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Polymorphism in cardiovascular diseases(CvD)susceptibility loci in the azores islands(Portugal)

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Open Journal of Genetics 2011年第3期1卷 48-53页

作者： Mafalda Raposo Paul sousa stefan Nemeth Ana Rita Couto Margarida Rodrigues santos Joao Paulo Pinheiro Maria Joao Peixoto Christian Oberkanins Nadiya Kazachkova teresa Cymbron Manuela Lima Jacome Bruges-Armas Center of Research in Natural Resources(CIRN)and Department of Biology University of the AzoresPonta DelgadaPortugal specialized service of epidemiology and Molecular Biology(seeBMO) Hospital of Santo EspiritoAngra do HeroismoPortugal Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal viennaLab Diagnostics GmbH ViennaAustria

Background: Atherosclerosis and thrombosis are the major manifestations underlying cardiovascular diseases (CvD), which are the leading cause of mortality and morbidity worldwide. Both result from an interaction between genetic and environmental risk factors. The goal of our study was to evaluate several polymorphisms identified as predisposing factors to atherosclerosis and thrombosis. Material and Methods: A series of 155 healthy unrelated individuals of Azorean origin were analyzed using the CvD stripAssay (viennaLab Diagnostics, Austria) for the most established polymorphisms involved in blood coagulation (F2, F5, F13A1, FGB), fibrinolitic system (seRPINe1), platelet adhesion (ITGB3), homocysteine metabolism (MTHFR), reninangio-tensin system (ACe) and lipid metabolism (APOe). Results: No significant differences were observed in allelic frequencies when comparing our data to mainland Portugal. Group stratification according to the number of “increased” risk alleles, demonstrated that 116/155 (75%) individuals belong to the moderate risk group (5 - 10 risk alleles). Conclusions: Although acknowledging the fact that the allelic states at the analysed loci lack predictive value, the fact that a high frequency of individuals presents at least 5 risk alleles (124/155;80%) is important for the establishment of the appropriate preventive measures in the Azorean population.

关键词： Atherosclerosis Thrombosis Cardiovascular Diseases susceptibility Genes Genetic Risk Poly-morphism

Managing natural grasslands in a changing world:grazing ecology insights to accomplish reoriented management expectations

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Managing natural grasslands in a changing world:grazing ecol...

Purification of the Drosophila melanogaster Proteins Inscuteable and staufen expressed in escherichia coli

ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： Paulo C.de F.Carvalho sila C.da silva Carlos Nabinger Anibal de Moraes teresa C.M.Genro Plantas Forrageiras e Agrometeorologia-UFRGs.Av.Bento Goncalves 7712 CeP 91501-970 Porto Alegre-RSBrazil.Depto.

＜正＞Key points: *** is an increasing debate regarding the quality of pastoral *** than the production per se,a series of multifunctional responsibilities have been attributed to the pastoral ecosystems,that they always had,but have only became imperative as the world natural resources became threatened. *** quality of the use of a pastoral ecosystem can be interpreted through signals emitted by their biotic and abiotic

关键词： biodiversity ingestive behaviour plant functional types Brazilian Pampa sward structure

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Advances in Bioscience and Biotechnology 2015年第7期6卷 485-493页

作者： Xristo Zárate Megan M.Mcevoy teresa vargas-Cortez Jéssica J.Gómez-Lugo Claudia J.Barahona elena Cantú-Cárdenas Alberto Gómez-Trevino Universidad Autónoma de Nuevo León Facultad de Ciencias QuímicasCd.UniversitariaSan Nicolás de los GarzaMéxico Department of Chemistry and Biochemistry University of ArizonaTucsonUSA

The proteins Inscuteable and staufen are key components during asymmetric cell division of neuroblasts for the development of Drosophila melanogaster. expression and purification of both proteins has been a difficult task for structure-function studies. Based on codon optimization for protein expression in escherichia coli, we have been able to produce, in soluble form, the C-terminal domains of Inscuteable and staufen as chimeras with N-terminal maltose binding protein tag that contains a rigid linker between them for feasible crystallization. In addition, using an optimized synthetic gene, corresponding to the amino acid region 250 - 623 of Inscuteable fused to glutathione-s-transferase, low-scale expression experiments showed production of soluble protein. Finally, eukaryotic expression of Inscuteable in the methylothropic yeast Pichia pastoris failed to produce the Drosophila protein at detectable amounts, reinforcing the fact that e. coli still was the microorganism of choice for high-yield protein expression.

关键词： Inscuteable staufen Protein expression and Purification Maltose-Binding Protein escherichia coli

作业治疗专业思维在中国的发展历程(1986-2006)——历史文献研究(上)

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中国康复理论与实践 2019年第6期25卷 676-682页

作者：崔金龙施晓畅廖鹏赵美莉湘雅博爱康复医院工伤职业与社会康复部湖南长沙市410100 黄土学说研究组香港999077 云南省残疾人康复中心社区康复部云南昆明市650100

目的梳理出1986年至2006年作业治疗专业思维在中国的发展历程。方法采用作业治疗历史文献研究方法,共搜集1986年至2006年公开发表的与作业治疗有关的历史文献1308篇,筛选得到52篇,进行深入分析。每一篇文献由3名研究员分别进行分析和审... 详细信息

目的梳理出1986年至2006年作业治疗专业思维在中国的发展历程。方法采用作业治疗历史文献研究方法,共搜集1986年至2006年公开发表的与作业治疗有关的历史文献1308篇,筛选得到52篇,进行深入分析。每一篇文献由3名研究员分别进行分析和审阅,并应用定性研究的主题分析提取文献的专业思维轴心。结果得出两条主线。第一条是有关思维改变的三个主题:早期作业治疗作为一门治疗技术而不是专业被引入中国后,历经作业治疗从业者由康复相关者(并不一定是作业治疗)逐渐演变成专职从事作业治疗的治疗师;由简单和粗浅的思考,演变为深入和周密的思维;从向国外学习到逐渐本土化。第二条是维持不变而足以影响专业思维发展的状况,包括三个主题:作业治疗专业人才数量严重不足;大众对作业治疗服务有误解,专业人员对作业治疗专业思维理解不准确;作业治疗服务范围局限于肢体康复和医院服务。结论梳理出1986年至2006年的21年时间里作业治疗专业思维在中国的发展历程。虽然作业治疗思维渐趋专业化,但早期影响专业发展的问题仍然存在,专业思维还需优化。

关键词：专业思维历史文献研究作业治疗

Diabetes is Associated with Worse executive Function in both eastern and Western populations:shanghai Aging study and Mayo Clinic study of Aging

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Diabetes is Associated with Worse Executive Function in both...

Bio-fuel Production From Carbondioxide Gas Using s. elongatus PCC 7942 from Cyanobacteria

第四届全国痴呆与认知障碍学术研讨会及高级讲授班

作者： zhao qianhua Roberts Rosebud O ding ding Cha Ruth guo qihao luo jianfeng Machulda Mary M Pankratz shane bei wang Christianson teresa J.H Aakre Jeremiah A Knopman David s Boeve Bradley F zhen hong Petersen Ronald C 复旦大学附属华山医院神经内科

Background and Objectives It remains unknown whether the association between diabetes mellitus(DM)and cognitive function differs in eastern and Western *** study aimed to elucidate whether DM is associated with worse cognitive performance in both *** The shanghai Aging study(sAs)and the Mayo Clinic study of Aging(MCsA)are two population-based studies with similar design and methodology in shanghai,China and

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Non-Metallic Material science 2020年第1期2卷 9-11页

作者： Delia teresa sponza Cansu Doganx environmental engineering Department Engineering FacultyDokuz Eylul UniversityBuca-izmirTurkey sciences Institute Deparment of BiologyScience FacultyxAgean UniversityTurkey

The aim of this study,is 1-butanol production using CO2 with *** PCC 7942 *** yields of 1-butanolproduced/CO2utilized have been *** maximum concentration of produced 1-butanol is 35.37 mg/L and 1-butanolproduced/CO2utilized efficiency is *** optimum operational conditions were 30°C temperature,60 W intensity of light,pH=7.1,120 mv redox potential,0.083 m^3/sn flow rate with CO2 and 0.5 mg/l dissolved O2 *** the enzymes on the metabolic trail of the production of 1-butanol via using *** PCC 7942 *** maximum yield;the measured concentrations are 0.016μg/ml for hbd;0.0022μg/ml for Ter and 0.0048μg/ml for *** cost analyses necessary for 1-butanol production has been done and the cost of 1 liter 1-butanol has been determined as 1.31 TL/L.

关键词： Bio-Fuel Carbondioxide GAs s.elongatus Cyanobacteria 1-butanol

Clinical and prognostic implications of atrial fibrillation in patients undergoing transcatheter aortic valve implantation

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World Journal of Cardiology 2012年第1期4卷 8-14页

作者： Pablo salinas Raúl Moreno Luis Calvo santiago Jiménez-valero Guillermo Galeote Angel sánchez-Recalde teresa López-Fernández sergio Garcia-Blas Diego Iglesias Luis Riera Isidro Moreno-Gómez Jose María Mesa Ignacio Plaza Rocio Ayala Rosa Gonzalez José-Luis López-sendón Division of Interventional Cardiology University Hospital La Paz Unit of echocardiography University Hospital La Paz Department of Cardiology University Hospital La Paz vascular surgery University Hospital La Paz Department of Cardiac Anaesthesia University Hospital La Paz Cardiac surgery University Hospital La Paz Department of Cardiology Hospital Infanta Sofia Department of Cardiology Hospital de la Cruz Roja

AIM: To study a cohort of consecutive patients under-going transcatheter aortic valve implantation (TAvI) and compare the outcomes of atrial fibrillation (AF) patients vs patients in sinus rhythm (sR). MeTHODs: All consecutive patients undergoing TAvI in our hospital were included. The AF group comprised patients in AF at the time of TAvI or with history of AF, and were compared with the sR group. Procedural, echocardiographic and follow-up variables were compared. Likewise, the CHA 2 Ds 2-vAsC stroke risk score and HAs-BLeD bleeding risk score and antithrombotic treatment at discharge in AF patients were compared with that in sR patients. ResULTs: From a total of 34 patients undergoing TAvI, 17 (50%) were allocated to the AF group, of whom 15 (88%) were under chronic oral anticoagulation. Patients in the AF group were similar to those in the sR group except for a trend (P = 0.07) for a higher logistic eurosCORe (28% vs 19%), and a higher prevalence of hypertension (82% vs 53%) and chronic renal failure (17% vs 0%). Risk of both stroke and bleeding was high in the AF group (mean CHA 2 Ds 2-vAsC 4.3, mean HAs-BLeD 2.9). In the AF group, treatment at discharge included chronic oral anticoagulation in all except one case, and in association with an antiplatelet drug in 57% of patients. During a mean follow-up of 11 mo (maximum 32), there were only two strokes, none of them during the peri-procedural period: one in the AF group at 30 mo and one in the sR group at 3 mo. There were no statistical differences in procedural success, and clinical outcome (survival at 1 year 81% vs 74% in AF and sR groups, respectively, P = Ns). CONCLUsION: Patients in AF undergoing TAvI show a trend to a higher surgical risk. However, in our cohort, patients in AF did not have a higher stroke rate compared to the sR group, and the prognosis was similar in both groups.

关键词： Aortic stenosis Transcatheter aortic valve implantation stroke Atrial fibrillation

《香港國安法》為成功實踐“一國兩制”開創新格局

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中国法律（中英文版） 2020年第4期 57-66,138-148页

作者：鄭若驛香港特別行政區律政司

—、前言香港特別行政區(以下简称香港特區)自“修例風波”以來經歷了社會動盪,暴力事件不時發生,市民及警務人員受到傷害,而店鋪、港鐵鐵路站、政府設施及很多其他地方遭受惡意毀壞。有激進份子公然鼓吹“港獨”,宣揚分離主義思想,更... 详细信息

—、前言香港特別行政區(以下简称香港特區)自“修例風波”以來經歷了社會動盪,暴力事件不時發生,市民及警務人員受到傷害,而店鋪、港鐵鐵路站、政府設施及很多其他地方遭受惡意毀壞。有激進份子公然鼓吹“港獨”,宣揚分離主義思想,更可恥地乞求境外勢力施加制裁、干預中國內政及香港特區事務,以達到其目的。甚至出現有人私藏槍械及彈藥,製造爆炸物品的情況,確實構成恐怖主義風險。這些情況,如果不加以遏制,對香港特區的公共安全將構成巨大威脅。更重要的是,這些情況對中國的國家安全亦構成實際風險。

关键词：爆炸物品公共安全新格局暴力事件制裁香港

Partially defatted black soldier fly larva meal inclusion in piglet diets: effects on the growth performance, nutrient digestibility,blood profile, gut morphology and histological features

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Journal of Animal science and Biotechnology 2019年第3期10卷 708-718页

作者： Ilaria Biasato Manuela Renna Francesco Gai sihem Dabbou Marco Meneguz Giovanni Perona silvia Martinez Ana Cristina Barroeta Lajusticia stefania Bergagna Luca sardi Maria teresa Capucchio enrico Bressan Andrea Dama Achille schiavone Laura Gasco Department of Agricultural Forest and Food SciencesUniversity of TurinLargo P.Braccini 210095 Grugliasco(TO)Italy Department of veterinary sciences University of TurinLargo P.Braccini 210095 Grugliasco(TO) TurinItaly National Research Council Institute of Science of Food ProductionLargo P.Braccini 210095 Grugliasco(TO)Italy sDsv-Teaching structure of veterinary Medicine University of TurinLargo P.Braccini 210095 Grugliasco(TO)Italy Department of Animal Production University of MurciaCampus de Espinardo30071 MurciaSpain Department of Animal and Food science Autonomous University of BarcelonaCerdanyola del Vallès08193 BellaterraBarcelonaSpain veterinary Medical Research Institute for Piemonte Liguria and the Valle D’AostaVia Bologna 14810154 TurinItaly Department of veterinary Medical sciences University of BolognaVia Tolara di Sopra 5040064 Ozzano dell’Emilia(BO)Italy

Background:The aim of this trial was to investigate the effects of different inclusion levels of a partially defatted black soldier fly (BsF,Hermetia illucens L.) larva meal on the growth performance,nutrient digestibility,blood profile,gut morphology and histological features of piglets.A total of 48 newly weaned piglets were individually weighed (initial body weight (IBW):6.1 ± 0.16 kg) and randomly allocated to 3 dietary treatments (4 boxes as replicates/treatment and 4 animals/box).BsF larva meal was included at increasing levels (0% [BsF0],5% [BsFs] and 10% [BsF10]) in isonitrogenous and isoenergetic diets formulated for two feeding phases:Ⅰ (from d 1 to d 23) and Ⅱ (from d 24 to d 61).The weight gain (WG),average daily gain (ADG),average daily feed intake (ADFI) and feed conversion ratio (FCR) were calculated for each feeding phase and for the whole *** haematochemical parameters and nutrient digestibility of the piglets were also evaluated.A total of 3 piglets per box were slaughtered on d 61 and the slaughtered piglets were submitted to morphometric investigations and histopathological ***:No overall significant differences were observed for growth performance (P > 0.05),except for the ADFI of phase Ⅱ,which showed a linear response to increasing BsF meal levels (P e BsF10 group).Dietary BsF meal inclusion did not significantly influence the blood profile,except as far as monocytes and neutrophils are concerned,and these showed a linear and quadratic response,respectively,to increasing BsF meal levels (P e BsF10 and BsF5 groups,respectively).On the other hand,the nutrient digestibility,gut morphology and histological features were not affected by dietary BsF meal inclusion (P > 0.05).Conclusions:The obtained results show that a partially defatted BsF larva meal can be used as a feed ingredient in diets for weaned piglets without negatively affecting their growth performance,nutrient digestibilit

关键词： Hermetia il ucens L. Histopathology Insect meal Performance Weaning pigs