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Setting a highway for converting skin into neurons

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分子细胞生物学报:英文版 2011年第6期3卷 322-323页

作者： Vania Broccoli Massimiliano Caiazzo Maria teresa Dell’Anno San Raffaele Scientific Institute Via Olgettina 58Milan 20132Italy

Direct conversion of human skin fibroblasts into induced neuronal(iN)cells has been recently achieved by using different combi-nations of transcription factors eventually associated with *** findings lay the ground for a straightforward and effi-cient generation of human neurons in vitro with elaborated functional properties instrumental for disease modeling and cell-based approaches of brain repair.

关键词： eventually straight finding

Early life stress-induced neuroinflammation and neurological disorders: a novel perspective for research

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Neural Regeneration Research 2022年第9期17卷 1971-1972页

作者： Clarissa Catale Valeria Carola Maria teresa Viscomi Division of Experimental Neuroscience IRCCS Santa Lucia FoundationRomeItaly Department of Dynamic and Clinical Psychology and Health StudiesSapienza University of RomeRomeItaly Department of Life Science and Public Health Section of Histology and EmbryologyUniversitàCattolica del S.CuoreRomeItaly

Childhood maltreatment(CM)has been consistently linked with numerous detrimental outcomes concerning physical and psychological ***,few studies have explored vulnerability to neurological disorders after *** life adversity,in the form of poverty,stress and abuse,has been associated with decline in cognitive function and dementia later in life(Short and Baram,2019).Robust preclinical data suggest that early life stress(ELS)may increase the risk and worsen the course of neurological disorders such as Alzheimer’s(AD)and Parkinson’s(PD)diseases,and traumatic brain injury(TBI)(Lesuis et al.,2018;Short and Baram,2019;He et al.,2020;Catale et al.,2021;Sanchez et al.,2021).

关键词： neurological disorders inflammation

Evaluation of the ability of arsenic species to traverse cell membranes by simple diffusion using octanol-water and liposome-water partition coefficients

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Journal of Environmental Sciences 2016年第11期28卷 222-232页

作者： teresa Chavez-Capilla William Maher Tamsin Kelly Simon Foster Ecochemistry Laboratory Institute for Applied Ecology University of Canberra Canberra ACT 2601 Australia National Centre for Forensic Studies Faculty of Education Science Technology and Mathematics University of Canberra CanberraACT 2601 Australia

Arsenic metabolism in living organisms is dependent on the ability of different arsenic species to traverse biological membranes. Simple diffusion provides an alternative influx and efflux route to mediated transport mechanisms that can increase the amount of arsenic available for metabolism in cells. Using octanol-water and liposome-water partition coefficients, the ability of arsenous acid, arsenate, methylarsonate, dimethylarsinate, thio-methylarsonate, thiodimethylarsinic acid, arsenotriglutathione and monomethylarsonic diglutathione to diffuse through the lipid bilayer of cell membranes was investigated. Molecular modelling of arsenic species was used to explain the results. All arsenic species with the exception of arsenate, methylarsonate and thio-methylarsonate were able to diffuse through the lipid bilayer of liposomes, with liposome-water partition coefficients between 0.04 and 0.13. Trivalent arsenic species and thio-pentavalent arsenic species showed higher partition coefficients, suggesting that they can easily traverse cell membranes by passive simple diffusion. Given the higher toxicity of these species compared to oxo-pentavalent arsenic species, this study provides evidence supporting the risk associated with human exposure to trivalent and thio-arsenic species.

关键词： ArsenicLiposomesPartition coefficientsPassive simple diffusionTrivalent arsenic speciesThio-arsenic species

Life on Earth teresa Audesirk, Gerald Audesirk, Bruce E. Byers 4th ed.

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Analyzing the role of extracellular matrix during nervous system development to advance new regenerative strategies

2006年

作者： teresa Audesirk Gerald Audesirk Bruce E. Byers

Includes index.

ISBN: (纸本)0131469126

Includes index.

关键词： Biology.

来源：畅想之星图书光盘版（南... 评论

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Neural Regeneration Research 2017年第4期12卷 566-567页

作者： teresa Caprile Hernán Montecinos Axon Guidance Laboratory Department of Cell Biology Faculty of Biological Sciences Universidad de Concepción

Regeneration in the central nervous system （CNS） is limited, and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss. Impaired regenerative capacity is multifactorial and includes inflammation, loss of the blood-brain barrier, and alteration in the extracellular matrix （ECM）. One of the main problems is the formation of a glial scar and the production of inhibitory ECM, such as proteoglycans, that generates a physical and mechanical barrier, impeding axonal regrowth （Figure 1A）.

关键词： ECM Analyzing the role of extracellular matrix during nervous system development to advance new regenerative strategies

Glycoproteins and glycoproteomics in pancreatic cancer

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World Journal of Gastroenterology 2016年第42期22卷 9288-9299页

作者： Sheng Pan teresa A Brentnall Ru Chen Department of Medicine University of Washington

Aberrations in protein glycosylation and polysaccharides play a pivotal role in pancreatic tumorigenesis, influencing cancer progression, metastasis, immunoresponse and chemoresistance. Abnormal expression in sugar moieties can impact the function of various glycoproteins, including mucins, surface receptors, adhesive proteins, proteoglycans, as well as their effectors and binding ligands, resulting in an increase in pancreatic cancer invasiveness and a cancerfavored microenvironment. Recent advance in glycoproteomics, glycomics and other chemical biology techniques have been employed to better understand the complex mechanism of glycosylation events and how they orchestrate molecular activities in genomics, proteomics and metabolomics implicated in pancreatic adenocarcinoma. A variety of strategies have been demonstrated targeting protein glycosylation and polysaccharides for diagnostic and therapeutic development.

关键词： Glycoproteins Glycosylation Proteomics Glycoproteomics Pancreatic cancer Pancreatic ductal adenocarcinoma

The sequestrate genus Rosbeeva ***&Orihara ***.(Boletaceae)from Australasia and Japan:new species and new combinations

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Fungal Diversity 2012年第1期52卷 49-71页

作者： teresa Lebel Takamichi Orihara Nitaro Maekawa National Herbarium of Victoria Royal Botanic Gardens MelbournePrivate Bag 2000Birdwood AveSouth YarraVIC 3141Australia The United Graduate School of Agriculture Sciences Tottori University4–101 Koyama-cho-minamiTottori 680–8553Japan Fungus/Mushroom Resource and Research Center Faculty of AgricultureTottori University4–101 Koyama-cho-minamiTottori 680–8553Japan Kanagawa Prefectural Museum of Natural History 499 IriudaOdawara-shiKanagawa 250–0031Japan

The sequestrate genus Chamonixia has been shown to have affinities to the Boletales,in particular the genus *** and Japanese species of Chamonixia were examined using morphological and molecular(ITS and nLSU rDNA)data and found to also have affinities with Leccinum and Leccinellum,however they form a distinct clade separate from the European type species *** Rolland and North American species.A new genus,Rosbeeva ***&Orihara ***.,is proposed for the Australasian,Japanese and Chinese *** species ***(Petri)*** *** restricted in distribution to Singapore and Borneo,and ***(Zeller&***)*** *** New Zealand,with Australian collections considered to belong to a revised ***(***,Pegler&***)*** *** a new species *** *** *** Chinese species ***(***&***)***&Orihara *** is transferred to the new genus based upon morphological *** new species from Japan,Rosbeeva eucyanea Orihara and *** Orihara,are also described and illustrated.A key to all species of Rosbeeva is *** to the highly modified gastroid sporocarp forms of both Chamonixia and Rosbeeva,many macroscopic characters of use in agaricoid taxonomy are difficult to ***,color change and texture of sporocarps are of some use to distinguish genera and *** characters such as spore shape,dimensions,and ornamentation,and pileipellis and hymenophoral trama structure,are essential for determining genera and species.

关键词： Chamonixia Sequestrate fungi Leccinum Systematics Octaviania

Estrogen/Huntingtin:a novel pathway involved in neuroprotection

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Neural Regeneration Research 2016年第3期11卷 402-403页

作者： Maria teresa Nuzzo Maria Marino Department of Science-Division of Biomedical Sciences and Technologies University Roma Tre

Neurodegenerative diseases（NDs）include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive *** pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress,programmed cell death or abnormal protein aggregation,trafficking,and/or *** most cases,

关键词： programmed mitochondrial pathogenesis progressively aggregation oxidative abnormal neuronal caspase physiological

Sepsis during short bowel syndrome hospitalizations:Identifying trends,disparities,and clinical outcomes in the United States

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World Journal of Gastrointestinal Pathophysiology 2024年第1期15卷 26-36页

作者： Dushyant Singh Dahiya Jennifer Wachala Shantanu Solanki Dhanshree Solanki Asim Kichloo Samantha Holcomb Uvesh Mansuri Khwaja Saad Haq Hassam Ali Manesh Kumar Gangwani Yash R Shah teresa Varghese Hafiz Muzaffar Akbar Khan Simon Peter Horslen Thomas D Schiano Syed-Mohammed Jafri Division of Gastroenterology Hepatology&MotilityThe University of Kansas School of MedicineKansas CityKS 66160United States Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Division of Gastroenterology Hepatology&Nutrition The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Medicine Institute for Foreign Medical Graduate EducationHoustonTX 77030United States Department of Internal Medicine MedStar Harbor HospitalBaltimoreMD 21225United States Department of Internal Medicine WellStar Spalding Regional HospitalGriffinGA 30224United States Division of Gastroenterology Hepatology and NutritionEast Carolina University/Brody School of MedicineGreenvilleNC 27858United States Department of Gastroenterology and Hepatology University of Arkansas for Medical SciencesLittle RockAR 72205United States Department of Internal Medicine Trinity Health Oakland/Wayne State UniversityPontiacMI 48341United States Division of Gastroenterology and Hepatology SUNY Upstate Medical UniversitySyracuseNY 13210United States Department of Pediatrics School of Medicine and UPMC Children’s Hospital of PittsburghUniversity of PittsburghPittsburghPA 15219United States Division of Liver Diseases Icahn School of Medicine at Mount SinaiNew YorkNY 10029United States Division of Gastroenterology and Hepatology Henry Ford HospitalDetroitMI 48202United States

BACKGROUND Short bowel syndrome(SBS)hospitalizations are often complicated with *** is a significant paucity of data on adult SBS hospitalizations in the United States and across the *** To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United *** The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between *** study cohort was further divided based on the presence or absence of *** were identified,and hospitalization characteristics and clinical outcomes were *** of mortality for SBS hospitalizations complicated with sepsis were *** Of 247097 SBS hospitalizations,21.7%were complicated by *** SBS hospitalizations had a rising trend of hospitalizations from 20.8%in 2005 to 23.5%in 2014(P trend<0.0001).Compared to non-septic SBS hospitalizations,septic SBS hospitalizations had a higher proportion of males(32.8%vs 29.3%,P<0.0001),patients in the 35-49(45.9%vs 42.5%,P<0.0001)and 50-64(32.1%vs 31.1%,P<0.0001)age groups,and ethnic minorities,i.e.,Blacks(12.4%vs 11.3%,P<0.0001)and Hispanics(6.7%vs 5.5%,P<0.0001).Furthermore,septic SBS hospitalizations had a higher proportion of patients with intestinal transplantation(0.33%vs 0.22%,P<0.0001),inpatient mortality(8.5%vs 1.4%,P<0.0001),and mean length of stay(16.1 d vs 7.7 d,P<0.0001)compared to the non-sepsis cohort.A younger age,female gender,White race,and presence of comorbidities such as anemia and depression were identified to be independent predictors of inpatient mortality for septic SBS *** Septic SBS hospitalizations had a rising trend between 2005-2014 and were associated with higher inpatient mortality compared to non-septic SBS hospitalizations.

关键词： Short bowel syndrome Sepsis Outcomes Mortality Trends