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Genome-Wide Analysis of ETS Transcription Factor Binding Specificities,Target Genes and Regulatory Polymorphisms

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Genome-Wide Analysis of ETS Transcription Factor Binding Spe...

High-performance portable grating-based surface plasmon resonance sensor using a tunable laser at normal incidence

21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Gong-Hong Wei Kimmo Palln Gwenael Badis Michael F.Berger teemu kivioja Martin Bonke Tilna Wahlfors Arttu Jolma Markku Varjosalo Andrew R.Gehrke Jian Yan Shaheynoor Talukder Ralner Lehtonen Outl Hallikas Mikko Tunnen Mikko Taipale Teuvo L.J.Tammela Laurl A.Aaltonen Hendrlk G.Stunnenberg Johanna Schleutker Timothy R.Hughes Martha L.Bulyk Esko Ukkonen Jussi Talpale THL University of Helsinki Finland University of Toronto Canada Harvard University USA University of Tampere Tampere Radboud University Nijmegen the Netherlands University of Tampere Tampere University Hospital Finland

＜正＞To comprehensively decipher the regulatory networks downstream of ETS transcription factors（TFs）,we systematically analyzed the binding specificities of all the human and mouse ETS family members,revealing the...

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Photonics Research 2024年第5期12卷 947-958页

作者： DUC LE ANNI RANTA-LASSILA teemu SIPOLA MIKKO KARPPINEN JARNO PETAJA MINNA KEHUSMAA SANNA AIKIO TIAN-LONG GUO MATTHIEU ROUSSEY JUSSI HILTUNEN ALEXEY POPOV VTT Technical Research Centre of Finland 90570 OuluFinland Department of Physics and Mathematics University of Eastern FinlandFI-80101 JoensuuFinland

Surface plasmon resonance(SPR)sensors are among the most sensitive *** such devices,a grating is a compelling alternative to a prism for the excitation of a surface plasmon,especially in the development of sensors for point-of-care applications due to their compactness and ***,we demonstrate the use of a tunable laser in a grating-based SPR system for further miniaturization and *** tunable laser working at normal incidence replaces spectral and moving components,while also simplifying the optical *** incidence is conventionally avoided due to the complexity of the control of degenerated SPR *** investigate,both computationally and experimentally,the splitting of the SPR modes at small nonzero incidences,which is lacking in previously reported *** optimizing the grating configuration,we were able to diminish the SPR mode splitting phenomenon when the excitation was feasible with the normal incidence *** fabricated sensor showed a high sensitivity of 1101.6 nm/***,the figure of merit of the sensor,defined as the ratio between the sensitivity and bandwidth of the SPR dip,was *** experimental results were consistent with the simulation *** also demonstrate its capability for detecting low concentrations of glucose and creatinine with the limit of detection of 14.2 and 19.1 mmol/L,respectively.

关键词： tunable splitting excitation

Use of partially shrouded impeller in a small centrifugal compressor

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Journal of Thermal Science 2008年第1期17卷 21-27页

作者： teemu Turunen-Saaresti JaakkoLarjola Department of Energy and Environmental Technology Lappeenranta University of TechnologyLappeenrantaFinland

Numerical analysis is conducted for the 3-dimensional impeller and vaneless diffuser of a small centrifugal com- pressor. The influence of impeller tip clearance on the flow field of the impeller is investigated. Detailed investigation on the leaking flow across the tip clearance of the impeller shows that the leaking flow rate is higher near the exit of the impeller than that near the inlet of the impeller. Based on this phenomenon, a new partially shrouded impeller is designed. The impeller is shrouded near the exit of the impeller. Numerical results show that the secondary flow region becomes smaller at the exit of the impeller. Better performance is achieved than that with the unshrouded impeller.

关键词： centrifugal compressor tip clearance partial shroud CFD.

Unsteady Pressure Field in a Vaneless Diffuser of a Centrifugal Compressor: An Experimental and Computational Analysis

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Journal of Thermal Science 2004年第4期13卷 302-309页

作者： teemu TURUNEN-SAARESTI Jaakko LARJOLA Lappeenranta University of Technology Laboratory of Fluid Dynamics P.O. Box 20 53851 Lappeenranta FinlandLappeenranta University of Technology Laboratory of Fluid Dynamics P.O. Box 20 53851 Lappeenranta Finland

Unsteady static pressure was measured and time-accurate numerical simulations were conducted in order to analyze unsteady behaviour of the centrifugal compressor diffuser. The unsteady static pressure was measured at the diffuser inlet and outlet at three different circumferential positions. Operation points near the surge, the design operation point and operation point near the choke were used in measurements. The time-accurate simulations were conducted at the design operation point and operation point near the choke. The whole compressor was modelled and the low Reynolds number k-εturbulence model was utilized in numerical simulations. The gathered numerical and experimental unsteady pressures were compared with each other.

关键词： centrifugal compressor vaneless diffuser unsteady pressure.

Optimization of the Mean Radius Flow Path of a Multi-Stage Steam Turbine with Evolution Algorithms

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Journal of Thermal Science 2011年第4期20卷 318-323页

作者： Jukka Huttunen Jaakko Larjola teemu Turunen-Saaresti Jari Backman Savonia Power ljytie 678710 VarkausFinlandjukka Lappeenranta University of Technology P.O.Box 2053851 LappeenrantaFinland

A prototype model of the mean radius flow path of a four-stage, high speed 1 MWe axial steam turbine was optimized by using evolution algorithms, DE （differential evolution） algorithm in this case. Also the cost-benefits of the optimization were inspected. The optimization was successfully performed but the accuracy of the optimization was slightly less than hoped when compared to the control modeling executed with the CFD （computational fluid dynamics）. The mentioned inaccuracy could have been hardly avoided because of problems with an initial presumption involving semi-empiric calculations and of the uncertainty concerning the absolute areas of qualification of the functions. This kind of algebraic modeling was essential for the success of the optimization because e.g. CFD-calculation could not have been done on each step of the optimization. During the optimization some problems occurred with the adequacy of the computer capacity and with finding a suitable solution that would keep the algorithms within mathematically allowable boundaries but would not restrict the progress of the opti- mization too much. The rest of the problems were due to the novelty of the application and problems with pre- ciseness when handling the areas of qualification of the functions. Although the accuracy of the optimization re- suits was not exactly in accordance with the objective, they did have a favorable effect on the designing of the turbine. The optimization executed with the help of the DE-algorithm got at least about 3.5 % more power out of the turbine which means about 150 000 ε cost-benefit per turbine in the form of additional electricity capacity.

关键词： steam turbine evolution algorithm optimization mean radius flow path semi-empirical loss correlations

Effect of high negative incidence on the performance of a centrifugal compressor stage with conventional vaned diffusers

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Journal of Thermal Science 2011年第2期20卷 97-105页

作者： Ahti Jaatinen Aki Grnman teemu Turunen-Saaresti Jari Backman Lappeenranta University of Technology

Three vaned diffusers, designed to have high negative incidence (-8°) at the design operating point, are studied experimentally. The overall performance (efficiency and pressure ratio) are measured at three rotational speeds, and flow angles before and after the diffuser are measured at the design rotational speed and with three mass flow rates. The results are compared to corresponding results of the original vaneless diffuser design. Attention is paid to the performance at lower mass flows than the design mass flow. The results show that it is possible to improve the performance at mass flows lower than the design mass flow with a vaned diffuser designed with high negative incidence. However, with the vaned diffusers, the compressor still stalls at higher mass flow rates than with the vaneless one. The flow angle distributions after the diffuser are more uniform with the vaned diffusers.

关键词： centrifugal compressor vaned diffuser efficiency performance flow field

Numerical Modelling of a Supersonic Axial Turbine Stator

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Journal of Thermal Science 2010年第3期19卷 211-217页

作者： Aki Grnman teemu Turunen-Saaresti Ahti Jaatinen Jari Backman LUT Energy Lappeenranta University of TechnologyP.O.Box 20FI-53851 LappeenrantaFinland

In order to improve the turbocharging process,a supersonic axial turbine stator was modelled numerically with a pulsatile inlet mass *** main objectives of the study were to find out how pulsation affects the flow field and the performance of the *** the beginning of the study,a supersonic turbine stator was modelled using three different techniques:quasi-steady,time-accurate with constant boundary conditions and time-accurate with a pulsatile inlet mass *** time-averaged and quasi-steady flow fields and performance were compared,and the flow field and stator performance with a pulsatile inlet mass flow was studied in detail at different time-steps.A hysteresis-like behaviour was captured when the total-to-static pressure ratio and efficiency were plotted as a function of the inlet mass flow over one pulse *** total-to-static pressure ratio and efficiency followed the sinusoidal shape of the inlet flow as a function of *** was also concluded that the stator efficiency decreases downstream from the stator trailing edge and the amplitude of the pulsating mass flow is decreased at the stator throat.

关键词： CFD Supersonic Turbine Stator Turbocharging

TheUltraWeakVariational FormulationUsing Bessel Basis Functions

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Communications in Computational Physics 2012年第2期11卷 400-414页

作者： teemu Luostari Tomi Huttunen Peter Monk Department of Applied Physics University of Eastern FinlandP.O.Box 1627FI-70211 KuopioFinland Department of Mathematical Sciences University of DelawareNewarkDE 19716USA

We investigate the ultra weak variational formulation(UWVF)of the 2-D Helmholtz equation using a new choice of basis *** the UWVF basis functions are chosen to be plane ***,we instead use first kind Bessel *** compare the performance of the two ***,we show that it is possible to use coupled plane wave and Bessel bases in the same *** test cases we shall consider propagating plane and evanescent waves in a rectangular domain and a singular 2-D Helmholtz problem in an L-shaped domain.

关键词： The ultra weak variational formulation Helmholtz problem planewave basis Bessel basis non-polynomial basis.

Norway spruce(Picea abies) laccases:Characterization of a laccase in a lignin-forming tissue culture

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Journal of Integrative Plant Biology 2015年第4期57卷 341-348页

作者： Sanna Koutaniemi Heli A.Malmberg Liisa K.Simola teemu H.Teeri Anna K?rk?nen Department of Agricultural Sciences University of Helsinki Department of Food and Environmental Sciences University of Helsinki Department of Biosciences University of Helsinki

Secondarily thickened cell walls of water-conducting vessels and tracheids and support-giving sclerenchyma cells contain lignin that makes the cell walls water impermeable and strong. To what extent laccases and peroxidases contribute to lignin biosynthesis in muro is under active evaluation. We performed an in silico study of Norway spruce （Picea abies （L.） Karst.） laccases utilizing available genomic data. As many as 292 laccase encoding sequences （genes, gene fragments, and pseudogenes） were detected in the spruce genome. Out of the 112 genes annotated as laccases, 79 are expressed at some level. We isolated five fun-length laccase cDNAs from developing xylem and an extracellular lignin-forming cell culture of spruce. In addition, we purified and biochemically characterized one culture medium laccase from the lignin-forming cell culture. This laccase has an acidic pH optimum （pH 3.8-4.2） for coniferyl alcohol oxidation. It has a high affinity to coniferyl alcohol with an apparent Km value of 3.5μM; however, the laccase has a lower catalytic efficiency （Vmax/Km） for coniferyl alcohol oxidation compared with some purified culture medium peroxidases. The properties are discussed in the context of the information already known about laccases/coniferyl alcohol oxidases of coniferous plants.

关键词： Coniferyl alcohol oxidase developing xylem laccase ligninbiosynthesis Norway spruce Picea abies tissue culture