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A network based efficient drug repurposing strategy for targeting diabesity

Genes & Diseases 2023年第2期10卷 340-343页

作者： Subhajit Dutta ted natoli Deep Chanda Sindhuja Rajavelu Debojyoti De Laboratory of Cellular Differentiation & Metabolic Disorder Department of BiotechnologyNational Institute of TechnologyDurgapurWest Bengal 713209India Cancer Program Broad Institute of MIT and HarvardCambridgeMA 02142USA

Type II diabetes and obesity are two of the most prevalent metabolic disorders effecting a huge population throughout the world. Research over the last decade has unequivocally established considerable molecular links between them and hence they are often described in conjugation as ‘diabesity’. The hallmarks of type II diabetes are primarily reduced insulin sensitivity, progressive insulin resistance and consequent hyperinsulinemia.1 Whereas, hyperinsulinemia promotes a plethora of fat synthesis from excess circulating carbohydrate and hyperactive fat storage mechanisms, ultimately inducing hepatic steatosis, myosteatosis and pancreatic steatosis.1 This in turn, aggravates the insulin sensitivity further, inflicting more insulin resistance and even more hyperinsulinemia. Needless to mention that the vicious process in turn, promotes uncontrolled weight gain1 and many secondary metabolic disorders. The prevalent anti-diabetic and anti-obesity medications comes with several limitations ranging from inefficiency to adverse side effects.2 Here, we report an efficient strategy of repositioning previously approved drugs with novel indication in the context of diabesity by investigating deregulated signalling axes affecting patients with both the disorders. Our approach relies extensively on deciphering the strength of gene association in various interactomes, as it is known that within networks, genes linked to similar disease phenotypes tend to be functionally similar3 and remain proximal to each other.4 Moreover, the potential drug targets associated to a disease pathway also cluster proximal to the disease pathways.

关键词： hence primarily network

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Impact of temporal modulations on laser-induced damage of fused silica at 351 nm

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High Power Laser Science and Engineering 2023年第2期11卷 1-9页

作者： C.Bouyer R.Parreault N.Roquin J.-Y.natoli L.Lamaignère CEA CESTA Le BarpFrance Aix-Marseille Univ CNRSCentrale MarseilleInstitut FresnelMarseilleFrance

Laser-induced damage(LID)on high-power laser facilities is one of the limiting factors for the increase in power and *** confinement fusion(ICF)facilities such as Laser Mégajoule or the National Ignition Facility use spectral broadening of the laser pulse that may induce power modulations because of frequency modulation to amplitude modulation *** this paper,we study the impact of low and fast power modulations of laser pulses both experimentally and *** MELBA experimental testbed was used to shape a wide variety of laser pulses and to study their impact on LID.A 1D Lagrangian hydrodynamic code was used to understand the impact of different power profiles on LID.

关键词： fused silica high-power laser laser diagnostics laser-induced damage

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Oxycodone plus naloxone for chronic pain in Parkinson＇s disease

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中华物理医学与康复杂志 2016年第2期38卷 99-99页

作者： Madeo G Schirinzi T natoli S

BACKGROUND AND OBJECTIVE Pain is a fundamental symptom of Parkinson''s disease (PD) that is often unrecognized and undertreated. This study was designed to evaluate the safety and efficacy of using opioids in patients with *** This eight week, single center, prospective, observational trial included 14 patients with PD and chronic pain syndromes. The participants were prescribed oxycodone hydrochloride, combined with naloxone hydrochloride dehydrate (OXN PR 5/325), beginning at once a day and titrated to twice per day after one week. Pain intensity was assessed by the 11-point Numeric Rating Scale (NRS) and the Brief Pain Inventory (BPI), motor status by the Unified Parkinson''s Disease Rating Scale Section-III (UPDRS-III) and cognitive status by the Mini Mental State Examination (MMSE). In addition, the patients were assessed with the Global Impression of Change (CGI-C). All were followed with weekly examinations for eight *** A significant reduction was seen in the NRS scores during the entire observation (ANOVAPted from baseline to eight weeks in 56% of the patients. The ratings were much improved for 42.86% of the patients. Bowel function was not worsened by the analgesic treatment, as demonstrated by changes in BFI *** This study of patients with Parkinson''s disease found that a combination of oxycodone XR and naloxone may be a safe and effective treatment for chronic pain.

关键词：帕金森病药物治疗纳洛酮疼痛慢性状态检查无法识别氧氮化物

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与甜高粱品质有关的数量性状位点的鉴定

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国外作物育种 2003年第4期22卷 57-58页

作者： A．natoli C．Gomi 谢国禄

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Mapping QTLs for Yield Stability in Durum Wheat Grown under Different Water Regimes

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分子植物育种 2007年第2期5卷 223-223页

作者： M.C. Sanguineti M. Maccaferri E. natoli J.L. Araus-Ortega M.B. Salem J.Bort E. de Ambrogio L. F.G. del Moral A. de Montis A. El-Ahmed I. Elouafi F. Maalouf V. Martos M.M. Nachit N. Nserallah H. Ouabbou Y. Rharrabti S. Rhouma C. Royo A. Slama D. Villegas R. Tuberosa Dept. of Agroenvironmental Sciences and Technology University of BolognaViale Fanin 44 40127 Bologna Italy Departament de Biologia Vegetal Universitat de Barcelona Spain Tunisian National Institute of Agronomic Research Tunis 1002 Tunisia Società Produttori Sementi Bolo-gna Divisione Ricerca Argelato 40050 Italy Dpto. Fisiologia Vegetal University of Granada 18200 Spain Plant Protection Department Aleppo University Aleppo Syria ICARDA Aleppo Syria Department of Plant Breeding Lebanese Agricultural Research Institute Bekaa Lebanon CRRA-INRA Settat 26000 Morocco Area de Conreus Extensius Centre Udl-IRTA Lleida 25131 Spain

Among the most important Mediterranean annual crops, durum wheat is widely grown in drought-prone areas. Therefore, improving water-use effi ciency (WUE) of durum wheat represents a major breeding goal. IDu-

关键词：小麦产量干旱灌溉水

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