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TRPm2 mediates Hepatic Ischemia–Reperfusion Injury via Ca^(2+) -Induced mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

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Research 2024年第1期2023卷 351-368页

作者： Cheng Zhong Jing Yang Yiyin Zhang Xiaoxiao fan Yang fan Ning Hua Duguang Li Shengxi Jin Yirun Li Peng Chen Yongle Chen Xiaobo Cai Yi Zhang Linhua Jiang wei Yang Peilin Yu Hui Lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouP.R.China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000P.R.China Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University453003 XinxiangHenanP.R.China School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLS29JT LeedsUK Department of Toxicology and Department of medical Oncology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouP.R.China Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020P.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310058P.R.China

Hepatic ischemia–reperfusion(IR)injury is a serious clinical problem that complicates liver resection and *** recent advances in understanding of the pathophysiology of hepatic IR injury,effective interventions and therapeutics are still ***,we examined the role of transient receptor potential melastatin 2(TRPm2),a Ca^(2+)-permeable,non-selective cation channel,in mediating hepatic IR *** data showed that TRPm2 deficiency attenuated IR-induced liver dysfunction,inflammation,and cell death in ***,RNA sequencing analysis indicated that TRPm2-induced IR injury occurs via ferroptosis-related ***,as a ferroptosis inducer,(1S,3R)-RSL3 treatment induced mitochondrial dysfunction in hepatocytes and a TRPm2 inhibitor suppressed ***,TRPm2-mediated calcium influx caused mitochondrial calcium accumulation via the mitochondrial Ca^(2+)-selective uniporter and increased the expression level of arachidonate 12-lipoxygenase(ALOX12),which results in mitochondrial lipid peroxidation during hepatic IR ***,hepatic IR injury-induced ferroptosis was obviously relieved by a TRPm2 inhibitor or calcium depletion,both in vitro and in ***,these findings demonstrate a crucial role for TRPm2-mediated ferroptosis in hepatic IR injury via increased Ca^(2+)-induced ALOX12 expression,indicating that pharmacological inhibition of TRPm2 may provide an effective therapeutic strategy for hepatic IR injury-related diseases,such as during liver resection and transplantation.

关键词： TRPm2 Lipid Hepatic

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Experimental evaluation of factors affecting performance of concentrating photovoltaic/thermal system integrated with phase‐change materials(PV/T‐CPCm)

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Energy Storage and Saving 2024年第1期3卷 30-41页

作者： Zhaoyang Luan Lanlan Zhang Xiangfei Kong Han Li man fan School of Energy and Environmental Engineering Hebei University of TechnologyTianjin300401China School of mechanical Engineering Beijing Institute of TechnologyBeijing100081China

The photovoltaic/thermal(PV/T)system is a promising option for countering energy *** improve the performance of PV/T systems,compound parabolic concentrators(CPCs)and phase-change materials(PCms)were jointly applied to construct a concentrating photovoltaic/thermal system integrated with phase-change materials(PV/T-CPCm).An open-air environment is used to analyze the effects of different parameters and the intermittent operation strategy on the system *** results indicate that the short-circuit current and open-circuit voltage are positively correlated with the solar irradiance,but the open-circuit voltage is negatively correlated with the temperature of the PV *** the solar irradiance is 500 w⋅m^(−2) and the temperature of the PV modules is 27.5℃,the short-circuit current and open-circuit voltage are 1.0 A and 44.5 V,*** solar irradiance results in higher thermal power,whereas the thermal efficiency is under lower solar irradiance(136.2-167.1 w⋅m^(−2) is twice under higher solar irradiance(272.3-455.7 w⋅m^(−2))).In addition,a higher mass flow rate corresponds to a better cooling effect and greater pump energy *** the mass flow rate increases from 0.01 to 0.02 kg⋅s^(-1),the temperature difference between the inlet and outlet decreases by 1.8℃,and the primary energy-saving efficiency decreases by 0.53%.The intermittent operation of a water pump can reduce the energy consumption of the system,and the combination of liquid cooling with PCms provides better thermal regulation and energy-saving effects under various conditions.

关键词： Compound parabolic concentrator Factor analysis Open-air experiment Phase-change materials Photovoltaic/thermal system

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The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

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military medical Research 2024年第3期11卷 323-344页

作者： Ping wu Lin Shen Hui-fan Liu Xiang-Hui Zou Juan Zhao Yu Huang Yu-fan Zhu Zhao-Yu Li Chao Xu Li-Hua Luo Zhi-Qiang Luo min-Hao wu Lin Cai Xiao-Kun Li Zhou-Guang wang Key Laboratory of Imaging Diagnosis and minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and musculoskeletal Tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:most bone-related injuries to grassroots troops are caused by training or accidental *** establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone ***:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)*** physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were *** and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in ***:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated *** to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to m2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECm)mineralization of mC3T3-E1 *** in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury *** underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage m2 ***:The piezoelectric Cs/Gel/PHA/PBT hy

关键词： Piezoelectric hydrogel Tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

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multi-objective structural optimization and degradation model of magnesium alloy ureteral stent

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medicine in Novel Technology and Devices 2024年第2期22卷 19-28页

作者： Lin Zhu Qiao Li Yuanming Gao Lizhen wang Yubo fan Key Laboratory for Biomechanics and mechanobiology of ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of Engineering medicine Beihang UniversityBeijing100191China

Background:mg alloys have attractive properties,including biocompatibility,biodegradability,and ideal mechanical ***,mg alloys are regarded as one of the promising candidates for manufacturing ureteral *** study proposed a multi-objective optimization method based on the Kriging surrogate model,NSGA-III,and finite element analysis to improve the degradation performance of mg alloy ureteral ***:The finite element model for the degradation of mg alloy ureteral stents has been established to compare the degradation performance of the stents under different *** hypercube sampling was adopted to generate train sample points in the design ***,the Kriging surrogate model was constructed between strut parameters and stent degradation *** NSGA-III was utilized to determine the optimal solution in the global design ***:The optimized stent achieved 5.52degradation uniformity(m),10degradation time(DT),and 4work time(FT).The errors between the Kriging surrogate model and the finite element calculation results were less than 6%.Conclusion:The optimized stent achieved better degradation *** degradation behavior of stents was dependent on the design *** multi-objective optimization method based on the Kriging surrogate model and finite element analysis was effective in stent design optimization problems.

关键词： mg alloys ureteral stent Kriging surrogate model NSGA-III multi-objective optimization Degradation model

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Research advances in enhanced coal seam gas extraction by controllable shock wave fracturing

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International Journal of Coal Science & Technology 2024年第3期11卷 1-31页

作者： Chaojun fan Hao Sun Sheng Li Lei Yang Bin Xiao Zhenhua Yang mingkun Luo Xiaofeng Jiang Lijun Zhou College of mining Liaoning Technical UniversityFuxin123000China College of Safety Science and Engineering Liaoning Technical UniversityFuxin123000China Energy Business Department Shanxi Lu’an Chemical GroupChangzhi046200China

with the continuous increase of mining in depth,the gas extraction faces the challenges of low permeability,great ground stress,high temperature and large gas pressure in coal *** controllable shock wave(CSw),as a new method for enhancing permeability of coal seam to improve gas extraction,features in the advantages of high efficiency,eco-friendly,and low *** order to better utilize the CSw into gas extraction in coal mine,the mechanism and feasibility of CSw enhanced extraction need to be *** this paper,the basic principles,the experimental tests,the mathematical models,and the on-site tests of CSw fracturing coal seams are reviewed,thereby its future research directions are *** on the different media between electrodes,the CSw can be divided into three categories:hydraulic effect,wire explosion and excitation of energetic materials by detonating *** the process of propagation and attenuation of the high-energy shock wave in coal,the shock wave and bubble pulsation work together to produce an enhanced permeability effect on the coal *** stronger the strength of the CSw is,the more cracks created in the coal is,and the greater the length,width and area of the cracks *** repeated shock on the coal seam is conducive to the formation of complex network fracture system as well as the reduction of coal seam strength,but excessive shock frequency will also damage the coal structure,resulting in the limited effect of the enhanced gas *** the influence of ground stress,the crack propagation in coal seam will be *** difference of horizontal principal stress has a significant impact on the shape,propagation direction and connectivity of the CSw induced *** permeability enhancement effect of CSw is affected by the breakage degree of coal *** shock wave is absorbed by the broken coal,which may hinder the propagation of CSw,resulting in a poor effect of permeability *** arranging two a

关键词： Controllable shock wave Permeability enhancement Gas extraction Basic principle Experimental test mathematical models On-site test

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Sharp Isolated Toughness Bound for Fractional(k,m)-Deleted Graphs

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Acta mathematicae Applicatae Sinica 2024年

作者： wei GAO wei-fan wANG Yao-jun CHEN Department of mathematics Nanjing University School of Information Science and Technology Yunnan Normal University Department of mathematics Zhejiang Normal University

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Highly dispersed Ru nanospecies on N-doped carbon/mXene composite for highly efficient alkaline hydrogen evolution

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Chinese Chemical Letters 2024年第4期35卷 153-159页

作者： minying wu Xueliang fan wenbiao Zhang Bin Chen Tong Ye Qian Zhang Yuanyuan fang Yajun wang Yi Tang Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative Materialsand Laboratory of Advanced MaterialsFudan UniversityShanghai 200438China College of Chemistry&materials Engineering Wenzhou UniversityWenzhou 325027China

Hydrogen has emerged as a promising environmentally friendly energy source. The development of lowcost, highly active, stable, and easily synthesized catalysts for hydrogen evolution reactions(HER) remains a significant challenge. This study explored the synthesis of nitrogen-doped mXene-based composite catalysts for enhanced HER performance. By thermally decomposing RuCl_(3) coordinated with melamine and formaldehyde resin, we successfully introduced nitrogen-doped carbon(N–C) with highly dispersed ruthenium(Ru) onto the mXene surface. The calcination temperature played a crucial role in controlling the size of Ru nanoparticles(Ru NPs) and the proportion of Ru single-atom(Ru SA), thereby facilitating the synergistic enhancement of HER performance by Ru NPs and Ru SA. The resulting catalyst prepared with a calcination temperature of 600℃, Ti_(3)C_(2)T_x-N/C-Ru-600(TNCR-600), exhibited exceptional HER activity(η10= 17 m V) and stability(160 h) under alkaline conditions. This work presented a simple and effective strategy for synthesizing composite catalysts, offering new insights into the design and regulation of high-performance Ru-based catalysts for hydrogen production.

关键词： HER activity Highly dispersed Ru-based catalysts mXene Alkaline condition

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Solar-assisted photocatalytic water splitting using defective UiO-66 solids from modulated synthesis

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Nano Research 2024年第5期17卷 4134-4150页

作者： Celia m.Rueda-Navarro maría Cabrero-Antonino Paula Escamilla Valentín Díez-Cabanes Dong fan Pedro Atienzar Belén Ferrer Ignacio Vayá Guillaume maurin Herme G.Baldoví Sergio Navalón Departamento de Química Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto de Ciencia molecular(ICmOL) Universitat de ValènciaPaterna 46980Spain ICGm Univ.MontpellierCNRSENSCMMontpellier34095France Instituto de Tecnología Química(UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

metal-organic frameworks(mOFs)are attracting increasing interests as photocatalysts for solar-driven hydrogen production from *** paper reports on a comparative study of using either acetic acid(AA)or trifluoroacetic acid(TFA)as the representative UiO-66 organic modulators for synthesizing visible light responsive UiO-66(Zr)-X(X:NH_(2) or NO_(2))photocatalysts for water *** results show that photocatalytic hydrogen generation from a water/methanol mixture can be improved by varying the nature and amount of the modulator employed to prepare the different UiO-66(Zr)-X(X:NH_(2) or NO_(2))solid ***-66(Zr)-NH_(2) was the most active photocatalyst,followed by UiO-66(Zr)-NO_(2),both prepared with 12 equivalents of AA with respect to the organic *** UiO-66(Zr)-NH_(2) solid was more active than the parent mOF in photocatalytic overall water splitting(OwS)(H_(2) and O_(2) production of 450 and 160μmol·g^(-1),respectively,in 5 h;apparent quantum yield(AQY)at 400 nm of 0.06%)in the absence of methanol and compares favourably with analogous *** on the photocatalytic activity of the most active solids of both series was obtained by means of a series of techniques,including ultraviolet-visible(UV-vis)diffuse reflectance,X-ray photoelectron spectroscopy(XPS),laser flash photolysis(LFP),electron spin resonance(ESR),photoluminescence and photoelectrochemical measurements together with density functional theory(DFT)*** results showed that organic acid modulators can be used to enhance the photocatalytic activity of missing linker UiO-66 defective materials in solar-powered water splitting.

关键词： heterogeneous photocatalysis metal-organic frameworks(mOFs) UiO-66 materials carboxylic acid modulators water splitting solar light

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EHmT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1187-1203页

作者： Yongyun Li Tianyu Zhu Jie Yang Qianqian Zhang Shiqiong Xu Shengfang Ge Renbing Jia Jianming Zhang Xianqun fan Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200001China National Research Center for Translational medicine(Shanghai) State Key Laboratory of Medical GenomicsShanghai Institute of HematologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Translational medicine Zhangjiang Institute for Advanced StudyShanghai Jiao Tong UniversityShanghai 200240China

Constitutive activation of GNAQ/11 is the initiative oncogenic event in uveal melanoma(Um).Direct targeting GNAQ/11 has yet to be proven feasible as they are vital for a plethora of cellular *** search of genetic vulnerability for Um,we found that inhibition of euchromatic histone lysine methyltransferase 2(EHmT2)expression or activity significantly reduced the proliferation and migration capacity of cancer ***,elevated expression of EHmT2 had been validated in Um ***,Kaplan-meier survival analysis indicated high EHmT2 protein level was related to poor recurrence-free survival and a more advanced T *** immunoprecipitation sequencing analysis and the following mechanistic investigation showed that ARHGAP29 was a downstream target of *** transcription was suppressed by EHmT2 in a methyltransferasedependent pattern in GNAQ/11-mutant Um cells,leading to elevated RhoA *** constitutively active RhoA in Um cells lacking EHmT2 restored oncogenic *** blocking EHmT2 and GNAQ/11 signaling in vitro and in vivo showed a synergistic effect on Um growth,suggesting the driver role of these two key *** summary,our study shows evidence for an epigenetic program of EHmT2 regulation that influences Um progression and indicates inhibiting EHmT2 and mEK/ERK simultaneously as a therapeutic strategy in GNAQ/11-mutant Um.

关键词： Uveal melanoma EHmT2 RhoA pathway ARHGAP29 G protein GNAQ GNA11

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Accurate Shortwave Radiation Simulation with a Two-Layer Aerosol model in Xinjiang Region

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Journal of meteorological Research 2024年第1期38卷 69-87页

作者： Guan HUANG Yonghang CHEN Qiong LIU Pengtao wANG Qianshan HE Qing HE Shuai LI weiling SHAO Ting fan School of Tourism&Research Institute of Human Geography Xi’an International Studies UniversityXi’an 710128 Center for Silk Road and Eurasian Civilization Studies Xi’an International Studies UniversityXi’an 710128 College of Environmental Science and Engineering Donghua UniversityShanghai 201620 Shanghai meteorological Service Shanghai 200030 Shanghai Key Laboratory of meteorology and Health Shanghai 200030 Taklimakan Desert meteorology Field Experiment Station of China meteorological Administration Institute of Desert MeteorologyUrumqi 830002 Xinjiang Climate Centre Xinjiang Meteorological ServiceUrumqi 830002

To harness the rich solar energy resources in Xinjiang Region of Northwest China,this study tries to address the issue of lack of downward surface shortwave radiation(DSSR)observations and the need to improve the accuracy of satellite retrieval and numerical simulation of DSSR under varied sky and meteorological conditions.(1)A two-layer aerosol model specific to Xinjiang was developed to capture the vertical distributions of aerosols based on multiple data sources including lidar,GPS sounding,ground meteorological observations,and profiles from the ECmwF reanalysis version 5(ERA5)*** results show that the ERA5/PBLH(planetary boundary layer height)and ERA5/ALH(aerosol layer height)could be used to establish the two-layer aerosol model and characterize the vertical distribution of aerosols in Xinjiang Region.(2)Using the Santa Barbara Discrete Atmospheric Radiative Transfer(SBDART)model,a localized inverse model of clear-sky DSSR was *** parameter adjustment and using the optimal combination of input parameters for DSSR simulation together with the two-layer aerosol model,the model-simulated DSSR(DSSRSBD)under clear-sky conditions improved significantly compared to the initial results,with all fitting indices greatly improved.(3)In addition,the study demonstrated that the impact of the two-layer aerosol model on DSSR was more pronounced under dust conditions than clear-sky conditions.(4)Using the localized clear-sky DSSR inversion model and its required parameters,simulations were also conducted to capture the spatiotemporal distribution of DSSR under clear-sky conditions in Xinjiang from 2017 to *** annual average DSSR_(SBD)under clear-sky conditions in Xinjiang during 2017–2019 was 606.78 w m^(-2),while DSSR from CERES(DSSR_(CER))under the same conditions was generally higher(703.95 w m^(-2)).(5)It is found that satellite remote sensing products experienced data loss in high-altitude snow areas,where numerical simulation technology could ser

关键词： downward surface shortwave radiation(DSSR) aerosol vertical distribution Clouds and the Earth’s Radiant Energy System(CERES) Santa Barbara Discrete Atmospheric Radiative Transfer(SBDART) Xinjiang

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