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Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model

World Journal of Experimental Medicine 2024年第1期14卷 113-123页

作者： Suriati Mohd Nasir Anis Farihan Ismail Tuan Salwani Tuan Ismail Wan Faiziah Wan Abdul Rahman Wan Amir Nizam Wan Ahmad tengku Ahmad Damitri Al-Astani tengku Din Kuttulebbai Nainamohammed Salam Sirajudeen Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Endocrinology Laboratory Department of Chemical PathologySchool of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Biomedicine Program School of Health SciencesHealth CampusUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Department of Basic Medical Sciences Kuliyyah of MedicineInternational Islamic University MalaysiaBandar Indera MahkotaKuantan 25200PahangMalaysia

BACKGROUND Diabetes is known damage the liver and kidney,leading to hepatic dysfunction and kidney *** is believed to help in lowering the blood glucose levels of diabetic patients and reducing diabetic ***,the effect of stingless bee honey(SBH)administration in relieving liver and kidney damage in diabetes has not been *** To investigate the effect of SBH administration on the kidney and liver of streptozotocin-induced(STZ;55 mg/kg)diabetic Sprague Dawley *** The rats were grouped as follows(n=6 per group):non-diabetic(ND),untreated diabetic(UNT),metformin-treated(MET),and SBH+metformin-treated(SBME)*** successful diabetic induction,ND and UNT rats were given normal saline,whereas the treatment groups received SBH(2.0 g/kg and/or metformin(250 mg/kg)for 12 *** biochemical parameters and histological changes using hematoxylin and eosin(H&E)and periodic acid–Schiff(PAS)staining were *** On H&E and PAS staining,the ND group showed normal architecture and cellularity of Bowman’s capsule and tubules,whereas the UNT and MET groups had an increased glomerular cellularity and thickened basement *** SBH-treated group showed a decrease in hydropic changes and mild cellularity of the glomerulus vs the ND group based on H&E staining,but the two were similar on PAS ***,the SBME-treated group had an increase in cellularity of the glomerulus on H&E staining,but it was comparable to the SBH and ND groups on PAS *** diabetic rats had tubular hydropic tubules,which were smaller than other *** fatty vacuole formation and dilated blood sinusoids in liver tissue were seen in the SBH ***,the UNT group had high glucose levels,which subsequently increased MDA levels,ultimately leading to liver *** treatment reduced this damage,as evidenced by having the lowest fasting glucose,serum alanine transaminase,aspartate transaminase,and alkaline phosphatase l

关键词： Diabetes Streptozotocin Stingless bee honey Hematoxylin and eosin Periodic acid-Schiff Liver Kidney

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IoT Technologies for Tackling COVID-19 in Malaysia and Worldwide:Challenges, Recommendations, and Proposed Framework

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Computers, Materials & Continua 2021年第2期66卷 2141-2164页

作者： Ali Saadon Al-Ogaili Ameer Alhasan Agileswari Ramasamy Marayati Binti Marsadek tengku Juhana tengku Hashim Ammar Al-sharaa Mastura Binti Aadamand Lukman Audah Institute of Power Engineering(IPE) Universiti Tenaga NasionalSelangor43000Malaysia Faculty of Electrical and Electronic Engineering Universiti Tun Hussein Onn MalaysiaJohor86400Malaysia Faculty of Built Environment University of MalayaKuala Lumpur50603Malaysia

The Coronavirus(COVID-19)pandemic is considered as a global public health *** contain this pandemic,different measures are being taken *** Internet of Things(IoT)has been represented as one of the most important schemes that has been considered to fight the spread of COVID-19 in the world,practically *** fact,there are many sectors in Malaysia would be transformed into smart services by using IoT technologies,particularly energy,transportation,healthcare *** manuscript presents a comprehensive review of the IoT technologies that are being used currently in Malaysia to accelerate the measures against *** IoT technologies including smart thermal detection,surveillance network,and healthcare delivery *** addition,the most potential IoT technologies developed by other nations to tackle COVID-19 are reviewed,including tracking and tracing systems based on IoT,adoption of IoT technologies in hospitals,and self-monitoring devices based on *** these technologies to be incorporated in Malaysia,the main challenges with possible recommendations are discussed in this ***,this work proposes a conceptual framework to accelerate the battle pace with spread of COVID-19 in Malaysia by integrating IoT technologies used in fighting the outbreak of COVID-19 globally.

关键词： Coronavirus Internet of Things healthcare urban health system

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Effect of Curcuma longa *** on the AP1 expression in rat cochlear fibroblasts under noise conditions

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Journal of Chinese Pharmaceutical Sciences 2016年第9期25卷 690-694页

作者： tengku Siti Hajar Haryuna Ramsi Lutan Faathir Agung Ainu Taufika Ratna Anggraeni tengku Siti Harilza Zubaidah Department of Otorhinolaryngology Faculty of MedicineUniversity of North SumateraMedan 20155Indonesia Department of Otorhinolaryngology Faculty of MedicinePadjadjaran UniversityBandung 45363Indonesia Department of Ophthalmology Faculty of MedicineUniversity of North SumateraMedan 20155Indonesia

Noise-induced cellular stress can cause damage to fibroblasts within the cochlear supporting tissues and lateral wall. In the present study, we aimed to evaluate the role of curcumin as the safe and effective therapeutic agent in the prevention and treatment of this condition according to the expression of activator protein-1(AP1). A total of 24 Rattus norvegicus were randomly divided into four groups(n = 6). Group 1: control; group 2: noise(+); group 3: noise(+), 50 mg/day curcumin(+); group 4: noise(+), 100 mg/day curcumin(+). All groups(except for group 1) were subjected to a sound pressure level(SPL) of 100 d B for 2 h/day during 2 weeks. Curcumin used in this study was derived from Curcuma longa L.(Turmeric), and it was orally administered for 2 weeks. All samples were immunohistochemistrically examined for the expression of AP1 in cochlear fibroblasts. The results showed that there were significant differences for the AP1 expression(P<0.05) among all groups, except for between groups 1 and 3, or between groups 1 and 4. Our data proved that curcumin was potentially effective in the prevention and treatment of damage of fibroblasts within the cochlear supporting tissues and lateral wall due to the decreased AP1 expression following noise exposure.

关键词： Noise Curcumin AP1 Fibroblast Cochlea

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Phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos

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Asian Pacific Journal of Tropical Biomedicine 2018年第11期8卷 554-564页

作者： Zalilawati Mat Rashid Abdul M. Ali Philippe Douzenel Nathalie Bourgougnon Khozirah shaari Yosie Andriani tengku Sifzizul tengku Muhammad Habsah Mohamad Faculty of Bioresources and Food Industry Universiti Sultan Zainal Abidin Besut Campus School of Agriculture Science & Biotechnology Universiti Sultan Zainal Abidin Besut Campus Faculté des Sciences et Sciences de l'Ingénieur (UFR SSI) Centre Yves Coppens Université Européenne de Bretagne Campus de Tohannic - BP 573 LBCM Université Européenne de Bretagne Campus de Tohannic BP573 Laboratory of Natural Products Institute of Bioscience Universiti Putra Malaysia Institute of Marine Biotechnology University Malaysia Terengganu Mengabang Telipot

Objective: To investigate phenolics, fatty acids composition and biological activities of various extracts and fractions of Malaysian Aaptos aaptos. Methods: Fatty acid methyl ester was analyzed by gas chromatography-flame ionization detector. Antioxidant activity was determined using 2,2-diphenyl-picrylhydrazyl radical scavenging assay and total phenolics content by Folin-Ciocalteu procedure. Vero cells viability was evaluated using methyl thiazole tetrazolium and the inactivation of herpes simplex virus type 1 by neutral red uptake assay. p-Hydroxybenzamide isolated by column chromatography was characterized by utilizing nuclear magnetic resonance spectroscopy and electron impact mass spectrometry. Results: The chloroform, ethyl acetate and methanol extracts of Aaptos aaptos produced higher portions of straight-chain saturated fatty acid, while hexane extract mainly consisted of unsaturated fatty acid. The five majors of fatty acid methyl ester were identified as behenic acid, cis-10-heptadecenoic acid and cis-10-pentadecenoic acids, palmitic acid and tricosanoic acid. In addition, among all organic extracts, chloroform extract inactivated herpes simplex virus type 1 while exhibited weak cytotoxic activity against normal Vero cells and also exhibited strong cytotoxic activity on HL-60, MCF-7, K562, CEM-SS and WEHI-3 B cells. A phenolic compound, p-hydroxybenzamide was also isolated from the sponge. Conclusions: Aaptos aaptos could be a source to derive the potential antiviral and anticancer agents. However, further studies are needed to determine the mechanism involved in the process.

关键词： Aaptos aaptos Fatty acid p-Hydroxybenzamide Antioxidant Cytotoxicity Antivirus

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Anthropogenic disturbance of aquatic biodiversity and water quality of an urban river in Penang, Malaysia

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Water Science and Engineering 2023年第3期16卷 234-242页

作者： Nur Azalina Suzianti Feisal Noor Haziqah Kamaludin Muhammad Firdaus Abdullah Sani Dayang Khairulnisa Awang Ahmad Mohd Azwan Ahmad Nur Faiza Abdul Razak tengku Nilam Baizura tengku Ibrahim Department of Environmental Health Faculty of Health SciencesMAHSA UniversityBandar Saujana Putra42610 JenjaromMalaysia Center of Environmental Health&Safety Faculty of Health SciencesUniversiti Teknologi MARA42300 Puncak AlamMalaysia NaturePRO Services Port Dickson71000 Negeri SembilanMalaysia Department of Environmental Health Faculty of Health SciencesUniversiti Teknologi MARACawangan Pulau PinangKampus Bertam13200 Pulau PinangMalaysia

Malaysia's rapid economic and demographic development have placed negative pressure on its water supplies and the quality of the Juru River, which is close to the nation's capital and its major source of water. Healthy aquatic ecosystems are supported by physicochemical properties and biological diversity. This study evaluated the anthropogenic impacts on aquatic biodiversity, especially plankton, fish, and macrobenthos, as well as the water quality of the Juru River in the Penang area. Aquatic biodiversity and river water parameters were collected from ten sampling stations along the Juru River. Seven variables were used to assess the physicochemical environment: pH, temperature, total suspended solids (TSS), salinity, dissolved oxygen (DO), biochemical oxygen demand (BOD), and chemical oxygen demand. At each sampling station, the total number of plankton, fish, and macrobenthic taxa were counted and analyzed. The relationships between the physicochemical parameters and aquatic biodiversity were investigated with biotypological analysis, principal component analysis, hierarchical cluster analysis, and linear regression analysis. These analyses showed that the richness and diversity indices were generally influenced by salinity, temperature, TSS, BOD, and pH. The data obtained in this study supported the bioindicator concept. The findings, as they related to scientifically informed conservation, could serve as a model for Juru River management, as well as for river management throughout Malaysia and other tropical Asian countries.

关键词： Anthropogenic disturbance Aquatic biodiversity River water quality Urban river Hierarchical cluster analysis

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Insecticide resistance status of Aedes aegypti and Aedes albopictus in Malaysia(2010 to 2022):A review

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Asian Pacific Journal of Tropical Medicine 2023年第10期16卷 434-445页

作者： Sabar Nurul-Nastasea Ke-Xin Yu Ahmad Rohani Mohamed Nor Zurainee tengku Idzzan Nadzirah tengku-Idris Roza Dianita Masse Rezki Sabrina Wan Mohamad Ali Wan Najdah School of Graduate Studies Management and Science UniversitySeksyen 1340100Shah AlamSelangorMalaysia Faculty of Health and Life Sciences Management and Science UniversitySeksyen 1340100 Shah AlamSelangorMalaysia Medical Entomology Unit Institute for Medical ResearchNational Institute of HealthMinistry of Health MalaysiaPersiaran Setia MurniSetia Alam40170 Shah AlamSelangorMalaysia Department of Parasitology Faculty of MedicineUniversity of Malaya50603Kuala LumpurMalaysia School of Biology Faculty of Applied SciencesUniversiti Teknologi MARA40450Shah AlamSelangorMalaysia School of Pharmaceutical Sciences Universiti Sains Malaysia11800GelugorPenangMalaysia

This review aimed to determine the prevalence of the insecticide resistance status of the field-collected Aedes(Ae.)aegypti and *** in Malaysia from 2010 to 2022 towards carbamates,organochlorines,organophosphates and *** and environmental controls were summarized with an emphasis on the mosquito vector control strategies in *** information in this review was extracted from several databases such as PubMed(MEDLINE),Science Direct and Scopus by using keywords including“insecticide resistance”,“carbamate resistance”,“organochlorine resistance”,“organophosphate resistance”,“pyrethroid resistance”,“Aedes”and“Malaysia”,between January 2022 and December *** of resistant *** and *** in Malaysia was mapped using QGIS *** resistance in both *** and *** is widespread in Malaysia,although the rates vary by *** most notable was the steep increase in permethrin resistance of *** in Selangor,Malaysia,over the past *** also displayed moderate resistance to permethrin,though not as widespread as *** in Selangor,but showed sign of resistance in Sarawak,East *** towards four main classes of insecticides have been widely documented in *** extensive resistance towards permethrin in Malaysia which is one of the current insecticides used in Malaysia suggested that policies supporting the widespread use of permethrin fogging needs further evaluation.

关键词： Aedes Pyrethroids Insecticide resistance Malaysia Vector control

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Effect of hand hygiene intervention on the absenteeism of pre-school children in Klang Valley,Malaysia:a quasi-experimental study

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World Journal of Pediatrics 2020年第4期16卷 416-421页

作者： Nurul Azmawati Mohamed Mohd Dzulkhairi Mohd Rani tengku Zetty Maztura tengku Jamaluddin Zarini Ismail shalinawati Ramli Habibah Faroque Farisha Nur Abd Samad Abdul Rashid Ariffien Aisyah Ar Redha Che Amir FaridIlina Isahak Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaPandan Indah55100Kuala LumpurMalaysia Faculty of Medicine and Health Sciences Universiti Putra Malaysia43400SerdangSelangorMalaysia

Background Absenteeism amongst pre-school children is often due to illnesses such as hand,foot,and mouth disease,acute gastroenteritis,cold and flu,which are easily spread amongst *** is because of weak immunity and lack of knowledge on proper hand *** quasi-experimental study assessed the efficacy of an intervention consisting of a hand hygiene education programme,along with digital tools in bringing about a change in behaviour and health conditions amongst pre-school children in Klang Valley,*** A total of 377 school children,male and female,aged 5–6 years old,participated and were assigned to either the intervention or a control *** the 2 months intervention period,children in the test group were trained on proper hand hygiene practices and techniques with the aid of the interactive android-based *** numbers of absent days of all the children were recorded for 2 months before the intervention and during the *** In the test group,there was a 25%increase in the total number of absent days from the pre-intervention period to the intervention period,a much lesser increment observed as compared to that of control group in which the increase was much higher at 89%.Results showed a significant difference(Puate the benefit further.

关键词： Absenteeism Hand hygiene Povidone-iodine Pre-school children

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Prevalence and risk factors of Blastocystis infection among underprivileged communities in rural Malaysia

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Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 467-473页

作者： Nabilah Amelia Mohammad Hesham M.Al-Mekhlafi Norhayati Moktar tengku shahrul Anuar Centre of Medical Laboratory Technology Faculty of Health SciencesUniversiti Teknologi MARAPuncak Alam Campus Endemic and Tropical Disease Unit Medical Research CenterJazan University Department of Parasitology Faculty of Medicine and Health SciencesSana’a University Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSungai Long Campus Integrative Pharmacogenomics Institute Universiti Teknologi MARAPuncak Alam Campus

Objective:To determine the prevalence and risk factors of Blastocystis among underprivileged communities living in rural Malaysia. Methods:This cross-sectional study was conducted among 253 participants aged between 1 and 85 years. Stool samples were examined using Wheatley's trichrome stain after in-vitro cultivation in Jones' medium to detect the presence of Blastocystis. Information pertaining to the demography,socioeconomic and environment were collected using pre-validated questionnaires. Results:The total prevalence of Blastocystis infection was 40.7%. The multiple logistic regression analysis revealed that age ≥15 years(OR = 2.72; 95%CI = 1.47-5.04) and presence of infected family members(OR = 8.56; 95%CI = 4.47-16.38) were the significant risk factors associated with blastocystosis in these communities. Conclusions:Blastocystosis is revealed through this study to be still prevalent among Orang Asli communities in rural Malaysia. The two main approaches that should be implemented by the public health authority in battling this infection would be the screening of other family members and giving treatment to the infected individuals. Moreover,it is imperative for health education on good personal and food hygiene practices are provided in order to reduce the morbidity and transmission of Blastocystis infection among the Orang Asli in their communities meaningfully.

关键词： Blastocystis Prevalence Risk factors Malaysia

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Impact of seasonality on the prevalence and risk factors of Giardia lamblia infections among the aborigines

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Asian Pacific Journal of Tropical Medicine 2019年第7期12卷 315-320页

作者： Samseh Abdullah Noradilah Norhayati Moktar Ii Li Lee Fatmah Md Salleh tengku shahrul Anuar Department of Medical Sciences II Faculty of Medicine and Health SciencesUniversiti Sains Islam MalaysiaPandan Indah55100 Kuala LumpurMalaysia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSungai Long CampusSelangorMalaysia Kulliyyah of Medicine and Health Sciences Sultan Abdul Halim Mu'adzam Shah International Islamic UniversityKuala KetilKedahMalaysia Department of Parasitology and Medical Entomology Faculty of MedicineUniversiti Kebangsaan Malaysia Medical CentreCherasKuala LumpurMalaysia Centre of Medical Laboratory Technology Faculty of Health SciencesUniversiti Teknologi MARAPuncak Alam CampusSelangorMalaysia Integrative Pharmacogenomics Institute Universiti Teknologi MARAPuncak Alam CampusSelangorMalaysia

Objective: To determine the prevalence and risk factors of Giardia(G.) lamblia infections among the aboriginal community during the wet and dry seasons. Methods: A total of 473 stool samples from the aborigines in Temerloh, Pahang, Malaysia were collected during wet(n=256) and dry seasons(n=217). Smear of all the PVA-preserved stool samples were subjected to Trichrome staining and microscopic examination under 1 000 伊magnification(Nikon eclipse E100) for the detection of G. lamblia. Positivity was recorded based on the presence of G. lamblia in trophozoite and/or cyst forms. Results: The prevalence of giardiasis was 12.10% and 8.29% during the wet and dry season, respectively. Age of less or equal to 15 years old and presence of other family members with G. lamblia infection were found to be the significant risk factors to acquire G. lamblia infections during both seasons. Untreated water supply was the significant risk factor of giardiasis during the dry season. This study highlighted the possibility of anthroponotic transmission of G. lamblia during both seasons and waterborne transmission during the dry season in the aboriginal community. Conclusions: This study suggests that seasonal variation plays an important role in the prevalence and risk factor of G. lamblia infection in the aboriginal community. Therefore, close contact with Giardia-infected family members and water-related activities or usage of untreated water must be avoided to reduce the burden of G. lamblia infection in this community.

关键词： Giardia Seasonality Aborigine Anthroponotic Waterborne

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Kinetic chain disruption contributes to shoulder and elbow injuries

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Sports Medicine and Health Science 2021年第4期3卷 252-253页

作者： Qais Gasibat tengku Fadilah tengku Kamalden Department of Sport Studies University Putra Malaysia(UPM)Kuala LumpurMalaysia

The kinetic chain or link theory provides the basis for understanding and evaluating human movement patterns as well as the justification for using exercise training and recovery services that emphasise the whole body,despite the damage to a specific joint or anatomical *** motion of one segment affects all proximal and distal segments to the first *** overhead throwing motion is produced and regulated by a sequential position and motion of the body,involving sequential activation.

关键词： Shoulder injuries Elbow injuries Kinetic chain Range of motion

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