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Mirrorless MEMS imaging:a nonlinear vibrational approach utilizing aerosol-jetted PZT-actuated fiber MEMS scanner for microscale illumination

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Microsystems & Nanoengineering 2024年第1期10卷 175-192页

作者： Wei-Chih Wang Ming-Yao Li Kuan-Chang Peng Yi-Feng Hsu Benjamin Estroff Pao-Yun yen David Schipf Wen-Jong Wu Department of Power Mechanical Engineering National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchuTaiwan 30013China Institute of NanoEngineering and Microsystems National Tsing Hua UniversityNo.101Section 2Kuang-Fu RoadHsinchuTaiwan 30013China Department of Mechanical Engineering University of WashingtonSeattleWA 98195USA Department of Electrical Engineering University of WashingtonSeattleWA 98195USA Department of Engineering Science and Ocean Engineering National Taiwan UniversityTaiwanChina

This study introduces a novel image capture and lighting techniques using a cutting-edge hybrid MEMS scanner system designed for compact microscopic *** scanner comprises a tapered optical fiber waveguide and innovative aerosol-jet printed PZT(lead zirconate titanate)bimorph push-pull actuators on a stainless-steel substrate,effectively addressing issues that are commonly associated with PZT on silicon substrates such as fracture and layer *** leveraging nonlinear vibration,the scanner achieves a spiral scan pattern from a single signal input,in addition to the expected two-dimensional scanning and target illumination from two phase-shifted *** capability is further enhanced by a novel process to taper the optical fiber,which reduces illumination scattering and tunes the fiber to the resonant frequencies of the *** precisely tapered tip enables large fields of view while maintaining independent 2-axis scanning through one-degree-of-freedom *** validation showcases the successful generation of a spiral scan pattern with a 60μm diameter scan area and a 10 Hz frame rate,effectively reconstructing scanned images of 5μm lines,cross patterns(15μm in length with a 5μm gap),and structures of a Psychodidae wing.

关键词： steel fiber scanner

ON101 Cream Increases the Wound Healing Rate in Diabetic Patients with Uremia—Cases Report

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Case Reports in Clinical Medicine 2024年第5期13卷 178-186页

作者： Yu-Hsiu yen Chi-Ming Pu Division of Plastic Surgery Department of Surgery Cathay General Hospital Taipei City School of Medicine College of Medicine Fu Jen Catholic University New Taipei School of Medicine College of Life Science National Tsing Hua University Hsinchu

Diabetic patients who underwent long-term dialysis may increase the prevalence of foot ulceration. In addition, diabetic foot ulcer (Dfus) patients with end-stage renal disease (ESRD) do not heal well, and the amputation rate is 6.5 - 10 times higher compared to the non-nephropathic diabetic population. Thus, a suitable therapeutic agent was needed. ON101 is a topical cream that promotes diabetic wound healing through a unique macrophage-regulating ability. In this case series, we included 5 diabetes patients (mean age 54.6 ± 8.7 years, 4 mal) with ESRD (mean eGFR 7.4 ± 3.35 mL/min/1.73m2) and had experienced dialysis for at least 4.5 years. These patients also have UT (University of Texas) grade 2A Dfus that have existed for at least 1.5 months (mean ulcer duration 8.3 ± 8.97 months). These subjects were applied ON101 twice daily for up to 20 weeks, and wound size was recorded during treatment. Among these subjects, three ulcers (patient No. 1, 2, and 3) completely healed within 10 weeks upon ON101 application, and one ulcer was 99% reduced at 20th weeks (patient No. 4). Only one ulcer didn’t show an obvious response that may due to poor compliance in wound care and glucose control. In summary, the overall healing rate was 60%, suggesting ON101 performed equivalence healing efficacy in dialysis patients compared with those who did not have dialysis.

关键词： Diabetic Foot Ulcer (Dfu) Uremia Dialysis Wound Healing

Designing simple non-fused terthiophene-based electron acceptors for efficient organic solar cells

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Journal of Energy Chemistry 2024年第9期96卷 501-508页

作者： Jiayu Li Kun Li Zhe Mei Yu Chen Qian Xie Chenxu Yu Xuefeng Liu Yanqi Wang Yishi Wu Qing Liao Cunbin An Hongbing fu Beijing Key Laboratory for Optical Materials1nd Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China Beijing Synchrotron Radiation Laboratory Institute of High Energy PhysicsChinese Academy of Sciences(CAS)Beijing 100049China

Low-cost photovoltaic materials are essential for realizing large-scale commercial applications of organic solar cells(OSCs).However,highly efficient OSCs based on low-cost photovoltaic materials are scarce due to a deficiency in understanding the structure-property ***,we investigated two low-cost terthiophene-based electron acceptors,namely,3TC8 and 3teh,with 3,4-bis(octan-3-yloxy)thiophene,differing only in the alkylated *** acceptors exhibit low optical gaps(∼1.43 eV)and possess deep highest occupied molecular orbital(HOMO)levels(∼−5.8 eV).Notably,the single-crystal structure of 3teh demonstrates highly planar conjugated backbone and strongπ-πstacking between intermolecular terminal groups,attributed to the presence of the bulky alkylated noncovalently conformational *** utilizing both acceptors to fabricate OSCs,the 3TC8-based device exhibited a power conversion efficiency(PCE)of 11.1%,while the 3teh-based OSC demonstrated an excellent PCE of 14.4%.This PCE is the highest among OSCs based on terthiophene-containing electron *** results offer a new strategy for designing low-cost electron acceptors for highly efficient OSCs.

关键词： Organic solarcells Low cost Terthiophene Non-fused electron acceptor

Valorization of poly-β-hydroxybutyrate(PHB)-based bioplastic waste in anaerobic digesters of food waste for bioenergy generation:reactor performance,microbial community analysis,and bioplastic biodegradation

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碳中和(英文) 2022年第1期1卷 523-536页

作者： Le Zhang To-Hung Tsui Jiahua fu Yanjun Dai yen Wah Tong NUS Environmental Research Institute National University of Singapore1 Create WayCreate Tower#15-02Singapore 138602Singapore Energy and Environmental Sustainability for Megacities(E2S2)Phase II Campus for Research Excellence and Technological Enterprise(CREATE)1 CREATE WaySingapore 138602Singapore Department of Chemical and Biomolecular Engineering National University of Singapore4 Engineering Drive 4Singapore 117585Singapore School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghaiChina

This study aims to investigate the significance and biodegradation pathways of PHB-based bioplastic in anaerobic digesters treating food waste,where the reactor performance of changed methane generation,bioplastic biodegradation efficiency,and bioinformatic analysis of functional microbes were *** results showed that PHB-based plastic film could be partially biodegraded in the food waste digester,and a bioaugmentation use of Alcaligenes Faecalis(AF)and Bacillus Megaterium(BM)was beneficial to largely accelerate the degradation process through a beneficial shift of both the functional bacterial and archaeal *** community analysis indicated that the major bacterial species belonged to genera Candidatus_Cloacimonas,Rikenellaceae,and Defluviitoga,while the dominant methanogenic archaeal species belonged to genera Methanomassiliicoccus,Methanosarcina,and *** biodegradation analysis suggested that the optimal fractions of AF and BM for PHB-based plastic degradation were 50% AF and 75% BM,respectively,which deserves further optimization and scale-up *** finding of this study would contribute to the combined management of PHB-based bioplastic with food waste for clean energy recovery and a greener environment.

关键词： Anaerobic digestion Biodegradable plastic Waste management Energy recovery Bioinformatic analysis Poly-β-hydroxybutyrate(PHB)

Flavonoids in safflower extract reduce cisplatin-induced damage to human follicle dermal papilla cells by inhibiting DNA damage and Rad17/Chk1/Cdc25C signaling

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BIOCELL 2023年第8期47卷 1793-1802页

作者： fu-MING TSAI PING-HSUN LU LU-KAI WANG CHAN-yen KUO MAO-LIANG CHEN CHUN-HUA WANG Department of Research Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan Department of Chinese Medicine Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Post-Baccalaureate Chinese Medicine Tzu Chi UniversityHualien970Taiwan Department of Life Sciences National Science and Technology CouncilTaipei106Taiwan Department of Dermatology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231Taiwan School of Medicine Tzu Chi UniversityHualien970Taiwan

Background:Cisplatin is a chemotherapeutic agent commonly used clinically for the treatment of various human *** often reduce the use of cisplatin due to its side effects,which in turn affects its *** study explored the mechanism of action of safflower extract as an adjuvant traditional Chinese medicine for ***:Primary human follicle dermal papilla cells(HFDPCs)were used as target cells for cisplatininduced damage to hair *** blotting was used to investigate the molecular targets of cisplatin and safflower extract in causing HFDPCs *** survival and cell cycle were analyzed by mitochondrial staining reagent WST-1 and propidium ***:Cisplatin could reduce the viability of HFDPCs without causing cell *** increased the level of phospho-Rad17 in HFDPCs and activated the Chk1/Cdc25C signaling to reduce the expression of Cdc2 protein,thereby arresting the cells in the G2/M *** combination of safflower extract and the flavonoids could effectively inhibit the signal transduction of Rad17/Chk1/Cdc25 in cisplatin-treated cells and reduce the cell population in the G2/M ***,we also confirmed that safflower extract could effectively inhibit the damage to HFDPCs caused by cisplatin,mainly at the level of reducing the DNA damage caused by ***:Safflower extract can be used as an adjuvant Chinese medicine for chemotherapy to reduce the damage caused by chemotherapy to normal hair follicle cells.

关键词： Safflower extract Cisplatin Human hair follicle dermal papilla cells Rad17 Hair loss Cell cycle

Frontiers in auditory bioscience and technology: a special feature on recent advances in hearing research

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第2期20卷 109-110页

作者： yen-fu CHENG Department of Otology and Laryngology Harvard Medical School Eaton-Peabody Laboratory Massachusetts Eye and Ear Infirmary Department of Medical Research Taipei Veterans General Hospital Department of Otolaryngology-Head and Neck Surgery Taipei Veterans General Hospital School of Medicine Yang-Ming University Department of Speech Language Pathology and Audiology Taipei University of Nursing and Health Science

IwasgreatlyhonoredtobeaskedbyHelen ZHANG,Former Managing Editor,to serve as a guest editorofthisspecialfeatureofJournalofZhejiang University-SCIENCEB(Biomedicine&Biotechnology)on'FrontiersinAuditoryBioscienceand Techn... 详细信息

关键词： auditory bioscience and technology a special feature

Spatiotemporally dynamic therapy with shape-adaptive drug-gel for the improvement of tissue regeneration with ordered structure

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Bioactive Materials 2022年第2期7卷 165-176页

作者： Ya-nan fu Yongsan Li Bo Deng Yingjie Yu Fang Liu Lei Wang Guang Chen Lei Tao yen Wei Xing Wang Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China Department of Oncology of Integrative Chinese and Western Medicine China-Japan Friendship HospitalBeijing100029China Institute of Translational Medicine Shenzhen Second People’s HospitalThe First Affiliated Hospital of Shenzhen UniversityHealth Science CenterShenzhen518035China The Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology(Ministry of Education) Department of ChemistryTsinghua UniversityBeijing100084China

A spatiotemporally dynamic therapy(SDT)is proposed as a powerful therapeutic modality that provides spatially dynamic responses of drug-carriers for adapting to the wound ***,dynamic chitosan-poly(ethylene glycol)(CP)Schiff-base linkages are employed to perform SDT by directly converting a liquid drug Kangfuxin(KFX)into a gel *** obtained KFX-CP drug-gel with shape-adaptive property is used to treat a representative oral mucositis(OM)model in a spatiotemporally dynamic *** KFX-CP drug-gel creates an instructive microenvironment to regulate signaling biomolecules and endogenous cells behavior,thereby promoting OM healing by the rule of dynamically adjusting shape to fit the irregular OM regions first,and then provides space for tissue regeneration,over KFX potion control and the general hydrogel group of CP hydrogel and *** interestingly,the regenerated tissue has ordered structure like healthy ***,the SDT provides a new approach for the design of next generation of wound dressing and tissue engineering materials.

关键词： Spatiotemporally dynamic therapy Drug-gel Shape-adaptive Tissue regeneration Ordered structure

Using a consensus acupoints regimen to explore the relationship between acupuncture sensation and lumbar spinal postoperative analgesia: A retrospective analysis of prospective clinical cooperation

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Journal of Integrative Medicine 2022年第4期20卷 329-337页

作者： yen-Lin Chao Yi-Ai Rau Hong-Sheng Shiue Jiun-Lin Yan Yuan-Yun Tang Shao-Wen Yu Bo-Yan Yeh yen-Lung Chen Tsung-Hsien Yang Shu-Chen Cheng Yi-Wen Hsieh Hsin-Chia Huang fu-Kuang Tsai Yu-Sheng Chen Geng-Hao Liu Division of Acupuncture and Moxibustion Department of Traditional Chinese MedicineChang Gung Memorial HospitalTaoyuan 333TaiwanChina School of Traditional Chinese Medicine College of MedicineChang Gung UniversityTaoyuan 333TaiwanChina Department of Neurosurgery Keelung Chang Gung Memorial HospitalKeelung 204TaiwanChina Department of Traditional Chinese Medicine New Taipei Municipal TuCheng HospitalChang Gung Memorial HospitalNew Taipei 236TaiwanChina Sleep Center Chang Gung Memorial HospitalTaoyuan 333TaiwanChina

Objective: This study evaluated the effectiveness of acupuncture treatment on postoperative pain in patients with degenerative lumbar spine disease, and explored the relationship between the postoperative analgesic effect of acupuncture and the sensation of acupuncture experienced by the ***: This retrospective study analyzed the medical records of 97 patients who had undergone an operation by the same surgeon due to degenerative lumbar disease. These patients were divided into acupuncture group(n = 32), patient-controlled analgesia(PCA) group(n = 27), and oral analgesia group(n = 38) according to the different postoperative analgesic methods. During their hospitalization, patients completed daily evaluations of their pain using a visual analogue scale(VAS), and injection times of supplemental meperidine were recorded. Also, the Chinese version of the Massachusetts General Hospital Acupuncture Sensation Scale(C-MASS) was used in the acupuncture ***: Each of the three treatment groups showed significant reductions in postoperative pain, as shown by reduced VAS scores. The acupuncture group, however, had less rebound pain(P < 0.05) than the other two groups. Both the acupuncture and PCA groups experienced acute analgesic effects that were superior to those in the oral analgesia group. In addition, the higher the C-MASS index on the second day after surgery, the lower the VAS score on the fourth day after surgery. There was also a significant difference in the“dull pain” in the acupuncture ***: The results demonstrated that acupuncture was beneficial for postoperative pain and discomfort after simple surgery for degenerative spinal disease. It is worth noting that there was a disproportionate relevance between the patient’s acupuncture sensation and the improvement of pain VAS score.

关键词： Acupuncture analgesia Postoperative period Neurodegenerative diseases Lumbosacral region Acupuncture sensation De-qi

Efficient Cloud Image Retrieval System Using Weighted-Inverted Index and Database Filtering Algorithms

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Journal of Electronic Science and Technology 2017年第2期15卷 161-168页

作者： Shuo-fu yen Jiann-Jone Chen Yao-Hong Tsai Electrical Engineering Department Taiwan University of Science and Technology Information Management Department Hsuan Chuang University

With the advance of multimedia technology and communications, images and videos become the major streaming information through the Internet. How to fast retrieve desired similar images precisely from the Internet scale image/video databases is the most important retrieval control target. In this paper, a cloud based content-based image retrieval （CBIR） scheme is presented. Database-categorizing based on weighted-inverted index （DCWII） and database f＇dtering algorithm （DFA） is used to speed up the features matching process. In the DCWII, the weights are assigned to discrete cosine transform （DCT） coefficients histograms and the database is categorized by weighted features. In addition, the DFA filters out the irrelevant image in the database to reduce unnecessary computation loading for features matching. Experiments show that the proposed CBIR scheme outperforms previous work in the precision-recall performance and maintains mean average precision （mAP） about 0.678 in the large-scale database comprising one million images. Our scheme also can reduce about 50% to 85% retrieval time by pre-filtering the database, which helps to improve the efficiency of retrieval systems.

关键词： Index Terms-Content-based image retrieval cloud computing MPEG-7.