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Finding an Effective Distance Between T-Cell and B-Cell Using S/W ARQ in an Immune System Communication

China Communications 2020年第1期17卷 174-185页

作者： Sanjit Ningthoujam tekcham chingkheinganba Swarnendu K Chakraborty Dept.of Computer Science and Engineering NIT Arunachal Pradesh

In this paper,we present the effective distance between T-cell and B-cell in an immune system using Stop and Wait(S/W)Automatic Repeat Request(ARQ).The concentration of the molecules can be increased by increasing the transmitting number of molecules but it may reduce the performance of communication due to higher collision or interference with other *** is also reported in the literature that the concentration of the emitted molecules reduces if the distance from Transmitter(Tx)to Receiver(Rx)***,this paper mainly focuses on enhancing the receiver’s capture probability and higher successful complete transmission of the desired molecules by obtaining the effective distance from T-cell to *** order to find the effective distance,T-cell transmits the molecules 1(Interleukins-2)to B-cell,upon successful reception of molecules 1,antibodies(molecules 2)transmit back to ***,the effective distance of an immune system can be obtained after T-cell detects the concentration of the molecules 2 with respect to *** schemes of S/W ARQ protocols have implemented in Molecular Communication(MC)but it requires retransmission of duplicate copies due to the lack of addressing an effective ***,the simulations are performed in MATLAB and the results obtain higher capture probability and also successful complete transmission of the desired molecules.

关键词： T-cell B-cell MC antigens antibodies diffusion coefficient(D) round trip time(RTT)

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Biochemical reactions in metabolite-protein interaction

引用

Chinese Chemical Letters 2018年第5期29卷 645-647页

作者： Wen Wang Dinesh Singh tekcham Min Yan Zhichao Wang Huan Qi Xiaolong Liu Hai-Long Piao Scientific Research Center for Translational Medicine Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China University of Chinese Academy of Sciences Beijing 100049 China CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China

Active endogenous metabolites regulate the viability of cells. This process is controlled by a series ofinteractions between small metabolites and large proteins. Previously, several studies had reported thatmetabolite regulates the protein functions, such as diacylglycerol to protein kinase C, lactose regulationof the lac repressor, and HIF-1α stabilization by 2-hydroxyglutarate. However, decades old traditionalbiochemical methods are insufficient to systematically investigate the bio-molecular reactions for a high-throughput discovery. Here, we have reviewed an update on the recently developed chemical proteomicscalled activity-based protein profiling （ABPP）. ABPP is able to identify proteins interacted eithercovalently or non-covalently with metabolites significantly. Thus, ABPP will facilitate the characteriza-tion of specific metabolite regulating; proteins in human disease progression.

关键词： Post translational modification Activity-based protein profiling Metabolite-protein interaction Chemical probe Mass spectrometry

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