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The unclear role of VEGF in POEMS syndrome: therapeutic implications of neoangiogenesis in a rare plasma cell disorder

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 809-814页

作者： Gianfranco Lapietra Francesca Fazio Maria teresa petrucci Hematology Department of Translational and Precision MedicineSapienza UniversityRome 00161Italy.

POEMS syndrome is a rare paraneoplastic disorder due to an underlying clone of aberrant plasma *** name POEMS is an acronym for some of the major disease manifestations,namely polyneuropathy,organomegaly,endocrinopathy,presence of monoclonal component,and skin *** clinical presentation can be various and could lead to delayed diagnosis and *** is known about the pathogenic mechanism,although the neoangiogenesis due to overproduction of vascular endothelial growth factor(VEGF)by plasma cells seems to play a key *** latest evidence suggests that the blood concentration of this cytokine correlates with the activity of the syndrome:VEGF could then be used as a therapeutic target and a marker to monitor *** case reports have shown the efficacy of this approach,but extended studies are required to better define the use of anti VEGF in patients affected by POEMS syndrome.

关键词： POEMS syndrome VEGF anti-VEGF plasma cell disorder

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qSanger:Quantification of Genetic Variants in Bacterial Cultures by Sanger Sequencing

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BioDesign Research 2023年第1期5卷 49-57页

作者： Satya Prakash Adrian Racovita teresa petrucci Roberto Galizi Alfonso Jaramillo School of Life Sciences University of WarwickCoventryUK. De Novo Synthetic Biology Lab I2SysBioCSIC-University of ValenciaPaternaSpain. Department of Biotechnology Chemistry and PharmacyUniversity of SienaSienaItaly. Centre for Applied Entomology and Parasitology School of Life SciencesKeele UniversityKeeleUK.

Genetic variations such as mutations and recombinations arise spontaneously in all cultured *** it is possible to identify nonneutral mutations by selection or counterselection,the identification of neutral mutations in a heterogeneous population usually requires expensive and time-consuming methods such as quantitative or droplet polymerase chain reaction and high-throughput *** mutations could even become dominant under changing environmental conditions enforcing transitory selection or *** propose a novel method,which we called qSanger,to quantify DNA using amplitude ratios of aligned electropherogram peaks from mixed Sanger sequencing *** expressing enhanced green fluorescent protein and mCherry fluorescent markers were used to validate qSanger both in vitro and in cotransformed Escherichia coli via quantitative polymerase chain reaction and fluorescence *** show that qSanger allows the quantification of genetic variants,including single-base natural polymorphisms or de novo mutations,from mixed Sanger sequencing reads,with substantial reduction of labor and costs compared to canonical approaches.

关键词： neutral consuming transformed

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