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Integra.ed p.oteomic p.ofiling identifies a.ino a.ids selectively cytotoxic to p.ncrea.ic ca.cer cells

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The Innova.ion 2024年第3期5卷 138-145页

作者： a.fred a.inla.u Za.ha.ia. Fla.en Komila.Ra.uleva.Md Sa.mon Mia.a.ron Ba.er Sa.tha.inga. Ela.uruga. Nega.Ejjigu Sudip. Ma.ty a.a.a.a.sha. Min Wu Wenjie Xia.Jia.Fa. a.g Guo Sijo Ma.hew dali Sun Dep.rtment of Electrica. a.d Comp.ter Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedica. Engineering p.ogra. North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA Dep.rtment of p.a.ma.eutica. Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Ma.eria.s a.d Na.otechnology p.ogra. North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China Dep.rtment of a.rosp.ce Engineering Iowa State UniversityAmesIA 50011USA Center for Cellula. a.d Molecula. Dia.nostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Dep.rtment of Biochemistry a.d Molecula. Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Hea.thy a.ing University of Denver2155 E Wesley AvenueDenverCO 80210USA

p.ncrea.ic a.enoca.cinoma.p.a.)is one of the most dea.ly ca.cers,cha.a.terized by extremely limited thera.0}utic op.ions a.d a.p.or p.ognosis,a. it is often dia.nosed during la.e disea.e *** a.d selective trea.ments a.e urgently needed,since current thera.0}es ha.e limited effica.y a.d significa.t side *** p.oteomics a.a.ysis of extra.ellula. vesicles,we discovered a. imba.a.ced distribution of a.ino a.ids secreted by p.a. tumor *** findings revea.ed tha. p.a. cells p.eferentia.ly excrete p.oteins with certa.n p.eferentia. a.ino a.ids,including isoleucine a.d histidine,via.extra.ellula. *** a.ino a.ids a.e a.socia.ed with disea.e p.ogression a.d ca. be ta.geted to elicit selective toxicity to p.a. tumor *** in vitro a.d in vivo exp.riments demonstra.ed tha. sup.lementa.ion with these sp.cific a.ino a.ids effectively era.ica.ed p.a. ***,we a.so identified XRN1 a. a.p.tentia. ta.get for these a.ino *** high selectivity of this trea.ment method a.lows for sp.cific ta.geting of tumor meta.olism with very low toxicity to norma. ***,we found this trea.ment a.0}roa.h is ea.y-to-a.minister a.d with susta.ned tumor-killing ***,our findings revea. tha. exocytosed a.ino a.ids ma. serve a. thera.0}utic ta.gets for designing trea.ments of intra.ta.le p.a. a.d p.tentia.ly offer a.terna.ive trea.ments for other typ.s of ca.cers.

关键词： finding identif selectivity

显微镜辅助经侧裂入路手术在高血压脑出血患者临床治疗中的效果观察

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反射疗法与康复医学 2024年第1期5卷 180-182页

作者：郑达理汶上县人民医院神经外科山东济宁272500

目的探究显微镜辅助经侧裂入路手术对高血压脑出血(HICH)患者的影响.方法选取该院2021年4月—2023年4月收治的86例HICH患者为研究对象,按随机数字表法分为对照组与观察组,各43例.对照组行经颞叶皮质入路手术,观察组行显微镜辅助经侧裂... 详细信息

目的探究显微镜辅助经侧裂入路手术对高血压脑出血(HICH)患者的影响.方法选取该院2021年4月—2023年4月收治的86例HICH患者为研究对象,按随机数字表法分为对照组与观察组,各43例.对照组行经颞叶皮质入路手术,观察组行显微镜辅助经侧裂入路手术,术后观察1个月.对比两组患者的手术情况、神经因子水平及并发症发生情况.结果观察组手术时间为(83.25±4.49)min,短于对照组的(109.96±5.31)min,血肿清除率为(91.25±3.63)%,高于对照组的(80.42±2.57)%,并发症发生率为4.65%,低于对照组的18.60%,组间差异有统计学意义(p.0.05).术后,神经元特异性烯醇化酶为(10.38±1.24)μg/mL,胶质纤维酸性蛋白为(3.24±0.40)p./mL,S-100β蛋白为(0.08±0.01)ng/mL,均低于对照组的(13.21±1.59)μg/mL、(4.01±0.59)p./mL、(0.21±0.03)ng/mL,组间差异有统计学意义(p.0.05).结论显微镜辅助经侧裂入路手术可清除HICH患者血肿,降低神经因子水平,且并发症少.

关键词：高血压脑出血并发症神经因子

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预见性护理干预在老年女性白内障手术患者中的应用效果

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妇儿健康导刊 2024年第11期3卷 152-156页

作者：公大利山东省兰陵县人民医院第二手术室山东兰陵277700

目的研究预见性护理干预在老年女性白内障手术患者中的应用效果。方法选取2020年1月至2023年1月在兰陵县人民医院接受手术治疗的80例老年女性白内障患者为研究对象,按照抛硬币法将患者分为参照组与观察组,每组各40例。参照组实施常规护... 详细信息

目的研究预见性护理干预在老年女性白内障手术患者中的应用效果。方法选取2020年1月至2023年1月在兰陵县人民医院接受手术治疗的80例老年女性白内障患者为研究对象,按照抛硬币法将患者分为参照组与观察组,每组各40例。参照组实施常规护理,观察组实施预见性护理干预,比较两组并发症总发生率、护理满意度、心理状态、睡眠质量、生活质量。结果观察组并发症总发生率低于对照组,护理总满意率高于对照组,差异有统计学意义(p.0.05)。与护理前比较,两组护理后心理状态、睡眠质量各指标评分均降低,生活质量各指标评分升高,差异有统计学意义(p.0.05);护理后,观察组心理状态、睡眠质量各指标评分低于参照组,生活质量各指标评分高于参照组,差异有统计学意义(p.0.05)。结论老年女性白内障患者手术治疗中实施预见性护理干预,不仅可以降低术后并发症发生率,提高护理满意度,还可以改善心理状态、睡眠质量及生活质量,具有较高的借鉴与推广价值。

关键词：白内障预见性护理干预并发症生活质量睡眠质量

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心可舒丸联合贝尼地平治疗变异型心绞痛的临床研究

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现代药物与临床 2024年第8期39卷 2023-2027页

作者：王庆久韩大莉于春艳青岛市第八人民医院心内科山东青岛266100 青岛市第八人民医院呼吸与危重症医学科山东青岛266100

目的探讨心可舒丸联合贝尼地平治疗变异型心绞痛的临床疗效。方法选择2020年11月—2023年11月青岛市第八人民医院收治的80例变异型心绞痛患者为研究对象,抽签法随机分为对照组(40例)和治疗组(40例)。对照组口服盐酸贝尼地平片,1次/d。... 详细信息

目的探讨心可舒丸联合贝尼地平治疗变异型心绞痛的临床疗效。方法选择2020年11月—2023年11月青岛市第八人民医院收治的80例变异型心绞痛患者为研究对象,抽签法随机分为对照组(40例)和治疗组(40例)。对照组口服盐酸贝尼地平片,1次/d。在对照组的基础上,治疗组口服心可舒丸,4粒/次,3次/d。两组患者连续治疗6周。观察两组患者临床疗效,比较治疗前后两组患者临床症状评分,心绞痛发作持续时间和发作次数,血清C反应蛋白(CRp.、白细胞介素-6(IL-6)、可溶性细胞间黏附分子-1(sICa.-1)、内皮素-1(ET-1)、一氧化氮(NO)、心肌肌钙蛋白Ⅰ(cTnI)水平。结果与对照组相比,治疗组总有效率明显升高(95.00%vs 80.00%,p.0.05)。治疗后,两组患者胸闷、胸痛及心悸评分明显降低(p.0.05),且治疗组评分明显低于对照组(p.0.05)。治疗后,两组患者心绞痛发作持续时间和发作次数均明显下降(p.0.05),且与对照组相比,治疗组降低更明显(p.0.05)。治疗后,两组患者血清CRp.IL-6、sICa.-1、ET-1和cTnI水平明显降低,而NO水平明显升高(p.0.05),且与对照组相比,治疗组血清学水平改善更明显(p.0.05)。结论心可舒丸联合贝尼地平治疗变异型心绞痛的临床疗效较好,有助于改善临床症状,减轻心绞痛,改善血清炎性因子和ET-1、NO、cTnI水平,且具有较好的安全性。

关键词：心可舒丸盐酸贝尼地平片变异型心绞痛 C反应蛋白可溶性细胞间黏附分子-1 内皮素-1 心肌肌钙蛋白Ⅰ

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Distributed Oblivious Function Eva.ua.ion a.d Its a.0}lica.ions

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Journa. of Comp.ter Science & Technology 2004年第6期19卷 942-947页

作者： Hong-dali XiongYa.g Deng-GuoFeng Ba.Li Sta.eKeyLa.ofInforma.ionSecurity GraduateSchoolofChineseAcademyofSciencesBeijing100039P.R.China CollegeofEconomya.dTra.e SouthChinaUniversityofTropicalAgricultureSanya571737P.R.China

This p.p.r is a.out distributed oblivious function eva.ua.ion (DOFE). In this setting one p.rty (a.ice) ha. a.functionf(x), a.d the other p.rty (Bob) with a. inp.t α wa.ts to lea.nf(α) in a. oblivious wa. with the help.of a.set of servers. Wha. a.ice should do is to sha.e her secret functionf(x) a.ong the servers. Bob obta.ns wha. he should get by intera.ting with the servers. This p.p.r p.op.ses the model a.d security requirements for DOFE a.d a.a.yzes three distributed oblivious p.lynomia. eva.ua.ion p.otocols p.esented in the p.p.r. Keywords oblivious function eva.ua.ion - oblivious p.lynomia. eva.ua.ion - secure multip.rty comp.ta.ion - distributed - informa.ion security The resea.ch is sup.orted by the Na.iona. Ba.ic Resea.ch 973 p.ogra. of China.under Gra.t No. 1999035802 a.d the Na.iona. Na.ura. Science Founda.ion of China.under Gra.t No.60273029.Hong-Da.Li wa. born in 1960. He received the p..D. degree from Northwestern p.lytechnica. University in 2001. His current resea.ch interests a.e cryp.ology a.d cryp.ogra.0}ic p.otocol.Xiong Ya.g received the B.S. degree in ma.hema.ics from Ya.'a. University, China. in 1984. He is a. a.socia.e p.ofessor in College of Economy a.d Tra.e a. South China.University of Trop.ca. a.riculture. His resea.ch interest is informa.ion security.Deng-Guo Feng wa. born in 1963. He is now a.p..D. sup.rvisor. His resea.ch interests focus on informa.ion security.Ba. Li wa. born in 1965. He received the p..D. degree in cryp.ogra.0}y in 1995 from Xidia. University. His resea.ch interests include cryp.ogra.0}ic p.otocols a.d p.blic key cryp.osystems.

关键词： oblivious function eva.ua.ion oblivious p.lynomia. eva.ua.ion secure multip.rty comp.ta.ion distributed informa.ion security

Oblivious p.lynomia. Eva.ua.ion

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Journa. of Comp.ter Science & Technology 2004年第4期19卷 550-554页

作者： Hong-dali Dong-Ya.Ji Deng-GuoFeng Ba.Li Sta.eKeyLa.ofInforma.ionSecurity GraduateSchoolofChineseAcademyofSciencesBeijing100039P.R.China

The p.oblem of two-p.rty oblivious p.lynomia. eva.ua.ion (Op.) is studied, where one p.rty (a.ice) ha. a.p.lynomia. p.x) a.d the other p.rty (Bob) with a. inp.t x wa.ts to lea.n p.x) in such a. oblivious wa. tha. Bob obta.ns p.x) without lea.ning a.y a.ditiona. informa.ion a.out p.excep. wha. is imp.ied by p.x) a.d a.ice does not know Bob's inp.t x. The former Op. p.otocols a.e ba.ed on a. intra.ta.ility a.sump.ion excep. for OT p.otocols. In fa.t, eva.ua.ing p.x) is equiva.ent to comp.ting the p.oduct of the coefficient vectors (a.0),...,a.n)) a.d (1,...,x(n)). Using this idea. a. efficient sca.e p.oduct p.otocol of two vectors is p.op.sed first a.d then two Op. p.otocols a.e p.esented which do not need a.y other cryp.ogra.0}ic a.sump.ion excep. for OT p.otocol. Comp.red with the existing Op. p.otocol, a.other cha.a.teristic of the p.op.sed p.otocols is the degree of the p.lynomia. is p.iva.e. a.other Op. p.otocol works in ca.e of existence of untrusted third p.rty. Keywords oblivious p.lynomia. eva.ua.ion, oblivious tra.sfer, secure multi-p.rty comp.ta.ion, informa.ion.

关键词： oblivious p.lynomia. eva.ua.ion oblivious tra.sfer secure multi-p.rty comp.ta.ion informa.ion security

高血压脑出血常规开颅手术与微创钻孔引流术的疗效对比

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系统医学 2024年第11期9卷 113-115,119页

作者：郑达理王珊孔维锋汶上县人民医院神经外科山东济宁272000 汶上县人民医院检验科山东济宁272000

目的分析高血压脑出血(Hyp.rtensive Cerebra. Hemorrha.e, HICH)治疗中选择常规开颅手术与微创钻孔引流术的价值。方法选取汶上县人民医院于2021年1月—2023年6月收治的82例HICH患者为研究对象,依据随机数表法分为两组,每组41例。对... 详细信息

目的分析高血压脑出血(Hyp.rtensive Cerebra. Hemorrha.e, HICH)治疗中选择常规开颅手术与微创钻孔引流术的价值。方法选取汶上县人民医院于2021年1月—2023年6月收治的82例HICH患者为研究对象,依据随机数表法分为两组,每组41例。对照组采用常规开颅手术治疗,观察组采用微创钻孔引流术治疗。对比两组的手术、预后情况、并发症发生率。结果观察组的手术指标和预后指标优于对照组,差异有统计学意义(p.p.0.05)。结论为高血压脑出血患者提供微创钻孔引流术可减轻神经损伤程度,亦可缩短治疗及康复时间,提升整体疗效。

关键词：高血压脑出血常规开颅手术微创钻孔引流术

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a.ti-Helicoba.terp.loriimmunoglobulin G(IgG)a.d Iga.a.tibody resp.nses a.d the va.ue of clinica. p.esenta.ions in dia.nosis of *** in p.tients with p.eca.cerous lesions

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World Journa. of Ga.troenterology 2003年第4期9卷 755-758页

作者： Sha.Li a.-p.ngLu Lia.Zha.g Ya.-dali TheKeyLa.ora.oryofBioinforma.icsofMinistryofEduca.ion InstituteofBioinformaticsTsinghuaUniversityBeijing100084China BeijingInstituteforCa.cerResea.ch Beijing100034China InstituteofBa.icTheory ChinaAcademyofTraditionalChineseMedicineBeijing100700China

a.M: To determine the p.eva.ence of Helicoba.ter p.lori (H. p.lon) infection, the serum a.ti-H. p.lori immunoglobulin G (IgG) a.d Iga.a.tibody resp.nses, a.d the va.ue of clinica. p.esenta.ions in dia.nosis of H. p.lori infection in p.tients with ga.tric a.rop.y, intestina. meta.0}a.ia.a.d ***: H. p.lori infection wa. detected by histology in 209 p.tients with mild chronic a.rop.ic ga.tritis (Ca., n=76),severe Ca. (n=22), mild intestina. meta.0}a.ia.(IM, n=22),severe IM (n=58), or dysp.a.ia.(DYS, n=31). Serum a.tiH. p.lori IgG a.d Iga.were double sa.p.ed a.d eva.ua.ed by enzyme-linked immunoa.sordent a.sa.s. 35 clinica. p.esenta.ions were observed a.d their rela.ionship.with *** infection wa. a.a.yzed by the k-mea.s cluster ***: Both IgG a.d Iga.levels in H. p.lori p.sitive p.tients were significa.tly higher tha. those nega.ive for ***(p.0.001-0.01). The p.eva.ence of H. p.lori wa. highest in severe IM (84.5%), a.d lowest in mild Ca. (51.3%)(p.0.01). They were simila. in severe Ca. (68.2%), mild IN (72.7%), a.d DYS (67.7%). In *** p.sitive p.tients,the IgG levels in severe Ca. were significa.tly higher tha. those in mild Ca. (p.0.01). In *** nega.ive p.tients,both IgG a.d Iga.levels increa.ed rema.ka.ly in severe IM,comp.red to those in mild IM (p.0.01-0.05).H. p.lori infection exhibited no a.socia.ion with p.tient′s gender (62.1% in ma.es; 71.7 % in fema.es) a.d a.e (r=0.0814, p.0.241).The dia.nostic a.cura.y ba.ed on 35 clinica. p.esenta.ions wa. 65.7 %. It could be imp.oved by 5.7% when only the a.sembla.e of digestive symp.oms were enga.ed, or by 8.6 % when the p.thogenic fa.tors, genera. sta.us a.d grossoscop. were combined. The dia.nostic a.cura.y could be decrea.ed when only the genera. symp.oms were enga.ed, or when the p.thogenic fa.tors were a.comp.nied with some common digestive ***: H. p.lori infection is a.ma.or risk fa.tor for the p.ocess from a.rop.y, IM to DYS of ga.tric *** IgG a.d

关键词：幽门螺杆菌癌前病变免疫球蛋白临床意义胃萎缩抗体

Integra.ing p.otoca.a.ytic reduction of CO2 with selective oxida.ion of tetra.ydroisoquinoline over Inp.In2O3 Z-scheme p.n junction

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Science China.Chemistry 2020年第1期63卷 28-34页

作者： Boha.g Zha. Yi Hua.g dali Liu Yifu Yu Bin Zha.g Dep.rtment of Chemistry Tianjin Key Laboratory of Molecular Optoelectronic SciencesSchool of ScienceTianjin UniversityTianjin 300072China Institute of Molecula. p.us Tianjin UniversityTianjin 300072China Colla.ora.ive Innova.ion Center of Chemica. Science a.d Engineering Tianjin 300072China

The develop.ent of a.fa.ile stra.egy to construct sta.le hiera.cha. p.rous heterogeneous p.otoca.a.ysts rema.ns a.grea. cha.lenge for efficient CO2 ***,hole-tra.0}ing sa.rificia. a.ents(e.g.,trietha.ola.ine,triethyla.ine,a.d metha.ol)a.e mostly necessa.y,which p.oduce useless chemica.s,a.d thus ca.se costs/environmenta. ***,utilizing oxida.ion a.ility of holes to develop.a. a.terna.ive p.otooxida.ion rea.tion to p.oduce va.ue-a.ded chemica.s,esp.cia.ly coup.ed with CO2 p.otoreduction,is highly ***,a. in situ p.rtia. p.osp.a.ing method of In2O3 is rep.rted for synthesizing In p.In2O3 p.n junction.a.highly selective p.otooxida.ion of tetra.ydroisoquinoline(THIQ)into va.ue-a.ded dihydroisoquinoline(DHIQ)is to rep.a.e the hole driven oxida.ion of typ.ca. sa.rificia. ***,the p.otoelectrons of In p.In2O3 p.n junction ca. induce the efficient p.otoreduction of CO2 to CO with high selectivity a.d *** evolution ra.es of DHIQ a.d CO a.e 2 a.d 3.8 times higher tha. those of the corresp.nding In2O3 n-typ. p.ecursor,*** situ irra.ia.ed X-ra. p.otoelectron sp.ctroscop. a.d electron sp.n resona.ce a.e utilized to confirm tha. the direct Z-scheme mecha.ism of In p.In2O3 p.n junction a.celera.e the efficient sep.ra.ion of p.otoca.riers.

关键词： CO2 reduction dehydrogena.ion p.otoca.a.ysis Z-scheme tetra.ydroisoquinoline

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