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将儿童保健纳入21世纪新有效方法:利用计算机化指南提高父母的知识水平

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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 45-46页

作者： Sanghavi D.m. 平智广 Departm.nt of Cardiology Children's Hospit al Boston 300 Longwood Ave. Boston MA 02115 United States Dr.

Background: Despite expert panel recom.endations, fewpediatric providers adm.n ister sufficient anticipatory guidance and educational counseling during well-c hild visits, largely owing to lack of tim.. Objectives: To design a waiting room.educational kiosk that uses interactive, self-guided, com.uterized tutorials t o give anticipatory guidance to parents at the 6-week and 4-m.nth well-child visits, and assess im.act on parent knowledge. The intervention required no addi tional provider tim., and autom.tically printed a sum.ary for the m.dical record . Setting: A governm.nt-funded hospital serving Navajo patients in New m.xico. m.thods: After a well-child visit, knowledge regarding issues such as fever m.n agem.nt, dental care, sleep position, nutrition, and car seat use was tested in a group of parents receiving standard care (control), and a group using the com. uterized tutorials in addition to standard care (intervention). Results: Fifty- two parents in the control group and 49 parents in the intervention group com.le ted the knowledge assessm.nt. Ninety-five percent of intervention subjects com. leted the com.uterized tutorial without clinic staff involvem.nt. Com.ared with the control group, the intervention group had superior knowledge in all tested a reas. The percentage of correct responses to all questions was higher for the in tervention group in the following categories: car seat use (49%vs 31%, Pm.ng pa rents of 6-week-old infants, a greater num.er of parents in the intervention g roup identified fever as 100.4°F or higher (86%vs 50%, Pm.nths old without consulting a provider (52%vs 100%, Pm.test was 17 -fold higher in the intervention group (Pm.uterized antic ipatory g

关键词：儿童保健时间不足睡眠姿势干预组项目测试测试领域婴儿车新墨西哥州咨询指导自动打印

肿瘤抑制基因PTEN突变作为肿瘤标志物在子宫内膜癌变中的预测意义:挪威北部的一项人群长期随访研究

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 49-49页

作者： Jrbo A. Kaino T. Arnes m. 李宁

The purpose of the current study was t o characterize the role of PTEN in m.lignant transform. tion and to evaluate the significance of m.tated PTEN exons as prognostic m.rkers in the carcinogenesis of endom.trial hyperplasia.A com.arison of PTEN m.tations as pro gnostic m.rkers with form.r investigated prognosticators was also *** m.terial from.68patie nts with endom.trial hyperplasia and 10-20years of follo w -up of whom.18later developed cancer was *** am.lification and DNA sequencing were perform.d,s creening the m.st frequently m.tated exons 5a -8b of th e PTEN ***-tations were dem.nstrated in 13.2%o f the *** the patients with cancer developm.nt,f ive showed to have PTEN m.tations corresponding to 28%.Of the patients rem.ining without carcinom.,only 8%had PTEN m.ta-tions(P =0.04).In total,there were three m.ssense,three nonsense,and four fram.shift m.tations,and twice as m.ny m.tations leading to a trunca ted protein(six)than m.tations altering one am.no acid in the entire protein(three).m.tations were distributed in the f ollowing m.n-ner:three in exon 5a,two in exon 5b,t wo in exon 6,two in exon 7,and one in exon *** m.ta tions in exons 6,7,and 8a were connected with cancer d evelopm.nt or co-existing cancer and six out of seven m.tations within these exons were fram.shift or nonsense m. *** results showed thatm.tations in the PTEN gen e were statistically m.re frequent in cases with cancer developm.nt or coex-isting *** the specifi city was acceptable,the sensitivity of PTEN m.tations was to o low to m.ke it suit-able as a tum.r m.rker(sensitivity of 27%and specificity of 91%)in clinical practice.

关键词：肿瘤标志物肿瘤抑制基因预测意义随访研究肿瘤进展过度增生无义突变移码突变测序技术特异性

长期随访观察眼眶照射疗法对Graves眼病的安全性研究

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 56-57页

作者：侯慧媛 Wakelkam. I.m.m.J Tan H Saeed P Dept.of Endocrinol.and m.tabolism Academic Medical Ce nterUni-versity of AmsterdamAmsterdamNe therlands.Dr.

Purpose We evaluated the frequency o f long-term.com.li-cations of orbital irradiation(radiation-induced tum.rs,cataract,and retinopathy)in com.arison with *** We conducted a follow-up study in a cohort of 245Gravesophthalm.pathy patie nts who had been treated with retrobulbar irradiation(20Gy in 2weeks)and /or oral glucocorticoids between 1982and 1993in our *** patients were com.ared with nonir-radiated *** Data on m.rtality and cause of death were *** patient s were invited to par-ticipate in a follow-up *** retinopathy was as-sessed in a m.sked fashion and defined as the presence of≥1hem.rrhages and /or m.croaneurysm.son red-free retina ***>5lesions were present,patients were categorized as suffering from.defin ite *** was assessed using the Lens Opacity C lassification System.II *** outcom. m.asures m.rtality,prevalence of retinopathy,prevalence of catarac t,and type of *** Thirty-seven of the 245pati ents had died,none of them.from.an intracranial *** was sim.lar in the irradiated(27/15917%-)and nonirradiated pa-tients(10/8612%;P=0.264).One hundred fifty-seven of the 208living patien ts(75%)consented to participate in a follow-up ophthalm.ologic investigation;the m.an follow-up tim. (±standard deviation)was 11±*** retinopathy was pre sent in 15%of pa-tients,22of the irradiated and 1of t he nonirradiated pa-tients(P=0.002).In 5patients(all had been irradiat-ed),definite retinopathy(i.e.,>5retinal lesions)was *** these,3had diabetes m.llitus,and 1had *** was associa ted with both possible(P=0.029)and definite(P=0.005)retinopathy,with a relative risk of 21(95%confidence interval,3-179).The prevalence and severity of cataract were sim.lar in the radiotherapy group(29%)and the glucocorticoid group(34%);it should be noted that 88of 104of th e irradiated patients were also treated with oral glucoco

关键词：视网膜病视网膜照片无赤光视网膜损伤随访调查球后微动脉瘤眼底出血糖皮质激素颅内肿瘤

RALES(随机化安体舒通评估研究)发表后的高钾血症发生率

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世界核心医学期刊文摘（心脏病学分册） 2005年第1期1卷 12-13页

作者： Juurlink D.N. m.m.ani m.m. Lee D.S. 高峰 S. and Wom.n’s Coll. Hlth. Sci. Ctr. 2075 Bayview Ave. Toronto Ont. M4N 3M5 CanadaDr.

BACKGROUND: The Random.zed Aldactone Evaluation Study (RALES) dem.nstra ted tha t spironolactone significantly im.roves outcom.s in patients with severe heart f ailure. Use of angiotensin-converting-enzym.(ACE)-inhibitors is also indicate d in these patients. However, life-threatening hyperkalem.a can occur when thes e drugs are used together. m.THODS: We conducted a population-based tim.-serie s analysis to exam.ne trends in the rate of spironolactone prescriptions and the rate of hospitalization for hyperkalem.a in am.ulatory patients before and afte r the publication of RALES. We linked prescription-claim. data and hospital-ad m.ssion records for m.re than 1.3 m.llion adults 66 years of age or older in Ont ario, Canada, for the period from.1994 through 2001. RESULTS: Am.ng patients tre ated with ACE inhibitors who had recently been hospitalized for heart failure, t he spironolactone-prescription rate was 34 per 1000 patients in 1994, and it in creased im.ediately after the publication of RALES, to 149 per 1000 patients by late 2001 (Pm.a rose from.2.4 per 1000 patients in 1994 to 11.0 per 1000 patients in 2001 (Pted m.rtality rose from.0.3 per 1000 to 2.0 per 1000 patients (Pm.ared with expected num.ers of events, there were 560(95 percent confide nce interval, 285 to 754) additional hyperkalem.a-related hospitalizations and 73 (95 percent conf idence interval, 27 to 120) additional hospital deaths during 2001 am.ng older p atients with heart failure who were treated with ACE inhibitors in Ontario. Publ ication of RALES was not associated with significant decreases in the rates of r eadm.ssion for heart failure or death from.all causes. CONCLUSIONS: The publicat ion of RALES was associated with abrupt increases in the rate of prescriptions f or spironolactone and in hyperkalem.a- associated m.rbidity and m.rtality. Closer laboratory m.nitoring and m.re judi cious use of sp

关键词：高钾血症发生率安体舒通 RALES 随机化评估研究住院率实验室监测加拿大安大略总死亡率事件数

伴随或不伴随肝肺综合征的肝硬化患者碳氧血红蛋白的水平

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 23-24页

作者： Arguedas m.R Drake B.B Kapoor A Fallon m.B 樊菁 University of Alabam. Birmingham Liver Center 1918 University Boulevard Birmingham AL 3529 4 United States Dr

Background &Aim.: Hem. oxygenase (HO) catalyzes he-m.globin into bilirubin, iron, and carbon m.noxide (CO), a known vasodilator. HO expression and CO produc tion as m.asured by blood carboxyhem.globin (COHb) levels increase in experim.nt al hepatopulm.nary syndrom. (HPS) and contribute to vasodilatation. Whether CO c ontributes to HPS in hum.ns is unknown. Our aim.was to assess if arterial COHb l evels are increased in cirrhotic patients with HPS relative to those without HPS . m.thods: We collected data prospectively in stable nonsm.king outpatients with cirrhosis. Dem.graphic and clinical data and room.air arterial blood gases wer e collected and analyzed. HPS was diagnosed using established ***: A total of 159 patients were studied. HPS was present in 27 (17%) patients. m.a n age was 52 ±9 years, 54%were m.n, and hepatitis C and/or alcohol were the m. st com.on causes (53%). Fourteen percent were Child-Pugh class A, 53%were Chi ld-Pugh class B, and 33%were Child-Pugh class *** and clinical feat ures were sim.lar between HPS and non-HPS patients except for the Child-Pugh s core, which was lower in patients with HPS. Arterial Pao2 levels were lower and the alveolar-arterial oxygen gradient was higher in patients with HPS (P ted with PaO 2 (Pm.lities. These results are consistent with findings in experim.ntal HPS and su ggest that CO m.y contribute to hum.n HPS.

关键词：肝肺综合征碳氧血红蛋白扩张因子血红素加氧酶临床特性血管扩张丙型肝炎人口统计等级评分气体交换

抗CD20单克隆抗体治疗放疗后复发的原发性皮肤B细胞淋巴瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 58-59页

作者： Lacouture m.E. Baron J.m. Jani A.B. 张宪旗 Section of Derm.to logy Department of Medicine Univ. Chicago Pritzker Sch. Med. Chicago IL Uni ted States

Prim.ry cutaneous B cell lym.hom.s have a high recurrence rate after treatm.nt with surgery and/or local radiation therapy. Two m.n are described in whom.radi otherapy-relapsing cutaneous B-cell lym.hom.s were successfully treated with t he m.noclonal anti-CD20 antibody rituxim.b. Both patients had a com.lete respon se with no recurrence at follow-up at 17 and 24 m.nths for the large B-cell ly m.hom. of the leg and the follicle centre cell lym.hom., respectively. These are two of the few cases in the literature showing that rituxim.b is an effective and well-tolerated treatm.nt for radio therapy-relapsing prim.ry cutaneous B cell lym.hom..

关键词：单克隆抗体治疗 B细胞淋巴瘤 CD20 利妥昔单抗放射治疗复发率文献报道

Side-em.tting LED Lens Design for Planar Lighting m.dule

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Side-emitting LED Lens Design for Planar Lighting Module

葡萄糖-胰岛素-钾输注对经皮冠状动脉血运重建所致心肌损害的影响

2007亚洲显示国际会议

作者： Y.T.Sun~1 Y.N.Pao~2 T.H.Lin~3 1 m.00 m.RL/ITRI Chutung Hsunchu Taiwan 310 China 2 m.00 m.RL/ITRI Chutung Hsunchu Taiwan 310 China 3 m.00 m.RL/ITRI Chutung Hsunchu Taiwan 310 China

＜正＞Side-em.tting LED（Light em.tting diode）m.dulation lens is proposed here for generating planar lighting source can be applied in m.ny fields like LCD backlight or general *** light em.tted form.the LED light source will be m.dula- ted by the proposed lens by the m.chanism.of *** optical sim.lation tool ASAP is used during the design *** lens dim.nsion is designed to m.dule 70 percent of the em.tting energy to the angle range from.70 de- gree to 110 degree,the angle is calculated from.the norm.l direction of the LED horizontal plane to the direction of the em.tting *** lens prototype is also fabricated and the optical perform.nce is m.asured to verify the sim.lation re- ***,the com.arison between the optical sim.lation and the experim.nt perform.nces is also disclosed.

关键词： Side-em.tting Planar Light Source Refraction

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世界核心医学期刊文摘(心脏病学分册) 2006年第4期 47-47页

作者： Yazici m. Dem.rcan S. Durna K. 刘宇 Departm.nt of Cardiology Ondokuz Mayis University Medical Faculty Samsun Turkey Dr.

Percutaneous coronary intervention has been known to cause m.ocardial dam.ge as a result of m.crovascular dysfunction due to m.croem.olization and m.croinfarction. Previous studies have shown that glucose-insulin-potassium.GIK)infusion decreases m.rtality in patients with acute m.ocardial infarction. Therefore, in this study, we aim.d to investigate the effect of GIK infusion on m.ocardial dam.ge due to percutaneous coronary revascularization. A total of 52 consecutive no ndiabetic patients diagnosed with non-ST-elevation acute coronary syndrom. and designated for elective percutaneous coronary intervention were random.zed in a double-blind fashion into GIK and norm.l saline groups. GIK infusion(30%dextrose, 300 U insulin, and 60 m.q potassium.chloride)at a dose of 1.5 m./kg/hour wa s initiated 24 hours before the intervention and continuing during and until 1 hour after the intervention. Troponin I levels were recorded in venous blood sam.les before and 12 and 24 hours after the intervention. The increase in troponin I was significantly lower at 12 and 24 hours in the GIK group com.ared with thos e of the saline controls(p=0.022 and p=0.005, respectively). GIK infusion initia ted 24 hours before coronary stenting for non-ST-elevation acute coronary synd rom. resulted in less m.ocardial dam.ge as determ.ned by postprocedure troponin I levels.

关键词：血运重建经皮冠状动脉胰岛素多肽输注葡萄糖右旋糖己糖心肌损害

在眼眶减压术当时及以后行上睑退缩矫正术对治疗甲状腺性眼眶病的疗效比较

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同方期刊数据库

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 60-61页

作者： Ben Sim.n G.J. m.nsury A.m. Schwarcz R.m. 王永强 Jules Stein Eye Institute 100 Stein Plaza LosAngeles CA 90095-7006United States Dr.

Purpose: To evaluate the outcom. of eyelid retraction surgery in thyroid-rela ted orbitopathy (TRO) patients in 2 different surgical settings: done sim.ltaneo usly with orbital decom.ression or as a staged procedure after orbital decom.res sion. Design: Retrospective, com.arative, nonrandom.zed clinical study. Particip ants: Ninety-six patients (158 eyes). m.thods: A review of electronic m.dical r ecords of TRO patients who underwent surgery for upper eyelid retraction and orb ital decom.ression at the Jules Stein Eye Institute in 1999 to 2003 was perform. d. Data regarding eyelid position, com.rehensive eye exam.nation, surgical outco m., and com.lications were analyzed. m.in Outcom. m.asures: Anatom.cal and funct ional success based on m.rgin reflex distance (m.D1; ≤5 m. was graded as m.ld r etraction; > 5m. and m., m.derate; and > 7 m., severe), and patients’discom.fort. Results: One hundred fifty-eight eyelid retraction surgeries were perform.ed on 96 TRO patients (18 m.le and 78 fem.le; m.an age, 48 years); m.an follow u p tim. was 15 (±12) m.nths. Group 1 consisted of patients undergoing sim.ltaneo us eyelid retraction surgery and orbital decom.ression and com.rised 97 cases (s urgeries). Group 2 included 61 cases of staged surgery: orbital decom.ression an d eyelid retraction at a later stage. The groups had sim.lar surgical outcom.s, and >85%had a better eyelid position postoperatively. Reoperation rates for res idual or recurrent eyelid retraction were sim.lar, overcorrection was higher in group 2 (5%vs. 0%, P=0.03). Changes in m.D1, lagophthalm.s, and exophthalm.s w ere sim.lar (P>0.05, independent sam.les t test). Correction of eyelid retractio n was effective in treating patients’discom.ort and exposure keratopathy (P=0.0 4, χ2). No severe com.lications occurred after orbital decom.ression or eyelid retraction surgery in this group of patients. Conclusions: Transconjunctival m. ller’s m.scle recession for correction of eyelid retraction in m.ld to m.

关键词：上睑退缩眼眶减压术矫正术眼眶病暴露性角膜病睑缘上睑下垂复位术矫正过度眼科检查