检索结果-南通市图书馆

C-reactive protein and telomerase reverse transcriptase(TERT)associate with chronic disease markers in a sample from low-income neighborhoods in Detroit,Michigan

引用

Sports Medicine and health Science 2022年第4期4卷 275-279页

作者： David P.Ferguson Eric C.Leszczynski teresa h.horton Karin A.Pfeiffer Joseph Gardiner Amber L.Pearson Department of Kinesiology Michigan State UniversityUnited States Department of Anthropology Northwestern UniversityUnited States Department of Epidemiology and Biostatistics Michigan State UniversityUnited States Department of Geography Environment and Spatial SciencesMichigan State UniversityUnited States

Racial and ethnic minorities in economically deprived inner cities experience high rates of chronic diseases compared to neighborhoods with higher socioeconomic status(SES).however,these economically deprived populations are understudied in terms of biomarkers associated with chronic disease risk which include C-reactive protein(CRP),telomerase reverse transcriptase(TERT),and glycosylated hemoglobin(A1C).We examined relationships between CRP and TERT and chronic disease indicators(body mass index[BMI]and A1C)in two lowincome,predominantly African American(AA)neighborhoods in Detroit,***-nine adults(43 females,26 males,mean age 46 years[y],standard deviation[SD]=15.9)completed a health survey,anthropometry,and finger stick blood tests.A1C was measured using A1CNow test strips,and CRP and TERT levels were measured using enzyme-linked immunosorbent assay(ELISA)with samples extracted from dried blood *** examined CRP(mean=4.9,SD=3.1),TERT(mean=32.5,SD=15.1),and A1C(mean=5.4,SD=1.0)by BMI *** fitted restricted maximum likelihood regression models to evaluate associations between CRP,TERT,BMI,and A1C,after adjustment for demographics and inclusion of a random effect for the *** this predominantly AA sample(91%,63/69),68%had levels of CRP(means=4.8 mg/L,SD=3.0 for AAs;6.4 mg/L,SD=3.9 for all others)indicative of chronic inflammation(CRP greater than 3 mg/L).BMI was significantly associated with CRP(p=0.004)and TERT(p=0.026).TERT levels indicate that being overweight is associated with markers of chromosome remodeling,suggestive of chronic *** followed a similar trend with overweight individuals having higher inflammation and risk of chronic *** findings warrant further exploration of additional factors that may influence CRP and ***,examining populations in a more ethnically and/or economically diverse,yet still high proportion minority,sample will fill a knowledge gap in this understudied field.

关键词： Ethnic minority Inequality Chronic disease Urban Biomarkers

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：