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Phenolics, fatty acids composition and biological activities of various extracts and fractions of malaysian Aaptos aaptos

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Asian Pacific Journal of Tropical Biomedicine 2018年第11期8卷 554-564页

作者： Zalilawati mat Rashid Abdul m. Ali Philippe Douzenel Nathalie Bourgougnon Khozirah Shaari Yosie Andriani tengku sifzizul tengku muhammad habsah mohamad Faculty of Bioresources and Food Industry Universiti Sultan Zainal Abidin Besut Campus School of Agriculture Science & Biotechnology Universiti Sultan Zainal Abidin Besut Campus Faculté des Sciences et Sciences de l'Ingénieur (UFR SSI) Centre Yves Coppens Université Européenne de Bretagne Campus de Tohannic - BP 573 LBCm Université Européenne de Bretagne Campus de Tohannic BP573 Laboratory of Natural Products Institute of Bioscience Universiti Putra Malaysia Institute of marine Biotechnology University Malaysia Terengganu Mengabang Telipot

Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of malaysian Aaptos aaptos. methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vero cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results: The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, mCF-7, K562, CEm-SS and WEHI-3 B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions: Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process.

关键词： Aaptos aaptos Fatty acid p-Hydroxybenzamide Antioxidant Cytotoxicity Antivirus

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