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Benefit-Risk Assessment of Chinese Medicine Injections for Primary Liver Cancer Based on Multi-criteria Decision Analysis

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Chinese Journal of Integrative Medicine 2024年第6期30卷 559-564页

作者： ZHANG Rong-rong SHAO Ming-yi FU yu ZHAO Rui-xia WANG Jing-wen FANG yu-xuan The First Clinical Medical College of Henan University of Traditional Chinese Medicine Zhengzhou450046China Personal Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Scientific Research Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Digestive Department the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China

ObjectiveTo evaluate the benefit-risk of 3 commonly used Chinese medicine injections, Aidi Injection (ADI), Cinobufagin Injection (CINI) and Compound Kushen Injection (CKI), in the treatment of primary liver cancer (PLC), so as to provide a reference for clinical *** controlled trials (RCTs) of ADI, CINI and CKI in the treatment of PLC published in the databases of China National Knowledge Infrastructure, Wanfang, China Science and Technology Journal Database, SinoMed, PubMed, Cochrane Library, and Web of Science were retrieved from January 2020 to October 2022. The data of benefit and risk indicators were combined to obtain the effect value. The multi-criteria decision analysis (MCDA) model was applied to build the decision tree. The benefit value, risk value and benefit risk value of the 3 injections in PLC treatment were calculated. Monte Carlo simulation was carried out to calculate the 95% confidence interval and probability of differences among the 3 injections, so as to optimize the evaluation *** total of 71 RCTs were included. The benefit values of ADI, CINI and CKI combined with transcatheter arterial chemoembolization (TACE) were 42, 38 and 36, respectively. The risk values were 42, 25 and 37, respectively. The benefit risk values were 42, 31 and 37, respectively. The benefit risk differences of ADI vs. CINI, ADI vs. CKI, and CKI vs. CINI were 11 (−0.86, 17.75), 5 (−5.01, 11.09), and 6 (−1.87, 12.63), respectively. The probability that ADI superior to CINI, ADI superior to CKI, and CKI superior to CINI was 96.26%, 77.27%, and 92.62%, *** on the results of MCDA model, CINI combined with TACE has the greatest risk in the treatment of the PLC. Considering the efficacy and safety, the possible priority of the 3 Chinese medicine injections combined with TACE in the treatment of PLC is ADI, CKI and CINI.

关键词： multi-criteria decision analysis benefit-risk assessment Chinese medicine injections primary livercancer

Computed tomography-based radiomics combined with machine learning allows differentiation between primary intestinal lymphoma and Crohn's disease

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World Journal of Gastroenterology 2024年第25期30卷 3155-3165页

作者： Meng-Jun Xiao yu-teng Pan Jia-He Tan Hai-Ou Li Hai-Yan Wang Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250000Shandong ProvinceChina University of California DavisCA 95616United States Qilu Hospital Cheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Due to similar clinical manifestations and imaging signs,differential diagnosis of primary intestinal lymphoma(PIL)and Crohn's disease(CD)is a challenge in clinical *** To investigate the ability of radiomics combined with machine learning methods to differentiate PIL from *** We collected contrast-enhanced computed tomography(CECT)and clinical data from 120 patients form center 1.A total of 944 features were extracted singlephase images of CECT *** the last absolute shrinkage and selection operator model,the best predictive radiographic features and clinical indications were *** from 54 patients were collected at center 2 as an external validation set to verify the robustness of the *** area under the receiver operating characteristic curve,accuracy,sensitivity and specificity were used for *** A total of five machine learning models were built to distinguish PIL from *** on the results from the test group,most models performed well with a large area under the curve(AUC)(>0.850)and high accuracy(>0.900).The combined clinical and radiomics model(AUC=1.000,accuracy=1.000)was the best model among all *** Based on machine learning,a model combining clinical data with radiologic features was constructed that can effectively differentiate PIL from CD.

关键词： Primary intestinal lymphoma Crohn's disease Radiomics Machine learning Diagnosis

Cancer profiles in China and comparisons with the USA:a comprehensive analysis in the incidence,mortality,survival,staging,and attribution to risk factors

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Science China(Life Sciences) 2024年第1期67卷 122-131页

作者： Siyi He Changfa Xia He Li Maomao Cao Fan Yang Xinxin Yan Shaoli Zhang yi teng Qianru Li Wanqing Chen Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

China faces a disproportionate cancer burden to the population size and is undergoing a transition in the cancer *** extracted data in five aspects of cancer incidence,mortality,survival,staging distributions,and attribution to risk factors in China,the USA and worldwide from open-source *** conducted a comprehensive secondary analysis of cancer profiles in China in the above aspects,and compared cancer statistics between China and the USA.A total of 4,546,400 new cancer cases and 2,992,600 deaths occurred in China in 2020,accounting for 25.1%and 30.2%of global cases,***-related cancers including lung cancer,colorectal cancer,and breast cancer showed an upward trend and have been the leading cancer types in China.41.6%of new cancer cases and 49.3%of cancer deaths occurred in digestive-system cancers in China,and the cancers of esophagus,nasopharynx,liver,and stomach in China accounted for over 40%of global ***-related cancers showed the highest population-attributable fractions among Chinese adults,and most cancers could be attributed to behavioral and metabolic *** proportions of stage I for most cancer types were much higher in the USA than in China,except for esophageal cancer(78.2%vs.41.1%).The 5-year relative survival rates in China have improved substantially during 2000–2014,whereas survival for most cancer types in the USA was significantly higher than in China,except for upper gastrointestinal *** findings suggest that although substantial progress has been made in cancer control,especially in digestive system cancers in China,there was still a considerable disparity in cancer burden between China and the *** robust policies on risk factors and standardized screening practices are urgently warranted to curb the cancer growth and improve the prognosis for cancer patients.

关键词： cancer burden survival rate neoplasm staging risk factors China

Versatile MXene Gels Assisted by Brief and Low‑Strength Centrifugation

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Nano-Micro Letters 2024年第5期16卷 231-247页

作者： Weiyan yu yi Yang yunjing Wang Lulin Hu Jingcheng Hao Lu Xu Weimin Liu State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000People’s Republic of China Shandong Laboratory of Advanced Materials and Green Manufacturing at Yantai Yantai 264006People’s Republic of China Key Laboratory of Colloid and Interface Chemistry and Key Laboratory of Special Aggregated Materials Shandong UniversityJinan 250100People’s Republic of China

Due to the mutual repulsion between their hydrophilic surface terminations and the high surface energy facilitating their ran-dom restacking,2D MXene nanosheets usually cannot self-assemble into 3D macroscopic gels with various applications in the absence of proper linking *** this work,a rapid spontaneous gelation of Ti3C2Tx MXene with a very low dispersion concentration of 0.5 mg mL^(-1) into multifunctional architectures under moderate centrifugation is *** as-prepared MXene gels exhibit reconfigurable internal structures and tunable rheological,tribological,electrochemical,infrared-emissive and photothermal-conversion properties based on the pH-induced changes in the surface chemistry of Ti_(3)C_(2)T_(x) *** adopting a gel with optimized pH value,high lubrication,exceptional specific capacitances(~635 and~408 F g^(-1) at 5 and 100 mV s^(-1),respectively),long-term capacitance retention(~96.7%after 10,000 cycles)and high-precision screen-or extrusion-printing into different high-resolution anticounterfeiting patterns can be achieved,thus displaying extensive potential applications in the fields of semi-solid lubrication,control-lable devices,supercapacitors,information encryption and infrared camouflaging.

关键词： MXene Centrifugation-assisted rapid gelation Lubrication Supercapacitor Anti-counterfeiting applications

Accuracy evaluation for in-situ machining reference points binocular measurement based on credibility probability

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Chinese Journal of Aeronautics 2024年第1期37卷 472-486页

作者： Binchao yu Wei LIU Yanze ZHANG Dazhi MA Zhenyuan JIA yi yuE Jiabo ZHANG Key Laboratory for Precision and Non-Traditional Machining Technology of the Ministry of Education Dalian University of TechnologyDalian 116024China Beijing Spacecrafts China Academy of Space TechnologyBeijing 100081China

Passive binocular measurement systems are being increasingly utilized in the in-situ industries of automobiles,aviation,and aerospace,*** to their excellent qualities of accuracy,efficiency,and cost *** the barrier of evaluating the accuracy of measured objects resulted from the unequal equivalent focal length and quantization of pixels,has limited their further development and application of high requirements for in-situ machining,e.g.,the measurement of machining reference points for the positioning of robotic drilling in aerospace *** this paper,an accuracy evaluation method is proposed to address the ***,the unequal equivalent focal length is considered to improve the accuracy of 3D ***,the credibility probability model is developed to calculate the probability of the observed error in the public view of the binocular measurement system and indicates the direction of ***,the in-situ experiment is carried out to validate the method within the effective public view range of 300 mm×300 *** experiment results show that the RMSs of observed errors are superior to 0.035 mm,and the credibility probabilities are all higher than 0.91;the maximum 3D reconstruction accuracy improvement is 60.3%,with the error reduced from 0.078 mm to 0.031 mm.

关键词： Aerospace manufacturing Binocular vision Credibility probability Pixel quantization Unequal equivalent focal length

A Symmetric-Actuating Linear Piezoceramic Ultrasonic Motor Capable of Producing a Scissoring Effect

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Research 2024年第1期2023卷 571-581页

作者： Zhanmiao Li Xingyu yi Rongqi Zhu Zhonghui yu Xiaoting yuan MohammadJavad PourhosseiniAsl Shuxiang Dong School of Materials Science and Engineering Peking UniversityBeijing 100871China College of Mechatronics and Control Engineering and Institute for Advanced StudyShenzhen UniversityShenzhen 518051China

Conventionally,to produce a linear motion,one motor’s stator is employed to drive one runner moving forward or *** far,there is almost no report of one electromechanical motor or piezoelectric ultrasonic motor that can directly generate two symmetrical linear motions,while this function is desired for precise scissoring and grasping in the minimally invasive surgery ***,we report a brandnew symmetric-actuating linear piezoceramic ultrasonic motor capable of generating symmetrical linear motions of two outputs directly without additional mechanical transmission *** key component of the motor is an(2×3)arrayed piezoceramic bar stator operating in the coupled resonant mode of the first longitudinal(L_(1))and third bending(B_(3))modes,leading to symmetric elliptical vibration trajectories at its two ends.A pair of microsurgical scissors is used as the end-effector,demonstrating a very promising future for high-precision microsurgical operations.

关键词： field symmetric backward

Recent advances in transition metal phosphide materials:Synthesis and applications in supercapacitors

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Nano Materials Science 2024年第2期6卷 174-192页

作者： Ge Li yu Feng yi Yang Xiaoliang Wu Xiumei Song Lichao Tan College of Chemistry Chemical Engineering and Resource UtilizationNortheast Forestry University26 Hexing RoadHarbin150040PR China Institute of Carbon Neutrality Zhejiang Wanli UniversityNingbo315100PR China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin150040PR China

Supercapacitors(SCs)are considered promising energy storge systems because of their outstanding power density,fast charge and discharge rate and long-term cycling *** exploitation of cheap and efficient electrode materials is the key to improve the performance of *** the battery-type materials,transition metal phosphides(TMPs)possess high theoretical specific capacity,good electrical conductivity and superior structural stability,which have been extensively studied to be electrode materials for *** this review,we summarize the up-to-date progress on TMPs materials from diversified synthetic methods,diverse nanostructures and several prominent TMPs and their composites in application of *** the end,we also propose the remaining challenges toward the rational discovery and synthesis of high-performance TMP electrodes materials for energy storage.

关键词： Transition metal phosphides Cobalt phosphide Nickel phosphides Electrode materials Supercapacitor

Astronomical Test with CMOS on the 60 cm Telescope at the Xinglong Observatory,NAOC

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Research in Astronomy and Astrophysics 2024年第5期24卷 85-102页

作者： Hai-Yang Mu Zhou Fan yi-Nan Zhu yu Zhang Hong Wu Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101People’s Republic of China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049People’s Republic of China

This work shows details of an evaluation of an observational system comprising a complementary metal-oxidesemiconductor detector, 60 cm telescope and filter complement. The system’s photometric precision and differential photometric precision, and extinction coefficients were assessed through observations of Supersky flat fields, open clusters, standard stars and exoplanets. Photometry was precision achieved at the 0.02 mag level, with differential photometry of 0.004 mag precision. Extinction was found to agree with previous studies conducted at Xinglong Observatory. Ultimately, the results demonstrate this observing system is capable of precision scientific observations with a charge-coupled device across the optical wavelengths.

关键词： atmospheric effects-instrumentation detectors-techniques polarimetric-stars atmospheres-eclipses

Sequential enantioselective Ugi-4CR/post-Ugi transformation strategy:a precise construction of structurally diverse azaspiro polycyclic scaffolds

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Science China Chemistry 2024年第2期67卷 576-586页

作者： Xiao-Bao Wu Jun-Xiu Shi yi-Ming Ou Hua-Jie Jiang yi-Jun Fang Qi-Ming Wang Quan Gao Jie yu Department of Applied Chemistry Anhui Province Engineering Laboratory for Green Pesticide Development and ApplicationAnhui Province Key Laboratory of Crop Integrated Pest ManagementAnhui Agricultural UniversityHefei230036China

A privileged strategy has been developed for the precise construction of enantioenriched azaspiro polycyclic *** diverse azaspiro polycycles bearing multiple contiguous stereocenters are obtained with excellent results(up to 99:1 e.r.,>95:5 d.r.) via sequential enantioselective four-component Ugi reactions/post-Ugi transformations with substrates containing prerequisite functional groups in the presence of anionic stereogenic-at-cobalt(Ⅲ) complexes.

关键词： asymmetric catalysis post-Ugi transformation anionic stereogenic-at-cobalt(Ⅲ)complex azaspiro polycyclic scaffold one-pot synthesis