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Neural Regeneration Research 2016年第7期11卷 1147-1152页

作者： Tigran R. Petrosyan Anna S. ter-Markosyan Anna S. Hovsepyan yerevan State Medical University YerevanArmenia SPC"Armbiotechnology"SNPO NAS RA YerevanArmenia

The study aims to confirm the neuroregenerative effects of bacterial melanin （BM） on central nervous system injury using a special staining method based on the detection of Ca^2＋-dependent acid phosphatase activity. Twenty-four rats were randomly assigned to undergo either unilateral destruction of sensorimotor cortex （group I; n = 12） or unilateral rubrospinal tract transection at the cervical level （C3-4）（group II; n = 12）. In each group, six rats were randomly selected after surgery to undergo intramuscular injection of BM solution （BM subgroup） and the remaining six rats were intramuscularly in）ected with saline （saline subgroup）. Neurological testing confirmed that BM accelerated the recovery of motor function in rats from both BM and saline subgroups. Two months after surgery, Ca^2＋-dependent acid phosphatase activity detection in combination with Chilingarian＇s calcium adenoside triphosphate method revealed that BM stimulated the sprouting of fibers and dilated the capillaries in the brain and spinal cord. These results suggest that BM can promote the recovery of motor function of rats with central nervous system injury; and detection of Ca^2＋-dependent acid phosphatase activity is a fast and easy method used to study the regeneration-promoting effects of BM on the injured central nervous system.

关键词： nerve regeneration bacterial melanin histochemical analysis rubrospinal tract sensorimotor cortex Ca^2+-dependent acid phosphatase activity rats neural regeneration

Effects of diabetes type 2 and metformin treatment in Swedish patients with colorectal cancer

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World Journal of Gastroenterology 2022年第19期28卷 2148-2151页

作者： Jan Dimberg Levar Shamoun Kalle Landerholm Dick Wågsäter Department of Natural Science and Biomedicine School of Health and WelfareJönköping UniversityJönköping 55111Sweden Department of Laboratory Medicine and Pathology Region Jönköping CountyJönköping 55305Sweden Department of Medical Cell Biology Uppsala UniversityUppsala 75123Sweden Department of Surgery Region Jönköping CountyJönköping 55305Sweden Department of Biomedical and Clinical Sciences Linköping UniversityLinköping 58185Sweden

The association between type 2 diabetes mellitus(DM)and colorectal cancer(CRC)has been thoroughly investigated and reports have demonstrated that the risk of CRC is increased in DM *** association between DM and the survival of patients with CRC is *** suggests that metformin with its anti-inflammatory effects is a protective factor against the development of CRC among DM patients and that metformin therapy is associated with a better prognosis in patients with *** our cohort,we did not find any associations between the presence of DM or metformin and cancer specific survival or any relation to plasma levels of a panel of 40 inflammatory factors and *** the other hand,we identified that the insulin-like growth factor binding protein 7 single nucleotide polymorphism rs2041437 was associated with DM in CRC *** dominance of the T bearing genotypes in patients with DM was statistically significant(P=0.038),with an odds ratio of 1.66(95%confidence interval:1.03-2.69).

关键词： Diabetes Metformin Cytokines Survival Colorectal cancer Polymorphism

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新概念英语第三册教学参考书练习答案

新概念英语第三册教学参考书练习答案

Real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

作者：浙江大学语言系nce(Ⅲ)教学参考书编写组

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World Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter Róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás Réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor Réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István Peták Oncompass Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(years)were involved in our precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(WES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(MTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded WES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of WES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

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拉彭兰塔城市剧院芬兰拉彭兰塔

世界建筑导报 2024年第2期39卷 114-116页

作者： Juho Grönholm Antti Nousjoki Janne teräsvirta Samuli Woolston Harri Ahokas Tiina Liisa Juuti Julius Kekoni Auvo Lindroos Niklas Mahlberg Marlène Oberli-Räihä Pekka Sivula Tuomas Uusheimo(摄影) ALA建筑师事务所不详

拉彭兰塔城市剧院的概念与众不同:剧院建在一个购物中心的顶层。然而,这个概念很古老,这也是剧院回归本源、回归市场、回归公众的原因。购物中心每年有数百万客流,这些人可以欣赏各种戏剧,然后在餐厅用餐休息或下榻酒店。门厅采用平静... 详细信息

拉彭兰塔城市剧院的概念与众不同:剧院建在一个购物中心的顶层。然而,这个概念很古老,这也是剧院回归本源、回归市场、回归公众的原因。购物中心每年有数百万客流,这些人可以欣赏各种戏剧,然后在餐厅用餐休息或下榻酒店。门厅采用平静的单色氛围,与购物中心繁忙的明亮色彩形成对比。一块几乎透明的波浪形金属丝网帘将门厅与下方的购物中心分隔开来。楼梯从拱廊通向剧院门厅,观众穿过巨大的白色楼梯后抵达剧院。

关键词：购物中心金属丝网波浪形塔城市楼梯剧院回归

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校园城市村落芬兰埃斯波

世界建筑导报 2024年第2期39卷 104-105页

作者： Juho Grönholm Antti Nousjoki Janne teräsvirta Samuli Woolston Willem Barendregt Vladimir Ilic Julius Kekoni Auvo Lindroos Aleksi Niemeläinen Pekka Sivula Pekka Tainio Jussi Vuori Haley Zhou ErikaÖsterlund ALA建筑师事务所

ALA建筑师事务所在阿尔托大学的2015校园国际设计竞赛中提出了“大型联合建筑群——活动孵化器”的理念。他们的目标是连接现有的结构和项目,创建一个新的区域热点,一个充满街道生活气息的城市集中区,促进创造力的展示。

关键词：建筑师事务所国际设计竞赛孵化器创造力生活气息阿尔托大学校园集中区

Classical Chinese Novels in Hungarian Translation

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中国比较文学 2014年第4期 110-119页

作者： Peter Hajdu Institute for Literary Studies Hungarian Academy of Sciences

社会主义时期(1957-1989)的匈牙利迎来了翻译的黄金时代:不以盈利为目的的国有出版社能够赞助长期的翻译项目,并因拥有可靠的编辑人员和众多优秀的译者而生产佳作。在此期间,《金瓶梅》和中国古典小说四大名著中的三部被译为匈牙利语,不... 详细信息

社会主义时期(1957-1989)的匈牙利迎来了翻译的黄金时代:不以盈利为目的的国有出版社能够赞助长期的翻译项目,并因拥有可靠的编辑人员和众多优秀的译者而生产佳作。在此期间,《金瓶梅》和中国古典小说四大名著中的三部被译为匈牙利语,不过,其中只有《水浒传》(1961)和《西游记》(1969)是由一位杰出的汉学家直接从中文译入的,而《红楼梦》(1959)和《金瓶梅》(1964)均转译自德文删简版。然而,那些转译的作品却更受欢迎,不断再版。究其原因,也许是原作的异国因素在经过转译后,更易引起匈牙利读者的共鸣,但也可能是因为家族题材的小说与西方小说更为相类,更易为本土读者所接受。1989年之后匈牙利对中国文学的翻译急剧减少,此种状况今后或许会有改善。

关键词：直译转译中国古典小说匈牙利的翻译传统莫言

结石通胶囊联合经皮肾镜取石术治疗感染性肾结石的临床疗效

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国际泌尿系统杂志 2024年第4期44卷 581-585页

作者：庞松强罗功唐宋瑶肖博北京市顺义区医院泌尿外科北京101300 北京清华长庚医院泌尿外科北京102218

目的探究结石通胶囊联合经皮肾镜取石术(PCNL)治疗感染性肾结石的临床疗效。方法选取2020年6月至2022年7月本院收治的120例感染性肾结石患者为研究对象,按随机数字表法将患者分为对照组(60例)和研究组(60例),对照组采用PCNL及安慰剂治疗... 详细信息

目的探究结石通胶囊联合经皮肾镜取石术(PCNL)治疗感染性肾结石的临床疗效。方法选取2020年6月至2022年7月本院收治的120例感染性肾结石患者为研究对象,按随机数字表法将患者分为对照组(60例)和研究组(60例),对照组采用PCNL及安慰剂治疗,研究组在对照组基础上联合结石通胶囊治疗。记录并比较两组患者的总疗效、红细胞免疫功能[红细胞C3b受体花环率(C3bRR)、红细胞免疫复合物花环率(ICRRR)、肿瘤红细胞花环率(ter)]、术后指标[结石残留率、结石排出时间、肠功能恢复时间]、中医证候积分和并发症发生情况。结果治疗后研究组患者的总治疗有效率高于对照组,而C3bRR、ICRRR和ter水平、结石残留率、结石排出时间、肠功能恢复时间及中医证候积分均低于对照组(均P0.05]。结论结石通胶囊联合PCNL应用于感染性肾结石能有效提高疗效,减轻患者症状,提高红细胞免疫力,促进患者的术后恢复。

关键词：肾结石感染经皮肾镜取石术结石通胶囊

Hyperactive learning for data-driven interatomic potentials

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npj Computational Materials 2023年第1期9卷 599-612页

作者： Cas van der Oord Matthias Sachs Dávid Péter Kovács Christoph Ortner Gábor Csányi University of Cambridge Cambridge CB21PZUK University of Birmingham Birmingham B152TTUK University of British Columbia VancouverBC V6T 1Z2Canada

Data-driven interatomic potentials have emerged as a powerful tool for approximating ab initio potential energy *** most time-consuming step in creating these interatomic potentials is typically the generation of a suitable training *** aid this process hyperactive learning(HAL),an accelerated active learning scheme,is presented as a method for rapid automated training database *** adds a biasing term to a physically motivated sampler(*** dynamics)driving atomic structures towards uncertainty in turn generating unseen or valuable training *** proposed HAL framework is used to develop atomic cluster expansion(ACE)interatomic potentials for the AlSi10 alloy and polyethylene glycol(PEG)polymer starting from roughly a dozen initial *** HAL generated ACE potentials are shown to be able to determine macroscopic properties,such as melting temperature and density,with close to experimental accuracy.

关键词： starting generating consuming

Interleukin-6 secretion is limited by self-signaling in endosomes

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Journal of Molecular Cell Biology 2019年第2期11卷 144-157页

作者： Danielle R.J.Verboogen Natalia H.Revelo Martin ter Beest Geert van den Bogaart Departme nt of Tumor Immuno logy Radboud Institute for Molecular Life Sciences Radboud University Medical Center 6525 GA Nijmegen The Netherlands Department of Molecular Immunology Groningen Biomolecular Sciences and Biotechnology Institute University of Groningen Nijenborgh 7 9747 AG Groningen The Netherlands

Cells producing cytokines often express the receptor for the same cytokine, which makes them prone to autocrine signaling. How cytokine release and signaling are regulated in the same cell is not understood? In this study, we demonstrate that signaling by exogenous and self-synthesized inflammatory cytokine interleukin-6 (IL-6) within endosomal compartments acts as a cellular brake that limits the synthesis of IL-6. Our data show that IL-6 is internalized by dendritic cells and signals from endosomal compartments containing the IL-6 receptor. Newly synthesized IL-6 also traffics via these endosomal compartments and signals in transit to the plasma membrane. This allows activation of STAT3 which in turn limits toll-like receptor 4 stimulant lipopolysaccharide (LPS) triggered transcription of IL-6. Long-term exposure to LPS removes this brake via inhibition of STAT3 by increased expression of suppressor of cytokine signaling 3 and results in fully fledged IL-6 production. This transient regulation could prevent excessive IL-6 production during early infections.

关键词： membrane trafficking cytokine release exocytosis interleukin-6 endosomal signaling