检索结果-南通市图书馆

Prostacyclin inhibition by indomethacin aggravates hepatic damage and encephalopathy in rats with thioacetamide-induced fulminant hepatic failure

引用

World Journal of Gastroenterology 2005年第2期11卷 232-236页

作者： Chi-JenChu Ching-ChinHsiao teh-fangwang Cho-YuChan Fa-YauhLee Full-YoungChang Yi-ChouChen Hui-ChunHuang Sun-SangWang Shou-DongLee DivisionofGastroenterology DepartmentofMedicineTaipeiVeteransGeneralHospitalTaipeiTaiwanChina ArmedForcesSungshanHospital TaipeiTaiwanChina DepartmentofMedicalResearchandEducation TaipeiVeteransGeneralHospitalTaipeiTaiwanChina//NationalYang-MingUniversitySchoolofMedicineTaipeiTaiwanChina DivisionofGastroenterology DepartmentofMedicineTaipeiVeteransGeneralHospitalTaipeiTaiwanChina//DivisionofGeneralMedicineDepartmentofMedicineTaipeiVeteransGeneralHospitalTaipeiTaiwanChina TaipeiMunicipalGan-DauHospital TaipeiTaiwanChina//NationalYang-MingUniversitySchoolofMedicineTaipeiTaiwanChina DivisionofGastroenterology DepartmentofMedicineTaipeiVeteransGeneralHospitalTaipeiTaiwanChina//NationalYang-MingUniversitySchoolofMedicineTaipeiTaiwanChina

AIM: Vasodilatation and increased capillary permeability have been proposed to be involved in the pathogenesis of acute and chronic form of hepatic encephalopathy. Prostacyclin (PGI2) and nitric oxide (NO) are important contributors to hyperdynamic circulation in portal hypertensive states. Our previous study showed that chronic inhibition of NO had detrimental effects on the severity of encephalopathy in thioacetamide (TAA)-treated rats due to aggravation of liver damage. To date, there are no detailed data concerning the effects of PGI2 inhibition on the severity of hepatic encephalopathy during fulminant hepatic failure. METHODS: Male Sprague-Dawley rats weighing 300-350 g were used. Fulminant hepatic failure was induced by intraperitoneal injection of TAA (350 mg/(kg·d) for 3 d. Rats were divided into two groups to receive intraperitoneal injection of indomethacin (5 mg/(kg·d), n = 20) or normal saline (N/S, n = 20) for 5 d, starting 2 d before TAA administration. Severity of encephalopathy was assessed by the counts of motor activity measured with Opto-Varimex animal activity meter. Plasma tumor necrosis factor-α (TNF-α, an index of liver injury) and 6-keto-PGF1α (a metabolite of PGI2) levels were measured by enzyme-linked immunosorbent assay. RESULTS: As compared with N/S-treated rats, the mortality rate was significantly higher in rats receiving indomethacin (20% vs5%, P0.05), as compared with rats treated with N/S. CONCLUSION: Chronic indomethacin administration has detrimental effects on the severity of encephalopathy in TAA-treated rats and this phenomenon may be attributed to the aggravation of live

关键词： Hepatic Encephalopathy Fulminant hepatic failure Prostacyclin Indomethacin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：