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Management of oligometastatic non-small cell lung cancer patients:Current controversies and future directions

World Journal of Clinical Oncology 2019年第10期10卷 318-339页

作者： Felipe Counago Javier Luna Luis Leonardo Guerrero Blanca Vaquero María Cecilia Guillén-Sacoto teresa gonzález-merino Begona Taboada Verónica Díaz Belén Rubio-Viqueira Ana Aurora Díaz-Gavela Francisco JoséMarcos Elia del Cerro Department of Radiation Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain Department of Radiation Oncology Hospital La LuzMadrid 28003Spain Clinical Department Faculty of BiomedicineUniversidad EuropeaMadrid 28223Spain Department of Radiation Oncology Hospital Fundación Jiménez DíazMadrid 28040Spain Department of Medical Oncology Hospital La LuzMadrid 28003Spain Department of Radiation Oncology Complexo Hospitalario Universitario Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology Hospital Universitario Puerta del MarCádiz 11009Spain Department of Medical Oncology Hospital Universitario Quirónsalud MadridPozuelo de AlarcónMadrid 28223Spain

Oligometastatic non-small cell lung cancer(NSCLC)describes an intermediate stage of NSCLC between localized and widely-disseminated *** stage of NSCLC is characterized by a limited number of metastases and a more indolent tumor ***,the management of oligometastatic NSCLC involves radical treatment(radiotherapy or surgery)that targets the metastatic lesions and the primary tumor to achieve disease *** approach offers the potential to achieve prolonged survival in patients who,in the past,would have only received palliative *** optimal therapeutic strategies for the different scenarios of oligometastatic disease(intracranial vs extracranial disease,synchronous vs metachronous)remain *** the lack of head-to-head studies comparing radiotherapy to surgery in these patients,the decision to apply surgery or radiotherapy(with or without systemic treatment)must be based on prognostic factors that allow us to classify *** classification will allow us to select the most appropriate therapeutic strategy on an individualized *** the future,the molecular or microRNA profiles will likely improve the treatment selection *** objective of the present article is to review the most relevant scientific evidence on the management of patients with oligometastatic NSCLC,focusing on the role of radiotherapy and *** also discuss areas of controversy and future directions.

关键词： Non-small cell lung cancer Metastasectomy Oligometastases Stereotactic ablative radiotherapy Stereotactic body radiation therapy Radiosurgery

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Acquired hepatocerebral degeneration in a metastatic neuroendocrine tumor long-term survivor——an update on neuroendocrine neoplasm’s treatment:A case report

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World Journal of Hepatology 2021年第5期13卷 611-619页

作者： Oriol Mirallas Nadia Saoudi Diego Gómez-Puerto Mar Riveiro-Barciela Xavier merino Cristina Auger Stefania Landolfi Laia Blanco Amparo Garcia-Burillo Xavier Molero Maria teresa Salcedo-Allende Jaume Capdevila Medical Oncology Department Vall d'Hebron University HospitalVall Hebron Institute of OncologyBarcelona 08035CatalunyaSpain Liver Unit Department of Internal MedicineCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasHospital Universitari Vall d'HebronUniversitat Autònoma de BarcelonaBarcelona 08035CatalunyaSpain Radiodiagnostic Department Vall d’Hebron University HospitalBarcelona 08035CatalunyaSpain Pathology Department Vall d'Hebron University HospitalBarcelona 08035CatalunyaSpain Hepatobiliopancreatic Surgery and Transplantation Department Vall d'Hebron University HospitalBarcelona 08034CatalunyaSpain Nuclear Medicine Department Vall d'Hebron University HospitalBarcelona 08035CatalunyaSpain

BACKGROUND Metastatic small bowel low-grade neuroendocrine tumors(NETs)have a good *** is the only curative treatment;however,this may induce advanced liver disease,particularly in long-term survivor *** hepatocerebral degeneration or Parkinsonism in cirrhosis is characterized by rapidly progressive extrapyramidal symptoms in patients with advanced liver *** SUMMARY A 70-year-old man presented to the emergency department with diminished consciousness and disorientation,and was diagnosed with hepatic *** patient was diagnosed in 1993 with a metastatic small bowel NET,for which he twice underwent hepatic surgery,with metastatic resection in 1993 and a right hepatectomy in 2002 to remove two hepatic *** 2003,the patient started first-line chemotherapy and in 2004 started the first of three consecutive biological treatments,followed by radio-molecular therapy,achieving stable disease for 14 *** progression was identified and he underwent an endoscopic retrograde ***,in 2019 advanced liver disease was *** diagnosed the development of acquired hepatocerebral degeneration,an unusual long-term side effect after multiple hepatic *** The importance of regular and ongoing surveillance in long-term NET survivors who undergo hepatic procedures should be integrated into the therapeutic management plan,as some of these negative outcomes could be prevented.

关键词： Neuroendocrine tumors Hepatocerebral degeneration Parkinsonism Somatostatin analogues Everolimus Hepatic metastases Peptide radionuclide receptor therapy Encephalopathy Paramagnetic deposits Case report

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