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Specific changes in the expression of imprinted genes in prostate cancer--implications for cancer progression and epigenetic regulation

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Asian Journal of Andrology 2012年第3期14卷 436-450,I0007页

作者： teodora Ribarska Klaus-Marius Bastian Annemarie Koch Wolfgang A Schulz Department of Urology Heinrich Heine University 40225 Duesseldorf Germany 1

Epigenetic dysregulation comprising DNA hypermethylation and hypomethylation, enhancer of zeste homologue 2 （EZH2） overexpression and altered patterns of histone modifications is associated with the progression of prostate cancer. DNA methylation, EZH2 and histone modifications also ensure the parental-specific monoallelic expression of at least 62 imprinted genes. Although it is therefore tempting to speculate that epigenetic dysregulation may extend to imprinted genes, expression changes in cancerous prostates are only well documented for insulin-like growth factor 2 （IGF2）. A literature and database survey on imprinted genes in prostate cancer suggests that the expression of most imprinted genes remains unchanged despite global disturbances in epigenetic mechanisms. Instead, selective genetic and epigenetic changes appear to lead to the inactivation of a sub-network of imprinted genes, which might function in the prostate to limit cell growth induced via the PI3K/Akt pathway, modulate androgen responses and regulate differentiation. Whereas dysregulation of IGF2 may constitute an early change in prostate carcinogenesis, inactivation of this imprinted gene network is rather associated with cancer progression.

关键词： androgen signalling imprinted genes loss of imprinting PI3K signalling prostate cancer

Platinum nanoparticles coated by graphene layers: A low-metal loading catalyst for methanol oxidation in alkaline media

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Journal of Energy Chemistry 2020年第1期29卷 81-88,I0004页

作者： Camelia Berghian-Grosan teodora Radu Alexandru R.Biris Monica Dan Cezara Voice Fumiya Watanabe Alexandru S.Biris Adriana Vulcu National Institute for Research and Development of Isotopic and Molecular Technologies 67-103 Donat StreetCluj-Napoca 400293Romania Center for Integrative Nanotechnology Sciences University of Arkansas at Little Rock2801 S.University Ave.Little RockAR 72204USA

Platinum catalysts play a major role in the large scale commercialization of direct methanol fuel cells(DMFC).Here,we present a procedure to create a nanostructural graphene-platinum(Gr Pt)composite containing a small amount(5.3 wt%)of platinum nanoparticles coated with at least four layers of *** composite,as Gr Pt ink,was deposited on a glassy carbon electrode and its electrocatalytic activity in a methanol oxidation reaction(MOR)was evaluated in a 1 M CH3OH/1 M NaOH *** results indicated an enhanced catalytic performance of GrPt towards MOR in alkaline media compared with the Pt/C *** energy-loss spectroscopy and X-ray photoelectron spectroscopy(recorded before and after the electrochemical assays)were employed to analyze the changes in the chemical composition of the nanomaterial and to explain the transformations that took place at the electrode *** findings suggest that growing of graphene on platinum nanoparticles improve the catalytic performance of platinum-graphene composites towards MOR in alkaline media.

关键词： Low-platinum loading electrocatalyst Graphene layers Methanol oxidation Electrocatalysis Alkaline fuel cell

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Ellen MacArthur

商周刊 2006年第8期 76-77页

作者： teodora Lazarova

Just over a year since breaking the round theworld solo record on board her 75 foot trimaranB&O,Ellen MacArthur embarked on a newventure:the Asian Record Circuit 2006,incorpo-rating the ‘Tour Of China’,and bringing a differ-ent set of challenges into new *** to Ellen and her team during their recent(April)stopover in *** did you start sailing and what inspiredyou(you grew up in Derbyshire,in the UK,quite far away from the water)?I was introduced to sailing by my Aunt Thea ona small sailing boat called *** wentsailing along the east coast of EngLand andbefore I knew it,I was hooked on sailing.I wasso inspired that when I was at school,I saved

关键词： Ellen MacArthur

On Divine Love as the Foundation of Creation

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Journal of Philosophy Study 2011年第3期1卷 205-212页

作者： teodora-Liliana Prelipcean ＂Petre Andrei＂ University of Iasi

The core of this study is Saint John the Apostle＇s statement that says God is love. From Love, God created the world and man. Also from love, He sent His Son, Jesus Christ, to redeem the sin committed by the primordial couple. In other words, the absolute Love that belongs to the Supreme Being is the source and sap of Creation, the source of life and the whole meaning of existence. Thus, Love is a gift through which God shows His Love for men, making possible, at the same time, their Love for themselves and for others. Moreover, the Resurrection is the victory of Love over death. The keys that open the gates of Love are faith and allegiance, accomplishing His commandments andprayer As a result, an entire Theology of Love develops, stressing the fact that divine Love is accomplished and is a Love without death to which we all should aspire.

关键词： God Christian Love gift mystery Sacrifice communion

Cross-talks among GBA mutations,glucocerebrosidase,and a-synuclein in 66/4-associated Parkinson's disease and their targeted therapeutic approaches:a comprehensive review

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Translational Neurodegeneration 2021年第1期10卷 27-39页

作者： Tapan Behl Gagandeep Kaur Ovidiu Fratila Camelia Buhas Claudia teodora Judea-Pusta Nicoleta Negrut Cristiana Bustea Simona Bungau Chitkara College of Pharmacy Chitkara UniversityRajpuraPunjabIndia Departm ent of Medical Disciplines Faculty of Medicine and PharmacyUniversity of OradeaOradeaRomania Department of Morphological Disciplines Faculty of Medicine and PharmacyUniversity of OradeaOradeaBihor CountyRomania Departm ent of Psycho-Neuroscience and Recovery Faculty of Medicine and PharmacyUniversity of OradeaOradeaRomania Department of Preclinical Disciplines Faculty of Medicine and PharmacyUniversity of OradeaOradeaRomania Department of Pharmacy Faculty of Medicine and PharmacyUniversity of OradeaOradeaRomania

Current therapies for Parkinson's disease(PD)are palliative,of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of *** to the complication of such a multifactorial disorder and significant limitations of the therapy,numerous genetic approaches have been proved effective in finding out genes and mechanisms implicated in this *** the observation of a higher frequency of PD in Gaucher's disease(GD),a lysosomal storage condition,mutations of glycosylceramidase beta(GBA)encoding glucocerebrosidase(GCase)have been shown to be involved and have been explored in the context of *** mutations are the most common genetic risk factor of *** studies have revealed the relationships between PD and GM gene mutations,facilitating a better understanding of this *** hypotheses delineate that the pathological mutations of GBA minimize the enzymatic activity of GCase,which affects the proliferation and clearance of α-synuclein;this affects the lysosomal homeostasis,exacerbating the endoplasmic reticulum stress or encouraging the mitochondrial *** of the pathological mechanisms underlying the GM-associated parkinsonism(GBA+PD)advances our understanding of *** review based on current literature aims to elucidate various genetic and clinical characteristics correlated with GBA mutations and to identify the numerous pathological processes underlying GBA+*** also delineate the therapeutic strategies to interfere with the mutant GCase function for further improvement of the related asynuclein-GCase ***,the various therapeutic approaches such as gene therapy,chaperone proteins,and histone deacetylase inhibitors for the treatment of GBA+PD are discussed.

关键词： Parkinson's disease Glycosylceramidase Glucocerebrosidase Gaucher's disease Mutations α-Synuclein

Psychosocial determinants of irritable bowel syndrome

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World Journal of Gastroenterology 2012年第7期18卷 616-626页

作者： teodora Surdea-Blaga Adriana Bban Dan L Dumitrascu 2nd Medical Department University of Medicine and Pharmacy IuliuHatieganuCluj-Napoca 400006Romania Department of Psychology Babes-Bolyai UniversityCluj-Napoca 400006Romania

From a pure motor disorder of the bowel,in the past few years,irritable bowel syndrome (IBS) has become a multifactorial disease that implies visceral hypersensitivity,alterations at the level of nervous and humoral communications between the enteric nervous system and the central nervous system,alteration of the gut microflora,an increased intestinal permeability and minimum intestinal *** and social factors can interfere with the communication between the central and enteric nervous systems,and there is proof that they are involved in the onset of IBS and influence the response to treatment and *** is evidence that abuse history and stressful life events are involved in the onset of functional gastrointestinal *** order to explain clustering of IBS in families,genetic factors and social learning mechanisms have been *** psychological features,such as anxiety,depression as well as the comorbid psychiatric disorders,health beliefs and coping of patients with IBS are discussed in relation to the symptoms and outcome.

关键词： Anxiety Depressive symptoms Irritablebowel syndrome Personality Psychosocial factors Sexual abuse Stressful events

Elapidae Snake BitesmBiophysical Aspects of the Neuroparalytic Envenomation

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Journal of Pharmacy and Pharmacology 2016年第12期4卷 715-720页

作者： Yuliyan Naydenov teodora Karachorova Detelina Ilieva Department of Medicine Medical University of Varna Varna 9002 Bulgaria Department of Medical Physics and Biophysics Faculty of Pharmacy Medical University of Varna Varna 9002 Bulgaria

Snakebite is classified by the WHO （World Health Organization） as a neglected tropical disease, envenoming in a significant public health problem in tropical and subtropical regions. Neurotoxicity is a key feature of different types of envenomations and there are many unanswered questions regarding this manifestation. Acute neuromuscular weakness with respiratory involvement is the most clinically important neurotoxic effect. We present how the neuroparalytic poison affects the human body and what actually happens when the poison is injected into the human body. Neuroparalytic poisons are one of the most lethal, because they cause paralysis of the eye, throat and chest muscles. A well-known member of the Elapidae family is the cobra. Bungarotoxins are a group of closely related neurotoxin proteins. The α-bungarotoxin inhibits the binding of acetylcholine （ACh） to nicotinic acetylcholine receptors; β-bungarotoxin and T-bungarotoxins act presynaptically causing excessive acetylcholine release and subsequent depletion.

关键词： Elapidae action potential neuromuscular synapse poison bungarotoxin paralysis.

Theoretical and Technological Aspects on the Inverse Structure in the Fields of High Speed Electric Machines

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Journal of Energy and Power Engineering 2012年第3期6卷 456-462页

作者： Mircea Ignat teodora Paraschiv Ioan Cristinel Haraguta National Institute for Research and Development in Electrical Engineering （INCDIE CA） Bucharest 030138 Romania National Research ＆ Development Institute for Gas Turbine Bucharest 061126 Romania

The paper presents the design and technological aspects on the high speed electrical machines which include the mechanical radial and axial strees because of the centrifugal forces. It presents a reverse structure with outlet rotor and inlet stator that have high speed 20.000 rpm-24.000 rpm and power 1 kW for the pecific of the ventilanting centrifugal fan domain. This unconventional type of machine is not still in the phase of specific tests.

关键词： Asyncrone machine cage high speed magnetic circuit mechanical stress motor reverse structure.

Lexicographic Constant-Weight Equidistant Codes over the Alphabet of Three, Four and Five Elements

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Intelligent Information Management 2010年第3期2卷 183-187页

作者： Todor Todorov Galina Bogdanova teodora Yorgova Institute of Mathematics and Informatics Bulgarian Academy of Sciences

In this paper we consider the problem of finding bounds on the size of lexicographic constant-weight equidistant codes over the alphabet of three, four and five elements with 2 ≤ w 详细信息

In this paper we consider the problem of finding bounds on the size of lexicographic constant-weight equidistant codes over the alphabet of three, four and five elements with 2 ≤ w

关键词： Lexicographic Codes Equidistant Codes Constant-Weight Codes Bounds of Codes