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Identification of optimal contemporary antiemetic prophylaxis for doxorubicin-cyclophosphamide chemotherapy in Chinese cancer patients: post-hoc analysis of 3 prospective studies

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Cancer Biology & Medicine 2021年第3期18卷 825-832页

作者： Winnie yeo Leung li Thomas Kh Lau Kwai T Lai Vicky,TC Chan Kwan h wong Christopher Ch yip Elizabeth Pang Maggie Cheung Vivian Chan Carol Ch Kwok Joyce JS Suen Frankie KF Mo Department of Clinical Oncology Prince of Wales HospitalFaculty of MedicineHong Kong Cancer InstituteHong KongChina State Key Laboratory of Translational Oncology The Chinese University of Hong KongHong KongChina Department of Clinical Oncology Princess Margaret HospitalHong KongChina

Objective:Chemotherapy-induced nausea and vomiting(CINV)are common with doxorubicin-cyclophosphamide(AC)*** antiemetic regimens incorporate neurokinin-1 receptor antagonist(NK1 RA),5-hydroxytryptamine type-3 receptor antagonist(5 hT3 RA),corticosteroid,and dopamine *** post-hoc analysis compared results of 3 prospective antiemetic studies conducted among Chinese breast cancer patients who received(neo)adjuvant AC,in order to identify optimal antiemetic ***:A total of 304 patients were included:Group 1,ondansetron/dexamethasone(D1);Group 2,aprepitant/ondansetron/dexamethasone(D1);Group 3,aprepitant/ondansetron/dexamethasone(D1–3);Group 4,aprepitant/ondansetron/dexamethasone(D1–3)/olanzapine;and Group 5,netupitant/palonosetron/dexamethasone(D1–3).Antiemetic efficacies of Groups 3,4,and 5 during cycle 1 of AC were individually compared with Group *** addition,emesis outcomes of patients in Groups 3 and 5,and those of Groups 2 and 3,were ***:When comparing efficacies of a historical doublet(5 hT3 RA/dexamethasone)with triplet antiemetic regimens(NK1 RA/5 hT3 RA/dexamethasone)with/without olanzapine,complete response(CR)percentages and quality of life(QOL)in overall phase of cycle 1 AC were compared between Group 1 and the other groups:Group 1 vs.3,41.9%vs.38.3%(P=0.6849);Group 1 vs.4,41.9%vs.65.0%(P=0.0107);and Group 1 vs.5,41.9%vs.60.0%(P=0.0460).Groups 4 and 5 achieved a better *** comparing netupitant-based(Group 3)with aprepitant-based(Group 5)triplet antiemetics,CR percentages were 38.3%vs.60.0%,respectively(P=0.0176);Group 5 achieved a better *** comparing 1 day(Group 2)vs.3 day(Group 3)dexamethasone,CR percentages were 46.8%and 38.3%,respectively(P=0.3459);Group 3 had a worse ***:Aprepitant-containing triplets were non-superior to doublet ***-containing triplets and adding olanzapine to aprepitant-containing triplets were superior to ***/palono

关键词： Netupitant palonosetron aprepitant olanzapine NEPA Asians

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Unc-51-like kinase(ULK)complex-independent autophagy induced by hypoxia

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Protein & Cell 2019年第5期10卷 376-381页

作者： yan Feng helen h.Kang Pui-Mun wong Minghui Gao Ping Wang Xuejun Jiang Shanghai Tenth People's hospital of Tongji University School of MedicineTongji UniversityShanghai 200072China Cell Biology Program Memorial Sloan-Kettering Cancer CenterNew YorkNY 10065USA Immunology and Microbial Pathogenesis Program Weill Cornell Graduate School of Medical SciencesNew YorkNY 10065USA human Genetics and Embryology Laboratory Agency for ScienceTechnology and ResearchInstitute of Medical BiologySingapore 138632Singapore hIT Center for life Sciences The School of Life Sciences and TechnologyHarbin Institute of TechnologyHarbin 150001China

Dear Editor,Macroautophagy(referred to as autophagy herein)is an evolutionarily con served,lysosomal degradatio n process by which cells rid themselves of aggregated proteins and damaged organelles(he and Klionsky,2009).This process involves a finely orchestrated molecular pathway comprising a plethora of ATG proteins essential for autophagosome *** mammalian Unc-51-like kinase(ULK)complex plays an essential role to initiate canonical autophagy pathway by relaying upstream nutrient and stress signals to downstream autophagy machinery(Mizushima,2010;wong et al.,2013).

关键词： Unc-51-like kinase ULK hypoxia

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Virtual colonoscopy-induced perforation in a patient with Crohn's disease

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World Journal of Gastroenterology 2007年第6期13卷 978-979页

作者： Sunny h wong Vincent WS wong Joseph Jy Sung Institute of Digestive Disease and Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China

We report a case of sigmoid colon perforation in a patient with Crohn's disease undergoing computed-tomographic (CT) colonography. A 70-year-old patient with Crohn's disease with terminal ileitis and sigmoid stricture underwent CT colonography after incomplete conventional colonoscopy. During the procedure, the colon was inflated by air insufflation and the patient developed abdominal pain with radiological evidence of retroperitoneal and intraperitoneal free gas. hartmann's operation was performed. This case highlights that CT colonography is not risk-free. The risk of perforation may be higher in patients with inflammatory bowel disease.

关键词： Perforation Colonography Crohn's disease Stricture hartmann's Inflammatory bowel disease

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Features of Ciguatera Fish Poisoning Cases in hong Kong 2004-2007

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Biomedical and Environmental Sciences 2008年第6期21卷 521-527页

作者： ChUN-KWAN wong PATRICIA hUNG KELliE L. h. LEE TINA MOK ThOMAS ChUNG KAI-MAN KAM Biotoxin Laboratory Public Health Laboratory Services Branch Centre for Health Protection Department of Health Shek Kip Mei Kowloon Food and Environmental hygiene Department Queensway Government Offices

Ohjective To review the clinical features and laboratory investigations of ciguatera patients in hong Kong between 2004 and 2007 in order to show the timely sampling of implicated fish from ciguatera victims and application of validated mouse bioassay for confirming suspected clinical cases of ciguatera. Methods Diagnosis of the ciguatera victims was based on history of coral fish consumption and clinical presentations stated in official guidelines for clinical diagnosis of ciguatera fish poisoning in hong Kong. Food remnants of coral fish samples were collected swiftly from ciguatera victims between 2004 and 2007 for ciguatoxins （CTXs） analysis. Results Major clinical symptoms in ciguatera patients included gastrointestinal and neurological effects including limb numbness and diarrhoea, which developed at 0.5 to 15 hours after consumption of fish. In most cases, neurological symptoms were more common than gastrointestinal symptoms. A broad range of attack rate （10%-100%） was observed in each ciguatera outbreak. Validated mouse bioassay on ether extracts of the food remnant samples confirmed that all were CTXs-positive （〈0.5 - 4.3 MU/20 mg ether extract） and directly linked to the corresponding ciguatera cases. Conclusion Consistency between clinical and laboratory analysis for ciguatera poisoning illustrates the application of laboratory mouse bioassay in a timely fashion for confirming ciguatera poisoning cases and implementing effective public health measures. With further improvement in laboratory techniques, features of ciguatera fish poisoning cases can be better defined, Further studies are needed to determine the risk of each class of CTXs （Pacific-, Indian- and Caribbean-CTXs） in hong Kong.

关键词： Ciguatera poisoning Ciguatoxin Food remnants hong Kong Mouse bioassay

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Design and fabrication of computer-generated holograms for testing optical freeform surfaces

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Chinese Optics Letters 2013年第3期11卷 64-68页

作者：沈华朱日宏高志山 E. y. B. PUN W. h. wong 朱效立 School of Electronic Engineering and Photo-Electric Technology Nanjing University of Science and Technology Department of Electronic Engineering City University of Hong Kong Key Laboratory of Nano-Fabrication and Novel Devices Integrated Technology Institute of Microelectronic of Chinese Academy of Sciences

Freeform optical surfaces （FOSs） will be the best elements in the design of compact optical systems in the future. however, it is extremely difficult to measure freeform surface with sufficient accuracy, which im- pedes the development of the freeform surface. The design and fabrication of computer-generated hologram （CGh） , which has been successfully applied to the tests for aspheric surfaces, cannot be directly adopted to test FOSs due to their non-rotational asymmetry. A novel ray tracing planning method combined with successively optimizing even and odd power coefficients of phase polynomials in turn is proposed, which can successfully design a non-rotational asymmetry CGh for the tests of FOSs with an F-O lens. A new eight-step fabrication process is also presented aiming to solve the problem that the linewidth on the same circle of the CGh for testing freeform surface is not uniform. This problem cannot be solved in the original procedure of CGh fabrication. The test results of the step profiler show that the CGh fabricated in the new nrocedure meets the reauirements.

关键词： Computer generated holography Design Electron holography Optical systems

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Digital Processing of Synthetic Aperture Radar Data: Algorithms and Implementation

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2005年

作者： Ian G. Cumming Frank h. wong

来源：畅想之星图书光盘版（南... 评论

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Supramolecular Metal Complex with Ferrocene-conjugated Macrocyclic Triaza Crown Ether as ligand and Its Electrochemical Property

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Chinese Chemical Letters 1998年第3期9卷 269-272页

作者： yin, yG Cheung, KK wong, WT Jingzhou Teachers Coll Dept Chem Jingsha 434100 Hubei Peoples R China Univ hong Kong Dept Chem Hong Kong Peoples R China

A tetranuclear complex [Co(III)(2)(L)(2)(AcO)(2)(Oh)](AcO)(2I). 4h(2)O (L = N-ferrocenylmethyl-1,4,7-triaza-cyclononane) was prepared from ligand L . hI and its crystal structure was determined. The crystal exists in P2(1)(/)a space group and its cell parameters are a = 14.285(3)Angstrom, b = 19.888(3)Angstrom, c = 19.133(3)Angstrom; beta = 109.12(2)degrees; V = 5135.8 Angstrom(3); Z = 4. Electrochemical investigation reveals that the oxidation potential of ferrocenyl group in 1 has a 0.11V-positive-shift from that of the ferrocenyl group in ***.

关键词： supermolecule ferrocene host-guest electronic interaction

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Deficiency of the transcription factor PLAG1 results in aberrant coiling and morphology of the epididymis

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Asian Journal of Andrology 2020年第4期22卷 342-347页

作者： Joanne wong Almas R Juma Stephanie C Tran Jemma G Gasperoni Sylvia V h Grommen Bert De Groef Department of Physiology Anatomy and MicrobiologyLa Trobe UniversityBundooraVictoria 3086Australia

Mice deficient in the transcription factor pleomorphic adenoma gene 1(PLAG1)exhibit reproductive issues that are characterized,in part,by decreased progressive sperm motility in the ***,the underlying cause of this impairment is *** epididymal transit is critical for sperm maturation and motility,the morphology of the epididymis of Plag1-deficient mice was investigated and the spatial expression patterns of PLAG1 protein and mRNA were *** X-gal staining and in situ hybridization,PLAG1 was shown to be widely expressed in both the epithelium and stroma in all regions of the mouse ***,the X-gal staining pattern was markedly different in the cauda,where it could be suggestive of PLAG1 secretion into the epididymal *** all ages investigated,the morphology of epididymides from Plag1 knockout(KO)mice was aberrant;the tubule failed to elongate and coil,particularly in the corpus and cauda,and the cauda was malformed,lacking its usual bulbous ***,the epididymides from Plag1 KO mice were significantly reduced in size relative to body *** 20%of Plag1-deficient mice,the left testicle and epididymis were *** impaired morphogenesis of the epididymal tubule is likely to be a major contributing factor to the fertility problems observed in male Plag1-deficient *** results also establish PLAG1 as an important regulator of male reproduction,not only through its involvement in testicular sperm production,but also via its role in the development and function of the epididymis.

关键词： development epididymis pleomorphic adenoma gene 1 tubule coiling Wolffian duct

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Slide-free histological imaging by microscopy with ultraviolet surface excitation using speckle illumination

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Photonics Research 2022年第1期10卷 120-125页

作者： IVy h.M.wong yAN ZhANG zhenghUI ChEN LEI KANG TERENCE T.W.wong Translational and Advanced Bioimaging Laboratory Department of Chemical and Biological EngineeringHong Kong University of Science and TechnologyHong KongChina

Microscopy with ultraviolet surface excitation(MUSE)is a promising slide-free imaging technique to improve the time-consuming histopathology ***,since the penetration depth of the excitation light is tissue dependent,the image contrast could be significantly degraded when the depth of field of the imaging system is shallower than the penetration ***-resolution cellular imaging normally comes with a shallow depth of field,which also restricts the tolerance of surface roughness in biological *** we propose the incorporation of MUSE with speckle illumination(termed MUSES),which can achieve sharp imaging on thick and rough *** experimental results demonstrate the potential of MUSES in providing histological images with~1μm spatial resolution and improved contrast,within 10 minutes for a field of view of 1.7 mm×1.2 *** the extended depth of field feature,MUSES also relieves the constraint of tissue ***,with a color transformation assisted by deep learning,a virtually stained histological image can be generated without manual tuning,improving the applicability of MUSES in clinical settings.

关键词： excitation illumination speckle

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Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma-a cost-effectiveness analysis

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hepatobiliary Surgery and Nutrition 2021年第3期10卷 301-307页

作者： Kevin K.W.Chu Albert C.y.Chan Ka Wing Ma wong hoi She Wing Chiu Dai Kenneth S.h.Chok Tan To Cheung Chung Mau Lo Department of Surgery The University of Hong KongHong KongChina

Background:We aimed to identify predictive factors for positron emission tomography(PET)-detected hepatocellular carcinoma(hCC)metastasis and a cost-effective approach to preoperative PET-computed tomography(CT)for detecting ***:Clinicopathological and survival data of hCC patients having PET-CT with 18F-fludeoxyglucose(FDG)and 11C-acetate(ACT)following contrast-enhanced CT/magnetic resonance imaging(MRI)for preoperative tumor staging were *** logistic regression was performed to identify predictive factors for PET-detected metastasis.A cost-benefit analysis model was built for the incurred costs and the impact of PET-CT findings on treatment strategy was ***:Totally 152 patients were ***-tracer PET-CT detected metastasis in 17 patients(11%).By multivariate analysis,alpha-fetoprotein(AFP)≥400 ng/mL[relative risk(RR):4.30,95%confidence interval(CI):1.41-13.15,P=0.011]and bilobar disease(RR:3.94,95%CI:1.24-12.52,P=0.014)were independent predictive factors for PET-detected ***-CT findings altered the treatment strategy for 12 patients(7.9%);three partial hepatectomies,eight episodes of transarterial chemoembolization(TACE)and one episode of ablation were avoided,with an estimated cost-saving of US$91,000,$150,000 and$10,600 *** the PET-CT been performed only for patients with AFP≥400 ng/mL or bilobar disease(n=74),metastasis would have been confirmed in 14 patients(18.9%),and the cost-saving per patient was estimated at US$1,***:Dual-tracer PET-CT is cost-effective and useful for preoperative hCC staging in patients with AFP≥400 ng/mL or bilobar *** routine use in preoperative workup for all hCC patients is not *** disease with AFPhieve good negative predictive value for PET-detected *** patients with either factor can avoid unnecessary procedures and is thus cost-effective for preoperative hCC workup.

关键词： Cost-effectiveness study dual-tracer positron emission tomography-computed tomography(dual-tracer PET-CT) hepatocellular carcinoma(hCC) metastatic screening preoperative investigation

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