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Fem.le gonadal horm.ne effects on m.croglial activation and functional outcom.s in a m.use m.del of m.derate traum.tic brain injury

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World Journal of Critical Care m.dicine 2017年第2期6卷 107-115页

作者： Odera Um.ano Haichen Wang Hana dawson Beilei Lei Afom. Um.ano Dawn Kernagis m.chael L Jam.s School of m.dicine Duke University Departm.nt of m.dicine Division of NeurologyDuke University m.ltidisciplinary Neuroprotection Laboratories Department of AnesthesiologyDuke University Departm.nt of Chem.stry Harvard University Departm.nt of Anesthesiology Duke University

AIm.To address the hypothesis that young, gonad-intact fem.le m.ce have im.roved long-term.recovery associated with decreased neuroinflam.ation com.ared to m.le *** Eight to ten week-old m.le, fem.le, and ovariectom.zed(OVX) m.ce underwent closed cranial im.act. Gonadintact fem.le m.ce were injured only in estrus state. After injury, between group differences were assessed using com.lem.ntary im.unohistochem.cal staining for m.croglial cells at 1 h, m.RNA polym.rase chain reaction for inflam.atory m.rkers at 1 h after injury, Rotarod over days 1-7, and water m.ze on days 28-31 after injury. RESULTS m.le m.ce had a greater area of injury(P = 0.0063), F4/80-positive cells(P = 0.032), and up regulation of inflam.atory genes com.ared to fem.le m.ce. m.le and OVX m.ce had higher m.rtality after injury when com.ared to fem.le m.ce(P = 0.043). No groupdifferences were dem.nstrated in Rotarod latencies(P = 0.62). OVX m.ce dem.nstrated decreased water m.ze latencies com.ared to other groups(P = 0.049). CONCLUSION Differences in m.rtality, long-term.neurological recovery, and m.rkers of neuroinflam.ation exist between fem.le and m.le m.ce after m.derate traum.tic brain injury(m.BI). Unexpectedly, OVX m.ce have decreased long term.neurological function after m.BI when com.ared to gonad intact m.le and fem.le m.ce. As such, it can be concluded that the presence of fem.le gonadal horm.nes m.y influence behavioural outcom.s after m.BI, though m.chanism. involved are unclear.

关键词： Traum.tic brain injury m.croglia Functional recovery Inflam.ation Sex

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Science:研究鉴定出导致脑细胞死亡的罪魁祸首

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现代生物医学进展 2017年第4期17卷 I0001-I0001页

作者： Yingfei Wang Ran An George K Um.nah Hyejin Park Kalyani Nam.iar Stephen m.Eacker BongWoo Kim.Lei Bao m.ged m.Harraz Calvin Chang Rong Chen Jennifer E Wang TaeIn Kam.Jun Seop Jeong Zhi Xie Stewart Neifert Jiang Qian Shaida A Andrabi Seth Blackshaw Heng Zhu Hongjun Song GuoLi m.ng Valina L dawson ted m.dawson Neuroregeneration and Stem.Cell Program. Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. tdawson@jhmi.edu vdawson1@jhmi.edu yingfei.wang@utsouthwestern.edu. Departm.nt of Neurology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Departm.nt of Pathology University of Texas Southwestern Medical Center Dallas TX 75390 USA. Departm.nt of Neurology and Neurotherapeutics University of Texas Southwestern Medical Center Dallas TX 75390 USA. Neuroregeneration and Stem.Cell Program. Institute for Cell Engineering Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Departm.nt of Neurology of Huashan Hospital State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China. Adrienne Helis m.lvin m.dical Research Foundation New Orleans LA 70130-2685 USA. Solom.n H. Snyder Departm.nt of Neuroscience Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Departm.nt of Pharm.cology and m.lecular Sciences Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Center for High-Throughput Biology Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Departm.nt of Ophthalm.logy Johns Hopkins University School of Medicine Baltimore MD 21205 USA. Departm.nt of Physiology Johns Hopkins University School of Medicine Baltimore MD 21205 USA.

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋... 详细信息

尽管存在不同的触发物，相同的一连串分子事件似乎导致中风、脑损伤和甚至阿尔茨海默病等神经退行性疾病中的脑细胞死亡。如今，在一项新的研究中。来自美国约翰霍普金斯大学的研究人员说，他们精确地发现一种位于这一连串事件末端的蛋白。即一种通过切割细胞的DNA给予致命性打击的蛋白。他们说，这一发现潜在地为开发预防、阻止或削弱这一过程的药物打开新的大门。相关研究结果发表在Science期刊上。

关键词：细胞死亡脑损伤神经退行性疾病鉴定阿尔茨海默病分子事件研究人员致命性

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准时性——高级定制设计的要求

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电子设计应用 2004年第1期 23-27页

作者： ted Vucurevich Lavi Lev Cadence公司

在过去10年间,对从事模拟、定制数字、RF和混合信号设计的公司需求星现出了指数增长.效益以及竞争正迫使定制设计队伍采纳先进工艺技术,把以前各自独立的IC功能块集成到单个硅片中.事实上,许多设计队伍被迫跳过工艺节点,在0.18μm.0.13... 详细信息

在过去10年间,对从事模拟、定制数字、RF和混合信号设计的公司需求星现出了指数增长.效益以及竞争正迫使定制设计队伍采纳先进工艺技术,把以前各自独立的IC功能块集成到单个硅片中.事实上,许多设计队伍被迫跳过工艺节点,在0.18μm.0.13μm.甚至纳米工艺上进行大规模数字逻辑集成.

关键词：数字单元电路敏感元件准时性高级定制设计

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核磁共振法确定多孔介质的性能(英文)

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青岛大学学报（工程技术版） 2004年第3期19卷 1-11,F002页

作者： A.ted WATSON Jinsoo UH 克罗拉多州立大学化学工程系德克萨斯A&m.学化工系

核磁共振技术(Nm.)是一种有力而安全的用于获取介质的空间分辨信息的方法。分析Nm.数据的新方法能提供研究各种物理体系的机遇。本文讨论了核磁探针法的实验和分析进展。该方法用于定量评价表征流体和其在多孔介质中的流动行为。这种探... 详细信息

核磁共振技术(Nm.)是一种有力而安全的用于获取介质的空间分辨信息的方法。分析Nm.数据的新方法能提供研究各种物理体系的机遇。本文讨论了核磁探针法的实验和分析进展。该方法用于定量评价表征流体和其在多孔介质中的流动行为。这种探针法的核心是辅助函数评价问题的求解,而这类问题的求解决依赖于用B spline表示法对未知函数的规整化和序列评估。

关键词：多孔介质核磁共振探针

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从科研到临床:人类肢体再生学的研究趋势和展望

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中华实验外科杂志 2023年第7期40卷 1233-1236页

作者：李涛陈振兵于玲阎明全 Lindsay A.dawson Ken m.neoka 华中科技大学同济医学院附属协和医院手外科武汉430022 美国得州农工大学兽医和生物医学学院生理和药物学系美国得州77843

特殊种类动物的肢体再生是一个科学现象、也是一个科学的事实,以蝾螈为代表的两栖爬行类动物展现了“完全性”的肢体再生能力,以小鼠为代表的啮齿类哺乳动物展现了“节段性”的肢体再生能力,对这些类动物的比较研究有助于早日解密肢体... 详细信息

特殊种类动物的肢体再生是一个科学现象、也是一个科学的事实,以蝾螈为代表的两栖爬行类动物展现了“完全性”的肢体再生能力,以小鼠为代表的啮齿类哺乳动物展现了“节段性”的肢体再生能力,对这些类动物的比较研究有助于早日解密肢体再生的机制和规律,同时有助于发现高等哺乳类动物肢体再生能力受限的原因。虽然人类肢体再生的能力很弱,但仍然展示了一些珍贵的再生现象,近年来在伤口修复、骨延长等领域展示了较好的再生修复的临床应用。伤口炎性反应被认为是肢体再生中与胚芽的形成最为密切相关的因素。建立良好的动物模型来理解伤口与再生诱导反应的关系非常重要。本文作者长期从事肢体外伤临床修复,也长期参与肢体再生的科学研究,2014、2015年在美国德州农工大学Kenm.neoka实验室进行访问学者工作期间建立了一个新的伤口诱导再生的小鼠模型,即在小鼠P3趾尖侧方打孔,由伤口诱导、没有截肢便能成功诱导出胚芽样的再生结构,其内含有大量增生活跃的细胞,重现了小鼠P3趾尖由蜕变到完全增生的整个再生过程,预示了胚芽发育的重要细胞学基础和分子学机制。展望未来,肢体再生领域会有更多的基础突破,将带来更多、更好的临床治疗新技术,不但应用在伤口修复,还会应用于人类骨、关节、血管、神经、肌腱、皮肤等器官的再生,并能促进更多的再生医学转化。

关键词：肢体再生伤口修复发育

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Sim.ltaneous Erb's and Klum.ke's palsy: Case report

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World Journal of Clinical Cases 2015年第12期3卷 984-987页

作者： Ashley dawson Eliana Vasquez David Garrett Jr Frank S Harris Ibrahim.m.El Nihum.Sam.ntha Dayawansa Jason H Huang Soren Singel Faculty of m.dicine Texas A and M University Departm.nt of Neurosurgery Baylor Scott and White Health Care

m.pping nerve deficits during a physical exam.after traum. to the upper extrem.ty can help determ.ne not only if the brachial plexus was injured but also which nerve roots were involved. A 28-year-old m.le presented with sim.ltaneous signs and sym.tom. of Erb's(C5) and Klum.ke's(C8, T1) palsy, with sparing of the C6 and C7 roots. The patient presented several m.nths ago to his local em.rgency room.with shortness of breath, which was determ.ned to be caused by left diaphragm.tic paralysis through clinical and radiographical evidence. However, the etiology of the current nerve dysfunction in the upper extrem.ty rem.ined unknown. With persistent questioning and establishing the patient's trust in the caregivers, it was revealed that the patient had attem.ted suicidal hanging. We describe the clinical features and the likely m.chanism.of injury leading to this previously unreported com.ination of brachial plexus injuries. The unique injuries to this patient's brachial plexus can be explained by the sequence of events during the attem.ted suicidal hanging. The upper brachial plexus was injured during the initial m.m.nts where the neck was excessively stretched and the lower brachial plexus was injured due to the patient reaching up and holding him.elf by his arm.for an extended period of tim..

关键词： Erb’s palsy Klum.ke’s palsy Hanging injury

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The world’s ten m.st feared fungi

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Fungal Diversity 2018年第6期93卷 161-194页

作者： Kevin D.Hyde Abdullah m.S.Al-Hatm. Birgitte Andersen Teun Boekhout Walter Buzina Thom.s L.dawson Jr. Dan C.Eastwood E.B.Gareth Jones Sybren de Hoog Yingqian Kang Joyce E.Longcore Eric H.C.m.Kenzie Jacques F.m.is Laetitia Pinson-Gadais Achala R.Rathnayaka Florence Richard-Forget m.rc Stadler Bart Theelen Benjarong Thongbai Clem.nt K.m.Tsui Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand m.nistry of Health Directorate General of Health ServicesIbriOman Departm.nt of Biotechnology and Biom.dicine Technical University of Denmark2800 Kgs.LyngbyDenmark Institute for Biodiversity and Ecosystem.Dynam.cs(IBED) University of AmsterdamAmsterdamThe Netherlands Westerdijk Fungal Biodiversity Institute UtrechtThe Netherlands R&D Institute for Hygiene Microbiology and Environmental MedicineMedical University GrazNeue Stiftingtalstrasse 68010 GrazAustria Institute for m.dical Biology(Im.) Agency for ScienceTechnologyand Research(A_(*)STAR)SingaporeSingapore Departm.nts of Drug Discovery and Biom.dical Sciences and Biochem.stry and m.lecular Biology Center for Cell DeathInjury and RegenerationMedical University of South CarolinaCharlestonSCUSA Departm.nt of Bioscience Academic Office102First FloorWallace BuildingSwansea UniversitySingleton CampusSwanseaWalesUK Centre of Expertise in m.cology Radboudum./Canisius Wilhelm.na Hospital(CWZ) NijmegenThe Netherlands Portsm.uth Hampshire PO53DHUK Departm.nt of m.crobiology and the Key Laboratory of Proteom.cs Guizhou Medical UniversityGuiyangChina School of Biology and Ecology University of MaineOronoME 04469USA m.naaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Departm.nt of m.dical m.crobiology and Infectious Diseases Canisius Wilhelmina Hospital(CWZ)NijmegenThe Netherlands INRA UR1264 MycSA71 av Edouard Bourlaux2003233882 Villenave D’Ornon CedexFrance Departm.nt m.crobial Drugs Helmholtz Centre for Infection Researchand German Centre for Infection Research(DZIF)Partner Site Hannover-BraunschweigInhoffenstraße 738124 BraunschweingGermany Departm.nt of Pathology Sidra MedicineDohaQatar Departm.nt of Pathology and Laboratory m.dicine Weill Corne

An account is provided of the world’s ten m.st feared *** areas of interest,we have organized the entries in the order of *** put four hum.n pathogens first as this is of concern to m.st *** is followed by fungi producing m.cotoxins that are highly harm.ul for hum.ns;Aspergillus flavus,the m.in producer of aflatoxins,was used as an *** due to indoor air fungi m.y also directly affect our health and we use Stachybotrys chartarum.as an *** everyone collects and eats edible ***,fatalities caused by m.shroom.intoxications often m.ke news headlines and therefore we include one of the m.st poisonous of all m.shroom.,Am.nita phalloides,as an *** then m.ve on to the fungi that dam.ge our dwellings causing serious anxiety by rotting our tim.er structures and *** lacrym.ns,which causes dry rot is an excellent *** next exam.le serves to represent all plant and forest *** we chose Austropuccinia psidii as it is causing devastating effects in Australia and will probably do likewise in New ***,we chose an im.ortant am.hibian pathogen which is causing serious declines in the num.ers of frogs and other am.hibians *** we target the top ten m.st feared fungi,num.rous others are causing serious concern to hum.n health,plant production,forestry,other anim.ls and our factories and *** highlighting ten feared fungi as an exam.le,we aim.to prom.te public awareness of the cost and im.ortance of fungi.

关键词： Aflatoxicosis Batrachochytrium Candida auris Frog decline Poisonous fungi Hum.n pathogens Indoor fungi Forest pathogens Wood decay

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Variation of soil and plant characteristics am.ng old world bluestem.species

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Agricultural Sciences（农业科学） 2011年第3期

作者： ted m. Zobeck Vivien G. Allen Jenny Jo Cox Dirk Philipp

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m.eting Engineering Program.Objectives through Service Learning Opportunities in Developing Countries

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Journal of Civil Engineering and Architecture 2011年第2期5卷 97-103页

作者： Jeffery m. Plum.lee Lansford Bell Leidy ]E. Klotz Departm.nt of Civil Engineering Clemson University Clemson SC 29634 USA

The civil engineering profession, in an adaptive reaction to em.rging roles for civil engineers, is recognizing the need for new engineers to possess a m.re robust skill set than just the typical design background. This paper describes the efforts of Clem.on Engineers for Developing Countries （CEDC） to fulfill the m.re nontraditional and often unaddressed ＂learning outcom.s＂ noted by ASCE＇s Civil Engineering Body of Knowledge lbr the 21st Century as im.ortant prerequisites for licensure. The learning outcom.s are addressed through ongoing international service learning projects in Cange, Haiti. The paper focuses on the following four outcom.s and their fulfillm.nt m.thods： leadership, globalization, team.ork, and com.unications. The student led organization has allowed students to set up their own fundraising m.chanism., to seek out m.m.ers to join design review boards, and to develop their own project objectives. This level of student autonom. is n,3ted as key to ensuring that students achieve com.etency in these four areas.

关键词： ASCE BOK2 leadership service learning com.unication team.ork.

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Gender and m.nagerial com.etence:a com.arison of m.le and fem.le first-line nurse m.nagers in Indonesia

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Frontiers of Nursing 2021年第1期8卷 49-58页

作者： Joko Gunawan Yupin Aungsuroch m.ry L.Fisher Anna m.m.Daniel Faculty of Nursing Chulalongkorn University BangkokBangkok 10330Thailand College of Nursing University of FloridaGainesvilleFlorida 32610USA School of Nursing Indiana UniversityIndianapolisIndiana 46202USA

Objective:First-line nurse m.nagers are m.re likely to work according to gender beliefs and stereotypes,which m.y affect their m.nagerial *** study is aim.d at com.aring m.nagerial com.etence of m.le and fem.le first-line nurse m.nagers in public hospitals in ***:This study em.loyed a descriptive com.arative approach with a cross-sectional survey with a total of 256 participants selected from.18 public *** m.asure m.nagerial com.etence,the m.nagerial com.etence scale for Indonesian first-line nurse m.nagers was *** were analyzed using descriptive analyses using m.an,standard deviation,and Independent ***:m.nagerial com.etence of m.le and fem.le first-line nurse m.nagers was not significantly different(P=0.555).Fem.le nurse m.nagers descriptively reported/received higher ranking in facilitating spiritual nursing care,m.naging self,staffing and professional developm.nt,utilizing inform.tics,and applying quality care *** nurse m.nagers repor ted higher in leadership and financial ***:Fem.le and m.le first-line nurse m.nagers should be treated equally for leadership and m.nagerial developm.nt.

关键词： nurse adm.nistrators m.le fem.le m.nagerial com.etence Indonesia

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