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Current applications of big data and machine learning in cardiology

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Journal of Geriatric Cardiology 2019年第8期16卷 601-607页

作者： Renato Cuocolo teresa Perillo Eliana De Rosa Lorenzo Ugga Mario Petretta Department of Advanced Biomedical Sciences University of Naples “Federico II”NaplesItaly Department of Translational Medical Sciences University of Naples “Federico II”NaplesItaly

Machine learning (ML) is a software solution with the ability of making predictions without prior explicit programming, aiding in the analysis of large amounts of data. These algorithms can be trained through supervised or unsupervised learning. Cardiology is one of the fields of medicine with the highest interest in its applications. They can facilitate every step of patient care, reducing the margin of error and contributing to precision medicine. In particular, ML has been proposed for cardiac imaging applications such as automated computation of scores, differentiation of prognostic phenotypes, quantification of heart function and segmentation of the heart. These tools have also demonstrated the capability of performing early and accurate detection of anomalies in electrocardiographic exams. ML algorithms can also contribute to cardiovascular risk assessment in different settings and perform predictions of cardiovascular events. Another interesting research avenue in this field is represented by genomic assessment of cardiovascular diseases. Therefore, ML could aid in making earlier diagnosis of disease, develop patient-tailored therapies and identify predictive characteristics in different pathologic conditions, leading to precision cardiology.

关键词： Cardiac imaging techniques Cardiology Electrocardiography Machine learning Review

A configurational approach to innovation performance:The role of creativity

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International Journal of Innovation Studies 2023年第3期7卷 189-204页

作者： Victor del-Corte-Lora teresa Martinez-Fernandez teresa Vallet-Bellmunt Norat Roig-Tierno Departament of Business Administration and Marketing Universitat Jaume I12071CastellSpain Department of Economy and Social Sciences Universitat Politecnica de Valencia46022ValenciaSpain

In this study,we analyze new ways of conceptualizing improvements in firms'innovation by implementing the"right-factors configuration,"illustrated through an analog of a recipe and its ***,we research the multiple combinations of three ingredients(creativity,innovation networks,and resources)required to accomplish the innovation *** a sample of firms from a Spanish science and technology park,we apply qualitative comparative analysis(QCA)-specifically,fuzzy-set QCA(fsQCA)-to test the importance of each component in technological and non-technological ***,the results suggest a map of combinations of innovative ingredients with eight possible ***,they show that the only ingredient needed is the combination of a creative climate and creative ***,the methods of obtaining technological and non-technological innovations *** implications for management and policymakers are discussed,and directions for future research are highlighted.

关键词： Creativity Innovation networks Resources Innovation Creative climate Creative intensity Institutions fsQCA

Effect of Sn precursor on the synthesis of SnO2 and Sb-doped SnO2 particles via polymeric precursor method

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Frontiers of Materials Science 2013年第4期7卷 387-395页

作者： Francisco LOPEZ MORALES teresa ZAYAS Oscar E. CONTRERAS Leonardo SALGADO Department of Chemistry Metropolitan Autonomous University- Iztapalapa P.O. Box 55-534 C.P. 09340 Mexico D.F. Mexico Postgraduate in Environmental Sciences and Center of Chemistry of the Science Institute Meritorious Autonomous University of Puebla P.O. Box 1613 C.P. 72000 Puebla Mexico Center of Nanoscience and Nanotechnology Department of Nanostructures P.O. Box 14 C.P. 22800 Ensenada B.C. Mexico

SnO2 and Sb-doped SnO2 particles were synthesized using the polymeric precursor method with different Sn salt precursors： SnCl2.2H2O, SnCl4.5H20, or Sn citrate. Sb2O3 was used as the precursor of Sb, and the molar ratio of nsn：nsb was held constant. FTIR and TGA/DTA were used to examine the influence of the Sn precursor on the formation and thermal decomposition of the Sn and Sn-Sb complexes. The calcination products obtained from heating the Sn and Sn-Sb complexes at 500℃ in air were analyzed using XRD and TEM analysis. The results revealed that the SnO2 and Sb-doped SnO2 formation temperatures depended on the nature of the Sn precursor. The calcination products were found to be SnO2 and Sb-doped SnO2 particles, which crystallized in a tetragonal cassiterite structure with a highly preferred （110） planar orientation. The Sn precursor and the presence of Sb in the SnO2 matrix strongly influenced the crystallinity and lattice parameters.

关键词： SnO2 and Sb-doped SnO2 Sn precursor Pechini method thermal decomposition nanoparticle

Chemical and minero-petrographical changes on granulite rocks affected by weathering processes

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Frontiers of Earth Science 2019年第2期13卷 247-261页

作者： Carmine APOLLARO Francesco PERRI Emilia LE PERA Ilaria FUOCO teresa CRITELLI DiBEST University of Calabria1-87036 Arcavacata di Rende (CS)Italy

The purpose of this work is to study the weathering processes of the granulite rocks of the Serre Massif (southern Calabria,Italy) using a multidisciplinary approach based on field studies,geochemical modeling,and minero?petrographical *** granulite rocks are plagioclase-rich with minor amphibole,clinopyroxene,orthopyroxene,biotite,and garnet and their texture are *** reaction path modeling was performed to simulate the evolution of groundwaters upon interaction with local granulite by means of the software package EQ3/6,version *** were performed in kinetic (time) mode under a closed system at a constant temperature of 11.5℃,(which reproduces the average temperature of local area) and fixing the fugacity of CO2 at 10-2.34 bar (mean value).During the most advanced stage of weathering the main mineralogical changes are: partial destruction and transformation of biotite and plagioclase associated with neoformation of ferruginous products and secondary clay minerals producing a change in the origin rock *** secondary solid phases observed during the geochemical modeling (kaolinite,vermiculite and ferrihydrite) are similar to those found in this natural ***,the soil-like material mainly characterized by mostly sand to gravel grain-size fractions is the final result of the weathering processes.

关键词： Serre Massif granulitic rocks mineralogy petrography weathering profile reaction path-modeling

Hepatic failure caused by plasma cell infiltration in multiple myeloma

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World Journal of Gastroenterology 2009年第16期15卷 2038-2040页

作者： Fadi E Rahhal Robert R Schade Asha Nayak teresa A Coleman Section of Gastroenterology Department of MedicineMedical College of GeorgiaSchool of Medicine Section of Hematology/Oncology Department of MedicineMedical College of GeorgiaSchool of Medicine

Although plasma cell infiltration is not rare in autopsy of patients with multiple myeloma （MM）, it is very rarely detected in living patients. This is because MM rarely causes significant liver dysfunction that requires further evaluation. A 49-year-old man presented with acute renal failure and was diagnosed with kappa light chain MM stageⅡB. Thalidomide and dexamethasone were initiated. The patient developed a continuous increase in bilirubin that led to severe cholestasis. A liver biopsy revealed plasma cell infiltration. He then rapidly progressed to liver failure and died. Treatment options are limited in MM with significant liver dysfunction. Despite new drug therapies in MM, those patients with rapidly progressive liver failure appear to have a dismal outcome.

关键词： Hepatic failure Multiple myeloma Cell infiltration

Bioluminescent nanopaper for rapid screening of toxic substances

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Nano Research 2018年第1期11卷 114-125页

作者： Jie Liu Eden Morales-Narvaez Jahir Orozco teresa vicent Guohua Zhong Arben Merkoci Catalan Institute of Nanoscience and Nanotechnology (ICN2) CSIC and the Barcelona Institute of Science and Technology Campus UAB Bellaterra 08193 Barcelona Spain Laboratory of Insect Toxicology Key Laboratory of Pesticide and Chemical Biology Ministry of Education South China Agricultural University Guangzhou 510642 China Departamentd'Enginyeria Quimica UniversitatAutOnoma de Barcelona Bellaterra Barcelona 08193 Spain ICREA Pg. Llufs Companys 23 08010 Barcelona Spain

Environmental pollution is threatening human health and ecosystems as a result of modern agricultural techniques and industrial progress. A simple nanopaper-based platform coupled with luminescent bacteria Aliivibrio Jischeri （A. Jischeri） as a bio-indicator is presented here, for rapid and sensitive evaluation of contaminant toxicity. When exposed to toxicants, the luminescence inhibition of A. Jischeri-decorated bioluminescent nanopaper （BLN） can be quantified and analyzed to classify the toxicity level of a pollutant. The BLN composite was characterized in terms of morphology and functionality. Given the outstanding biocompatibility of nanocellulose for bacterial proliferation, BLN achieved high sensitivity with a low cost and simplified procedure compared to conventional instruments for laboratory use only. The broad applicability of BLN devices to environmental samples was studied in spiked real matrices （lake and sea water）, and their potential for direct and in situ toxicity screening was demonstrated. The BLN architecture not only survives but also maintains its function during freezing and recycling processes, endowing the BLN system with competitive advantages as a deliverable, ready-to-use device for large-scale manufacturing. The novel luminescent bacteria-immobilized, nanocelullose-based device shows outstanding abilities for toxicity bioassays of hazardous compounds, bringing new possibilities for cheap and efficient environmental monitoring of potential contamination.

关键词： bacterial nanocellulose nanopaper Aliivibrio jqscheri bioluminescent device toxicity bioassay

Immunotherapy-induced Hepatotoxicity:A Review

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Journal of Clinical and Translational Hepatology 2022年第6期10卷 1194-1204页

作者： teresa Da Cunha George Y.Wu Haleh Vaziri Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Immune checkpoint inhibitors(ICIs)suppress the func-tion of immune checkpoints,which are involved in down-regulating immune *** lead to an increased activation of the function of T cells,increased release of cytokines,and decreased activity of regulatory T *** allows for a more significant and less regulated im-mune response and subsequent enhanced cytotoxic activity against cancer cells.A number of cancers are now being treated with these agents and this increased use has re-sulted in more reports of *** almost every organ can be affected,the skin,gastrointestinal tract,liver,and endocrine glands are most commonly *** is neces-sary that gastroenterologists and hepatologists familiarize themselves with diagnostic steps and management plan in patients with these undesirable *** assessing for possible ICIs induced hepatotoxicity,it is of utmost im-portance to use a formal scoring system such as the Rous-sel Uclaf causality assessment method(RUCAM)to assess for risk factors,alternative causes,and response to cessa-tion and re-exposure of a given *** this review is based on studies with and without RUCAM,the conclusions were carefully established mainly from studies that used *** aim of this review is to provide information on the epidemiology,risk factors,clinical presentation,di-agnostic tools,and management plan based on the most recent studies of immunotherapy-induced hepatotoxicity.

关键词： Immune checkpoint inhibitors Immunotherapy Hepatitis Liver injury.

Rockfall localization from seismic polarization considering multiple triaxial geophones and frequency bands

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Journal of Mountain Science 2020年第7期17卷 1541-1552页

作者： Liang FENG Veronica PAZZI Emanuele INTRIERI teresa GRACCHI Giovanni GIGLI Grazia TUCCI Department of Earth Sciences University of FlorenceVia G.La Pira 450121FlorenceItaly Department of Civil and Environment Engineering University of FlorenceVia Santa Marta 350139FlorenceItaly

Boulder/rock mass movements generate ground vibrations that can be recorded by geophone ***,there are two methods applied to rockfall trajectory reconstruction or rockfall seismic *** method uses seismic wave arrival times and is achieved by minimizing the differences in signal arrival times between multiple stations by grid map *** other method uses seismic polarization and is achieved by calculating eventsource back azimuths from the seismic polarizations of rockfall *** this study,we proposed the use of an overdetermined matrix for joint localization based on the polarization *** overdetermined matrix considers the contributions of all geophones in the network,and at each geophone is assigned a different weight according to the recorded signal qualities and the reliability of the calibrated back *** method shows a great advantage relative to the case in which only two sensors are ***,we suggested three marker parameters for proper frequency band selection in back azimuth calculations:energy,rectilinearity,and a special permanent frequency band(SPF).We found that the back azimuths calculated with energy and an SPF are generally close to the real back azimuths measured in the field,while the SPF is limited by seismic attenuation due to a long-distance *** localization results of rockfalls were validated by using field camera videos and in situ *** typical cases and 43 artificially released rockfalls are presented in this *** proposed method provides an interesting way to locate rockfall events and track rockfall trajectories and avoids the difficulties of obtaining accurate arrival times,as required by the arrival times method.

关键词： Rockfall Localization Seismic polarization Seismic monitoring Early warning

Introduction to the special issue on “COVID-19”

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Geoscience Frontiers 2022年第6期13卷 208-209页

作者： Luis F.O.Silva Weijun Li teresa Moreno Department of Civil and Environmental Universidad de la CostaCUC Department of Atmospheric Sciences School of Earth SciencesZhejiang University Institute for Environmental Assessment and Water Research Consejo Superior de Investigaciones Científicas

COVID-19 pandemic is wreaking havoc and bringing the whole world into a standstill in an unprecedented fashion. Joint efforts from multiple sectors to address the various aspects of environment and public health through usage of green technologies have become essential. The application of cleaner and effective technologies can be expanded to management and control, pollution mitigation and valorization of waste. In this Special Issue of Geoscience Frontiers, we present contributions addressing the interactions of COVID-19 in relation to environment and human health.

关键词： bringing expanded COV