检索结果-南通市图书馆

Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia yue Ma Mingtong gao Shuai Hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein

Segmental nature of the Red River fault revealed by seismic anisotropy and geological structures

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年第8期67卷 2423-2443页

作者： Ying LI Yuan gao School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Earthquake Prediction Institute of Earthquake ForecastingChina Earthquake AdministrationBeijing 100036China

As the western boundary of the Sichuan-Yunnan block(SYB),the Red River fault(RRF)is a major fault that controls deep crustal movement and deformation in the southeast margin of the Tibetan Plateau and regulates middle-lower crustal *** data suggest that the RRF is segmented and exhibits distinct variations in seismicity,velocity structure and crustal deformation from north to *** anisotropy reveals a complex pattern of lateral spatial and vertical stratified distributions.(1)From the perspective of crustal stratification,in the upper crust,the fast wave polarization in the north segment of the RRF is complex and possibly influenced by the Sanjiang lateral collision zone and adjacent faults with varying *** fast wave polarization in the middle segment is in the NW-SE direction,indicating a localized area of closed down or locked up with consistent *** in the south segment,it presents a disordered pattern,signifying complex deep tectonics and stress conditions at the wedged intersection *** the middle-lower crust in the north and south segments of the RRF,the azimuthal anisotropy is strong and consistent with the spatial strike of the weak zone characterized by low-velocity and *** suggests a connection between the anisotropy and the material migration.(2)In the whole crustal scale,the fast wave directions in two sides of the RRF are consistent with the NW-SE tectonic *** indicates that the RRF,as a large fault potentially cutting through the whole crust,strongly controls the surrounding media.(3)In the lithospheric scale,the fast wave polarizations are oriented nearly E-W and independent of the fault strike,consistent with the low P-and S-wave velocity structures and positive radial anisotropy in the upper *** fast wave directions could be related to lithospheric olivine deformation and asthenospheric *** paper suggests a decoupling of deformation between the crust and the lithospheri

关键词： Red River fault Seismic anisotropy Geological structures Lithosphere Fault segmentation

Single-crystalline hole-transporting layers for efficient and stable organic light-emitting devices

在线全文

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第7期13卷 1341-1353页

作者： gao-Da Ye Ran Ding Su-Heng Li Lei Ni Shu-Ting Dai Nian-Ke Chen yue-Feng Liu Runda Guo Lei Wang Xian-Bin Li Bin Xu Jing Feng State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin University2699 Qianjin Street130012 ChangchunChina. State Key Laboratory of Supermolecular Structures and Materials The Institute of Theoretical ChemistryJilin University2699 Qianjin Street130012 ChangchunChina. Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology430074 WuhanChina

Efficient charge-carrier injection and transport in organic light-emitting devices(OLEDs)are essential to simultaneously achieving their high efficiency and long-term ***,the charge-transporting layers(CTLs)deposited by various vapor or solution processes are usually in amorphous forms,and their low charge-carrier mobilities,defectinduced high trap densities and inhomogeneous thickness with rough surface morphologies have been obstacles towards high-performance ***,organic single-crystalline(SC)films were employed as the hole-transporting layers(HTLs)instead of the conventional amorphous films to fabricate highly efficient and stable *** highmobility and ultrasmooth morphology of the SC-HTLs facilitate superior interfacial characteristics of both HTL/electrode and HTL/emissive layer interfaces,resulting in a high Haacke’s figure of merit(FoM)of the ultrathin top electrode and low series-resistance joule-heat loss ratio of the ***,the thick and compact SC-HTL can function as a barrier layer against moisture and oxygen *** a result,the SC-OLEDs show much improved efficiency and stability compared to the OLEDs based on amorphous or polycrystalline HTLs,suggesting a new strategy to developing advanced OLEDs with high efficiency and high stability.

关键词： crystalline amorphous charge

Improved RF power performance via electrostatic shielding effect using AlGaN/GaN/graded-AlGaN/GaN double-channel structure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第4期67卷 341-342页

作者： Chunzhou SHI Ling YANG Meng ZHANG Hao LU Mei WU Bin HOU Xuerui NIU Qian YU Wenliang LIU Wenze gao Xiaohua MA yue HAO School of Advanced Materials and Nanotechnology Xidian University State Key Discipline Laboratory of Wide Bandgap Semiconductor Technology Xidian University

GaN-based high-electric-mobility transistors(HEMTs) have been investigated thoroughly because of their promising applications in high-frequency,-voltage, and-power applications. However, the theoretical material limit prevents conventional single-heterostructure GaN HEMTs from achieving high performance despite numerous efforts [1–3].

关键词： Drain current

Radiative cooling for long-term building energy efficiency:An experimental comparison of seven coatings

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Open 2024年第3期3卷 50-69页

作者： yue He Biao Lu Jinzhong Fang yue Lei Shan gao Chi Feng School of Architecture and Urban Planning Chongqing University Key Laboratory of New Technology for Construction of Cities in Mountain Area Ministry of EducationChongqing University

Radiative cooling coatings are widely used owing to their excellent cooling performance and energy ***,there is a lack of comprehensive research on their weather resistance,long-term performance and effects on building *** fill this research gap,seven coatings were selected for experimental observation and simulation *** results revealed noticeable differences among different coatings regarding anti-aging properties,cooling performance and building load *** coatings exhibited yellowing,cracking and peeling after weathering tests,accompanied by a decline in their radiative ***-term tests showed that the cooling performance of all coatings gradually decreased due to natural aging,and the rate of decline was proportional to the weathering of the *** load simulations revealed the potential effect of coating selection on cooling and heating loads,thereby suggesting that different coatings should be selected based on actual usage scenarios in different climatic zones.

关键词： radiative cooling coating weather resistance long-term cooling performance building load

Effect of mesopore spatial distribution of HZSM-5 catalyst on zinc state and product distribution in 1-hexene aromatization

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第3期67卷 16-26页

作者： Chenhao Wei Di gao Guohao Zhang Liang Zhao Jinsen gao Chunming Xu The State Key Lab of Heavy Oil Processing China University of Petroleum(Beijing)Beijing 102249China SINOPEC Research Institute of Petroleum Processing Co. Ltd.Beijing 100083China

1-hexene aromatization is a promising technology to convert excess olefin in fluid catalytic cracking(FCC)gasoline to high-value benzene(B),toluene(T),and ***,the increasing market demand of xylene has put forward higher requirements for new generation of *** increasing xylene yield in 1-hexene aromatization,the effect of mesopore structure and spatial distribution on product distribution and Zn loading was *** with different mesopore spatial distribution were prepared by post-treatment of parent HZSM-5 zeolite,including NaOH treatment,tetra-propylammonium hydroxide(TPAOH)treatment,and *** was found the evenly distributed mesopore mainly prolongs the catalyst lifetime by enhancing diffusion properties but reduces the aromatics selectivity,as a result of damage of micropores close to the catalyst *** the selectivity of high-value xylene can be highly promoted when the mesopore is mainly distributed interior the ***,the state of loaded Zn was also affected by mesopores spatial *** the optimized catalyst,the xylene selectivity was enhanced by 12.4%compared with conventional Zn-loaded parent HZSM-5 catalyst at conversion over 99%.It was attributed to the synergy effect of mesopores spatial distribution and optimized acid *** work reveals the role of mesopores in different spatial positions of 1-hexene aromatization catalysts in the reaction process and the influence on metal distribution,as well as their synergistic effect two on the improvement of xylene selectivity,which can improve our understanding of catalyst pore structure and be helpful for the rational design of high-efficient catalyst.

关键词： 1-Hexene aromatization Alkali treatment Xylene selectivity Mesopores Zinc state

Concentration sensing system with monolithic InGaN/GaN photonic chips

在线全文

学校读者我要写书评

暂无评论

Chinese Optics Letters 2024年第6期22卷 170-176页

作者： Feifei Qin Xueyao Lu Yang Chen Xumin gao yue Cao Lei Zhang Junfeng Lu Xiaoxuan Wang Gangyi Zhu Yongjin Wang GaN Optoelectronic Integration International Cooperation Joint Laboratory of Jiangsu Province College of Telecommunications and Information EngineeringNanjing University of Posts and TelecommunicationsNanjing 210003China College of Physics and Key Laboratory of Aerospace Information Materials and Physics(MIIT) Nanjing University of Aeronautics and AstronauticsNanjing 211106China State Key Laboratory of Digital Medical Engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Using an identical monolithic InGaN/GaN light emitting diode (LED) array as the sensing module and a well-designed data processing module, we demonstrate a small-size concentration sensing prototype. Overlap between the emission and the response spectra of the InGaN/GaN LED makes each pair of LEDs in the arrayed chip form a sensing channel. The changes in liquid concentration can be transformed into variation of photocurrent. The system's sensing properties are further optimized by varying the position, number of receivers, and packaging reflectors. With methyl orange as a tracer agent, the sensing system's resolution is 0.286 μmol/L with a linear measurement region below 40 μmol/L.

关键词： InGaN/GaN diodes array liquid concentration sensing coexistence of luminescence detection

Impacts of central-Pacific El Niño and physical drivers on eastern Pacific bigeye tuna

在线全文

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2024年第3期42卷 972-987页

作者： Peng LIAN Le gao Key Laboratory of Ocean Observation and Forecasting and Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Bigeye tuna Thunnus obesus is an important migratory species that forages deeply,and El Niño events highly influence its distribution in the eastern Pacific *** sea surface temperature is widely recognized as the main factor affecting bigeye tuna(BET)distribution during El Niño events,the roles of different types of El Niño and subsurface oceanic signals,such as ocean heat content and mixed layer depth,remain *** conducted A spatial-temporal analysis to investigate the relationship among BET distribution,El Niño events,and the underlying oceanic signals to address this knowledge *** used monthly purse seine fisheries data of BET in the eastern tropical Pacific Ocean(ETPO)from 1994 to 2012 and extracted the central-Pacific El Niño(CPEN)indices based on Niño 3 and Niño ***,we employed Explainable Artificial Intelligence(XAI)models to identify the main patterns and feature importance of the six environmental variables and used information flow analysis to determine the causality between the selected factors and BET ***,we analyzed Argo datasets to calculate the vertical,horizontal,and zonal mean temperature differences during CPEN and normal years to clarify the oceanic thermodynamic structure differences between the two types of *** findings reveal that BET distribution during the CPEN years is mainly driven by advection feedback of subsurface warmer thermal signals and vertically warmer habitats in the CPEN domain area,especially in high-yield fishing *** high frequency of CPEN events will likely lead to the westward shift of fisheries centers.

关键词： bigeye tuna central-Pacific El Niño(CPEN) ocean heat content Argo explainable artificial intelligence(XAI) information flow

The late Early-Paleozoic granitic magmatism in Northwestern Fujian, China: constraints on intraplate orogeny in the South China block

在线全文

学校读者我要写书评

暂无评论

Acta Geochimica 2024年第1期43卷 134-149页

作者： WanLi gao ZongXiu Wang Institute of Geomechanics Chinese Academy of Geological ScienceBeijing 100081People’s Republic of China Key Laboratory of Paleomagnetism and Tectonic Reconstruction of Ministry of Natural Resources Beijing 100081People’s Republic of China

The Early Paleozoic tectono-thermal event was a significant orogenic activity during the Phanerozoic era,which had a profound impact on the early crust of the South China Block(SCB) and established the foundation for later tectonic *** Wuyi-Yunkai orogenic belt in Southeastern China was extensively exposed to Early Paleozoic magmatism,the genetic mechanism of which remains *** shed light on this issue,detailed petrological,geochemical,and zircon U-Pb-Hf isotopic studies were carried out on two granitoids,namely the Yuntongshan pluton and the gaoqiao pluton,identified in the central *** U-Pb chronology of the Yuntongshan and gaoqiao bodies yielded ages of437±4 Ma(MSWD=2.2) and 404±2 Ma(MSWD=12),respectively,indicating that they were emplaced during the Early Silurian and Early Devonian *** granitoids are primarily composed of biotite-granite and biotite-monzonitic-granites,with high concentrations of S_(i)O_(2)(73.59-75.91 wt%),K_(2)O+Na_(2)O(8.31-8.73wt%),and low contents of MgO,CaO,Cr,*** are classified as high-K calc-alkaline and weakly metaluminous-strongly peraluminous S-type *** granitoids are enriched in light rare earth elements(LREEs) and large ion lithophile elements(LILEs) and depleted in heavy rare earth elements(HREEs) and high field strength elements(HFSEs) with arc *** εHf(t) values of-3.3 to-15.4 with two-stage Hf model ages ranging from 2829 to 1644 Ma,combined with the presence of Neoproterozoic inherited zircons,suggest that the primary magma of these granitoids was derived from the partial melting of Neoproterozoic crust with a Paleoproterozoic crustal model *** findings,combined with the spatio-temporal distribution of regional magmatism,reveal that the late Early-Paleozoic granitoids formed in the intraplate orogenic background originating from the subduction of the proto-Tethys Ocean and proto-Pacific Ocean around the margin of the east Gondwana supercontinent.

关键词： Late Early-Paleozoic Granites Intraplate orogeny Cathysian block Zircon U-Pb-Hf Isotopic composition