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Lessons learned in delayed identification of a misplaced electrode array in the vestibule

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Journal of Otology 2024年第4期19卷 241-246页

作者： Huey Ting Diong Yuhan wong Shermaine Png Yeow Seng Raymond Ngo Department of Audiology Ng Teng Fong General Hospital1 Jurong East Street 21Singapore609606Singapore Manchester Centre for Audiology and Deafness Division of PsychologyCommunication and Human NeuroscienceThe University of ManchesterOxford RoadManchesterM139PLUnited Kingdom Department of Audiology and Speech Pathology School of Health SciencesThe University of Melbourne550 Swanston StreetVictoria3010Australia Department of Ear Nose and Throat–Head and Neck SurgeryNg Teng Fong General Hospital1 Jurong East Street 21Singapore609606Singapore Department of Otolaryngology–Head and Neck Surgery National University Hospital5 Lower Kent Ridge RdSingapore119074Singapore

To report a case of cochlear implantation with a misplaced electrode array in the vestibule and the causes for the delay in identification.A 23-year-old male with left single-sided deafness underwent cochlear *** intraoperative assessment did not reveal any major red flags of electrode array *** did not display any vestibular symptoms postoperatively but showed poor speech performance,even though the aided tone audiometry revealed good sound detection ***-resolution computed tomography(HRCT)showed that the entire perimodiolar electrode array was situated within the vestibule,and a revision surgery was *** analysis of the neural response telemetry(NRT)revealed subtle differences in responses between the misplaced and correctly placed electrode *** previously reported cases,the patient did not display vestibular symptoms despite the misplacement of the electrode in the vestibule due to existing weakness in otolithic *** investigation is warranted when a motivated patient with normal inner ear anatomy does not show benefit with the cochlear implant post-operatively.

关键词： Cochlear implantation Electrode misplacement Vestibule Poor CI outcome Neural response telemetry

Outcomes of emergency and interval hepatectomy for ruptured resectable hepatocellular carcinoma: a single tertiary referral centre experience

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Hepatoma Research 2017年第9期3卷 196-204页

作者： Andrew Kai Yip Fung Charing Ching Ning Chong Kit Fai Lee John wong Yue Sun Cheung Anthony Kwong Wai fong Paul Bo San Lai Department of Surgery the Chinese University of Hong KongPrince of Wales HospitalHong Kong 999077Hong KongChina

Aim: The short and long term outcomes of patients who underwent emergency and interval hepatectomy for ruptured and resectable hepatocellular carcinoma (HCC) were analysed. Methods: The data of patients with ruptured HCC presenting between April 2004 and October 2015 were analysed. Emergency hepatectomy was defined as hepatectomy within 48 h of the clinico-radiological diagnosis of HCC rupture. Results: Thirty patients underwent hepatectomy for ruptured HCC. Nine (30%) patients underwent emergency hepatectomy. The median age was 56 and 54 years (P = 0.13) with a similar gender distribution. The mean HCC size (10.5 vs. 8.3 cm, P = 0.17), total blood loss (3,000 vs. 850 mL, P = 0.002) and total units of red blood cell transfusion (1.9 vs. 0.5 units, P = 0.27) were greater in the emergency hepatectomy group. The complication rate was 44% and 38% (P = 0.53), with median length of hospital stay of 10 and 12 days (P = 0.07) in the emergency and interval hepatectomy groups, respectively, and no 30-day mortality in both groups. The median overall survival was 29 and 15.7 months (P = 0.25), with survival rates of 78%, 45%, 0% and 85%, 43% and 5% at 1, 3 and 5 years in the emergency and interval hepatectomy groups, respectively. Conclusion: Hepatectomy should be considered for ruptured HCC provided the patient could tolerate curative resection.

关键词： Hepatocellular carcinoma rupture hepatectomy

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非胎生红树植物繁殖体特征及潮间带分带现象

Acta Botanica Sinica 2004年第8期46卷 896-906页

作者：叶勇卢昌义黄玉山谭凤仪厦门大学海洋环境科学教育部重点实验室，厦门361005 香港城市大学生物及化学系，香港

研究了香港4种非胎生红树植物榄李(Lumnitzera racemosa(Jack．)Voigt．)、银叶树(Heritiera littoralis(Drgand．)Ait．)、海漆(Excoecaria agallocha L．)和老鼠筋(Acanthus ilicifotius L．)的繁殖体特征和萌发技术，并分析了其在潮间带分带的决定因素。所有直接种植的新鲜榄李繁殖体均不能萌发，但经湿润贮藏35d和50d的繁殖体能萌发，说明该物种具有种子休眠的特性。榄李萌发率随盐度升高而下降，盐度高于25则不能萌发。银叶树繁殖体果壳的去除可加速其萌发。海漆和老鼠筋的繁殖体分别在2d和3d开始萌根。在繁殖体萌发方面，老鼠筋的耐盐性比榄李强。4种非胎生红树植物对潮间带不稳定环境的适应方式有：(1)繁殖体的寿命较长，如榄李和银叶树；(2)萌根速度快，如海漆和老鼠筋；(3)具有沉性繁殖体，如榄李。繁殖体的悬浮性是决定这4种非胎生红树植物潮间带分带的最重要因素：榄李因具有沉性繁殖体而自然分布于最靠海的区域，而银叶树、海漆和老鼠筋因具有浮性繁殖体而更靠陆岸分布。对于繁殖体悬浮性相同的物种，萌根速度是影响潮间带分带的重要因素：完整的银叶树繁殖体需要108d才能萌根，因而分布于最靠陆岸的区域，而海漆和老鼠筋因萌根速度快而在相对更靠海的区域分布。环境盐度、繁殖体大小、动物啃食和幼苗大小等因素则不能解释香港非胎生红树植物在潮间带的分带现象。

关键词：榄李银叶树海漆红树林潮间带分带种子休眠

MACAO WOMEN PROMOTING DEVELOPMENT OF GREATER BAY AREA——Celebrating 25th Anniversary of Macao’s Return to Motherland

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Women of China 2024年第12期 16-27页

作者： Ho teng lat Lau Kam Ling wong Kit Cheng Ally Li Xu Bing Tam Nga Lei Huang Yin Standing Committee of the All-China Women’s Federation(ACWF) Women fs General Association of Macao(WGAM) China ACWF Executive Committee Chairperson of WGAM National Committee of the Chinese Peoples Political Consultative Conference(CPPCC) Legislative Assembly of Macao China WGAM Guangdong-Hong Kong-Macao Greater Bay Area Youth Theatre Association Greater Bay Area Youth Culture Company Limited International Commercial Mediation Association for the Belt and Road medical affairs department of University Hospital Macao China Bay Valley Technology Research(Zhuhai)Co. Ltd.

Nobody in China will forget December 20,*** that day,the national flag of the People’s Republic of China(PRC)and the regional flag of the Macao Special Administrative Region(SAR)were raised in Macao,marking Macao’s return to the ***,Macao region and South China’s Guangdong Province are working together on Hengqin Island(in the southern region of Zhuhai,a city in Guangdong),to further explore the practice of One Country,Two Systems,and to promote Macao’s appropriate economic diversification.

关键词： Macao return PROM

Bioactive Constituents from Nauclea orientalis （L.） L. （Rubiaceae）

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Bioactive Constituents from Nauclea orientalis （L.） L. （R...

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties

中国化学会第四届有机化学学术会议

作者： KONGMANY,Sydara BOUAMANIVONG,S． TAN,Ghee teng TAMEZ,Pamela SOUTHAVONG,Bounhoong SOEJART,D．Doel PEZZUTO,John M． fong,Harry H．S． Traditional Medicine Research Center （TMRC） Ministry of HealthVientianeLao People’s Democratic Republic Traditional Medicine Research Center （TMRC） Ministry of HealthVientianeLao People’s Democratic Republic Program for Collaborative Research in Pharmaceutical Sciences M/C 781Department of Medicinal Chemistry ＆ PharmacognosyCollege of Pharmacythe University of Illinois at Chicago833 S.Wood StreetChicagoIllinois 60612USA Program for Collaborative Research in Pharmaceutical Sciences M/C 781 Department of Medicinal Chemistry ＆ Pharmacognosy College of Pharmacythe University of Illinois at Chicago833 S.Wood StreetChicagoIllinois 60612USA Traditional Medicine Research Center （TMRC） Ministry of Health Vientiane Lao People’s Democratic Republic Program for Collaborative Research in Pharmaceutical Sciences M/C 781Department of Medicinal Chemistry ＆ PharmacognosyCollege of Pharmacythe University of Illinois at Chicago833 S.Wood StreetChicagoIllinois 60612USA Program for Collaborative Research in Pharmaceutical Sciences M/C 781 Department of Medicinal Chemistry ＆ Pharmacognosy College of Pharmacy the University of Illinois at Chicago 833 S. Wood Street Chicago Illinois 60612 USA Schools of Pharmacy Nursingand Health SciencesPurdue University 575 Stadium Mall DriveWest LafayetteIN 47907-2091USA Program for Collaborative Research in Pharmaceutical Sciences M/C 781Department of Medicinal Chemistry ＆ Pharmacognosy College of Pharmacy the University of Illinois at Chicago833 S.Wood StreetChicagoIllinois 60612USA

＜正＞Bioassay-guided fractionation of the antimalarial active CHCl3 extract of the dried stem of Nauclea orientalis （L.） L. （Rubiaceae） has resulted in the isolation of two novel tetrahydro-β-carboline monoterpene alkaloid gluco-sides, naucleaorine （1） and epi-methoxy-naucleaorine （2）, as well as the known compounds, strictosidine lactam （3）, 3,4,5-trimethoxyphenol （4）, 3α-hydroxy-urs-12-en-28-oic acidic methylester （5）, 3α,23-dihydroxy-urs-12-

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Acta Pharmaceutica Sinica B 2024年第1期14卷 421-432页

作者： Dexiu Yan Jemma Arakelyan teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda Department of Chemistry City University of Hong KongHong Kong SARChina iGEM Team“VarieCure” City University of Hong KongHong Kong SARChina Department of Biomedical Engineering City University of Hong KongHong Kong SARChina Moscow Clinical Research Center Named After A.S.Loginov Moscow 111123Russian Federation

A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC *** production of 1 and 2 was achieved in Aspergillus oryzae by expressing the sesterterpene synthase VrcA and the cytochrome P450 ***,the replacement of VrcB with homologous P450s from other fungal terpenoid pathways yielded three new variecolin analogues(5-7).Analysis of the compounds’anticancer activity in vitro and in vivo revealed that although 5 and 1 had comparable activities,5 was associated with significantly reduced toxic side effects in cancer-bearing mice,indicating its potentially broader therapeutic *** study describes the first tests of variecolin and its analogues in animals and demonstrates the utility of synthetic biology for creating molecules with improved biological activities.

关键词： Animal studies Anticancer properties Biosynthesis Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin

澳门地区市售即食海产中嗜水气单胞菌的污染情况及其致泻性毒力基因分析

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中国食品卫生杂志 2023年第3期35卷 411-415页

作者：李婉芬邓凯殷黄海怡莫嘉雯澳门理工大学健康科学及体育学院中国澳门999078

目的对澳门地区市售即食海产品进行嗜水气单胞菌的分离鉴定及致泻毒力基因检测。方法从甲壳类、鱼类、贝类、头足纲类共4类80份样本中分离嗜水气单胞菌,使用实时荧光定量聚合酶链式反应(qPCR)方法检测菌株16S rRNA基因进行菌株鉴定,使... 详细信息

目的对澳门地区市售即食海产品进行嗜水气单胞菌的分离鉴定及致泻毒力基因检测。方法从甲壳类、鱼类、贝类、头足纲类共4类80份样本中分离嗜水气单胞菌,使用实时荧光定量聚合酶链式反应(qPCR)方法检测菌株16S rRNA基因进行菌株鉴定,使用多重PCR测定分离菌株4种致泻毒力基因。结果澳门地区市售的80份即食海产品中,有57份样本(71.25%)分离出嗜水气单胞菌,其中6份(10.53%)带有致泻毒力基因。在6株携带毒力基因的嗜水气单胞菌中,4株携带2种毒力基因,其余的只携带1种毒力基因。其中携带alt有4株(7.02%)、aerA 3株(5.36%)、ast 2株(3.51%)及act 1株(1.75%)。即食海产品的4个分类与嗜水气单胞菌检出率,经χ^(2)检验分析差异无统计学意义(P>0.05)。此外,在15个经烹煮过样本中分离鉴定出13株嗜水气单胞菌。结论嗜水气单胞菌有较高的检出率可能是因不当包装、运输及处理过程中受到交叉污染。致泻性毒力基因检出率不高,但存在嗜水气单胞菌的致病风险。

关键词：澳门地区嗜水气单胞菌即食海产品致泻毒力基因

钢-混凝土组合薄壳屋盖的研究进展——施工阶段钢底壳的模型试验研究

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建筑钢结构进展 2005年第3期7卷 9-15页

作者：滕锦光王汉珽香港理工大学土木及结构工程系

钢-混凝土组合薄壳屋盖(Comshell屋盖体系)由兼作永久模板并替代钢筋的薄壁加劲钢底壳和现浇混凝土两部份组成。薄壁钢底壳由模块化单元件通过螺栓连接而成,单元件呈无盖扁盒状,由底板及周边板组成,其周边板在钢壳上构成两个方向的薄壁... 详细信息

钢-混凝土组合薄壳屋盖(Comshell屋盖体系)由兼作永久模板并替代钢筋的薄壁加劲钢底壳和现浇混凝土两部份组成。薄壁钢底壳由模块化单元件通过螺栓连接而成,单元件呈无盖扁盒状,由底板及周边板组成,其周边板在钢壳上构成两个方向的薄壁加劲板。这一新体系保留了混凝土薄壳屋盖的所有优点,又不需要使用临时模板,并大幅减少临时支撑。本文对这种新型结构体系及其各种可能的破坏模式进行了简单介绍,并给出了针对该结构体系施工阶段稳定性所进行模型试验的主要结果。

关键词：钢-混凝土施工阶段组合薄壳试验研究底壳研究进展结构体系现浇混凝土永久模板屋盖体系螺栓连接临时支撑破坏模式模型试验单元件薄壁模块化加劲板稳定性组成边板钢筋

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国产黄连属新植物

华西医科大学学报 1989年第2期20卷 150-152页

作者：王天志张浩方忻平帅红谢成科华西医大药学院生药学教研室

本文报道了黄连属植物二新种——线萼黄连和古蔺黄连,以及一新变种——爪萼黄连,并对其植物形态特征进行了描述。

关键词：黄连线萼黄连古蔺黄连