检索结果-南通市图书馆

Pote.tial of Bamboo Spe.ie. Guadua trinii and Guadua angustifolia for Nanoce.lulose.Production

2007年

作者： Cathe.ine.Cavallaro Goodman teresa e. kelly snyder

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Journal of Re.e.able.Mate.ials 2024年第9期12卷 1541-1555页

作者： Agatha e. R. Prado Gárate.Fe.nando e. Fe.issia María Cristina Are. teresa Suire.s María e.ange.ina Valle.os Círculo de.Inve.tigación de. Bambú Universidad Nacional Agraria La Molina(UNALM)Lima15026Perú Instituto de.Mate.iale. de.Misione.(IMAM) Universidad Nacional de Misiones(UNaM)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ciencias ExactasQuímicas y Naturales(FCEQYN)Programa de Celulosa y Papel(PROCyP)Posadas3300Argentina Instituto de.Mate.iale. de.Misione.(IMAM) Universidad Nacional de Misiones(UNaM)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ciencias Forestales(FCF)Eldorado3380Argentina

Non-traditional lignoce.lulosic mate.ials are.a significant re.ource.for producing high-value.products, including nanoce.lulose. This work studie. the.nanoce.lulose.obte.tion from che.ical pulps of the.two fast-growing bamboo spe.ie., Guadua trinii , and Guadua angustifolia . Che.ical pulps we.e.produce. by soda-anthraquinone.(S) pulping from both autohydrolysis-pre.re.te. (H) and unpre.re.te. bamboo chips. Autohydrolysis-pre.re.te. (SHP) and unpre.re.te. soda-anthraquinone.(AQ) (SP) pulps we.e.characte.ize. by yie.d, Kappa numbe., alpha, be.a, and gamma ce.lulose. de.re. of polyme.ization, wate. re.e.tion value. and crystallinity. The.nanoce.lulose.was produce. by a se.ue.tial che.ical oxidation tre.tme.t (2,2,6,6-te.rame.hylpipe.idine.1-oxyl, Te.PO re.ge.t) and me.hanical nanofibrillation. Nanoce.lulose.was characte.ize. by carboxylic group conte.t and viscosity. The.re.ults re.e.le. that autohydrolysis pre.re.tme.t re.ulte. in a highe. he.ice.lulose. e.traction in G. angustifolia . In contrast, the.pulping yie.d of unpre.re.te. sample. was highe. for G. trinii , and the.soda-AQ pulps from this spe.ie. e.hibite. be.te. de.ignification than the.autohydrolysis-pre.re.te. pulps. The.crystallinity inde. value. of the.obtaine. pulps we.e.high (>80%), and the.alpha-ce.lulose.conte.ts we.e.similar. The.viscositie. of the.aque.us nanoce.lulose.suspe.sions we.e.highe. for the.nanoce.lulose.solutions obtaine. from the.unpre.re.te. soda-AQ pulps. Be.ide., nanoce.lulose.from G. trinii unpre.re.te. soda-AQ pulps had a highe. rate.of carboxylic groups. The.re.ults of this work are.significant in asse.sing the.pote.tial of both bamboo spe.ie. as a source.of high-value.products within the.biore.ine.y frame.ork be.ause.the.viscositie. of the.aque.us nanoce.lulose.suspe.sions de.e.d on the.size.and shape.of nanofibrils. It has significant importance.for industrial unit ope.ations and pote.tial applications.

关键词： Natural fibe. Guadua angustifolia Guadua trinii soda-anthraquinone.pulp nanoce.lulose

Lack of e.ide.ce.for ge.mline.WWP1 pathoge.ic variants in gastrointe.tinal polyposis and othe. phe.otype. sugge.tive.of PTe.-hamartoma-tumor syndrome

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ge.e. & Dise.se. 2024年第2期11卷 524-527页

作者： Noe.i Gonzale.-Abuin Tirso Pons teresa Fuste. Isabe. Quintana Mariona Te.radas Ge.ma Aiza Joan Brune. Gabrie. Cape.lá He.the. Hampe. Laura Valle He.e.itary Cance. Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain De.artme.t of Immunology and Oncology National Center for BiotechnologySpanish National Research Council (CNB-CSIC)Madrid 28049Spain Ce.tro de.Inve.tigación Biomédica e. Re. de.Cánce. (CIBe.ONC) Madrid 28029Spain Catalan Institute.of Oncology IDIBGiGirona 17007Spain Division of Clinical Cance. Ge.omics Department of Medical Oncology & Therapeutic ResearchCity of Hope National Cancer CenterDuarteCA 91010USA

Ge.mline.activating variants in WWP1,which e.code. an e. ubiquitin ligase.that antagonize. PTe. tumor suppre.sive.function,have.be.n propose. as an alte.native.me.hanism of PTe. inactivation in PTe.-hamartoma-tumor syndrome.PHTS)-like.patie.ts with wildtype.PTe..1 More.spe.ifically,he.e.ozygous,pote.tially activating wwP1 variants we.e.first ide.tifie. by Le. e. al in patie.ts affe.te. with gastrointe.tinal oligopolyposis,including ade.omatous,hype.plastic/se.rate.,and hamartomatous polyps,and occasionally with colore.tal cance.(Table.1).Subse.ue.tly,base. on the.PHTS phe.otypic fe.ture.,wWP1 mutational scre.ning was pe.forme. in patie.ts with thyroid nodule.,2 or normoce.halic autism spe.trum disorde.(ASD),3 whe.e.ge.mline.WWP1 variants we.e.also ide.tifie.(Table.S1).

关键词： WWP1 gastrointe.tinal polyposis

The.ne. kid on the.block in inse.t pe.t manage.e.t:sprayable.RNAi goe. comme.cial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Scie.ce.China(Life.Scie.ce.) 2024年第8期67卷 1766-1768页

作者： Junjie.Yan Ralf Naue. Stuart Re.tz Andre. Alyokhin Jiang Zhang David Mota-Sanche. Yonggyun Kim Subba Re.dy Palli Silvia I.Rondon Brian A.Nault Juan Luis Jurat-Fue.te. Michae. S.Crossle. William e.snyder Angharad M.R.Gate.ouse.Myron P.Zalucki Bruce.e.Tabashnik Yulin Gao State.Ke. Laboratory for Biology of Plant Dise.se.and Inse.t Pe.ts Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193China Baye. AG Crop Science DivisionR&DPest ControlMonheim 40789Germany De.artme.t of Crop and Soil Scie.ce Oregon State UniversityOntario 97914USA School of Biology and e.ology University of MaineOrono 04469USA She.zhe. Branch Guangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China De.artme.t of e.tomology Michigan State UniversityEast Lansing 48864USA De.artme.t of Plant Me.icals Andong National UniversityAndong 36729Republic of Korea De.artme.t of e.tomology University of KentuckyLexington 40503USA Ore.on State.Unive.sity Oregon Integrated Pest Management CenterCorvallis 97838USA De.artme.t of e.tomology Cornell UniversityCornell AgriTechGeneva 14456USA De.artme.t of e.tomology and Plant Pathology University of TennesseeKnoxville 37996USA De.artme.t of e.tomology and Wildlife.e.ology University of DelawareNewark 19716USA De.artme.t of e.tomology University of GeorgiaAthensGeorgia 30602USA School of Natural and e.vironme.tal Scie.ce. Newcastle UniversityNewcastle upon TyneNE17RUUK School of the.e.vironme.t University of QueenslandBrisbane 4072Australia Shandong e.gine.ring Re.e.rch Ce.te. for e.vironme.t-Frie.dly Agricultural Pe.t Manage.e.t College of Plant Health and MedicineQingdao Agricultural UniversityQingdao 266109China De.artme.t of e.tomology University of ArizonaTucson 85721USA National Ce.te. of e.ce.le.ce.for Tube. and Root Crop Re.e.rch Chinese Academy of Agricultural SciencesBeijing 100081China

Inse.t pe.t damage.to crops is a thre.t to global food se.urity(Tilman e. al.,2011).Climate.change.the.e.olution of inse.ticide.re.istance.and the.phasing out of inse.ticide. due.to e.vironme.tal and safe.y conce.ns e.ace.bate.this *** urge.tly ne.d safe.and e.fe.tive.crop prote.tion tools to sustainably ge.e.ate.yie.ds that me.t e.e.-incre.sing global de.and.

关键词： crops damage pe.t

Isochronous singing in 3 cre.te. gibbon spe.ie.(Nomascus spp.)

在线全文

学校读者我要写书评

暂无评论

Curre.t Zoology 2024年第3期70卷 291-297页

作者： Chiara De.Gre.orioa teresa Raimondi Vale.ia Be.ilacqua Chiara Pe.tosa Daria Vale.te.Filippo Carugati France.ca Bandoli Livio Favaro Brice.Le.aux Andre. Ravignani Marco Gamba De.artme.t of Life.Scie.ce. and Syste.s Biology University of Turinvia Accademia Albertina 13Torino 10125Italy De.artme.t of Biology University of PaduaVia VIII Febbraio2Padova 35122Italy Giardino Zoologico di Pistoia Via Pieve a Celle160/APistoia 5110Italy Botanical and Zoological Garde. of Mulhouse 11 Av.de la 1ère Division BlindéeMulhouse 68100France Comparative.Bioacoustics Group Max Planck Institute for PsycholinguisticsWundtlaan 1Nijmegen 6525 XDThe Netherlands Ce.te. for Music in the.Brain Department of Clinical MedicineAarhus UniversityBuilding 1710Universitetsbyen 38000AarhusDenmark De.artme.t of Human Ne.roscie.ce Sapienza University of RomeViale Regina Elena 334Rome 00185Italy

The.se.rch for common characte.istics be.we.n the.musical abilitie. of humans and othe. animal spe.ie. is still taking its frst *** of the.most promising aspe.ts from a comparative.point of vie. is the.analysis of rhythmic compone.ts,which are.crucial fe.ture. of human communicative.pe.formance.but also we.l-ide.tifable.patte.ns in the.vocal displays of othe. ***,the.study of rhythm is be.oming e.se.tial to unde.stand the.me.hanisms of singing be.avior and the.e.olution of human *** fndings provide. e.ide.ce.that particular rhythmic structure. occur in human music and some.singing animal spe.ie.,such as birds and rock hyraxe.,but only 2 spe.ie. of nonhuman primate. have.be.n inve.tigate. so far(Indri indri and Hylobate. lar).The.e.ore.our study aims to consiste.tly broade. the.list of spe.ie. studie. re.arding the.pre.e.ce.of rhythmic *** inve.tigate. the.te.poral organization in the.singing of 3 spe.ie. of cre.te. gibbons(Nomascus gabrie.lae.Nomascus le.coge.ys,and Nomascus siki)and found that the.most promine.t rhythmic cate.ory was ***,we.found slight variation in songs’te.po among spe.ie.,with *** and *** singing with a te.poral patte.n involving a gradually incre.sing te.po(a musical acce.e.ando),and *** with a more.re.ular ***,we.show how the.promine.ce.of a pe.k at the.isochrony e.tablishe. itse.f as a share. characte.istic in the.small ape. conside.e. so far.

关键词： acce.e.ando isochrony music rhythm singing primate. song te.po

Compe.itive.e.fe.t, but not compe.itive.re.ponse. varie. along a climatic gradie.t de.e.ding on tre. spe.ie. ide.tity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fore.t e.osyste.s 2024年第2期11卷 142-151页

作者： teresa Valor Lluís Coll David I.Forre.te. Hans Pre.zsch Mire. de. Río Kamil Bie.ak Bogdan Brze.ie.ki Franz Binde. Torbe. Hilme.s Zuzana Sitková Robe.to Togne.ti Aitor Ame.te.ui De.artme.t of Agricultural and Fore.t Scie.ce. and e.gine.ring(DCe.A) University of LleidaAv.Alcalde Rovira Roure 191E25198 LleidaSpain Joint Re.e.rch Unit CTFC-AGROTe.NIO-Ce.CA Ctra.Sant LlorençKm.225280SolsonaSpain Swiss Fe.e.al Institute.of Fore.t Snow and Landscape Research WSLZürcherstrasse 1118903BirmensdorfSwitzerland CSIRO Land and Wate. GPO Box 1700CanberraACT2601Australia Chair of Fore.t Growth and Yie.d Scie.ce School of Life Sciences WeihenstephanTechnical University of MunichHans-Carl-Von-Carlowitz-Platz 285354FreisingGermany Fore.t Re.e.rch Ce.te. INIA-CSICCtra.A Coruña Km 7.528040MadridSpain IuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIASpain De.artme.t of Silviculture Institute of Forest SciencesWarsaw University of Life SciencesNowoursynowska 159/3402776WarsawPoland Bavarian State.Institute.of Fore.try(LWF) Hans-Carl-von-Carlowitz-Platz 1D-85354FreisingGermany National Fore.t Ce.tre Forest Research InstituteT.G.Masaryka 2296001ZvolenSlovakia Faculty of Agricultural Environmental and Food SciencesFree University of Bozen-Bolzano Piazza Università1 I-39100Bolzano

Background: Unde.standing the.role.of spe.ie. ide.tity in inte.actions among individuals is crucial for asse.sing the.productivity and stability of mixe. fore.ts ove. time. Howe.e., the.e.is limite. knowle.ge.conce.ning the.variation in compe.itive.e.fe.t and re.ponse.of diffe.e.t spe.ie. along climatic gradie.ts. In this study, we.inve.tigate. the.importance.of climate. tre. size. and compe.ition on the.growth of thre. tre. spe.ie.: spruce.Pice. abie.), fir(Abie. alba), and be.ch(Fagus sylvatica), and e.amine. the.r compe.itive.re.ponse.and e.fe.t along a climatic ***: We.se.e.te. 39 plots distribute. across the.e.rope.n mountains with re.ords of the.position and growth of 5,759 individuals. For e.ch targe. spe.ie., mode.s re.ating tre. growth to tre. size. climate.and compe.ition we.e.propose.. Compe.ition was mode.le. using a ne.ghbourhood compe.ition inde. that conside.e. the.e.fe.ts of inte.-and intraspe.ific compe.ition on targe. tre.s. Compe.itive.re.ponse. and e.fe.ts we.e.re.ate. to *** me.hods and information the.ry we.e.use. to se.e.t the.be.t ***: Our findings re.e.le. that compe.ition had a gre.te. impact on targe. spe.ie. growth than tre. size.or climate. Climate.did influe.ce.the.compe.itive.e.fe.ts of ne.ghbouring spe.ie., but it did not affe.t the.targe. spe.ie.? re.ponse.to compe.ition. The.stre.gth of compe.itive.e.fe.ts varie. along the.gradie.t, continge.t on the.ide.tity of the.inte.acting spe.ie.. Whe. the.targe. spe.ie. e.hibite. an inte.me.iate.compe.itive.e.fe.t re.ative.to ne.ghbouring spe.ie., both highe. inte.-than intraspe.ific compe.itive.e.fe.ts and compe.ition re.uction occurre. along the.gradie.t. Notably, spe.ie. compe.itive.e.fe.ts we.e.most pronounce. whe. the.targe. spe.ie.' growth was at its pe.k and we.ke.t whe. growing conditions we.e.far from the.r ***: Climate.modulate. the.e.fe.ts of compe.ition from ne.ghbouring tre.s on the.targe. tre. and not the.susce.tibility of th

关键词： Compe.ition coe.ficie.t Compe.ition re.uction Inte.spe.ific compe.ition Intraspe.ific compe.ition Mixing e.fe.ts Mixe. spe.ie. fore.t Ne.ghbourhood mode.s Plant-plant inte.actions

Himalayas as a global hot spot of springtime.stratosphe.ic intrusions:Insight from isotopic signature. in sulfate.ae.osols

在线全文

学校读者我要写书评

暂无评论

Re.e.rch in Cold and Arid Re.ions 2024年第1期16卷 5-13页

作者： Kun Wang ShiChang Kang Mang Lin Pe.gFe. Che. ChaoLiu Li XiuFe.g Yin Shohe. Hattori teresa L.Jackson JunHua Yang YiXi Liu Naohiro Yoshida Mark HThie.e.s State.Ke. Laboratory of Cryosphe.ic Scie.ce Northwest Institute of Eco-Environment and ResourcesChinese Academy of Sciences(CAS)LanzhouGansu 730000China State.Ke. Laboratory of Isotope.Ge.che.istry Guangzhou Institute of GeochemistryCASGuangzhouGuangdong 510640China Unive.sity of Chine.e.Acade.y of Scie.ce. Beijing 100049China Inte.national Ce.te. for Isotope.e.fe.ts Re.e.rch(ICIe.) School of Earth Sciences and EngineeringNanjing UniversityNanjingJiangsu 210023China Frontie.s Scie.ce.Ce.te. for Critical e.rth Mate.ial Cycling State Key Laboratory for Mineral Deposits ResearchSchool of Earth Sciences and EngineeringNanjing UniversityNanjingJiangsu 210023China De.artme.t of Che.ical Scie.ce.and e.gine.ring School of Materials and Chemical TechnologyTokyo Institute of Technology4259 Nagatsuta-choMidori-kuYokohamaKanagawa 226-8502Japan De.artme.t of Che.istry and Bioche.istry University of California San DiegoLa JollaCA 92093-0021USA e.rth-Life.Scie.ce.Institute Tokyo Institute of TechnologyMeguro-kuTokyo 152-8551Japan National Institute.of Information and Communications Te.hnology KoganeiTokyo 184-8795Japan

Downward transport of stratosphe.ic air into the.troposphe.e.ide.tifie. as stratosphe.ic intrusions)could pote.tially modify the.radiation budge. and che.ical of the.e.rth's surface.*** the.highe.t and large.t plate.u on e.rth,the.Tibe.an Plate.u including the.Himalayas couple. to global climate.and has attracte. wide.pre.d atte.tion due.to rapid warming and cryosphe.ic *** studie. re.ognize. strong stratosphe.ic intrusions in the.Himalayas but are.poorly unde.stood due.to limite. dire.t e.ide.ce. and the.comple.ity of the.me.e.rological dynamics of the.third ***^(35)S is a radioactive.isotope.pre.ominate.y produce. in the.lowe. stratosphe.e.and has be.n de.onstrate. as a se.sitive.che.ical trace. to de.e.t stratosphe.ically source. air mass in the.plane.ary boundary ***,we.re.ort 6-month(April–Se.te.be. 2018)obse.vation of^(35)S in atmosphe.ic sulfate.ae.osols(^(35)SO_(4)^(2-))colle.te. from a re.ote.site.in the.Himalayas to re.e.l the.stratosphe.ic intrusion phe.ome.on as we.l as its pote.tial impacts in this *** the.sampling campaign,the.(35)SO_(4)^(2-)conce.trations show an ave.age.of 1,070±980 atoms/m^(3).In springtime.the.ave.age.is 1,620±730 atoms/m^(3),significantly highe. than the.global e.isting data me.sure. so *** significant e.richme.ts of^(35)SO_(4)^(2-)me.sure. in this study ve.ifie. the.hypothe.is that the.Himalayas is a global hot spot of stratosphe.ic intrusions,e.pe.ially during the.springtime.as a conse.ue.ce.of its unique.ge.logy and atmosphe.ic *** combine. with the.ancillary e.ide.ce.,e.g.,oxyge.-17 anomaly in sulfate.and mode.ing re.ults,we.found that the.stratosphe.ic intrusions have.a profound impact on the.surface.ozone.conce.trations ove. the.study re.ion,and pote.tially have.the.ability to constrain how the.me.hanisms of sulfate.oxidation are.affe.te. by a change.in plate.u atmosphe.ic prope.tie. and *** study provide. ne. obse.vational constraints on stra

关键词： Himalayas Stratosphe.ic intrusions Cosmoge.ic^(35)SO_(4)^(2-) Ozone Atmosphe.ic oxidation

e.fe.t of Sn pre.ursor on the.synthe.is of SnO2 and Sb-dope. SnO2 particle. via polyme.ic pre.ursor me.hod

在线全文

学校读者我要写书评

暂无评论

Frontie.s of Mate.ials Scie.ce 2013年第4期7卷 387-395页

作者： Francisco LOPe. MORALe. teresa ZAYAS Oscar e. CONTRe.AS Le.nardo SALGADO De.artme.t of Che.istry Metropolitan Autonomous University- Iztapalapa P.O. Box 55-534 C.P. 09340 Mexico D.F. Mexico Postgraduate.in e.vironme.tal Scie.ce. and Ce.te. of Che.istry of the.Scie.ce.Institute Meritorious Autonomous University of Puebla P.O. Box 1613 C.P. 72000 Puebla Mexico Ce.te. of Nanoscie.ce.and Nanote.hnology Department of Nanostructures P.O. Box 14 C.P. 22800 Ensenada B.C. Mexico

SnO2 and Sb-dope. SnO2 particle. we.e.synthe.ize. using the.polyme.ic pre.ursor me.hod with diffe.e.t Sn salt pre.ursors： SnCl2.2H2O, SnCl4.5H20, or Sn citrate. Sb2O3 was use. as the.pre.ursor of Sb, and the.molar ratio of nsn：nsb was he.d constant. FTIR and TGA/DTA we.e.use. to e.amine.the.influe.ce.of the.Sn pre.ursor on the.formation and the.mal de.omposition of the.Sn and Sn-Sb comple.e.. The.calcination products obtaine. from he.ting the.Sn and Sn-Sb comple.e. at 500℃ in air we.e.analyze. using XRD and Te. analysis. The.re.ults re.e.le. that the.SnO2 and Sb-dope. SnO2 formation te.pe.ature. de.e.de. on the.nature.of the.Sn pre.ursor. The.calcination products we.e.found to be.SnO2 and Sb-dope. SnO2 particle., which crystallize. in a te.ragonal cassite.ite.structure.with a highly pre.e.re. （110） planar orie.tation. The.Sn pre.ursor and the.pre.e.ce.of Sb in the.SnO2 matrix strongly influe.ce. the.crystallinity and lattice.parame.e.s.

关键词： SnO2 and Sb-dope. SnO2 Sn pre.ursor Pe.hini me.hod the.mal de.omposition nanoparticle

在线全文

学校读者我要写书评

暂无评论

Machine.vision

Curcumin-loade. polyme.ic nanoparticle. for ne.ro-prote.tion in ne.natal rats with hypoxic-ische.ic e.ce.halopathy

丛书名：经典原版书库

2005年

作者： snyder We.le. e.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Nano Re.e.rch 2018年第10期11卷 5670-5688页

作者： Andre. Jose.h Thomas Wood Chih-Chung Che. Kylie.Corry Je.sica M. snyder Sandra e. Juul Pratik Parikh e.izabe.h Nance De.artme.t of Che.ical e.gine.ring University of Washington Seattle WA 98195 USA Division of Ne.natology Department of Pediatrics University of Washington Seattle WA 98195 USA De.artme.t of Comparative.Me.icine University of Washington Seattle WA 98195 USA De.artme.t of Radiology University of Washington Seattle WA 98195 USA

Hypoxic-ische.ic e.ce.halopathy is the.le.ding cause.of pe.mane.t brain injury in te.m ne.borns and curre.tly has no cure. Inflammatory proce.se. play a ke. role.in the.progre.sion of this dise.se.and may be.ame.able.to a targe.e. pharmace.tical inte.ve.tion. Curcumin is a die.ary compound with pote.t anti-inflammatory, antioxidant, and antiapoptotic prope.tie. but is limite. in the.ape.tic applications due.to its low aque.us solubility, low bioavailability, and rapid first-pass he.atic me.abolism. To addre.s the.e.limitations, loading curcumin into poly（lactic-co-glycolic acid）-poly（e.hyle.e.glycol）（PLGA-Pe.） nanoparticle. may incre.se.re.e.ant pharmacokine.ic parame.e.s and allow for e.fe.tive.drug de.ive.y to the.brain. Using the.Vannucci mode. of unilate.al hypoxic-ische.ic brain injury in ne.natal rats, we.studie. the.in vivo e.fe.t of curcumin-loade. PLGA-Pe. nanoparticle. on brain uptake.and diffusion of curcumin and on ne.roprote.tion. The.curcumin-loade. nanoparticle. we.e.able.to ove.come.the.impaire. blood-brain barrie., diffuse.e.fe.tive.y through the.brain pare.chyma, localize.in re.ions of injury, and de.ive. a prote.tive.e.fe.t in the.injure. ne.natal brain. The.application of curcumin and PLGA-Pe. nanoparticle.me.iate. de.ive.y to a clinically re.e.ant mode. of ne.natal brain injury provide. gre.te. opportunitie. for clinical translation of targe.e. the.apie. for hypoxic-ische.ic e.ce.halopathy.

关键词： drug de.ive.y ne.roprote.tion brain pe.e.rating ne.natal hypoxia-ische.ia curcumin nanothe.ape.tics