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Oxaliplatin-induced neuropathy and colo-rectal cancer patient's quality of life:Practical lessons from a prospective cross-sectional,real-world study

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World Journal of Clinical Cases 2022年第10期10卷 3101-3112页

作者： Iulian Prutianu teodora alexa-stratulat Elena Octaviana Cristea Andrei Nicolau Diana Cornelia Moisuc Alina alexandra Covrig Karina Ivanov Adina Emilia Croitoru Monica Ionela Miron Mihaela Ioana Dinu Anca Viorica Ivanov Mihai Vasile Marinca Iulian Radu Bogdan Gafton SC MNT Healthcare Europe SRL Iasi 700021Romania University of Medicine and Pharmacy Grigore T Popa Iasi Iasi 700483Romania Regional Oncology Institute Iasi Iasi 700483Romania Oral and Maxillo-facial Surgery University of Medicine and Pharmacy Grigore T Popa IasiIasi 700021Romania Department of Medical Oncology Fundeni Clinical InstituteBucuresti 022328Romania University of Medicine and Pharmacy“Grigore T Popa” Iasi 700021Romania Department of Surgery Department of Surgical OncologyUniversity of Medicine and Pharmacy“Grigore T Popa”Regional Institute of OncologyIasi 700021Romania

BACKGROUND Colon cancer is one the most common forms of cancer in both *** to important progress in the field of early detection and effective treatment,colon and rectal cancer survivors currently account for 10%of cancer survivors ***,the effects of anti-cancer treatments,especially oxaliplatinbased chemotherapy,on the quality of life(QoL)have been less *** the incidence of severe chemotherapy-induced neuropathy(CIPN)in clinical studies is below 20%,data from real-world studies is scarce,and CIPN is probably under-reported due to patient selection and the patients’fear that reporting side-effects might lead to treatment *** To determine the impact of CIPN on QoL in colorectal cancer patients with a recent history of oxaliplatin-based *** We performed a prospective cross-sectional study in two major Romanian oncology tertiary hospitals—the Regional Institute of Oncology Ia?i(Iasi,Romania)and the Fundeni Clinical Oncology Institute(Bucharest,Romania).All consecutive patients with colon or rectal cancer,undergoing Oxaliplatin-based chemotherapy that consented to enroll in the study,were assessed by means of two questionnaires—the EORTC QQ-CR29(quality of life in colon and rectal cancer patients)and the QLQ-CIPN20(assessment of neuropathy).Several demographical,social,clinical and treatment data were also *** analysis was performed by means of SPSS *** student t test was used to assess the relationship between the QLQ-CIPN20 and QLQ-CR29 *** Meyer-curves were used to report 3-year progression-free survival(PFS)in patients that discontinued chemotherapy vs those that completed the recommended *** Of the 267 patients that fulfilled the inclusion criteria in the pre-specified time frame,101(37.8%)agreed to participate in the clinical *** the time of the enrolment in the study,over 50%of the patients had recently interrupted their oxaliplatin-based chemotherapy,mo

关键词： Colorectal cancer Oxaliplatin Neuropathy Quality of Life Recurrence-free survival Cross-sectional study

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Ambient Air-Quality Impact as a Determinant External Factor of the Exposome in Cacica Area, Romania

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Journal of Environmental Science and Engineering(A) 2015年第11期4卷 567-577页

作者： Sorin Ioan stratulat Department of Medicine and Pharmacy "Gr. T. Popa " Faculty of Medicine and Dental Medicine lasi 700100 Romania Clinic of Rehabilitation Physical Medicine and Balneo-climatology C.F. Clinic Hospital Garabet lbraileanu lasi 700506 Romania Atmosphere Optics Spectroscopy and Lasers Laboratory Faculty of Physics "Alexandru Ioan Cuza" University of lasi Iasi 700506 Romania Department of Physics Gheorghe Asachi Technical University of lasi lasi 700050 Romania Regional Forecast Center Bacau National Meteorological Administration Bacau 600274 Romania

Some geographic regions induce beneficial effects on health status. The world health organization is interested in analyzing this type of climate area in order to establish a network health status. Understanding the parameters of this type of climate creates the prerequisites for further research to define their influence on humans, as an external determining factor of the exposome. Supported by historic and medical epidemioiogy data, the Cacica area, Roman has beneficial effects on human health. This climatic natural are, a will be characterized by monitoring their parameters. Thus, they will be rigorously defined and considered of major influence in the exposome. Air quality measurements were made and the local meteorological parameters were monitored. These were correlated with LIDAR data. The atmospheric layers have been evidenced and a possible scenario for the elimination of the pollutant ~erosols has been created, in case, the area suffers contamination during a certain season. The analyzed area shows as climatic characteristics both the absence of pollutant factors and the natural structure of the geo-system. The characterization of this area associated with the special terrain （the through）, involves the introduction of new local development directions： education, ecology and economy.

关键词： Aerosols climate-therapy environmental monitoring exposome

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Aging in epitaxial ferroelectric PbTiO_(3) films

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Journal of Advanced Dielectrics 2016年第4期6卷 5-11页

作者： Jari Hannu Jani Peräntie Sergiu Mihai stratulat Heli Jantunen Marina Tyunina Microelectronics Research Unit University of Oulu PO BOX 4500 FIN-90014 University of OuluFinland

Ability of epitaxial perovskite oxide ferroelectric films to maintain a poled polarization state on a long-term scale is crucial for advanced devices employing such *** polarization relaxation with time,or aging,is experimentally studied in epitaxial capacitor heterostructures of PbTiO3 sandwiched between SrRuO_(3)and Pt *** relaxation obeys logarithmic time-decay for the time 10^(2)–10^(5)s after poling *** decay is by factor10 slower than that reported for polycrystalline *** experimental results show that existing models are insufficient for epitaxial films.

关键词： Ferroelectric epitaxy capacitor aging.

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