% specimens in Groups I and II, and in 34.61% specimens of Group III. There were no significant differences between 0.2% cetrimide and 0.2% chlorhexidine. Final irrigation with 2% chlorhexidine showed greater residual activity than 0.2% chlorhexidine and 0.2% cetrimide in root canals infected with E. faecalis.

关键词： antimicrobial effects biofilms cetrimide chlorhexidine Enterococcus faecalis final irrigation residual activity

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Current Knowledge on Hepatitis E

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Journal of Clinical and Translational Hepatology 2015年第2期3卷 117-126页

作者： María teresa Pérez-Gracia Mario garcía Beatriz Suay María Luisa Mateos-Lindemann (A)rea de Microbiología Departamento de Farmacia Instituto de Ciencias Biomédicas Facultad de Ciencias de la Salud Universidad CEU Cardenal Herrera Valencia Spain Unidad de Virología Servicio de Microbiología Hospital Universitario Ramóny Cajal Madrid Spain

Although only a single serotype of hepatitis E virus (HEV),the causative agent of hepatitis E,has been identified,there is great genetic variation among the different HEV isolates *** are at least four major recognized genotypes of HEV:genotypes 1 and 2 are mainly restricted to humans and linked to epidemic outbreaks in nonindustrialized countries,whereas genotypes 3 and 4 are zoonotic in both developing and industrialized *** human strains,genotype 3 and 4 strains of HEV have been genetically characterized from swine,sika deer,mongooses,sheep,and ***,there are approximately 11,000 human and animal sequences of HEV available at the International Nucleotide Sequence Database *** is the major cause of waterborne outbreaks of hepatitis in areas of poor ***,it is responsible for sporadic cases of viral hepatitis in not only endemic but industrialized countries as *** of HEV occurs predominantly by the fecal-oral route,although parenteral and perinatal routes have been *** infection develops in most individuals as a self-limiting,acute,icteric hepatitis;with mortality rates around 1%.However,some affected individuals will develop fulminant hepatic failure,a serious condition that is frequently fatal without a liver *** complication is particularly common when the infection occurs in pregnant women,where mortality rates rise dramatically to up to 25%.Among the preventive measures available to avoid HEV infection,two separate subunit vaccines containing recombinant truncated capsid proteins of HEV have been shown to be highly effective in the prevention of *** of them,HEV 239,was approved in China,and its commercialization by Innovax began in November 2012 under the name Hecolin(R).

关键词： Hepatitis E virus Hepatitis E HEV Zoonosis

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On the Perturbation of Semi-Fredholm Relations with Complemented Ranges and Null Spaces

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1545-1554页

作者： teresa LVAREZ Department of Mathematics University of Oviedo

Multivalued semi-Fredholm type linear operators with complemented ranges and null spaces are introduced. Conditions are obtained under which the classes given are stable under compact, strictly singular and strictly c... 详细信息

关键词： Left-Atkinson relation right-Atkinson relation strictly singular strictly cosingular perturbation

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