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The bio-active components of the Mongolian medicine Horcha-6 and therapeutic mechanism in the rat migraine model

Traditional Medicine Research 2024年第2期9卷 8-17页

作者： Ao Qier Naren Mandula Qiburi Qiburi Manda Manda tegexi baiyin Xilinqiqige Bao Huricha Baigued Chang-Shan Wang Temuqile Temuqile De-Zhi Yang Pharmaceutical Laboratory Inner Mongolia International Mongolian HospitalHohhot 010065China College of Mongolian Medicine Inner Mongolia Medical UniversityHohhot 010110China Medical Innovation Center for Nationalities Inner Mongolia Medical UniversityHohhot 010110China Institute of Mongolian Medicinal Chemistry School of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot 010021China School of Life Sciences Inner Mongolia UniversityHohhot 010021China

Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass ***,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treating migraines through the use of network pharmacology and a rat migraine ***:After identifying the active components of Horcha-6,the corresponding genes of the active components’target were obtained from the Universal Protein database,and a“compound-target-disease”network was constructed using Cytoscape 3.9.0 *** the in vivo experiments,nitroglycerin was injected intraperitoneally into rats to create a migraine ***-treatment with Horcha-6 was administered orally for 14 days,and rats were subjected to migraine-related behavior *** sequencing was performed to identify the gene expression regulated by Horcha-6 in the trigeminal ***:A total of 903 chemical components of Horcha-6 have been collected in the liquid chromatography with tandem mass *** discovered 55 of the Horcha-6 bio-active components that were evaluated based on their Percent Human Oral Absorption(≥30%)and DL values(≥0.185)on the traditional Chinese medicine systems pharmacology ***“compound-target-disease”network contained 163 intersection targets with the migraine *** Ontology analysis indicated that these components significantly regulated the immune response,vascular function,oxidative stress,*** Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed,we observed that most of the target genes were significantly enriched in the inflammation and neuro-related signaling pathway,toll-like receptor signaling pathway,neuroactive ligand-receptor interaction,*** predictions were further demonstrated via in vivo animal model *** RNA sequencing results showed that 41 genes were down-regulated(P<0.05)and 86 genes were up-regulated(P<0.05)in the Horcha-6 treated group compared with the untreat

关键词： Horcha-6 bio-active components rat migraine model inflammation hormone metabolism neurotransmitter

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Study of the anti-inflammatory effect of the Traditional Mongolian Medicine Hohgardi-9 in acute lung injury

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Traditional Medicine Research 2023年第11期8卷 23-33页

作者： Aodeng Qimuge tegexi baiyin Bilige Bilige Temuqile Temuqile Sha-Na Chen Ying-Chun Bai Wuhan Qimuge Siqin Siqin Hugejile Hang Chang-Shan Wang Huricha Baigued De-Zhi Yang Pharmaceutical Laboratory Inner Mongolia International Mongolian HospitalHohhot 010065China Experimental Center Inner Mongolia Traditional Chinese&Mongolian Medical Research InstituteHohhot 010010China School of Life Sciences Inner Mongolia UniversityHohhot 010021China Inner Mongolia Key Laboraotry of Mongolian Medicinal Chemistry Inner Mongolia UniversityHohhot 010021China.

Background:Hohgardi-9 is a well-known traditional Mongolian drug that relieves cough and removes *** it is widely used to treat lung diseases clinically,Hohgardi-9’s bioactive constituents and mechanism of action are *** this study,we explored the bioactive compounds in Hohgardi-9 and the mechanism underlying its therapeutic effect against acute lung injury(ALI).Methods:We obtained the main components of Hohgardi-9 and analyzed the targets related to ALI by searching the traditional Chinese medicine systems pharmacology database and existing ***,we constructed the compound-target network using Cytoscape 3.8.0 software to obtain the bioactive compounds in Hohgardi-9 against *** used a string database to investigate the interaction between the possible protein targets of *** also performed Gene Ontology function annotation and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis to predict its anti-ALI ***,to verify the therapeutical effects of Hohgardi-9,we used an ALI rat model and analyzed the components of Hohgardi-9 found in the rat plasma using ultra-high-performance liquid chromatography coupled with Q-Exactive mass ***:The network pharmacology and plasma component analysis showed that Hohgardi-9 contained 31 potentially bioactive components,including quercetin,herbacetin,izoteolin,and columbinetin acetate,which affected the NF-κB,TLR,and TNF signaling pathways via key targets,such as RELA(p65)and *** in vivo experiments using hematoxylin and eosin staining revealed that Hohgardi-9 significantly improved lung tissue injury and pulmonary edema in ALI ***,Hohgardi-9 significantly reduced the expression levels of genes encoding inflammatory factors,such as TRL4,TNF-α,IL-1β,and ICAM1,in the lungs of ALI ***:Hohgardi-9 alleviated ALI by inhibiting inflammation-related gene expression through its active ingredients,such as quercetin and herbaceti

关键词： Hhohgardi-9 acute lung injury active components anti-inflammation

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高校后勤实体企业文化建设探析

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内蒙古财经大学学报 2014年第5期12卷 33-36页

作者：特格希内蒙古师范大学赛罕后勤服务集团内蒙古呼和浩特010022

对高校后勤实体来说,如何更好地对自身的企业文化进行促进和增强,将直接关系到其市场竞争力乃至整体的发展和水平的提高。以高校后勤实体的企业文化作为切入点,深入研究了其产生的背景和意义,并且将内蒙古师范大学的赛罕后勤集团作为视... 详细信息

对高校后勤实体来说,如何更好地对自身的企业文化进行促进和增强,将直接关系到其市场竞争力乃至整体的发展和水平的提高。以高校后勤实体的企业文化作为切入点,深入研究了其产生的背景和意义,并且将内蒙古师范大学的赛罕后勤集团作为视角,对高校后勤实体进行深入的剖析,从而找出提高高校后勤实体企业文化的可行性道路,以期对高校后勤实体的发展和进步起到积极的意义。

关键词：高校后勤实体企业文化建设学校制度

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对高校后勤职工思想政治工作的思考

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内蒙古师范大学学报（教育科学版） 2006年第11期19卷 146-148页

作者：特格希李岩内蒙古师范大学后勤服务集团内蒙古呼和浩特010022

高校后勤社会化改革过程中,后勤职工由原来的事业性管理转变为企业化管理,他们与学校原有的一体关系变成了经济服务合同中的甲、乙方关系。这一变化使得后勤职工在思考和处理问题时不得不把利益关系放在首位;后勤职工队伍构成复杂、文... 详细信息

高校后勤社会化改革过程中,后勤职工由原来的事业性管理转变为企业化管理,他们与学校原有的一体关系变成了经济服务合同中的甲、乙方关系。这一变化使得后勤职工在思考和处理问题时不得不把利益关系放在首位;后勤职工队伍构成复杂、文化素质相对偏低、从事的工作苦、脏、累,但收入明显低于教学人员。这些因素要求在进一步深化后勤改革的同时,抓好后勤职工的思想政治工作,以关心职工为切入点,以提高思想觉悟为目的,及时关注和解决职工中存在的“热点、难点、疑点”问题。

关键词：高校后勤职工思想政治工作

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荜茇宁对家兔实验性动脉粥样硬化的影响

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中国中药杂志 2008年第4期33卷 436-440,469页

作者：麻春杰博日吉汗格日勒图呼日乐巴根特格希苏日娜内蒙古大学生命科学学院内蒙古呼和浩特010021 内蒙古大学高分子化学及蒙药研究所内蒙古呼和浩特010021 内蒙古医学院内蒙古呼和浩特010020

目的:观察荜茇宁对家兔实验性动脉粥样硬化(AS)形成的影响,并探讨其作用机制。方法:采用高脂饲料喂养建立家兔AS模型,将兔随机分为5组:正常组,模型组,荜茇宁高、低剂量组分别给予荜茇宁5,2.5 ***-1.d-1,辛伐他汀组给予辛伐他汀5 ***-1.d... 详细信息

目的:观察荜茇宁对家兔实验性动脉粥样硬化(AS)形成的影响,并探讨其作用机制。方法:采用高脂饲料喂养建立家兔AS模型,将兔随机分为5组:正常组,模型组,荜茇宁高、低剂量组分别给予荜茇宁5,2.5 ***-1.d-1,辛伐他汀组给予辛伐他汀5 ***-1.d-1,连续喂养60 d。于实验前1 d及开始后第20,40,60天取空腹血检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),第60天检测血清超氧化物歧化酶(SOD)活力和丙二醛(MDA)、一氧化氮(NO)含量,随后处死动物,取主动脉和心脏做病理形态学检查。结果:与模型组相比,荜茇宁组的血清TC,TG,LDL-C水平降低(P<0.05或0.01),HDL-C有升高趋势,SOD,NO升高(P<0.05),MDA降低(P<0.05)。荜茇宁组主动脉斑块面积占总面积的百分比显著低于模型组(P<0.01);主动脉、心脏损伤程度减轻,冠状动脉狭窄程度轻于模型组(P<0.01);透射电镜观察显示荜茇宁组主动脉的超微结构病变程度明显轻于模型组。结论:荜茇宁能抑制AS斑块的形成和发展,其作用机制可能与调节血脂、抗氧化有关。

关键词：荜茇荜茇宁动脉粥样硬化家兔

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荜茇宁对动脉粥样硬化家兔抗氧化酶活性的影响

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中国药科大学学报 2008年第1期39卷 68-71页

作者：麻春杰博日吉汗.格日勒图呼日乐巴根特格希苏日娜内蒙古大学生命科学学院内蒙古大学高分子化学及蒙药研究所呼和浩特010021

目的:观察荜茇宁对实验性动脉粥样硬化(AS)家兔抗氧化酶类活性的影响。方法:以高脂饲料喂养家兔建立AS模型,给予高脂饲料的同时给予荜茇宁,连续60d。检测血清、肝脏和主动脉组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧... 详细信息

目的:观察荜茇宁对实验性动脉粥样硬化(AS)家兔抗氧化酶类活性的影响。方法:以高脂饲料喂养家兔建立AS模型,给予高脂饲料的同时给予荜茇宁,连续60d。检测血清、肝脏和主动脉组织中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)的活性和丙二醛(MDA)含量,并且测定血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)的含量,计算各组兔主动脉粥样硬化斑块面积比。结果:荜茇宁能提高AS家兔SOD、CAT、GSH-Px的活性(P<0.05),降低MDA(P<0.05),并且降低血清TC和LDL-C水平和主动脉斑块面积比(P<0.05)。结论:荜茇宁具有增强抗氧化酶活性、调节血脂作用,可预防动脉粥样硬化的发生。

关键词：荜茇宁动脉粥样硬化抗氧化酶

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