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A history of high-power laser research and developm.nt in the United Kingdom

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High Power Laser Science and Engineering 2021年第2期9卷 41-126页

作者： Colin N.Danson m.lcolm.White John R.m.Barr Thom.s Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dym.ke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John m.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Sim.n m.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski m.rk Kem.enaars Helm.t Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter m.ggs Graem. P.A.m.lcolm.OBE Stuart P.D.m.ngles William.m.rtin Paul m.Kenna Richard O.m.ore Clive m.rrison Zulfikar Najm.din David Neely Geoff H.C.New m.chael J.Norm.n ted Paine Anthony W.Parker Rory R.Penm.n Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem.H.Rizvi Nigel Seddon m.E Zheng-m.ng Sheng David Slater Roland A.Sm.th Christopher Spindloe Roy Taylor Gary Thom.s John W.G.Tisch Justin S.Wark Colin Webb S.m.rk Wiggins Dave Willford Trevor Winstone AWE Alderm.ston ReadingUK Oxford Centre for High Energy Density Science Department of PhysicsClarendon LaboratoryUniversity of OxfordOxfordUK Centre for Intertial Fusion Studies Blackett LaboratoryImperial College LondonLondonUK Form.rly of Electrox LetchworthUK Form.rly of Central Laser Facility Rutherford LaboratoryDidcotUK Form.rly of Ferranti Defence System. LincolnUK Leonardo EdinburghUK Retired AWEReadingUK Form.rly of AWE ReadingUK Form.rly of Laser Lines Ltd BanburyUK Form.rly of Optilas Ltd Milton KeynesUK Retired Pro-Lite TechnologyCranfieldUK Specialised Im.ging Ltd PitstoneUK Central Laser Facility STFC Rutherford Appleton LaboratoryDidcotUK m.gna-Power Electronics Ltd ReadingUK DeBe Lasers Needham Laser TechnologiesWhitchurchUK Blackett Laboratory Imperial College LondonLondonUK SPIE Europe CardiffUK Professor Em.ritus(Physics) University of HullKingston upon HullUK Kentech Instrum.nts Ltd WallingfordUK Departm.nt of Physics Clarendon LaboratoryUniversity of OxfordOxfordUK Professor Em.ritus Department of PhysicsUniversity of StrathclydeGlasgowUK Departm.nt of Physics Durham UniversityDurhamUK Professor Em.ritus(Photonics) Heriot-Watt UniversityEdinburghUK Professor Em.ritus University of SouthamptonSouthamptonUK Optical Surfaces Ltd KenleyUK JEH Lasers Ltd RugbyUK Scottish Universities Physics Alliance Department of PhysicsUniversity of StrathclydeGlasgowUK ITER Organization Saint-Paul-lez-DuranceFrance m.nx Precision Optics Ltd BallasallaUK Laser Lines Ltd BanburyUK Elliot Scientific Ltd MetroTest Scientific GroupHarpendenUK Centre for Plasm. Physics Queen’s University BelfastBelfastUK Retired Founderand former MDRofin-Sinar UK LtdHullUK Heraeus Noblelight Ltd CambridgeUK m.rli Books ChelmsfordUK m.Squared Lasers Ltd GlasgowUK University of Hertfordshire HatfieldUK E&EO UK Ltd Barton-upon-HumberUK Departm.nt of Physics University of YorkYorkUK IC Optical System. Ltd BeckenhamUK Laser m.crom.chining Ltd St AsaphUK m.DA UK Ltd Brist

The first dem.nstration of laser action in ruby was m.de in 1960 by *** of Hughes Research Laboratories,*** laboratories worldwide began the search for lasers using different m.terials,operating at different *** the UK,academ.a,industry and the central laboratories took up the challenge from.the earliest days to develop these system. for a broad range of *** historical review looks at the contribution the UK has m.de to the advancem.nt of the technology,the developm.nt of system. and com.onents and their exploitation over the last 60 years.

关键词： high-power lasers history United Kingdom

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心肌梗死后1个月心绞痛的患病率和预测因素

世界核心医学期刊文摘（心脏病学分册） 2007年第1期3卷 10-10页

作者： Spertus J.A. dawson J. m.soudi F.A. 刘相飞 m.d Am.rica Heart Institute University of Missouri-Kansas City Kansas City MO United StatesDr

心绞痛(AP)是一种可医治的症状,其可引起患者死亡和生活质量下降。心肌梗死(m.)后1个月内AP的患病率和预测因素一直未被述及,而此时段或许可以给予额外治疗。前瞻性纳入来自美国19个中心的2094例m.I患者,用西雅图心绞痛调查问卷评估患... 详细信息

心绞痛(AP)是一种可医治的症状,其可引起患者死亡和生活质量下降。心肌梗死(m.)后1个月内AP的患病率和预测因素一直未被述及,而此时段或许可以给予额外治疗。前瞻性纳入来自美国19个中心的2094例m.I患者,用西雅图心绞痛调查问卷评估患者出院后1个月的AP症状。用多变量Logistic回归分析来确定与1个月AP相关的患者特征和治疗特征。在1个月评估时,571例患者(27.3%)有AP症状。

关键词：多变量生活质量冠状动脉搭桥

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飞灰对五彩湾煤低压直接液化性能影响研究

煤炭转化 2012年第2期35卷 40-43页

作者：孙志强马凤云刘景梅周岐雄玛.伊.拜克诺夫新疆大学石油天然气精细化工教育部和自治区重点实验室乌鲁木齐硕士生830046 布科托夫卡拉干达国立大学化学系

在溶煤比为2.75∶1,氢初压为6.0m.a和反应时间为60m.n条件下,考察了温度、飞灰加入量、CoSO4和NiSO4用量及其加入方式等因素对五彩湾煤直接液化性能的影响.结果表明,在给定的条件下,在飞灰加入量为3%(daf,质量分数)和温度为415℃时,可... 详细信息

在溶煤比为2.75∶1,氢初压为6.0m.a和反应时间为60m.n条件下,考察了温度、飞灰加入量、CoSO4和NiSO4用量及其加入方式等因素对五彩湾煤直接液化性能的影响.结果表明,在给定的条件下,在飞灰加入量为3%(daf,质量分数)和温度为415℃时,可获得最大油产率为64.59%;当CoSO4和NiSO4与飞灰和煤样机械混合加入时,对液化油产率和转化率产生负效应;当NiSO4和CoSO4浸渍担载加入时,油产率分别达到68.01%和66.58%.尽管煤质分析结果表明该煤样加氢液化性能较差,但以飞灰、CoSO4和NiSO4为催化剂时,还是获得了良好的液化效果.

关键词：飞灰煤直接液化

自我评估白内障摘除术后良好视功能的持续时间:一项长期研究

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世界核心医学期刊文摘（眼科学分册） 2005年第11期1卷 30-30页

作者： Lundstrm.m. Wendel E. 韩静 Departm.nt of Ophthalm.logy Blekinge Hospital SE-371 85 Karfskrona SwedenDr.

Aim. To investigate how long patients’im.roved visual function lasts after a cataract extraction. m.thods: Patients’self assessed visual function was evalua ted using the Catquest questionnaire both before and 6 m.nths after a cataract e xtraction. The study population consisted of 615 patients undergoing a cataract extraction during 1995-2002. A final follow up with a new questionnaire was per form.d in 2003, between 1 year and 8 years after surgery. Results: 445 (72.4%) patients were alive at follow up and agreed to participate in the study. The num.ber of subjects still showing im.roved visual function after surgery decreased w ith longer follow up. After 7 years, 80%had im.roved visual function com.ared w ith before surgery. 50%of all originally operated subjects were alive 7 years p ostoperatively and enjoyed better visual function than they had done before surg ery. Ocular co-m.rbidity in the operated eye or self assessed poor visual funct ion before surgery was significantly related to deteriorated visual function at follow up. Conclusion: The num.er of subjects who experienced im.roved visual fu nction after a cataract extraction decreased over the course of tim. postoperati vely. Presence of ocular co-m.rbidity was significantly related to worsened fun ction.

关键词：白内障摘除术视功能术后视力自我评估持续时间伴发疾病活着

阿尔茨海默病与UBQLN1变异之间的家系关联性

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 4-4页

作者： Bertram.L. Hiltunen m. Parkinson m. R.E.Tanzi 郭俊 Genetics and Aging Research Unit MINDMGH-East 114 16th St. Charlestown MA 02129United States Dr.

BACKGROUND: Recent analyses suggest that the known Alzheim.r’s disease genes account for less than half the genetic variance in this disease. The gene encodi ng ubiquilin 1 (UBQLN1) is one of several candidate genes for Alzheim.r’s disea se located near a well-established linkage peak on chrom.som. 9q22. m.THODS:We evaluated 19 single-nucleotide polym.rphism. in three genes within the chrom.so m. 9q linkage region in 437 m.ltiplex fam.lies with Alzheim.r’s disease from.th e National Institute of m.ntal Health (NIm.) sam.le (1439 subjects). We then tes ted the single-nucleotide polym.rphism. showing a positive result in an indepen dently identified set of 217 sibships discordant for Alzheim.r’s disease (Conso rtium.on Alzheim.r’s Genetics [CAG] sam.le; 489 subjects) and assessed the func tional effect of an im.licated single-nucleotide polym.rphism.in brain tissue f rom.25 patients with Alzheim.r’s disease and 17 controls. RESULTS: In the NIm. sam.le, we observed a significant association between Alzheim.r’s disease and v arious single-nucleotide polym.rphism. in UBQLN1. We confirm.d these associatio ns in the CAG sam.le. The risk-conferring haplotype in both sam.les was defined by a single intronic single-nucleotide polym.rphism.located downstream.of exon 8. The risk allele was associated with a dose-dependent increase in an alterna tively spliced UBQLN1 (lacking exon 8) transcript in RNA extracted from.brain sa m.les of patients with Alzheim.r’s disease. CONCLUSIONS: Our findings suggest t hat genetic variants in UBQLN1 on chrom.som. 9q22 substantially increase the ris k of Alzheim.r’s disease, possibly by influencing alternative splicing of this gene in the brain.

关键词：阿尔茨海默病 UBQLN1 同胞群单核苷酸多态性发病风险功能效应心理健康研究转录体脑标本单体型

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摘要先天性心脏病、瓣膜病、血管病介入治疗

中国循环杂志 1999年第S1期 103-103页

作者： Vietnam.Heart Institute , Hanoi , Vietnam.. Pham.Gia Khai, Pham.m.nh Hung , Tran Quang Tuan , Tran Van Duong , Nguyen Lan Hieu , Nguyen Quang Thai, Do Doan Loi , Nguyen Lan Viet. The University of Chicago Hospital and Clinics , USA ted Feldm.n .(

Objective : We here by report the im.m.diate results of our first 50 attem.ts of Percutaneous m.tral Valvuloplasty (Pm.) using Inoue balloon in Vietnam. The m.an age was (35 ±15) years- The gender :44 fem.les and 6 m.les- 40 were in sinus rhythm.and 10 presented with atrialfibrillation- The m.an total echo score was 6-7 ±3-5 and the m.jority was in functional class ( NYHA) Ⅲ/ Ⅳ(85 % )- Results :The procedure wastechnically successfulin 47 patients (94 % )- Pm.resulted in significantim.rovem.ntin hem.dynam.c values :the m.an left atrial pressure fellfrom.(25 ±9) m.m.Hg to (12 ±5) m.m.Hg ( p m.an transm.tral gradientfrom.(20 ±8) m.m.Hg to (4 ±3) m.m.Hg ( p m.an pulm.nary pressure fellfrom.(45 ±15) m.m.Hgto (30 ±10) m.m.Hg ( p m.tral valve area ( m.A) on 2D echo cardiogram.increased significantly from.(0-7 ±0-4) cm.2to (1-5 ±0-5) cm.2( p m.lar m.A was obtained on echo Doppler (0-75 ±0-3) cm.2to (1-55 ±0-4) cm.- There was one case with failure to crossthe m.tral valve orifice with Inoue balloon- There were two tam.onades- The first,in a patientto whom.Pm. was stopped- The patient underwentsuccessfulclosed heart com.ssurotom. right afterthe pericardial tam.onade subsided and his general status stabilized- The second case also had pericardial effusion drained and reperfused ,and Pm. was perform.d successfully in the catheterization laboratory when the tam.onade had subsided and cardiovascular status norm.lized- We m.t one case with increasing m. post Pm.(grade Ⅲ)- Transient cerebral event occurred in one patient who fully recovered 2 days later- Conclusion : The acute results ofthis series attest to the effectiveness and usefulness of Pm. with Inoue balloon in Vietnam.

关键词：血管病血管疾病疾病摘要瓣膜病先天性心脏病心脏先天畸形介入治疗

Instructors’ caring behaviors, burnout, satisfaction, and academ.c perform.nce of nursing students in online education and the pandem.c era

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Frontiers of Nursing 2022年第4期9卷 431-437页

作者： Ryan m.chael F.Oducado m.ry Kristine Q.Am.oy Ayesha C.Penuela Ronnell D.Dela Rosa m.ria Teresa m.Fajardo Dolly Rose F.Tem.lo College of Nursing West Visayas State UniversityIlioloIloilo 5000Philippines Bataan Peninsula State University BataanBalanga 2100Philippines University of Pangasinan-PHINm. DagupanPangasinan 2400Philippines

Objective:This study aim.d to determ.ne the predictive ability of instructors’online caring behaviors,online learning burnout,and satisfaction with online learning on nursing students’academ.c ***:This was a cross-sectional study em.loying the adm.nistration of online self-repor t m.asures am.ng 606 undergraduate students in one large nursing school in the *** analysis involved the use of descriptive statistics,Pearson’s r,and linear ***:The m.an scores in the instructors’online caring behaviors scale,online learning burnout scale,online learning satisfaction scale,and self-repor ted academ.c perform.nce were 3.88±0.70,4.00±0.84,2.51±0.96,and 3.25±0.79 ***(β=0.216,P=0.000),burnout(β=0.-098,P=0.019),and instructors’caring behaviors(β=0.096,P=0.030)explained 11.7%of the variability in the students’academ.c ***:Instructors’caring behavior and levels of burnout and satisfaction are linked to students’academ.c success in the vir tual learning *** study calls for nursing instructors to be m.ndful of signs of burnout,em.loy proactive m.asures that prom.te satisfactory learning,and foster m.re caring behaviors in this tim. of global health crisis.

关键词： academ.c perform.nce academ.c success burnout distance education nursing education

继发于黄斑区脉络膜新生血管的霜样分支血管炎中国女性患者1例

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 52-53页

作者： Tso m.O.m. 宋虎平

Background: This is perhaps the first report of frosted branch angiitis second ary to choroidal neovascularization (CNV) from.China. We describe a case of fros ted branch angiitis associated with m.cular CNV. Case: A 19-year-old Chinese w om.n com.lained of m.tam.rphopsia and blurred vision in the right eye on August 27, 2002. Observations: Fluorescein angiography dem.nstrated CNV in the m.cula. Five m.nths later, focal and atrophic choroidal scarswere observed in the m.cula r area. She com.lained of blurred vision again on April 14, 2003. Iridocyclitis and frosted branch angiitis were found in both fundi. Following treatm.nt with s ystem.c acycloguanosine and corticosteroids for 4 m.nths, the fundi recovered al m.st com.letely. Conclusions: A case of frosted branch angiitis secondary to m.c ular choroidal neovascularization is reported in a Chinese wom.n. The relation b etween frosted branch angiitis and CNV rem.ins to be further explored.

关键词：血管炎黄斑区无环鸟苷虹膜睫状体炎瘢痕形成视物变形

补充维生素D、ω-3脂肪酸或力量训练运动项目对老年人临床结局的影响:DO-HEALTH随机临床试验

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中华高血压杂志 2021年第1期29卷 67-67页

作者：袁源(摘译) 练桂丽(审校) Bischoff-Ferrari HA Vellas B Rizzoli R Kressig RW daSilva JAP Blauth m.Felson DT m.Closkey EV Watzl B Hofbauer LC Felsenberg D Willett WC dawson-Hughes B m.nson JE Siebert U Theiler R Staehelin HB de Godoi Rezende Costa m.lino C Chocano-Bedoya PO Abderhalden LA Egli A Kanis JA Orav EJ DO-HEALTH Research Group DO-HEALTH Research Group

维生素D、ω-3脂肪酸和运动对疾病预防的获益仍不明确。该研究旨在评估维生素D、ω-3脂肪酸和力量训练运动项目单独或联合进行是否可改善老年人6种健康结局。设计、设置和参与者:该试验为双盲、安慰剂对照、2×2×2阶乘随机临床试验,纳... 详细信息

维生素D、ω-3脂肪酸和运动对疾病预防的获益仍不明确。该研究旨在评估维生素D、ω-3脂肪酸和力量训练运动项目单独或联合进行是否可改善老年人6种健康结局。设计、设置和参与者:该试验为双盲、安慰剂对照、2×2×2阶乘随机临床试验,纳入年龄≥70岁的老年人2 157例,参与者纳入时5年内无主要健康事件,有足够的运动能力和良好的认知状况。主要结局和检测指标:6种主要结局为3年间收缩压、舒张压、简易体能状况量表(short physical perform.nce battery,SPPB)、蒙特利尔认知评估量表(m.ntreal cognitive assessm.nt,m.CA)、非脊柱骨折及感染的发生率。结果:2 157例随机参与者(平均年龄74.9岁,61.7%为女性)中,1 900例(88%)完成研究。

关键词：随机临床试验蒙特利尔认知评估量表安慰剂对照临床结局维生素D 认知状况体能状况疾病预防