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Fe.al incontine.ce.in me.:Cause. and clinical and manome.ric fe.ture.

World Journal of Gastroe.te.ology 2014年第24期20卷 7933-7940页

作者： teresa Munoz-Yagüe.Pablo Solis-Munoz Constanza Ciriza de.los Rios Francisco Muoz-Garrido Je.us Vara Jose.Antonio Solis-He.ruzo De.artme.t of Gastroe.te.ology the University Hospital "12 de Octubre"28041-MadridSpain Institute.of Live. Studie. King’s College HospitalLondon SE5 9RSUnited Kingdom Pe.vic Floor Unit the University Hospital "12 de Octubre"28041-MadridSpain Re.e.rch Ce.te. University Hospital "12 de Octubre"Complutense University28041-MadridSpain

AIM:To de.e.mine.the.cause. and characte.istics of fe.al incontine.ce.in me. and to compare.the.e.fe.ture. with those.pre.e.te. by a group of wome. with the.same.***:We.analyze. the.me.ical history,clinical and manome.ric data from 119 me. with fe.al incontine.ce.studie. in our unit and compare. the.e.data with those.obtaine. from 645 wome. studie. for the.same.*** to tre.tme.t was e.aluate. afte. 6 mo of ***:Fifte.n pe.ce.t of patie.ts studie. in our unit for fe.al incontine.ce.we.e.*** took longe. than wome. be.ore.asking for me.ical *** surge.y was the.most common risk factor for me. re.ate. to fe.al *** diarrhe. was pre.e.t in more.than 40%of patie.ts in both *** re.ting and e.te.nal anal sphincte. pre.sure. we.e.more.fre.ue.t in *** significant diffe.e.ce. e.iste. be.we.n the.se.e. re.arding re.tal se.sitivity and re.to-anal inhibitory *** 17.8%of me.,all pre.e.ting soiling,manome.ric findings did not justify fe.al *** to tre.tme.t was good in both groups,as 80.4%of patie.ts improve. and fe.al incontine.ce.disappe.re. in 13.2%of ***:In our se.ie.,it was common that me. waite. longe. in se.king me.ical he.p for fe.al ***-re.tal surge.y was the.major cause.of this *** diarrhe. was a pre.isposing factor in both *** diffe.e.ce. be.we.n groups we.e.limite. to an incre.se. fre.ue.cy of hypotony of the.e.te.nal anal sphincte. in *** incontine.ce.was controllable.in most patie.ts.

关键词： Fe.al Incontine.ce Ge.de. Ano-re.tal surge.y Ano-re.tal manome.ry Tre.tme.t Biofe.dback

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Wate. Syste. Condition and Asse. Re.lace.e.t Prioritization

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Journal of Wate. Re.ource.and Prote.tion 2023年第5期15卷 165-178页

作者： Fre.e.ick Bloe.sche. Zachary Farme. Jame. Barton teresa Chapman Paula Fonse.a Monica Shane. Civil Environmental and Geomatics Engineering Florida Atlantic University Boca Raton Florida USA Boynton Be.ch FL USA

The.goal of asse. manage.e.t is to ide.tify and track the.mainte.ance.and re.lace.e.t of asse.s that have.re.che. the.r use.ul life. For that re.son, gathe.ing data and colle.ting information is a critical ste. whe. de.e.oping an asse. manage.e.t plan. Such data gathe.ing include. physical and ope.ational prope.tie. of the.asse.s as we.l as colle.ting and tracking important e.e.ts during the.life.pan of the.asse. (i.e., pipe.bre.ks, re.lace.e.t ye.r, mainte.ance.pe.forme., e.c.). Critical factors in the.asse. manage.e.t plan may be.ove.looke. whe. the.e.is no data or poor quality data. Howe.e., many utilitie. lack the.re.ource. for e.amining burie. infrastructure.and lack good quality work orde. data, so othe. me.hods of data colle.tion are.ne.de.. The.conce.t for this pape. was to de.e.op a me.ns to acquire.data on the.asse.s for a condition asse.sme.t to ide.tify pipe. that we.e.most like.y to bre.k and those.with the.highe.t conse.ue.ce. for same. Thre. utilitie. we.e.use. as e.ample.. It was found that for burie. infrastructure. much more.information was known than anticipate. but the.actual pre.ictions re.ie. on only a fe. factors re.ate. to pipe.type. Howe.e., the.e.is a ne.d to track the.conse.ue.ce., in this case.bre.ks, which would indicate.a failure. The.latte. would be.use.ul for pre.icting future.mainte.ance.ne.ds and the.most at-risk asse.s, but is ofte. missing in utility syste.s as many utilitie. do not ade.uate.y track bre.ks sufficie.tly. In this case.two utilitie. we.e.analyze. and pre.ication on a third was de.e.ope..

关键词： Wate. Main Pre.icte. Failure Asse. Manage.e.t Pipe.Failure Wate. Distributions

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Cough Modulation by Uppe. Airway Stimuli in Cat—Pote.tial Clinical Application?

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Ope. Journal of Mole.ular and Inte.rative.Physiology 2016年第3期6卷 35-43页

作者： Ivan Poliace. Jana Ple.kova teresa Pitts Zuzana Kotmanova Jan Jakus Michal Sime.a 1Institute.of Me.ical Biophysics Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Martin Slovakia Institute.of Me.ical Biophysics Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Martin Slovakia sime.a@jfme..uniba.sk Institute.of Pathophysiology Jessenius Faculty of Medicine in Martin Comenius University in Bratislava Martin Slovakia De.artme.t of Ne.rological Surge.y Kentucky Spinal Cord Injury Research Center University of Louisville Louisville USA

The.modulation of me.hanically induce. trache.bronchial cough was te.te. by applying various stimuli and the.e.icitation of othe. airway prote.tive.be.aviors in pe.tobarbital ane.the.ize. cats. Capsaicin and histamine.we.e.inje.te. in the.nose. and me.hanical nylon fibe. and/or air puff stimulation was applie. to the.nose.and nasopharynx. Re.le. re.ponse. of cough, sne.ze. aspiration re.le. and e.piration re.le. we.e.induce. me.hanically. Swallow was initiate. by the.inje.tion of wate. into oropharynx. Subthre.hold me.hanical stimulation of nasopharynge.l and nasal mucosa, as we.l as wate. stimulation in the.oropharynx and larynx, with no motor re.ponse. had no e.fe.t on rhythmic coughing. Cough re.ponsive.e.s and e.citability incre.se. with capsaicin and air puff stimuli de.ive.e. to the.nose. Vice.ve.sa, the.numbe. of cough re.ponse. was re.uce. and cough late.cy incre.se. whe. aspiration re.le.e. (>1) occurre. be.ore.the.cough stimulus or within inte.-cough inte.vals (passive.e. cough phase.. The.occurre.ce.of swallows incre.se. the.cough late.cy as we.l. Cough inspiratory and/or e.piratory motor drive.was e.hance. by the.occurre.ce.of e.piration re.le.e., swallows, and sne.ze. and also by aspiration re.le. within the.inspiratory phase.of cough and by nasal air puff stimuli. Comple. ce.tral inte.actions, orde.ing and se.ue.cing of motor acts from the.airways may re.ult in the.disruption of cough rhythmic se.ue.ce.but also in the.e.hance.e.t of cough. Our data confirm that numbe. of pe.iphe.al stimuli and re.piratory motor re.ponse. significantly alte.s cough pe.formance. We.propose.de.e.oping and te.ting stimulation paradigms that modify coughing and could be.e.ploye. in corre.ting of inappropriate.or e.ce.sive.coughing.

关键词： Aspiration Re.le. e.piration Re.le. Sne.ze Swallow Nasal Stimulation

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Naïve.he.atitis B e.antige.-ne.ative.chronic he.atitis B patie.ts are.at risk of carotid athe.oscle.osis:A prospe.tive.study

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World Journal of Gastroe.te.ology 2021年第30期27卷 5112-5125页

作者： Mar Rive.ro-Barcie.a Cristina Marcos-Fosch Fe.nando Martine.-Valle.Fabrizio Bronte.Olimpia Orozco Isidro Sanz-Pére. Danie.e.Torre. Maria-teresa Salce.o Salvatore.Pe.ta Rafae. e.te.an Antonio Craxi Maria Buti De.artme.t of Me.icine.of the.UAB Hospital Universitari Vall d’HebronBarcelona 08035Spain Ce.tro de.Inve.tigación Biomédica e. Re. de.e.fe.me.ade. He.áticas y Dige.tivas Instituto de Salud Carlos IIIMadrid 28029Spain Syste.ic Autoimmune.Dise.se. Unit Internal Medicine DepartmentHospital Universitari Vall d'HebronBarcelona 08035Spain Se.ione.di Gastroe.te.ologia Di.Bi.M.I.SUniversity of PalermoPalermo 90133Italy Pathology De.artme.t Hospital Universitari Vall d'HebronBarcelona 08035Spain

BACKGROUND The.e.is an incre.se. risk of athe.oscle.osis in patie.ts with chronic he.atitis C or human immunode.icie.cy virus,but the.e.is scarce.data on he.atitis B virus *** hypothe.is of this study is that he.atitis B virus infe.tion incre.se. the.risk of carotid plaque. and subclinical athe.oscle.osis in naïve.he.atitis B e.antige.(HBe.g)ne.ative.*** To asse.s the.rate.of carotid plaque. and subclinical athe.oscle.osis in naïve.HBe.g ne.ative.subje.ts in comparison with a cohort of he.lthy *** Prospe.tive.case.control collaborative.study conducte. in two te.tiary *** hundre. and two subje.ts prospe.tive.y re.ruite. at the.outpatie.t clinic we.e.include. from May 2016 to April 2017:201 naïve.HBe.g-ne.ative.he.atitis B virus-infe.te.[49 chronic he.atitis B(CHB)and 152 inactive.carrie.s(ICs)]and 201 he.lthy *** and me.abolic me.sure.,live. stiffne.s and carotid Dopple. ultrasound we.e.*** athe.oscle.osis was e.tablishe. on an intima-me.ia thickne.s incre.se.of≥1.2 mm and/or the.pre.e.ce.of carotid *** distribute. quantitative.variable. we.e.compare. with the.Stude.t t te.t and those.with a non-normal distribution with the.Mann-Whitne. U *** variable. we.e.compare. be.we.n groups using the.2 or Fishe. e.act *** Carotid plaque. we.e.found more.ofte. in CHB(32.7%)than ICs(17.1%)or controls(18.4%)(P=0.048).Subclinical athe.oscle.osis was also incre.se. in CHB(40.8%)vsICs(19.1%)or controls(19.4%)(P=0.003).No diffe.e.ce. in the.risk of athe.oscle.osis we.e.obse.ve. be.we.n controls and *** factors inde.e.de.tly associate. with the.pre.e.ce.of carotid plaque. we.e.age.odds ratio(OR)1.43,Pe.oscle.osis,age.OR 1.45,Pe.e.(OR 1.13,P=0.028).In the.subse. of young subje.ts(e.rs),carotid plaque.(12.5%vs 1.1%,P=0.027)and subclinical athe.oscle.osis(12.5%vs 2.2%,P=0.058

关键词： He.atitis B virus Carotid plaque. Subclinical athe.oscle.osis Cardiovascular risk e.dothe.ial dysfunction Intima-me.ia thickne.s

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ACe.Score.Ide.tifie. HBe.g-ne.ative.Inactive.Carrie.s at a Single.point e.aluation,Re.ardle.s of HBV Ge.otype

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Journal of Clinical and Translational He.atology 2022年第6期10卷 1068-1076页

作者： Luisa Roade.Mar Rive.ro-Barcie.a Adriana Palom Francisco Rodrígue.-Frías Marta Be. Ariadna Rando María teresa Salce.o Rosario Casillas e.e.a Vargas-Accarino David Tabe.ne.o Silvia Saule.a Rafae. e.te.an María Buti Live. Unit Internal Medicine DepartmentHospital Universitari Vall d’HebronVall d’Hebron Barcelona Hospital CampusBarcelonaSpain Unive.sitat Autònoma de.Barce.ona(UAB) Department of MedicineBarcelonaSpain Unive.sitat Au-tònoma de.Barce.ona(UAB) Department of Biochemistry and Molecular BiologyBarcelonaSpain Ce.tro de.Inve.tigación Biomédica e. Re. de.e.fe.me.ade. He.áticas y Dige.tivas(CIBe.e.d) Instituto de Salud Carlos IIIMadridSpain Live. Pathology Lab Biochemistry and Microbiology Departments(Clinical Laboratories)Hospital Universitari Vall d’HebronVall d’Hebron Barcelona Hospital CampusBarcelonaSpain Vall d’He.ron Institut de.Re.e.ca(VHIR) Liver Diseases GroupBarcelonaSpain Transfusion Safe.y Laboratory Banc de Sang i TeixitsServei Catalàde la SalutBarcelonaSpain De.partme.t of Pathology Hospital Universitari Vall d’HebronUniversitat Autònoma de BarcelonaBarcelonaSpain

Background and Aims:He.atitis B virus(HBV)biomark-e.s have.be.n use. for a be.te. cate.orization of patie.ts,e.e. though the.lack of simple.algorithms and the.impact of ge.otype. limit the.r *** aim was to asse.s the.use.ulne.s of noninvasive.marke.s for the.ide.tification of HBV inactive.carrie.s(ICs)in a single.point e.aluation and to de.ign a pre.ictive.mode. for the.r ***-ods:This re.rospe.tive.prospe.tive.study include. 343 conse.utive.HBe.g-ne.ative.***,analytical,and virological data we.e.colle.te.,and a live. biopsy was pe.forme. if *** we.e.classifie. at the.e.d of follow-up as ICs,chronic he.atitis B and gray zone.A pre.dictive.mode. was constructe.,and validate. by 1000-boot-strap ***:Afte. 39 months of follow-up,298 subje.ts we.e.ICs,36 we.e.chronic he.atitis B CHB,and nine.we.e.gray ***-nine.25.9%)individuals re.quire. a live. *** HBV DNA hazard ratio(HR)6.0,pe.re.ate. antige.(HBcrAg)(HR 6.5,pe.astography(HR 4.6,pe.e.inde.pe.de.tly associate. with the.IC *** ACe.score.HBV DNA,HBcrAg,e.astography),obtaine. by bootstrapping,yie.de. an are. unde. the.re.e.ve. ope.ating characte.is-tics(AUROC)of 0.925(95%CI:0.880-0.970,pe.tification of *** AUROC for ge.otype.D was 0.95,0.96 for A,0.90 for e.and 0.88 for H/*** ACe.score.ofe.pre.ictive.value.of 99.5%,and a score.12 points had a diagnostic accuracy of 93.8%.Conclusions:Low base.ine.HBV DNA,HBcrAg,and live. stiffne.s we.e.in-de.e.de.tly associate. with the.IC phase.A score.including those.variable. ide.tifie. ICs at a single.point e.aluation,and might be.applie. to imple.e.t le.s inte.sive.follow-up strate.ie..

关键词： He.atitis B virus Inactive.carrie. Live. stiffne.s HBV DNA Quan-titative.HBsAg Core.re.ate. antige..

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Pre.e.t and future.of me.astatic colore.tal cance. tre.tme.t: A re.ie. of ne. candidate.targe.s

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World Journal of Gastroe.te.ology 2017年第26期23卷 4675-4688页

作者： Giulia Martini teresa Troiani Claudia Cardone.Pie.ropaolo Vitie.lo Vince.zo Sforza Davide.Ciardie.lo Ste.ania Napolitano Carminia Maria De.la Corte.Floriana Morgillo Antonio Raucci Antonio Cuomo France.co Se.vaggi Fortunato Ciardie.lo e.ika Martine.li De.artme.t of Inte.nal and e.pe.ime.tal Me.icine.F.Magrassi e.A.Lanzara” Institute of Medical OncologyUniversitàdegli studi della Campania Luigi Vanvitelli De.artme.t of Inte.nal and e.pe.ime.tal Me.icine Magrassi-LanzaraInstitute of RadiologyUniversitàdegli studi della Campania Luigi Vanvitelli Gastroe.te.ology Unit Ospedale Umberto I Unit of Colore.tal Surge.y Department of MedicalSurgicalNeurologicalMetabolic and Ageing SciencesUniversità degli studi della Campania Luigi Vanvitelli

In the.last two de.ade., gre.t e.forts have.be.n made.in the.tre.tme.t of me.astatic colore.tal cance.(m CRC) due.to the.approval of ne. targe. age.ts for cytotoxic drugs. Unfortunate.y, a large.pe.ce.tage.of patie.ts pre.e.t with me.astasis at the.time.of diagnosis or re.apse.afte. a fe. months. The.comple. mole.ular he.e.oge.e.ty of this dise.se.is not comple.e.y unde.stood; to date. the.e.is a lack of pre.ictive.biomarke.s that can be.use. to se.e.t subse.s of patie.ts who may re.pond to targe. drugs. Only the.RAS-mutation status is use. to pre.ict re.istance.to anti-e.ide.mal growth factor re.e.tor age.ts in patie.ts with m CRC. In this re.ie., we.de.cribe.approve. targe.e. the.apie. for the.manage.e.t of me.astatic m CRC and discuss ne. candidate.targe.s on the.horizon.

关键词： Nove. biomarke.s Monoclonal antibodie. Re.istance Mutation RAS Targe. the.apy Me.astatic colore.tal cance.

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Mode. combining pre.transplant tumor biomarke.s and tumor size.shows more.utility in pre.icting he.atoce.lular carcinoma re.urre.ce.and survival than the.BALAD mode.s

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World Journal of Gastroe.te.ology 2018年第12期24卷 1321-1331页

作者： Nicha Wongjarupong Gabrie.a M Ne.ron-Ocasio Roongrue.e. Chaite.rakij Be.yam D Addissie.e.sa A Mohame. Kristin C Mara William S Harmse. J Paul The.bald Brian e.Pe.e.s Jose.h G Balsane. Me.issa M Ward Nasra H Giama Sudhakar K Ve.kate.h De.ise.M Harnois Michae. R Charlton Hiroyuki Yamada Alicia Alge.iras-Schimnich Me.issa R snyder Te.ry M The.ne.u Le.is R Robe.ts Division of Gastroe.te.ology and He.atology Mayo ClinicRochesterMN 55905United States Unive.sity of Pue.to Rico Me.ical Scie.ce. Campus San Juan 00921Puerto Rico De.artme.t of Me.icine Faculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10400Thailand Division of Biome.ical Statistics and Informatics Mayo ClinicRochesterMN 55905United States Division of Laboratory Me.icine Department of Laboratory Medicine and PathologyMayo Clinic College of MedicineRochesterMN 55905United States De.artme.t of Radiology Mayo Clinic College of MedicineRochesterMN 55905United States De.artme.t of Transplantation Mayo Clinic FloridaJacksonvilleFL 32224United States Wako Life.Scie.ce. IncorporatedMountain ViewCA 94043United States

AIM To asse.s the.pe.formance.of BALAD, BALAD-2 and the.r compone.t biomarke.s in pre.icting outcome.of he.atoce.lular carcinoma(HCC) patie.ts afte. live. *** BALAD score.and BALAD-2 class are.de.ive. from bilirubin, albumin, alpha-fe.oprote.n(AFP), Le.s culinaris agglutinin-re.ctive.AFP(AFP-L3), and de.-gammacarboxyprothrombin(DCP). Pre.transplant AFP, AFP-L3 and DCP we.e.me.sure. in 113 patie.ts transplante. for HCC from 2000 to 2008. Hazard ratios(HR) for re.urre.ce.and de.th we.e.calculate.. Univariate.and multivariate.re.re.sion analyse. we.e.conducte.. C-statistics we.e.use. to compare.biomarke.-base. to pre.ictive.mode.s. Re.ULTS During a me.ian follow-up of 12.2 ye.rs, 38 patie.ts re.urre. and 87 die.. The.HRs for re.urre.ce.in patie.ts with e.e.ate. AFP, AFP-L3, and DCP de.ine. by BALAD cut-off value. we.e.2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), re.pe.tive.y. For BALAD, the.HRs for re.urre.ce.and de.th pe. unit incre.se. score.we.e.1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the.HRs for re.urre.ce.and de.th pe. unit incre.se. class we.e.1.45(1.06-1.98) and 1.38(1.09-1.76). For re.urre.ce.pre.iction, the.combination of thre. biomarke.s had the.highe.t c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, re.pe.tive.y. Similarly, for de.th pre.iction, the.combination of thre. biomarke.s had the.highe.t c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A ne. mode. combining biomarke.s with tumor size.at the.time.of transplant(S-LAD) de.onstrate. the.highe.t pre.ictive.capability with c-statistics of 0.71 and 0.69 for re.urre.ce.and de.th. CONCLUSION BALAD and BALAD-2 are.valid in transplant HCC patie.ts, but le.s pre.ictive.than the.thre. biomarke.s in combination or the.thre. biomarke.s in combination with maximal tumor diame.e.(S-LAD).

关键词： alpha-fe.oprote.n AFP-L3 de.-gammacarboxyprothrombin BALAD BALAD-2 He.atoce.lular carcinoma Live. transplant Re.urre.ce Outcome

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《SHOCK》2021年第2期新观点

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实用休克杂志（中英文） 2021年第1期5卷 56-58,64页

作者： Linda e.Sousse.teresa A.Zimme.s 朱浙祥(译) 不详湖南省人民医院/湖南师范大学附属第一医院急诊科

本期《休克》包括4篇综述、6篇临床研究论文和5篇基础研究论文,这些文章旨在更好地了解脓毒症、心肺病理生理学、免疫学和复苏方面的知识。为描述中性粒细胞基本特征和功能,We.等人对其在脓毒症中的作用进行了有力且具有高度可读性的研... 详细信息

本期《休克》包括4篇综述、6篇临床研究论文和5篇基础研究论文,这些文章旨在更好地了解脓毒症、心肺病理生理学、免疫学和复苏方面的知识。为描述中性粒细胞基本特征和功能,We.等人对其在脓毒症中的作用进行了有力且具有高度可读性的研究。他们发现,中性粒细胞这些功能部分是通过形成中性粒细胞胞外陷阱(Ne.s)来实现的,包括吞噬和清除细菌。

关键词：临床研究论文中性粒细胞病理生理学脓毒症免疫学特征和功能

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老年受试者和AD患者横断面和纵断面脑体积的常规估计

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 48-49页

作者： Fote.os A.F. snyder A.Z. Girton L.e. 周永 HHMI at Washington Unive.sity Psychology Department Campus Box 1125 One Brookings Drive St. Louis MO 63108 United StatesDr.

Obje.tive. To te.t the.hypothe.e. 1) that whole.brain volume.de.line.be.ins in e.rly adulthood, 2) that cross-se.t- ional and longitudinal atrophy e.timate. agre. in olde., nonde.e.te. individua ls, and 3) that longitudinal atrophy acce.e.ate. in the.e.rlie.t stage. of Alzhe.ime. dise.se.(AD). Me.hods: Highre.olution, high-contrast structural MRIs we.e.obtaine. from 370 adults (age.18 to 97). Participants ove. 65 (n=192) we.e.chara cte.ize. using the.Clinical De.e.tia Rating (CDR) as e.the. nonde.e.te. (CDR 0, n=94) or with ve.y mild to mild de.e.tia of the.Alzhe.me. type.(DAT, CDR 0.5 and 1, n=98). Of the.e.olde. participants, 79 be.onge. to a longitudinal cohort and we.e.image. again a me.n 1.8 ye.rs afte. base.ine. e.timate. of gray matte. (nG M), white.matte. (nWM), and whole.brain volume.(nWBV) normalize. for he.d size. we.e.ge.e.ate. base. on atlas re.istration and image.se.me.tation. Re.ults: Hie.rarchical re.re.sion of nWBV e.timate. from nonde.e.te. individuals across the.a dult life.pan re.e.le. a strong line.r, mode.ate.quadratic patte.n of de.line.be.ginning in e.rly adulthood, with late. onse. of nWM than nGM loss. Whole.brain volume.diffe.e.ce. we.e.de.e.te. by age.30. The.cross-se.tional atrophy mode. o ve.lappe. with the.rate. me.sure. longitudinally in olde., nonde.e.te. individua ls (me.n de.line.of -0.45%pe. ye.r). In those.individuals with ve.y mild DAT, atrophy rate.more.than double. (-0.98%pe. ye.r). Conclusions: Nonde.e.te. indi viduals e.hibit a slow rate.of whole.brain atrophy from e.rly in adulthood with white.matte. loss be.inning in middle.age. in olde. adults, the.onse. of de.e. tia of the.Alzhe.me. type.is associate. with a marke.ly acce.e.ate. atrophy rate..

关键词： AD 阿尔茨海默病成年早期脑萎缩队列研究面萎缩高分辨率图像分割于非

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He.atitis B surface.antige. and he.atitis B core.re.ate. antige. kine.ics afte. adding pe.ylate.-inte.fe.on to nucle.s(t)ids analogue. in he.atitis B e.antige.-ne.ative.patie.ts

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World Journal of He.atology 2020年第11期12卷 1076-1088页

作者： teresa Broque.as Montse.rat Garcia-Re.ortillo Mique. Mico Lidia Canillas Marc Puigve.i Nuria Cane.e.Susana Coll Ana Viu Juan Jose.He.nande. Xavie. Be.sa Jose. Carrion De.artme.t of Gastroe.te.ology Liver SectionHospital del Mar Medical Research InstituteBarcelona 08003Spain De.artame.t of de.Me.icina Universitat Autònoma de BarcelonaBarcelona 08003Spain Laboratori de.Re.e.e.cia de.Catalunya El Prat de LlobregatBarcelona 08820Spain

BACKGROUND He.atitis B e.antige.-ne.ative.chronic he.atitis B patie.ts unde. nucle.s(t)ids analogue.(NAs)rare.y achie.e.he.atitis B surface.antige.(HBsAg)*** To e.aluate.if the.addition of pe.ylate. inte.fe.on(Pe.-IFN)could de.re.se.HBsAg and he.atitis B core.re.ate. antige.(HBcrAg)le.e.s and incre.se.HBsAg loss rate.in patie.ts unde. NAs *** Prospe.tive.non-randomize.,ope.-labe. trial e.aluating the.combination of Pe.-IFN 180μg/we.k plus NAs during forty-e.ght we.ks vs NAs in *** B e.antige.-ne.ative.non-cirrhotic chronic he.atitis B patie.ts of a te.tiary hospital,unde. NAs the.apy for at le.st 2 ye.rs and with unde.e.table.viral load,we.e.*** with he.atitis C virus,he.atitis D virus or human immunode.icie.cy virus co-infe.tion and live. transplante. patie.ts we.e.*** and HBcrAg le.e.s(log10 U/mL)we.e.me.sure. at base.ine.and during nine.y-six *** loss rate.was e.aluate. in both *** e.e.ts we.e.re.orde. in both *** kine.ic of HBsAg for e.ch tre.tme.t group was e.aluate. from base.ine.to we.ks 24 and 48 by the.slope.of the.HBsAg de.line.log10 IU/mL/we.k)using a line.r re.re.sion *** Sixty-five.patie.ts we.e.e.rolle.,61%re.e.ving te.ofovir and 33%***-six(55%)we.e.include. in Pe.-IFN-NA group and 29(44%)in NA *** matching by age.and tre.tme.t duration,base.ine.HBsAg le.e.s we.e.comparable.be.we.n groups(3.1 vs 3.2)(P=0.25).HBsAg le.e.s at we.ks 24,48 and 96 de.line. in Pe.-IFN-NA group(-0.26,-0.40 and-0.44)and re.aine. stable.in NA group(-0.10,-0.10 and-0.10)(Pe.slope.of HBsAg de.line.in Pe.-IFN-NA group(-0.02)was highe. than in NA group(-0.00)(P=0.015).HBcrAg le.e.s did not ***(22%)patie.ts discontinue. Pe.-IFN due.to adve.se.*** HBsAg loss was achie.e. in 3(8.3%)patie.ts of the.Pe.-IFN-NA group and 0(0%)of the.NA *** The.addition of Pe.-IFN to NAs cause. a gre.te. and faste. de.re.se.of HBsAg le.e.s compare. to N

关键词： Chronic he.atitis B He.atitis B e.antige.-ne.ative He.atitis B surface.antige. He.atitis B core.re.ate. antige. Pe.ylate.-inte.fe.on Nucle.s(t)ids analogue.©The.Author(s)2020.Publishe. by Baishide.g Publishing Group Inc.All rights re.e.ve.

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