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Outcomes of radical prostatectomy in a 20-year localized prostate cancer single institution series in China

Asian Journal of Andrology 2023年第3期25卷 345-349页

作者： Xiao-Hao Ruan Tsun Tsun Stacia chun Da Huang Hoi-Lung Wong Brian Sze-Ho Ho Chiu-Fung Tsang terence chun-ting lai Ada Tsui-Lin Ng Rong Na James Hok-Leung Tsu Division of Urology Department of SurgeryThe University of Hong KongHong KongChina Department of Urology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Division of Urology Department of SurgeryQueen Mary HospitalHong KongChina

The long-term survival outcomes of radical prostatectomy(RP)in Chinese prostate cancer(PCa)patients are poorly *** conducted a single-center,retrospective analysis of patients undergoing RP to study the prognostic value of pathological and surgical *** April 1998 to February 2022,782 patients undergoing RP at Queen Mary Hospital of The University of Hong Kong(Hong Kong,China)were included in our *** Cox regression analysis and Kaplan–Meier analysis with stratification were *** 5-year,10-year,and 15-year overall survival(OS)rates were 96.6%,86.8%,and 70.6%,respectively,while the 5-year,10-year,and 15-year PCa-specific survival(PSS)rates were 99.7%,98.6%,and 97.8%,*** International Society of Urological Pathology PCa grades(ISUP Grade Group)≥4 was significantly associated with poorer PSS(hazard ratio[HR]=8.52,95%confidence interval[CI]:1.42–51.25,P=0.02).Pathological T3 stage was not significantly associated with PSS or OS in our *** node invasion and extracapsular extension might be associated with worse PSS(HR=20.30,95%CI:1.22–336.38,P=0.04;and HR=7.29,95%CI:1.22–43.64,P=0.03,respectively).Different surgical approaches(open,laparoscopic,or robotic-assisted)had similar outcomes in terms of PSS and *** conclusion,we report the longest timespan follow-up of Chinese PCa patients after RP with different approaches.

关键词： China oncologic outcome prostate cancer radical prostatectom

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Comparison of systematic and combined biopsy for the detection of prostate cancer

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Asian Journal of Andrology 2024年第5期26卷 517-521页

作者： Jin-Lun Huang Da Huang Tsun-Tsun chun Chi Yao Yong-Le Zhan Xiao-Hao Ruan terence chun-ting lai Chiu-Fung Tsang Karl-Ho Pang Ada Tsui-Lin Ng Dan-Feng Xu Brian Sze-Ho Ho Rong Na Department of Urology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Division of Urology Department of SurgeryLKS Faculty of MedicineThe University of Hong KongHong KongChina Division of Urology Department of SurgeryQueen Mary HospitalHong KongChina

Systematic prostate biopsy has limitations,such as overdiagnosis of clinically insignificant prostate cancer and underdiagnosis of clinically significant prostate *** resonance imaging(MRI)-guided biopsy,a promising alternative,might improve diagnostic *** compare the cancer detection rates of systematic biopsy and combined biopsy(systematic biopsy plus MRI-targeted biopsy)in Asian men,we conducted a retrospective cohort study of men who underwent either systematic biopsy or combined biopsy at two medical centers(Queen Mary Hospital and Tung Wah Hospital,Hong Kong,China)from July 2015 to December *** statistics were calculated,and univariate and multivariate logistic regression analyses were *** primary and secondary outcomes were prostate cancer and clinically significant prostate cancer.A total of 1391 participants were *** overall prostate cancer detection rates did not significantly differ between the two groups(36.3%vs 36.6%,odds ratio[OR]=1.01,95%confidence interval[CI]:0.81-1.26,P=0.92).However,combined biopsy showed a significant advantage in detecting clinically significant prostate cancer(Gleason score≥3+4)in patients with a total serum prostate-specific antigen(tPSA)concentration of 2-10 ng ml−1(systematic vs combined:11.9%vs 17.5%,OR=1.58,95%CI:1.08-2.31,P=0.02).Specifically,in the transperineal biopsy subgroup,combined biopsy significantly outperformed systematic biopsy in the detection of clinically significant prostate cancer(systematic vs combined:12.6%vs 24.0%,OR=2.19,95%CI:1.21-3.97,P=0.01).These findings suggest that in patients with a tPSA concentration of 2-10 ng ml−1,MRI-targeted biopsy may be of greater predictive value than systematic biopsy in the detection of clinically significant prostate cancer.

关键词： clinically significant prostate cancer combined biopsy prostate cancer systematic biopsy transperineal biopsy

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Anterior perineal hernia after anterior exenteration

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Asian Journal of Urology 2017年第4期4卷 253-255页

作者： Ka Wing Wong terence chun-ting lai Ada Tsui-lin Ng Brian Sze-ho Ho James Hok-leung Tsu Chiu Fung Tsang W.K.Ma Ming Kwong Yiu Division of Urology Department of SurgeryQueen Mary HospitalUniversity of Hong KongHong KongChina

Perineal hernia is a rare complication of anterior *** reported this complication after an anterior exenteration for bladder cancer with bleeding complication requiring packing and second-look *** approach is a simple... 详细信息

关键词： Perineal hernia Anterior exenteration Bladder cancer Mesh repair

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Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第42期11卷 6701-6706页

作者： terence CW Poon Clarissa HS Chiu Paul BS lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson Department of Medicine and Therapeutics Sir YK Pao Cancer Centre the Chinese University of Hong Kong Prince of Wales Hospital NT Hong Kong China Department of Clinical Oncology Sir YK Pao Cancer Centre the Chinese University of Hong Kong Prince of Wales Hospital NT Hong Kong China Department of Surgery Sir YK Pao Cancer Centre the Chinese University of Hong Kong Prince of Wales Hospital NT Hong Kong China Cancer Research UK Institute for Cancer Studies University of Birmingham Vincent Drive Edgbaston Birmingham B15 2TT United Kingdom

AIM： To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance. METHODS： Preoperative sera, paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC. ST6Gal I activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay. RESULTS： The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage （r = -0.53, P = 0.019）. Both decreased tumor ST6Gal I activity and increased serum msAFP percentage were associated with poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal I activity （P = 0.028）, increased serum msAFP percentage （P = 0.034） and poor tumor cell differentiation （P = 0.031）were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage （P = 0.022） and tumor cell differentiation status （P = 0.048） were independent prognostic indicators for patient overall survival. CONCLUSION： Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.

关键词： Alpha-fetoprotein Beta-galactoside alpha-2,6-sialyltransferase Hepatocellular carcinoma Patientsurvival Cell differentiation

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