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Immunotherapy-induced Hepatotoxicity:A Review

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1194-1204页

作者： teresa Da Cunha George Y.Wu Haleh Vaziri Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Immune checkpoint inhibitors(ICIs)suppress the func-tion of immune checkpoints,which are involved in down-regulating immune *** lead to an increased activation of the function of T cells,increased release of cytokines,and decreased activity of regulatory T *** allows for a more significant and less regulated im-mune response and subsequent enhanced cytotoxic activity against cancer cells.A number of cancers are now being treated with these agents and this increased use has re-sulted in more reports of *** almost every organ can be affected,the skin,gastrointestinal tract,liver,and endocrine glands are most commonly *** is neces-sary that gastroenterologists and hepatologists familiarize themselves with diagnostic steps and management plan in patients with these undesirable *** assessing for possible ICIs induced hepatotoxicity,it is of utmost im-portance to use a formal scoring system such as the Rous-sel Uclaf causality assessment method(RUCAM)to assess for risk factors,alternative causes,and response to cessa-tion and re-exposure of a given *** this review is based on studies with and without RUCAM,the conclusions were carefully established mainly from studies that used *** aim of this review is to provide information on the epidemiology,risk factors,clinical presentation,di-agnostic tools,and management plan based on the most recent studies of immunotherapy-induced hepatotoxicity.

关键词： Immune checkpoint inhibitors Immunotherapy Hepatitis Liver injury.

Hepatic failure caused by plasma cell infiltration in multiple myeloma

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World Journal of Gastroenterology 2009年第16期15卷 2038-2040页

作者： Fadi E Rahhal Robert R Schade Asha Nayak teresa A Coleman Section of Gastroenterology Department of MedicineMedical College of GeorgiaSchool of Medicine Section of Hematology/Oncology Department of MedicineMedical College of GeorgiaSchool of Medicine

Although plasma cell infiltration is not rare in autopsy of patients with multiple myeloma （MM）, it is very rarely detected in living patients. This is because MM rarely causes significant liver dysfunction that requires further evaluation. A 49-year-old man presented with acute renal failure and was diagnosed with kappa light chain MM stageⅡB. Thalidomide and dexamethasone were initiated. The patient developed a continuous increase in bilirubin that led to severe cholestasis. A liver biopsy revealed plasma cell infiltration. He then rapidly progressed to liver failure and died. Treatment options are limited in MM with significant liver dysfunction. Despite new drug therapies in MM, those patients with rapidly progressive liver failure appear to have a dismal outcome.

关键词： Hepatic failure Multiple myeloma Cell infiltration

Chemical and minero-petrographical changes on granulite rocks affected by weathering processes

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Frontiers of Earth Science 2019年第2期13卷 247-261页

作者： Carmine APOLLARO Francesco PERRI Emilia LE PERA Ilaria FUOCO teresa CRITELLI DiBEST University of Calabria1-87036 Arcavacata di Rende (CS)Italy

The purpose of this work is to study the weathering processes of the granulite rocks of the Serre Massif (southern Calabria,Italy) using a multidisciplinary approach based on field studies,geochemical modeling,and minero?petrographical *** granulite rocks are plagioclase-rich with minor amphibole,clinopyroxene,orthopyroxene,biotite,and garnet and their texture are *** reaction path modeling was performed to simulate the evolution of groundwaters upon interaction with local granulite by means of the software package EQ3/6,version *** were performed in kinetic (time) mode under a closed system at a constant temperature of 11.5℃,(which reproduces the average temperature of local area) and fixing the fugacity of CO2 at 10-2.34 bar (mean value).During the most advanced stage of weathering the main mineralogical changes are: partial destruction and transformation of biotite and plagioclase associated with neoformation of ferruginous products and secondary clay minerals producing a change in the origin rock *** secondary solid phases observed during the geochemical modeling (kaolinite,vermiculite and ferrihydrite) are similar to those found in this natural ***,the soil-like material mainly characterized by mostly sand to gravel grain-size fractions is the final result of the weathering processes.

关键词： Serre Massif granulitic rocks mineralogy petrography weathering profile reaction path-modeling

Introduction to the special issue on “COVID-19”

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Geoscience Frontiers 2022年第6期13卷 208-209页

作者： Luis F.O.Silva Weijun Li teresa Moreno Department of Civil and Environmental Universidad de la CostaCUC Department of Atmospheric Sciences School of Earth SciencesZhejiang University Institute for Environmental Assessment and Water Research Consejo Superior de Investigaciones Científicas

COVID-19 pandemic is wreaking havoc and bringing the whole world into a standstill in an unprecedented fashion. Joint efforts from multiple sectors to address the various aspects of environment and public health through usage of green technologies have become essential. The application of cleaner and effective technologies can be expanded to management and control, pollution mitigation and valorization of waste. In this Special Issue of Geoscience Frontiers, we present contributions addressing the interactions of COVID-19 in relation to environment and human health.

关键词： bringing expanded COV

Differential diagnosis of uterine vascular anomalies:Uterine pseudoaneurysm as a cause of massive hemorrhage

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World Journal of Clinical Cases 2025年第9期13卷 60-64页

作者： teresa Gastañaga-Holguera Isabel Campo Gesto Laura Gómez-Irwin Marta Calvo Urrutia Department of Obstetrics and Gynecology San Carlos Clinical HospitalMadrid 28040Spain Department of Gastroenterology University Hospital of CrucesBaracaldo 48903BizkaiaSpain

In this article,we comment on the paper by Kakinuma et al published *** focus specifically on the diagnosis of uterine pseudoaneurysm,but we also review other uterine vascular anomalies that may be the cause of life-threating hemorrhage and the different causes of uterine *** artery pseudoaneurysm is a complication of both surgical gynecological and nontraumatic *** hemorrhage is the consequence of the rupture of the *** artery pseudoaneurysm can develop after obstetric or gynecological procedures,being the most frequent after cesarean or vaginal deliveries,curettage and even during ***,there are several cases described unrelated to pregnancy,such as after conization,hysteroscopic surgery or laparoscopic *** is the clinical manifestation and it can be life-threatening so suspicion of this vascular lesion is essential for early diagnosis and ***,there are other uterine vascular anomalies that may be the cause of severe hemorrhage,which must be taken into account in the differential *** tomography angiography and embolization is supposed to be the first therapeutic option in most of them.

关键词： Uterine artery pseudoaneurysm Vascular anomaly Uterine vascular malformation Massive hemorrhage Postpartum hemorrhage Angiography Uterine embolization Transarterial embolization

Bioluminescent nanopaper for rapid screening of toxic substances

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Nano Research 2018年第1期11卷 114-125页

作者： Jie Liu Eden Morales-Narvaez Jahir Orozco teresa vicent Guohua Zhong Arben Merkoci Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and the Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain Laboratory of Insect Toxicology Key Laboratory of Pesticide and Chemical Biology Ministry of Education South China Agricultural University Guangzhou 510642 China Departamentd'Enginyeria Quimica UniversitatAutOnoma de Barcelona Bellaterra Barcelona 08193 Spain ICREA Pg. Llufs Companys 23 08010 Barcelona Spain

Environmental pollution is threatening human health and ecosystems as a result of modern agricultural techniques and industrial progress. A simple nanopaper-based platform coupled with luminescent bacteria Aliivibrio Jischeri （A. Jischeri） as a bio-indicator is presented here, for rapid and sensitive evaluation of contaminant toxicity. When exposed to toxicants, the luminescence inhibition of A. Jischeri-decorated bioluminescent nanopaper （BLN） can be quantified and analyzed to classify the toxicity level of a pollutant. The BLN composite was characterized in terms of morphology and functionality. Given the outstanding biocompatibility of nanocellulose for bacterial proliferation, BLN achieved high sensitivity with a low cost and simplified procedure compared to conventional instruments for laboratory use only. The broad applicability of BLN devices to environmental samples was studied in spiked real matrices （lake and sea water）, and their potential for direct and in situ toxicity screening was demonstrated. The BLN architecture not only survives but also maintains its function during freezing and recycling processes, endowing the BLN system with competitive advantages as a deliverable, ready-to-use device for large-scale manufacturing. The novel luminescent bacteria-immobilized, nanocelullose-based device shows outstanding abilities for toxicity bioassays of hazardous compounds, bringing new possibilities for cheap and efficient environmental monitoring of potential contamination.

关键词： bacterial nanocellulose nanopaper Aliivibrio jqscheri bioluminescent device toxicity bioassay

Epigenomic mediation after adverse childhood experiences:a systematic review and meta-analysis

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Forensic Sciences Research 2021年第2期6卷 103-114页

作者： Inês Neves Ricardo Jorge Dinis-Oliveira teresa Magalhaes Department of Public Health and Forensic Sciences and Medical EducationFaculty of MedicineUniversity of PortoPortoPortugal IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies Department of SciencesUniversity Institute of Health Sciences(IUCS)CESPUCRLGandraPortugal UCIBIO REQUIMTELaboratory of ToxicologyDepartment of Biological SciencesFaculty of PharmacyUniversity of PortoPortoPortugal

Epigenetic mechanisms are potential mediators of the physiological response to abuse by altering the genetic predisposition of the cellular response to the environment,leading to changes in the regulation of multiple organ *** study was established to review the epigenetic mechanisms associated with childhood abuse as well as the long-term deter-minants that these epigenetic changes may have on future *** retrospectively ana-lysed the effect of exposure to adverse childhood experiences(ACEs,specifically those relating to childhood maltreatment)between the ages of 0 and 16years on the human epi-genome,as well as possible clinical *** meeting inclusion and exclusion crite-ria,36 articles were included in this systematic *** of these studies did not find a relationship between childhood maltreatment and DNA *** the remaining 28 studies,nine were genome-wide association studies,whereas the rest were candidate gene studies,mainly studying effects on neuroendocrine,serotoninergic and immunoregulatory ***-analysis of correlation coefficients from candidate gene studies estimated an association of childhood adversity and DNA methylation variation at r=0.291(Pfied 44 differen-tially methylated CpG *** conclusion,childhood maltreatment may mediate epigenetic mechanisms through DNA methylation,thereby affecting physiological responses and con-ferring a predisposition to an increased risk for psychopathology and forensic *** evidence for somatic illnesses is not yet available.

关键词： Forensic sciences forensic genetics child abuse DNA methylation epigenetics meta-analysis mental illness HPA axis

Rockfall localization from seismic polarization considering multiple triaxial geophones and frequency bands

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Journal of Mountain Science 2020年第7期17卷 1541-1552页

作者： Liang FENG Veronica PAZZI Emanuele INTRIERI teresa GRACCHI Giovanni GIGLI Grazia TUCCI Department of Earth Sciences University of FlorenceVia G.La Pira 450121FlorenceItaly Department of Civil and Environment Engineering University of FlorenceVia Santa Marta 350139FlorenceItaly

Boulder/rock mass movements generate ground vibrations that can be recorded by geophone ***,there are two methods applied to rockfall trajectory reconstruction or rockfall seismic *** method uses seismic wave arrival times and is achieved by minimizing the differences in signal arrival times between multiple stations by grid map *** other method uses seismic polarization and is achieved by calculating eventsource back azimuths from the seismic polarizations of rockfall *** this study,we proposed the use of an overdetermined matrix for joint localization based on the polarization *** overdetermined matrix considers the contributions of all geophones in the network,and at each geophone is assigned a different weight according to the recorded signal qualities and the reliability of the calibrated back *** method shows a great advantage relative to the case in which only two sensors are ***,we suggested three marker parameters for proper frequency band selection in back azimuth calculations:energy,rectilinearity,and a special permanent frequency band(SPF).We found that the back azimuths calculated with energy and an SPF are generally close to the real back azimuths measured in the field,while the SPF is limited by seismic attenuation due to a long-distance *** localization results of rockfalls were validated by using field camera videos and in situ *** typical cases and 43 artificially released rockfalls are presented in this *** proposed method provides an interesting way to locate rockfall events and track rockfall trajectories and avoids the difficulties of obtaining accurate arrival times,as required by the arrival times method.

关键词： Rockfall Localization Seismic polarization Seismic monitoring Early warning

Wastewater Based Surveillance of SARS-CoV-2:Challenges and Perspective from a Canadian Inter-laboratory Study

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Journal of Environmental Sciences 2022年第6期34卷 229-232页

作者： teresa Kumblathan Nicholas Piroddi Steve E.Hrudey Xing-Fang Li Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaAlbert T6G 2G3aCanada

The current rapidly rising 5^(th) wave of the Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2),dominated by the omicron variant,has clearly shown the challenges in monitoring,and tracing clinical cases of *** has been identified by the World Health Organization(WHO)as a variant of concern(VOC)on November 26^(th) of 2021,because of the reported higher risk of transmission,reinfection.

关键词： Wastewater infection. Canadian