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The Use of Erythropoietin in Liver Regeneration in Pigs after Partial Hepatectomy

Surgical Science 2015年第11期6卷 518-526页

作者： Henrique de Aguiar Wiederkehr Caroline Aragao de Carvalho Julio Cesar Wiederkehr Ricardo Ribeiro Gama Eros Luiz de Sousa teresa cristina cavalcanti Taíse Fuchs Barbara de Aguiar Wiederkehr Lucas Mansano Sarquis Faculdade Evangelica do Paraná CuritibaParanáBrazil Department of Surgery Federal University of ParanáCuritibaParanáBrazil Department of Experimental Surgery Faculdade Evangélica do ParanáCuritibaParanáBrazil Department of Veterinary Medicine Faculdade Evangélica do ParanáCuritibaParanáBrazil Department of Pathology Federal University of ParanáCuritibaParanáBrazil Department of Veterinary Anesthesiology Faculdade Evangélica do ParanáCuritibaParanáBrazil

A partial hepatectomy is a surgical procedure performed during the living-donor liver transplantation and sometimes the only option for patients with hepatocarcinoma. However the remnant liver after the hepatectomy is still a major concern. Therefore, the process of liver regeneration has been a constant theme of study in order to optimize this process. Erythropoietin, a hormone produced by the kidney and involved in protecting organs like heart, liver and kidney itself against injuries can be one of these factors that could accelerate the liver regeneration. This study aims to observe if erythropoietin can accelerate the process of liver regeneration after partial hepatectomy in pigs. Methods: 8 pigs were classified into 2 groups of 4 pigs each: the control group and the test group. The animals in the first group underwent an application of saline solution subcutaneous on the day before the hepatectomy. Instead of saline solution, the test groups received a subcutaneous injection of 200 UI/lg of recombinant erythropoietin also on the day before the surgical procedure. After 7 days since the hepatectomy, in each animal the liver was biopsied in two regions, one next to the hepatectomy section and other far from it. The liver regeneration was analyzed using Ki-67. Results: Pigs from control group presented the following results: Control pig I: 30% of regeneration in the hepatectomy section and 10% in the region far from it;control pig II 24% and 4%;control pig III 27% and 7%. The test group presented no significant liver regeneration since Ki-67 could not identify cell proliferation in neither the biopsied areas. Conclusion: Since the number of pigs was not statistically significant, we could not conclude any further hypothesis. We strong believe that enhancing the number of pigs and testing different doses, we will be able to reach further conclusions.

关键词： Liver Regeneration Partial Hepatectomy Erythropoietin Pigs

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Hydrocarbons in particulate samples from wildfire events in central Portugal in summer 2010

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Journal of Environmental Sciences 2017年第3期29卷 122-131页

作者： Ana Vicente Ana Calvo Ana P.Fernandes teresa Nunes cristina Monteiro Casimiro Pio Célia Alves Centre for Environmental and Marine Studies (CESAM) Department of EnvironmentUniversity of Aveiro Department of Physics IMARENABUniversity of León

In summer 2010, twenty eight （14 PM=2.5 samples plus 14 samples PM2.5-10） smoke samples were collected during wildfires that occurred in central Portugal. A portable high-volume sampler was used to perform the sampling, on quartz fibre filters of coarse （PM=2.5-10） and fine （PM2.5） smoke samples. The carbonaceous content （elemental and organic carbon） of particulate matter was analysed by a thermal-optical technique. Subsequently, the particulate samples were solvent extracted and fractionated by vacuum flash chromatog- raphy into three different classes of organic compounds （aliphatics, polycyclic aromatic hydrocarbons （PAHs） and carbonyl compounds）. The organic speciation was performed by gas chromatography-mass spectrometry （GC-MS）. Emissions were dominated by the fine particles, which represented around 92% of the PM10. A clear predominance of carbonaceous constituents was observed, with organic to elemental carbon （OC/EC） ratios ranging between 1.69 and 245 in both size fractions. The isoprenoid ketone 6,10,14-trimethyl-2-pentadecanone, a tracer for secondary organic aerosol formation, was one of the dominant constituents in both fine and coarse particles. Retene was the most abundant compound in all samples. Good correlations were obtained between OC and both aliphatic and PAH compounds. Pyrogenic processes, thermal release of biogenic com- pounds and secondary processing accounted for 97% of the apportioned PM2.5 levels.

关键词： WildfiresOrganic carbonOrganic compoundsBiomarkersParticulate matterPortugal

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Pain assessment and management in the newborn:A systematized review

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World Journal of Clinical Cases 2021年第21期9卷 5921-5931页

作者： Maria teresa Garcia-Rodriguez Sergio Bujan-Bravo Rocio Seijo-Bestilleiro cristina Gonzalez-Martin Research in Nursing and Health Care Institute of Biomedical Research of A Coruña(INIBIC)Complexo Hospitalario Universitario de A Coruña(CHUAC)SERGASAs Xubias 8415006 A Coruña Universidade da Coruña(UDC)A Coruña 15006Spain Health Sciences Complexo Hospitalario Universitario de A CoruñaA Coruña 15006Spain

BACKGROUND Neonatal pain has been underdiagnosed due to several false *** To determine the status of neonatal pain in newborns who are admitted to intensive care *** Different databases were *** reviews and research reports conducted in newborns that were written in English,Spanish,or Portuguese,published between 2010 and 2020,and having free access to the full text were selected.A total of 135 articles were found,and 18 articles were finally *** Newborns are exposed to numerous painful *** order to assess their pain levels,several scales have been used,although they are sometimes not correctly *** terms of pain management,the nursing team plays a very important role based mainly on both pharmacological and non-pharmacological *** Nursing staff members must be well trained in order to identify pain and to interpret the scales ***,they have an important role in performing non-pharmacological procedures for pain management.

关键词： Neonatal pain Intensive care unit Nursing Management Treatment Systematized review

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Irritable bowel syndrome: a disease still searching for pathogenesis, diagnosis and therapy

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World Journal of Gastroenterology 2014年第27期20卷 8807-8820页

作者： Massimo Bellini Dario Gambaccini cristina Stasi Maria teresa Urbano Santino Marchi Paolo Usai-Satta Gastrointestinal Unit Department of Gastroenterology University of Pisa 56124 Pisa Italy Department of Experimental and Clinical Medicine University of Florence 50134 Florence Italy Epidemiological Observatory Health Agency of Tuscany 50141 Florence Italy Gastrointestinal Unit P. Brotzu Hospital09124 Cagliari Italy

Irritable bowel syndrome (IBS) is the most frequently diagnosed functional gastrointestinal disorder in primary and secondary care. It is characterised by abdominal discomfort, pain and changes in bowel habits that can have a serious impact on the patient’s quality of life. The pathophysiology of IBS is not yet completely clear. Genetic, immune, environmental, inflammatory, neurological and psychological factors, in addition to visceral hypersensitivity, can all play an important role, one that most likely involves the complex interactions between the gut and the brain (gut-brain axis). The diagnosis of IBS can only be made on the basis of the symptoms of the Rome III criteria. Because the probability of organic disease in patients fulfilling the IBS criteria is very low, a careful medical history is critical and should pay particular attention to the possible comorbidities. Nevertheless, the severity of the patient’s symptoms or concerns sometimes compels the physician to perform useless and/or expensive diagnostic tests, transforming IBS into a diagnosis of exclusion. The presence of alarming symptoms (fever, weight loss, rectal bleeding, significant changes in blood chemistry), the presence of palpable abdominal masses, any recent onset of symptoms in patient aged over 50 years, the presence of symptoms at night, and a familial history of celiac disease, colorectal cancer and/or inflammatory bowel diseases all warrant investigation. Treatment strategies are based on the nature and severity of the symptoms, the degree of functional impairment of the bowel habits, and the presence of psychosocial disorders. This review examines and discusses the pathophysiological aspects and the diagnostic and therapeutic approaches available for patients with symptoms possibly related to IBS, pointing out controversial issues and the strengths and weaknesses of the current knowledge.

关键词： Irritable bowel syndrome Pathogenesis Diagnosis Therapy

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Qualitative Comparison between the Brazilian Labeling Program for Buildings and the Portuguese Energy Certification System for Buildings:Proposals for Improving Brazilian Regulations

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Energy Engineering 2021年第3期118卷 615-629页

作者： Jaime Francisco de Sousa Resende Andrea Lucia Teixeira Charbel teresa cristina Bessa Nogueira Assunção Graduate Program in Energy Engineering Federal University of São João del ReiSão João del ReiBrazil Department of Thermal and Fluid Sciences Federal University of São João del ReiSão João del ReiBrazil Department of Electrical Engineering Federal University of São João del ReiSão João del ReiBrazil

Buildings represent a significant share of the world’s energy consumption,and the sector has drawn the attention of governments,which have adopted policies to reduce energy *** Certifications of Energy Efficiency in Buildings stand out as one possible solution to achieve this goal,employed in several countries *** European Union presents advanced energy assessment programs for buildings,being a reference and model for several other regulations in the *** Energy Certification System for Buildings(SCE)of Portugal is considered a success case,reflected in the significant number of energy certificates *** Brazilian Labeling Program for Building(PBE Edifica),first launched in 2009,does not find a broad application today in the Brazilian *** work shows a synthesis of the European Energy Performance of Buildings Directive(EPBD)and the Brazilian and Portuguese regulations’history.A qualitative comparison is made between the SCE and the PBE Edifica to verify a European and a developing country’s regulations with a certain degree of cultural and climatic *** this comparison,proposals are made for improvements to Brazilian certification,seeking to improve its energy planning and energy policy concerning its building *** suggestions for improvement presented may also be appropriate for other developing countries that have started and have not yet successfully implemented their energy certification programs in buildings.

关键词： Energy efficiency energy policy building labeling energy certification improvement proposals

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Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy

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World Journal of Gastroenterology 2016年第30期22卷 6944-6954页

作者： Cristiana Lo Nigro Vincenzo Ricci Daniela Vivenza cristina Granetto teresa Fabozzi Emanuela Miraglio Marco C Merlano Department of Oncology S. Croce and Carle Teaching Hospital Department of Oncology San Raffaele Institute

AIM: To reviewing genetic and epigenetic make-up of metastatic colorectal cancers (mCRCs) addicted to epidermal growth factor receptor (EGFR) ***: The present study summarizes the potential value of prognostic and predictive biomarkers in selecting mCRC patients treated with anti-EGFR therapy. A meta-analysis was performed using a systematic search of PubMed, Medline and Web of Science to identify eligible papers until March 21st, 2016 using these following terms: ‘‘colorectal cancer’’, “predictive biomarkers’’, “anti-EGFR therapy”, “KRAS”, “NRAS’’, “PIK3CA”, “TP53”, “PTEN”, ‘‘EGFR”, “MET”, “HER2”, “epiregulin”, “amphiregulin”, “prognostic biomarkers”, “BRAF”, “miRNA” and “antibody-dependent cell-mediated cytotoxicity (ADCC) activity”. Two investigators independently evaluated and extracted data from each identified studies based on selected criteria of inclusion and ***: The introduction of agents targeting EGFR such as cetuximab and panitumumab increased overall survival of mCRCs. Nevertheless, it has firstly became evident that response rates to cetuximab regimens in unselected patient populations were typically lower than 30%. Clinical data confirmed the predictive value of RAS mutations for resistance to cetuximab and panitumumab leading to the license of these monoclonal antibodies exclusively for the management of patients with RAS-wild type colorectal cancers. So far the identification of predictive biomarkers have generated interesting, though preliminary and, at times, conflicting data on the importance of tumour mRNA levels of EGFR ligands, of activating mutations in other genes such as NRAS and PIK3CA. The pr

关键词： Metastatic colorectal cancer Anti-epidermal growth factor receptor therapy KRAS Biomarkers Antibody-dependent cell-mediated cytotoxicity

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Comparison between standard and wide-field autofluorescence in detection of retinal displacement after rhegmatogenous retinal detachment surgery

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Advances in Ophthalmology Practice and Research 2022年第3期2卷 32-37页

作者： Raquel Maroto Cejudo cristina Blanco Marchite teresa Prieto Moran Sergio Copete Piqueras Retina Department Service of OphthalmologyAlbacete University ComplexAlbaceteSpain

Purpose To analyse the differences between 30°blue autofluorescence(BAF30),55°blue autofluorescence(BAF55)and 200°green Ultra-Wide Field autofluorescence(UWF200)imaging to detect retinal displacement(RD)after vitrectomy surgery for rhegmatogenous retinal detachment(RRD).Methods This cross-sectional study considers forty-nine consecutive patients who underwent RRD surgery in the time period 4–8 months previous to image *** exclusion criteria contemplate previous retinal pathology,under 18-year-olds and non-assessable images in any of the 3 *** images were analysed by two masked graders that assessed either the presence or absence of retinal displacement.A third observer reviewed the images that presented *** A total of forty-nine patients were analysed.7 eyes were excluded due to poor quality in either of the imaging *** final analysis included 42 eyes of forty-two patients with a mean age of 60.3±11.9 *** patients underwent a 3 port 23-gauge pars plana vitrectomy as the technique of *** grade of RD was detectable in 45.2% of *** was similar between BAF30 and UWF200(42.9% of eyes).BAF55 showed RD to a lesser extent(38.1%).Agreement index between BAF30 and BAF55 was 0.901,0.903 between BAF30 and UWF200 and 0.803 between BAF55 and *** agreement index between graders was 0.775 for BAF30,0.798 for BAF50 and 0.808 for UWF200 *** All imaging modalities were able to detect RD after vitrectomy for RRD,with no inferiority of BAF30 and BAF55 over UWF200.

关键词： Blue fundus autofluorescence Green fundus autofluorescence Rhegmatogenous retinal detachment Retinal displacement Retinal vessel printings

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Born to sing!Song development in a singing primate

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Current Zoology 2021年第6期67卷 597-608页

作者： Chiara DE GREGORIO Filippo CARUGATI Vittoria ESTIENNE Daria VALENTE teresa RAIMONDI Valeria TORTI Longondraza MIARETSOA Jonah RATSIMBAZAFY Marco GAMBA cristina GIACOMA Department of Life Sciences and Systems Biology University of Torinovia Accademia Albertina 13Torino 10125Italy Groupe d’Etude et de Recherche sur les Primates de Madagascar(GERP) BP 779–Antananarivo 101Madagascar

In animal vocal communication,the development of adult-like vocalization is fundamental to interact appropriately with ***,the factors that guide ontogenetic changes in the acoustic features remain poorly *** contrast with a historical view of nonhuman primate vocal production as substantially innate,recent research suggests that inheritance and physiological modification can only explain some of the developmental changes in call structure during growth.A particular case of acoustic communication is the indris’singing behavior,a peculiar case among Strepsirrhine *** to a decade of intense data collection,this work provides the first long-term quantitative analysis on song development in a singing *** understand the ontogeny of such a complex vocal output,we investigated juvenile and sub-adult indris’vocal behavior,and we found that young individuals started participating in the chorus years earlier than previously *** results indicated that spectro-temporal song parameters underwent essential changes during *** particular,the age and sex of the emitter influenced the indris’vocal *** found that frequency parameters showed consistent changes across the sexes,but the temporal features showed different developmental trajectories for males and *** the low level of morphological sexual dimorphism and the marked differences in vocal behavior,we hypothesize that factors like social influences and auditory feedback may affect songs’features,resulting in high vocal flexibility in juvenile *** trait may be pivotal in a species that engages in choruses with rapid vocal turn-taking.

关键词： duet flexibility juveniles lemurs ontogeny rhythm

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Potential of Bamboo Species Guadua trinii and Guadua angustifolia for Nanocellulose Production

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Journal of Renewable Materials 2024年第9期12卷 1541-1555页

作者： Agatha E.R.Prado Gárate Fernando E.Felissia María cristina Area teresa Suirezs María Evangelina Vallejos Círculo de Investigación del Bambú Universidad Nacional Agraria La Molina(UNALM)Lima15026Perú Instituto de Materiales de Misiones(IMAM) Universidad Nacional de Misiones(UNaM)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ciencias ExactasQuímicas y Naturales(FCEQYN)Programa de Celulosa y Papel(PROCyP)Posadas3300Argentina Instituto de Materiales de Misiones(IMAM) Universidad Nacional de Misiones(UNaM)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Facultad de Ciencias Forestales(FCF)Eldorado3380Argentina

Non-traditional lignocellulosic materials are a significant resource for producing high-value products,including *** work studied the nanocellulose obtention from chemical pulps of the two fast-growing bamboo species,Guadua trinii,and Guadua *** pulps were produced by soda-anthraquinone(S)pulping from both autohydrolysis-pretreated(H)and unpretreated bamboo ***-pretreated(SHP)and unpretreated soda-anthraquinone(AQ)(SP)pulps were characterized by yield,Kappa number,alpha,beta,and gamma cellulose,degree of polymerization,water retention value,and *** nanocellulose was produced by a sequential chemical oxidation treatment(2,2,6,6-tetramethylpiperidine-1-oxyl,TEMPO reagent)and mechanical *** was characterized by carboxylic group content and *** results revealed that autohydrolysis pretreatment resulted in a higher hemicelluloses extraction in *** contrast,the pulping yield of unpretreated samples was higher for ***,and the soda-AQ pulps from this species exhibited better delignification than the autohydrolysis-pretreated *** crystallinity index values of the obtained pulps were high(>80%),and the alpha-cellulose contents were *** viscosities of the aqueous nanocellulose suspensions were higher for the nanocellulose solutions obtained from the unpretreated soda-AQ ***,nanocellulose from *** unpretreated soda-AQ pulps had a higher rate of carboxylic *** results of this work are significant in assessing the potential of both bamboo species as a source of high-value products within the biorefinery framework because the viscosities of the aqueous nanocellulose suspensions depend on the size and shape of *** has significant importance for industrial unit operations and potential applications.

关键词： Natural fiber Guadua angustifolia Guadua trinii soda-anthraquinone pulp nanocellulose

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Circulating cytokines and outcome in metastatic colorectal cancer patients treated with regorafenib

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 301-310页

作者： Vincenzo Ricci cristina Granetto Antonella Falletta Matteo Paccagnella Andrea Abbona Elena Fea teresa Fabozzi Cristiana Lo Nigro Marco Carlo Merlano Medical Oncology and Laboratory of Translational Oncology Oncology DepartmentS.Croce and Carle Teaching Hospital CuneoCuneo 12100Italy Arco Cuneo Foundation Cuneo 12100Italy Medical Oncology S.G.Bosco HospitalTorino 10154Italy S.Croce and Carle Teaching Hospital Cuneo Cuneo 12100Italy

BACKGROUND Regorafenib is an oral small-molecule multikinase inhibitor approved in third or later line of treatment for patients with metastatic colorectal cancer(mCRC).Regorafenib has shown significant benefits in overall survival and progression free survival in two phase III trials compared to placebo in patients with mCRC who had progressed on previous *** To identify an immune profile that might specifically correlate with the outcome in patients treated with *** Blood samples were collected from 17 patients before treatment with regorafenib and from 6 healthy *** proteins evaluated(TNF-α,TGF-β,VEGF,CCL-2,CCL-4,and CCL-5)were selected on the basis of their roles in angiogenesis and colorectal cancer *** We found that TNF-αbasal level was significantly higher in mCRC patients compared to healthy *** Responder(NR)patients showing progression of disease(n=12)had higher basal level of TGF-β,TNF-α,VEGF,CCL-2 and CCL-5 compared to Responder(R)patients(complete response CR,n=1;partial response PR,n=1;Stable Disease SD,n=3).On the contrary,plasma basal level of CCL-4 was higher in R compared to NR *** values of TGF-βand TNF-αnegatively correlated with progression free *** These results suggest a cytokine signature potentially able to discriminate between R and NR patients to treatment with regorafenib.

关键词： Colorectal cancer Multikinase inhibitor Cytokines Angiogenesis

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