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Non-coding RNAs in acute ischemic stroke:from brain to periphery

Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin Lin Zhu teng jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and disability.Accurate predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain undetermined.With innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental models.Differentially expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic stroke.Moreover,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.In particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic stroke.In this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and prognosis.Findings from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress

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新趋势下汽车消费金融发展思路

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中国金融 2024年第5期 62-64页

作者：蒋腾中国工商银行牡丹卡中心

我国汽车产业的升级,关键在需求侧。目前我国人均制造业增加值是美国的42%,但人均消费支出却只有美国的9%,消费的疲弱影响了我国汽车产能利用率的提高,也不利于投资扩大和产业升级。为了破局,国家层面在2023年密集出台了多项政策扶持汽... 详细信息

我国汽车产业的升级,关键在需求侧。目前我国人均制造业增加值是美国的42%,但人均消费支出却只有美国的9%,消费的疲弱影响了我国汽车产能利用率的提高,也不利于投资扩大和产业升级。为了破局,国家层面在2023年密集出台了多项政策扶持汽车消费市场。

关键词：人均消费支出制造业增加值产业升级产能利用率汽车消费市场政策扶持汽车消费金融我国汽车产业

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The Alzheimer's disease-associated gene TREML2 modulates inflammation by regulating microglia polarization and NLRP3 inflammasome activation

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Neural Regeneration Research 2023年第2期18卷 434-438页

作者： Si-Yu Wang Xin-Xin Fu Rui Duan Bin Wei Hai-Ming Cao Yan E Shuai-Yu Chen Ying-Dong Zhang teng jiang Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Clinical Pharmacy School of Basic Medicine and Clinical PharmacyChina Pharmaceutical UniversityNanjingJiangsu ProvinceChina

Triggering receptor expressed on myeloid cells-like 2(TREML2)is a newly identified susceptibility gene for Alzheimer's disease(AD).It encodes a microglial inflammation-associated receptor.To date,the potential role of mic roglial TREML2 in neuroinflammation in the context of AD remains unclear.In this study,APP/PS1 mice were used to investigate the dynamic changes of TREML2 levels in brain during AD progression.In addition,lipopolysaccharide(LPS)stimulation of primary microglia as well as a lentivirus-mediated TREML2 overexpression and knockdown were employed to explore the role of TREML2 in neuroinflammation in the context of AD.Our res ults show that TREML2 levels gradually increased in the brains of AP P/PS1 mice during disease progression.LPS stimulation of primary microglia led to the release of inflammato ry cytokines including interleukin-1β,inte rleukin-6,and tumor necrosis factor-a in the culture medium.The LPS-induced mic roglial release of inflammatory cytokines was enhanced by TREML2 overexpression and was attenuated by TREML2 knoc kdown.LPS increased the levels of mic roglial M1-type polarization marker inducible nitric oxide synthase.This effect was enhanced by TREML2 overexpression and ameliorated by TREML2 knockdown.Furthermore,the levels of microglial M2-type polarization markers CD206 and ARG1 in the primary microglia were reduced by TREML2 overexpression and elevated by TREML2 knockdown.LPS stimulation increased the levels of NLRP3 in primary microglia.The LPS-induced increase in NLRP3 was further elevated by TREML2 overexpression and alleviated by TREML2 knockdown.In summary,this study provides the first evidence that TREML2 modulates inflammation by regulating microglial polarization and NLRP3 inflammasome activation.These findings reveal the mechanisms by which TREML2 regulates microglial inflammation and suggest that TREML2 inhibition may represent a novel therapeutic strategy for AD.

关键词： Alzheimer's disease APP/PS1 mice inflammatory cytokine lipopolysaccharide microglia neuroinflammation NLRP3 inflammasome polarization susceptibility gene TREML2

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Lamotrigine protects against cognitive deficits,synapse and nerve cell damage,and hallmark neuropathologies in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2023年第1期18卷 189-193页

作者： Xin-Xin Fu Rui Duan Si-Yu Wang Qiao-Quan Zhang Bin Wei Ting Huang Peng-Yu Gong Yan E teng jiang Ying-Dong Zhang School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Pathology Nanjing Brain HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Lamotrigine(LTG)is a widely used drug for the treatment of epilepsy.Emerging clinical evidence suggests that LTG may improve cognitive function in patients with Alzheimer’s disease.However,the underlying molecular mechanisms remain unclear.In this study,amyloid precursor protein/presenilin 1(APP/PS1)double transgenic mice were used as a model of Alzheimer’s disease.Five-month-old APP/PS1 mice were intragastrically administered 30 mg/kg LTG or vehicle once per day for 3 successive months.The cognitive functions of animals were assessed using Morris water maze.Hyperphosphorylated tau and markers of synapse and glial cells were detected by western blot assay.The cell damage in the brain was investigated using hematoxylin and eosin staining.The levels of amyloid-βand the concentrations of interleukin-1β,interleukin-6 and tumor necrosis factor-αin the brain were measured using enzyme-linked immunosorbent assay.Differentially expressed genes in the brain after LTG treatment were analyzed by high-throughput RNA sequencing and real-time polymerase chain reaction.We found that LTG substantially improved spatial cognitive deficits of APP/PS1 mice;alleviated damage to synapses and nerve cells in the brain;and reduced amyloid-βlevels,tau protein hyperphosphorylation,and inflammatory responses.High-throughput RNA sequencing revealed that the beneficial effects of LTG on Alzheimer’s disease-related neuropathologies may have been mediated by the regulation of Ptgds,Cd74,Map3k1,Fosb,and Spp1 expression in the brain.These findings revealed potential molecular mechanisms by which LTG treatment improved Alzheimer’s disease.Furthermore,these data indicate that LTG may be a promising therapeutic drug for Alzheimer’s disease.

关键词： Alzheimer’s disease Alzheimer’s disease-related neuropathologies amyloid-βpathology APP/PS1 mice cognitive deficits damage of synapses and nerve cells high-throughput RNA sequencing lamotrigine neuroinflammation tau protein hyperphosphorylation

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Synchronized output regulation of switching networks based on synchronization observer

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控制理论与应用（英文版） 2013年第2期11卷 288-293页

作者： teng jiang Yanjun LI Key Laboratory of Intelligent System Zhejiang University City College Department of Control Science and Engineering Zhejiang University

This paper studies the synchronized output regulation （SOR） problem of networked dynamic systems with switching topology that is uniformly connected and leader-rooted. In these networked systems, the tracked signal or the rejected disturbance is generated by the same exosystem, and however, the state of the exosystem is only available for leader nodes. First, a synchronization observer of the exosystem is proposed in this paper to overcome the difficulty caused by the unavailable state of the exosystem for follower nodes with directed switching information flow. It is shown that the observer state will synchronize to the state of the exosystem. Then, two feedback controllers based on decentralized dynamic error and state are presented to solve this SOR problem. Furthermore, the main idea in this paper will provide a promising way for realizing the multirobot systems＇ tracking and formation requirement. Numerical simulation results are presented to demonstrate the effectiveness of the theoretical results.

关键词： Synchronized output regulation Synchronization observer Switching topology Networked systems

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Effect of Flow Directions on Multiphase Flow Boiling Heat Transfer Enhanced by Suspending Particles in a Circulating Evaporation System

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Transactions of Tianjin University 2019年第3期25卷 201-213页

作者： Feng jiang teng jiang Guopeng Qi Xiulun Li School of Chemical Engineering and Technology Tianjin University School of Biological and Environmental Engineering Tianjin Vocational Institute

A circulating fluidized bed evaporator(including down-flow, horizontal, and up-flow beds) was constructed to study the effect of flow directions on multiphase flow boiling heat transfer. A range of experimental investigations were carried out by varying amount of added particles(0-2%), circulation flow rate(2.15-5.16 m^3/h) and heat flux(8-16 kW/m^2). The comparison of heat transfer performance in different vertical heights of the horizontal bed was also discussed. Results reveal that the glass bead particle can enhance heat transfer compared with vapor-liquid two-phase flow for all beds. At a low heat flux(q = 8 kW/m), the heat-transfer-enhancing factor of the horizontal bed is obviously greater than those of the up-flow and down-flow beds. With the increase in the amount of added particles, the heat-transfer-enhancing factors of the up-flow and down-flow beds increase, whereas that of the horizontal bed initially increases and then decreases. However, at a high heat flux(q=16 kW/m), the heat-transfer-enhancing factors of the three beds show an increasing tendency with the increase in the amount of added particles and become closer than those at a low heat flux. For all beds, the heat-transfer-enhancing factor generally increases with the circulation flow rate but decreases with the increase in heat flux.

关键词： Heat transfer enhancement Circulating fluidized bed evaporator Flow direction Down-flow bed Up-flow bed Horizontal bed

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TREM2在阿尔茨海默病中的研究进展

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南京医科大学学报（自然科学版） 2024年第5期44卷 698-704,731页

作者：王诗铫黄志航蒋腾南京医科大学附属南京医院(南京市第一医院)神经内科江苏南京210006

阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病。大量证据表明,遗传因素在AD的发病机制中起重要作用。2型髓系细胞触发受体(triggering receptor expressed on myeloid cells 2,TREM2)基因是新发现的AD易感基因之一... 详细信息

阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病。大量证据表明,遗传因素在AD的发病机制中起重要作用。2型髓系细胞触发受体(triggering receptor expressed on myeloid cells 2,TREM2)基因是新发现的AD易感基因之一。文章搜索近年来相关高质量文献,结合课题组前期成果,从TREM2基因变异与AD易感风险,TREM2的结构、配体及信号传导,TREM2与AD病理进程,靶向TREM2的AD疗法等4个方面,对TREM2在AD中的研究现状进行了全面综述,期望能为后续AD的遗传及发病机制研究和药物研发提供理论参考。

关键词： TREM2 阿尔茨海默病小胶质细胞 β-淀粉样蛋白 tau

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高校网络意识形态领域风险防范化解机制研究

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湖北开放职业学院学报 2024年第9期37卷 133-135页

作者：江腾飞福建师范大学福建福州350117

本文主要通过对国内外相关文献的查阅,高校网络意识形态工作相关对象访谈,并结合自身在高校教育管理、学生管理、网络宣传等方面的管理工作经验,对网络意识形态可能存在的风险点进行梳理,提出防范、化解高校网络意识形态风险的体制机制... 详细信息

本文主要通过对国内外相关文献的查阅,高校网络意识形态工作相关对象访谈,并结合自身在高校教育管理、学生管理、网络宣传等方面的管理工作经验,对网络意识形态可能存在的风险点进行梳理,提出防范、化解高校网络意识形态风险的体制机制的具体做法和建议。

关键词：高校网络意识形态风险防范化解

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Intestinal gangrene secondary to congenital transmesenteric hernia in a child misdiagnosed with gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5294-5301页

作者： Xi-Xi Zheng Kun-Peng Wang Chao-Mei Xiang Chong Jin Peng-Fei Zhu teng jiang Shi-Hui Li Yong-Zhi Lin Department of Pediatric Surgery Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina Department of General Surgery Taizhou Central Hospital(Taizhou University Hospital)Taizhou 318000Zhejiang ProvinceChina

BACKGROUND Congenital transmesenteric hernia in children is a rare and potentially fatal form of internal abdominal hernia,and no specific clinical symptoms can be observed preoperatively.Therefore,this condition is not widely known among clinicians,and it is easily misdiagnosed,resulting in disastrous effects.CASE SUMMARY This report presents the case of a 13-year-old boy with a chief complaint of abdominal pain and vomiting and a history of duodenal ulcer.The patient was misdiagnosed with gastrointestinal bleeding and treated conservatively at first.Then,the patient’s symptoms were aggravated and he presented in a shock-like state.Computed tomography revealed a suspected internal hernia,extensive small intestinal obstruction,and massive effusion in the abdominal and pelvic cavity.Intraoperative exploration found a small mesenteric defect approximately 3.5 cm in diameter near the ileocecal valve,and there was about 1.8 m of herniated small intestine that was treated by resection and anastomosis.The patient recovered well and was followed for more than 5 years without developing short bowel syndrome.CONCLUSION In this report,we review the pathogenesis,presentation,diagnosis,and treatment of congenital transmesenteric hernia in children.

关键词： Congenital transmesenteric hernia Children Gastrointestinal bleeding Intestinal gangrene Case report

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Research on a MEMS pyrotechnic with a double-layer barrier safety and arming device

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Defence Technology（防务技术） 2022年第11期18卷 2034-2044页

作者： Ke-xin Wang teng-jiang Hu Yu-long Zhao Wei Ren State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong UniversityXi'an710049China Science and Technology on Applied Physical Chemistry Laboratory Shaanxi Applied Physical Chemistry Research InstituteXi'an710061China

As an essential component of ammunition, pyrotechnics can control ignition with high reliability.However, due to limits of fabrication technology, traditional pyrotechnics are bulky. To achieve both functionality and miniaturization, MEMS pyrotechnics integrate initiator, safety-and-arming(S&A) device and lead charge and keep all components within a small size. MEMS S&A devices, as the core component to ensure system safety, are difficult to achieve active and rapid response to control signals with high safety and reliability. In order to overcome the difficulty, we propose the design and characterization of a MEMS pyrotechnic with a double-layer barrier S&A device. The MEMS pyrotechnic is a high-integrated device with an overall size of 13.4 × 8.5 × 5.2 mm^(3). The initiator is a Ni Cr bridge foil covered with an Al/Cu O energetic film, which can generate flame when ignited by an excitation voltage.To match the flame energy, lead styphnate is chosen in this study as the lead charge. The S&A device contains four semi-circular barriers, which are directly driven by V-shape electro-thermal actuators to gain active control of the pyrotechnics’ ignition condition with rapid response. To improve the system’s reliability, the four barriers are axisymmetrically placed in two layers, two barriers for each layer, to constitute a double-layer structure with a thickness of 100 μm. The ignition test results show that the S&A device can prevent the initiator from detonating the lead charge in safety condition. In arming condition, the lead charge will be detonated.

关键词： MEMS Pyrotechnics Safety and arming device Initiator Electro-thermal actuator

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