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World Journal of Stem Cells 2024年第5期16卷 604-614页

作者： Edoardo Agosti Marco Zeppieri Mattia Ghidoni Tamara Ius Alessandro tel.Marco Maria Fontanella Pier Paolo Panciani Division of Neurosurgery Department of Medical and Surgical SpecialtiesRadiological Sciences and Public HealthUniversity of BresciaBrescia 25123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy Clinic of Maxillofacial Surgery Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy

BACKGROUND Gliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and *** stem cells(GSCs),a subset within tumors,contribute to resistance,tumor heterogeneity,and *** studies reveal GSCs’role in therapeutic resistance,driven by DNA repair mechanisms and dynamic transitions between cellular *** mechanisms can involve different cellular pathways,most of which have been recently reported in the *** progress,targeted therapeutic approaches lack consensus due to GSCs’high *** To analyze targeted therapies against GSC-mediated resistance to radio-and chemotherapy in gliomas,focusing on underlying *** A systematic search was conducted across major medical databases(PubMed,Embase,and Cochrane Library)up to September 30,*** search strategy utilized relevant Medical Subject Heading terms and keywords related to including“glioma stem cells”,“radiotherapy”,“chemotherapy”,“resistance”,and“targeted therapies”.Studies included in this review were publications focusing on targeted therapies against the molecular mechanism of GSC-mediated re-sistance to radiotherapy resistance(RTR).RESULTS In a comprehensive review of 66 studies on stem cell therapies for SCI,452 papers were initially identified,with 203 chosen for full-text *** them,201 were deemed eligible after excluding 168 for various *** temporal breakdown of studies illustrates this trend:2005-2010(33.3%),2011-2015(36.4%),and 2016-2022(30.3%).Key GSC models,particularly U87(33.3%),U251(15.2%),and T98G(15.2%),emerge as significant in research,reflecting their representativeness of glioma *** analysis indicates a focus on phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(mTOR)(27.3%)and Notch(12.1%)pathways,suggesting their crucial roles in resistance *** molecules with mTOR(18.2%),CHK1/2(15.2%),and ATP binding cassette

关键词： Glioma stem cells Chemoresistance Radioresistance Molecular pathways Targeted therapies Systematic review

Matrix Methods for Analysing Optical Resonators

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光电子.激光 1989年第2期 93-95页

作者： L(u|¨) BaidaDepartment of physics,Sichuan University, Chengdu,tel. 55411-962

This paper deals with the applications of matrix methods to optical resonators. It has been shown that the important characteristics of resonators i.e.,mode characteristic parameters, misalignment sensitivity,condition for dynamic stability etc, can be expressed in terms of ABCD-matrix elements or resonator g parameters in general, some typicalresonators are analysed in detail。

关键词： Matrix Methods for Analysing Optical Resonators mode

Microbial,immune and antioxidant responses of Nile tilapia with dietary nano-curcumin supplements under chronic low temperatures

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Aquaculture and Fisheries 2024年第1期9卷 57-65页

作者： Mohammed F.El Basuini Mohamed A.A.Zaki Abdelaziz M.El-Hais Mohamed G.Elhanafy Emad H.El-Bilawy Amr I.Zaineldin Mohamed F.A.Abdel-Aziz Ibrahim A.Abouelsaad Ibrahim tel.Ratel.Kumbukani Mzengereza Ronick S.Shadrack Islam I.Teiba Faculty of Agriculture Tanta UniversityTanta31527Egypt King Salman International University South Sinai46618Egypt Faculty of Agriculture Alexandria UniversityAlexandria21526Egypt Animal Health Research Institute(AHRI-DOKI) Agriculture Research CenterGiza12619Egypt Fish Rearing Lab. Aquaculture DivisionNational Institute of Oceanography and FisheriesAlexandria21556Egypt Horticulture Department Faculty of AgricultureDamanhour UniversityDamanhur22511Egypt Department of Poultry Production Faculty of AgricultureDamietta UniversityDamietta34517Egypt Laboratory of Aquatic Animal Nutrition Faculty of FisheriesKagoshima UniversityKagoshima890-0065Japan Department of Aquatic and Fisheries Science Mzuzu UniversityMzuzuPrivate Bag 201Malawi Faculty of Aquaculture and Marine Fisheries Arish UniversityArish45516Egypt

A 56-day feeding period was performed to investigate the possible impacts of dietary nano curcumin(0,50,100,150,and 200 ppm)on the growth,nutrient utilization,non-specific immune parameters,antioxidants in Nile tilapia under chronic low temperature(21.02±0.11◦C).Fishes(n=225;Initial weight=4.39±0.08 g/fish)were randomly stocked at 15 fish/tank for five experimental groups in *** low-temperature circumstances,dietary curcumin in nano form showed no notable alteration in growth variable,nutrient efficiency,digestive enzymes efficiency,biometric indices,survival rates,and hematological ***,the serum of fishes with nano curcumin diets under low-temperature stress displayed higher total protein as well as lower glucose,cortisol,and total cholesterol compared with the control ***,fish fed nano curcumin diets displayed higher lysozyme and bactericidal activities compared to the control group and the best performance was found at dietary nano curcumin level of≥100 ***,groups fed the basal diet demonstrated the poorest antioxidant capacity,and the best superoxide dismutase(SOD)and glutathione peroxidase(GPx)existed in fish with nano curcumin diets while the best catalase(CAT)efficiency occurred at higher nano curcumin levels≥100 *** addition,higher counts of intestinal microbiota in terms of total bacterial count(TBC),total yeast and molds count(TYMC),and coliform were noticed in fish consumed the basal diet compared to groups fed on nano curcumin *** conclusion,incorporating nano curcumin at a level of≥100 mg/kg diet(particularly at 150 mg/kg)improved a non-specific immune response,antioxidant,and healthier gastrointestinal microbiota in Nile tilapia under chronic low-temperature stress.

关键词： Nano curcumin Gastrointestinal microbiota Antioxidants Non-specific immune responses Temperature stress

Integrative Stability Analysis for A Class of Intel.igent Control Systems

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Journal of Systems Engineering and Electronics 1996年第4期7卷 13-18页

作者： Qin Shiyin(Institute of Systems Engineering, Xi’an Jiaotong University,Xi’an 710049, P.R. China, tel. (029)3235011-3677, Fax (029)3237910) Institute of Systems Engineering Xi'an Jiaotong University Xi'an 710049 P.R. China Tel. (029)3235011-3677 Fax (029)3237910

In this paper the integrative stability is studied for a class of intel.igent control systems which are described by an octette structural model. Based on the definitions Of state reachability and stabilizability of i... 详细信息

关键词： Integrative stability Intel.igent control systems Systems Engineering.

Theoretical determination of (d, n) and (d, 2n) excitation functions of some structural fusion materials irradiated by deuterons

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Nuclear Science and Techniques 2017年第11期28卷 242-250页

作者： Mustafa Yigit Eyyup tel Department of Physics Aksaray University Aksaray Turkey Department of Physics Osmaniye Korkut Ata UniversityOsmaniye Turkey

Nuclear fusion is one of the world's primary energy sources. Studies on the structural fusion materials are very important in terms of the development of fusion technology. Chromium, nickel, zinc, scandium, titanium,and yttrium are important structural fusion materials. In this paper, for use in nuclear science and technology applications, the excitation functions of the ^(50)Cr(d, n)^(51)Mn,^(58)Ni(d, n)^(59)Cu,^(64)Zn(d, n)^(65)Ga,^(66)Zn(d, n)^(67)Ga,^(45)Sc(d,2n)^(45)Ti,^(47)Ti(d, 2n)^(47)V,^(48)Ti(d, 2n)^(48)V, and ^(89)Y(d, 2n)^(89)Zr nuclear reactions were investigated. The calculations that are based on the pre-equilibrium and equilibrium reaction processes were performed using ALICE–ASH computer code. A comparison with geometry-dependent hybrid model has been made using the initial exciton numbers n_0= 4–6 and level density parameters α = A/5; A/8; A/***, the present model-based calculations were compared with the cross sections obtained using the formulae suggested from our previous studies. Furthermore, the cross section results have been compared with TENDL data based on TALYS computer code and the measured data in the literature.

关键词： Cross section Fusion materials Geometrydependent hybrid model

Extending the operational lifetimes of all-direct electron transfer enzymatic biofuel cells by magnetically assembling and exchanging the active biocatalyst layers on stationary electrodes

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Nano Research 2019年第4期12卷 767-775页

作者： Katharina Herkendell Andreas Stemmer Ran tel.Vered Saumerstrasse 4 Nanotechnology Group D-MAVT ETH Zurich Ruschlikon CH-8803 Switzerland

Enzymatic biofuel cells promise green power generation from a variety of natural resources, yet these systems all suffer from time-dependent degradati on effects, in particular progress! ng inactivation of enzymes, which severely limit the operati on al lifetimes of such power sources. To extend operational lifetimes, we introduce a method to magnetically exchange exhausted enzymes for fresh ones. To this end, anodic and cathodic enzymes or enzyme cascades are immobilized on carbon coated magnetic nanoparticles. Under the action of suitable magnetic field gradie nts, these nano particles are assembled on the respective stati onary electrodes, or released from the electrodes for collection and subsequent excha nge. We dem on strate this method on a fructose/oxygen con suming biofuel cell emplo ying fructose dehydroge nase and bilirubin oxidase as well as on anodic and cathodic cascades employing fructose dehydrogenase/invertase and bilirubin oxidase/catalase, respectively. The en zyme-modified nan oparticles support direct electro n transfer bioelectrocatalytic curre nts by wiring the redox active cofactors to the carbonaceous coating and from there to the electrode surfaces. The facile injection, assembly, and removal of enzyme-modified magnetic nan oparticles along with fuel solutio n provides a promisi ng approach to exte nd the operati on al lifetime of enzymatic biofuel cells without the need for exchanging entire systems including chambers and electrodes.

关键词： direct electron transfer magnetic nanoparticle enzymatic biofuel cell recharge lifetime enzyme cascade

AEROSOL BEHAVIOR IN CHROMIUM WASTE INCINERATION

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China Particuology 2003年第2期1卷 47-51页

作者： Suyuan YuInstitute of Nuclear Energy Technology, Tsinghua University, Beijing 100084, P. R. China tel. 0086-10-62784823, E-mail: suyuan@*** Institute of Nuclear Energy Technology Tsinghua University Beijing 100084 P. R. China

Cr2O3 is considered as the dominant incineration product during the combustion disposal of chromium waste. A hydrogen/air diffusion flame was employed to simulate the industrial process of incineration. Cr2O3 aerosols were generated inside the flame by the gas phase reaction of chromium and oxygen. Chromium came from the rapid decomposition of chromium hexacarbonyl (Cr(CO)6) at room temperature and was carried into the combustion chamber by hydrogen. Aerosol and clusters can then be easily formed in the flame by nucleation and coagulation. A two dimensional Discrete-Sectional Model (DSM) was adopted to calculate the Cr2O3 aerosol behavior. The experimental measurement method was Dynamic Light Scattering. The numerically predicted results agreed well with those of the experimental measurement. Both results show that the Cr2O3 aerosol size reached about 70 nanometers at the flame top.

关键词： chromium aerosol Dynamic Light Scattering Discrete-Sectional Model flame

CONTROL OF POLYMER PARTICLE SIZE USING POROUS GLASS MEMBRANE EMULSIFICATION A REVIEW

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China Particuology 2003年第3期1卷 105-114页

作者： Guanghui Ma State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100080, P. R. China tel. 0086-10-82627072, ghma@*** State Key Laboratory of Biochemical Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing 100080 P. R. China

Much attention has in recent years been paid to fine applications of polymer particles, e.g., carrier for enzyme, separation media for protein, DNA and cell, and carrier for drug in Drug Delivery System (DDS). Control of polymer particle size is especially important in such fine applications. For instance, when the particles are used as a carrier of anti-cancer agents, the locations of particles containing anti-cancer agents also depend on the size of the particles. In this paper, various techniques of controlling polymer particle size are described, with emphasis on Shirasu Porous Glass (SPG) membrane emulsification, as carried out in our research group.

关键词： particles polymerization emulsification Shirasu porous glass membrane microcapsule

The Characterisitic of Proton-Exchanged LiNbO_3 Waveguide Formed by Different Proton Source

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光学学报 2003年第S1期23卷 247-248页

作者： Qiying Zhu Guoliang Jing Yifang Yuan Baoxue ChenShanghai University for Science and Technology, 516,Jungong Road, Shanghai, 200093 China, tel.:86-21-65685972, E-mail: Yuan1306@*** Shanghai Jiaotong University Shanghai University for Science and Technology 516Jungong Road Shanghai 200093 China Shanghai Jiaotong University for Science and Technology 516Jungong Road Shanghai 200093 China

Benzoic acid as a source of proton is widely used in the technology of manufacture of proton exchanged ( PE) waveguide .But the diffusing speed of proton is too fast to make the waveguide stable in the pure benzoic ac... 详细信息

关键词： of in is it from The Characterisitic of Proton-Exchanged LiNbO3 Waveguide Formed by Different Proton Source mode by that