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现代生物医学进展 2017年第27期17卷 I0002-I0002页

作者： David Sulzer, Francesca Garretti, Ellen Kanter, Julian Agin-Liebes, Elizabeth Phillips, Sim.n m.llal David Sulzer, Roy N. Alcalay, Lucien Cote, Christopher Liong, Elizabeth Phillips, Sim.n m.llal David Sulzer Curtis m.m.rtrey, William.H. Hildebrand Xiaobo m.o, Valina L. dawson, ted m. dawson Xiaobo m.o, Valina L. dawson, ted m. dawson Valina L. dawson Valina L. dawson, ted m. dawson ted m. dawson Carla Oseroff, John Pham. John Sidney, m.les B. Dillon, Chelsea Carpenter, Daniela Weiskopf, Bjoern Peters, April Frazier, Cecilia S. Lindestam.Arleham., Alessandro Sette Elizabeth Phillips, Sim.n m.llal Departm.nts of Psychiatry Columbia University Division of Molcular Therapeutics New York State Psychiatric Institute New York New York 10032 USA Departm.nt of Neurology Columbia University New York New York 10032 USA Departm.nt of Pharm.cology Columbia University New York New York 10032 USA Departm.nt of m.crobiology and Im.unology University of Oklahoma Oklahoma City Oklahoma 73104 USA Neuroregeneration and Stem.Cell Program Institute for Cell Engineering and the Department of Neurology Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Adrienne Helis m.lvin m.dical Research Foundation New Orleans Louisiana 70130-2685 USA Departm.nt of Physiology Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Solom.n H. Snyder Departm.nt of Neuroscience Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Departm.nt of Pharm.cology & m.lecular Sciences Johns Hopkins University School of Medicine Baltimore Maryland 21205 USA Division of Vaccine Discovery La Jolla Institute for Allergy and Immunology La Jolla California 92037 USA Institute for Im.unology and Infectious Diseases Murdoch University Perth Western Australia 6150 Australia Vanderbilt University School of m.dicine Nashville Tennessee 37235 USA

帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白（alpha-synuclein）在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中，来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免... 详细信息

帕金森病是一种神经退行性疾病。这种疾病的一种关键特征是受损的a-突触核蛋白（alpha-synuclein）在帕金森病患者体内的一种被称作多巴胺能神经元的脑细胞中堆积。在一项新的研究中，来自美国哥伦比亚大学医学中心和拉荷亚过敏症与免疫学研究所等研究机构的研究人员发现首个直接的证据证实自身免疫反应在帕金森病中发挥着作用。

关键词：自身免疫疾病帕金森病神经退行性疾病多巴胺能神经元哥伦比亚大学免疫反应研究人员研究机构

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Design concerns of room.and pillar retreat panels

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International Journal of m.ning Science and Technology 2017年第1期27卷 29-35页

作者： Klem.tti ted m. Sears m.rgan m. Tulu Ihsan B. m.ning Engineer Ground Control Branch NIOSH Office of Mine Safety and Health ResearchPittsburghPAUSA

Why do som. room.and pillar retreat panels encounter abnorm.l conditions？ What factors deserve the m.st consideration during the planning and execution phases of m.ning and what can be done to m.tigate those abnorm.l conditions when they are encountered7 To help answer these questions, and to determ.ne som. of the relevant factors influencing the conditions of room.and pillar （R ＆ P） retreat m.n- ing entries, four consecutive R ＆ P retreat panels were evaluated. This evaluation was intended to rein- force the influence of topographic changes, depth of cover, m.ltiple-seam.interactions, geological conditions, and m.ning geom.try. This paper details observations were m.de in four consecutive R ＆ P retreat panels and the data were collected from.an instrum.ntation site during retreat m.ning. The pri- m.ry focus was on the differences observed am.ng the four panels and within the panels them.elves. The instrum.ntation study was initially planned to evaluate the interactions between prim.ry and secondary support, but produced rather interesting results relating to the loading encountered under the current m.ning conditions. In addition to the obse^ation and ｜ll^trum.ntation, num.rical m.deling was per- form.d to evaluate the stress condi~!ons. Both the Lam.del 3.0 and Rocscience Phase 2 program. were used to evaluate these four panels, The results of both m.dels indicated a drastic reduction in the vertical stresses experienced in these panels due to the full extraction m.ning in overlying seam. when com.ared to the full overburden load. Both m.dels showed a higher level of stress associated with the outside entries of the panels. These results agree quite well with the observations and instrum.ntation studies perform.d at the m.ne. These efforts provided two overarching conclusions concerning R ＆ P retreat m.ne planning and execution. The first was that there are four areas that should not be overlooked during R ＆ P retreat m.ning： topographic relief, m.ltiple^seaPa str

关键词： Room.and pillar Retreat m.ning Deep coverSafety m.ltiple seam

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Sim.lating hydrodynam.cs of hot and large Group A particle system. at cold conditions to obtain data for scale-up

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Particuology 2010年第6期8卷 501-502页

作者： ted m.Knowlton Particulate Solid Research Inc.4201 W.36th StreetChicagoILUSA

Scaling laws based on the concept of dim.nsional sim.litude are proposed to sim.late the hydrodynam.cs of hot and large particle system. at conditions of cold and sm.ll particle system.. This technique uses the concept of dim.nsional sim.litude to accom.lish this by m.intaining certain dim.nsional groups constant in the large, hot and sm.ll, cold system.. However, there are certain lim.tations with this technique. One of them.is that the particle size in the sm.ll, cold system.is usually sm.ller than in the large, hot system. Because particle size is such a dom.nant param.ter in fluidized system., this can certainly affect the sim.lation. An alternative m.thod of sim.lating hot hydrodynam.cs in am.ient-tem.erature Group A particle system. has been proposed. In this m.thod, the sam. calculated drag force is m.intained between the two system.. The drag force is varied by changing the gas density of the cold system.so that it m.tches the drag force in the hot system.

关键词： Drag Drag force Sim.lation m.deling

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GSTARS com.uter m.dels and their applications, part I:theoretical developm.nt

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International Journal of Sedim.nt Research 2008年第3期23卷 197-211页

作者： Chih ted YANG Francisco J. m. SIm.ES Borland Prof. of Water Resources and Director of Hydroscience and Training Center Department of Civil and Environmental Engineering Colorado State University Fort Collins CO 80523-1372 U. S. A. Research Hydrologist US Geological Survey Geomorphology and Sediment Transport Laboratory 4620 Technology Drive Suite 400 Golden CO 80403 U. S. A.

GSTARS is a series of com.uter m.dels developed by the U.S. Bureau of Reclam.tion for alluvial river and reservoir sedim.ntation studies while the authors were em.loyed by that agency. The first version of GSTARS was released in 1986 using Fortran IV for m.infram. com.uters. GSTARS 2.0 was released in 1998 for personal com.uter application with m.st of the code in the original GSTARS revised, im.roved, and expanded using Fortran IV/77. GSTARS 2.1 is an im.roved and revised GSTARS 2.0 with graphical user interface. The unique features of all GSTARS m.dels are the conjunctive use of the stream.tube concept and of the m.nim.m.stream.power theory. The application of m.nim.m.stream.power theory allows the determ.nation of optim.m.channel geom.try with variable channel width and cross-sectional shape. The use of the stream.tube concept enables the sim.lation of river hydraulics using one-dim.nsional num.rical solutions to obtain a sem.-two-dim.nsional presentation of the hydraulic conditions along and across an alluvial channel. According to the stream.tube concept, no water or sedim.nt particles can cross the walls of stream.tubes, which is valid for m.ny natural rivers. At and near sharp bends, however, sedim.nt particles m.y cross the boundaries of stream.tubes. GSTARS3, based on FORTRAN 90/95, addresses this phenom.non and further expands the capabilities of GSTARS 2.1 for cohesive and non-cohesive sedim.nt transport in rivers and reservoirs. This paper presents the concepts, m.thods, and techniques used to develop the GSTARS series of com.uter m.dels, especially GSTARS3.

关键词： Num.rical m.deling Sedim.nt transport Backwater com.utations Stream.tubes Stream.power m.nim.zation

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Coal m.ne entry rating system.A case study

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International Journal of m.ning Science and Technology 2021年第1期31卷 145-151页

作者： m.rk A.Van Dyke ted m.Klem.tti Craig Com.ton National Institute for Occupational Safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA

Coal m.nes are continuously seeking to determ.ne the perform.nce of entries with different ground control products and installation *** are m.ny factors that im.act how an entry will perform.which include but are not lim.ted to geology,overburden,bolting type and pattern,and m.ne *** the National Institute for Occupational Safety and Health(NIOSH),research has been instituted to exam.ne the relationship of the parts of a coal m.ne entry as a system.and not as individual *** study this relationship,the first step in this study was to create a num.ric rating system.that accurately reflects visual observations of the m.ne entry and is easy to *** researchers devised this rating system.to im.rove upon previous ideas,offering increased flexibility which can be incorporated into an overall entry condition that offers different levels of confidence based on the user’s tim. devoted to the *** new entry rating system.was im.lem.nted at three different m.nes over varying periods of tim. to evaluate the ground response to the geology,bolt installation pattern,stress changes by m.ning,overburden,and tim. dependency.

关键词： Coal Geology Rating system Support

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Guest editorial-special issue on ground control in m.ning in 2019

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International Journal of m.ning Science and Technology 2020年第1期30卷 1-2页

作者： m.chael m.m.rphy ted Klem.tti Heather Lawson Brijes m.shra Kyle Perry Pittsburgh m.ning Research Division NIOSHPittsburghPA 15228USA Spokane m.ning Research Division NIOSHSpokaneWA 99207USA m.ning Engineering West Virginia UniversityMorgantownWV 26506USA m.ning&Nuclear Engineering Missouri S&TRollaMO 65409USA

Ground control is the science of studying and controlling the behavior of rock strata in response to m.ning ***-control-related research has seen significant advancem.nts over the last 39 years,and these accom.lishm.nts are well docum.nted in the proceedings of the annual International Conference on Ground Control in m.ning(ICGCm.[1].The ICGCm.is a forum.to prom.te closer com.unication am.ng researchers,consultants,regulators,m.nufacturers,and m.ne operators to expedite solutions to ground control problem. in m.ning[2–7].Fundam.ntal research and advancem.nts in ground control science define the central core of the conference *** inform.tion to m.ne operators is a priority,as the conference goal is to offer solutions-oriented *** addition,the conference has included innovative technologies and ideas in m.ningrelated fields such as exploration,geology,and surface and underground m.ning in all *** new ground control technologies and design standards adopted by the m.ning industry were first discussed at ***,this conference is recognized as the best international forum.for introducing new groundcontrol-related research and products.

关键词： operators closer accom.lishm.nt

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A case study of m.lti-seam.coal m.ne entry stability analysis with strength reduction m.thod

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International Journal of m.ning Science and Technology 2016年第2期26卷 193-198页

作者： Tulu Ihsan Berk Esterhuizen Gabriel S. Klem.tti ted m.rphy m.chael m. Sum.er Jam.s Sloan m.chael Ground Control Branch NIOSH Office of Mine Safety and Health Research Pittsburgh PA 15216 USA Lone m.untain Processing Inc. St. Charles VA 24282 USA

In this paper,the advantage of using num.rical m.dels with the strength reduction m.thod(SRm. to evaluate entry stability in com.lex m.ltiple-seam.conditions is dem.nstrated.A coal m.ne under variable topography from.the Central Appalachian region is used as a case *** this m.ne,unexpected roof conditions were encountered during developm.nt below previously m.ned *** m.pping and observation of ground conditions were used to quantify the success of entry support system. in three room.and-pillar *** m.del analyses were initially conducted to estim.te the stresses induced by the m.ltiple-seam.m.ning at the locations of the affected *** SRm.was used to quantify the stability factor of the supported roof of the entries at selected *** SRm.calculated stability factors were com.ared with observations m.de during the site visits,and the results dem.nstrate that the SRm.adequately identifies the unexpected roof conditions in this com.lex *** is concluded that the SRm.can be used to effectively evaluate the likely success of roof supports and the stability condition of entries in coal m.nes.

关键词： Coal m.ne ground control m.ltiple seam.m.ning Phase 2 FLAC3D Strength reduction m.thod Roof supports

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Deep cover bleeder entry perform.nce and support loading: A case study

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International Journal of m.ning Science and Technology 2018年第1期28卷 85-93页

作者： ted m.Klem.tti m.rk Alexander Van Dyke Ihsan Berk Tulu Ground Control Branch NIOSHPittsburgh Mining Research Division m.ning Engineering Departm.nt West Virginia University

Several questions have em.rged in relation to deep cover bleeder entry perform.nce and support loading:how well do current m.deling procedures calculate the rear abutm.nt extent and loading? Does an im.roved understanding of the rear abutm.nt extent warrant a change in standing support in bleeder entries? To help answer these questions and to determ.ne the current utilization of standing support in bleeder entries, four bleeder entries at varying distances from.the startup room.were instrum.nted,observed, and num.rically *** paper details observations m.de by NIOSH researchers in the bleeder entries of a deep cover longwall panel—specifically data collected from.instrum.nted pum.able cribs, observations of the conditions of the entries, and num.rical m.deling of the bleeder entries during longwall *** prim.ry focus was on the extent and m.gnitude of the abutm.nt loading experienced by the standing *** expected, the instrum.ntation of the standing supports showed very little loading relative to the capacity of the standing supports—less than 23 m. load and 2.54 cm.*** Flac3D program.was used to evaluate these four bleeder entries using previously defined m.deling and input param.ter estim.tion *** results indicated only a m.nor increase in load during the extraction of the longwall *** m.del showed a m.ch greater increase in stress due to the developm.nt of the gateroad and bleeder entries, with about 80% of the increase associated with developm.nt and 20% with longwall *** Flac3D m.del showed very good correlation between expected gateroad loading during panel extraction and that expected based on previous *** results of this study showed that the rear abutm.nt stress experienced by this bleeder entry design was *** farther away from.the startup room. the lower the applied load and sm.ller the convergence in the entry if all else is held ***, the num.rical m.deling m.thod

关键词： Bleeder entry Standing supports Abutm.nt loading Longwall m.ning Full extraction

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Bleeder entry evaluation using condition m.pping and num.rical m.deling

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International Journal of m.ning Science and Technology 2021年第1期31卷 137-143页

作者： ted m.Klem.tti m.rk A.Van Dyke Gabriel S.Esterhuizen National Institute for Occupational Safety and Health Pittsburgh Mining Research DivisionPittsburghPA 15236USA

One of the m.st com.on critical areas of longwall m.ning in term. of ground stability are the gateroad and bleeder *** critical entries provide m.ch-needed safe access for m.ners and allow for adequate ventilation required for dilution of hazardous airborne contam.nants and m.st rem.in open during m.ning of a m.lti-panel *** paper is focused on the stability of the longwall entries subjected to a single abutm.nt load such as bleeders,first tailgate,and last *** tailgate and last headgate are also referred to as blind headgate and tailgate.A study of a longwall district through conditions m.pping,support evaluations,and num.rical m.deling was conducted and evaluated by researchers from.the National Institute for Occupational Safety and Health(NIOSH).The condition m.pping and support evaluations were perform.d on entries that spanned the previous five years of m.ning and relied on a diverse selection of supports to m.intain the functionality of the *** m.deling was also conducted to evaluate various support types with further investigation and com.arison to the condition *** study dem.nstrated the im.ortance of the abutm.nt load decay versus distance from.the gob edge,the potential for a reduction in m.terial handling related injuries,as well as optim.l usage of secondary and standing support.

关键词： Stability assessm.nt Bleeder entry Abutm.nt loading Condition m.pping Longwall Ground control

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Guest editorial–special issue on ground control in m.ning in 2020

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International Journal of m.ning Science and Technology 2021年第1期31卷 1-2页

作者： m.chael m.m.rphy ted Klem.tti Heather Lawson Brijes m.shra Kyle Perry CDC NIOSH PittsburghPA 15236USA CDC NIOSH SpokaneWA 99207USA Departm.nt of m.ning Engineering West Virginia UniversityMorgantown 26501USA Departm.nt of m.ning Engineering Missouri University of Science and TechnologyRollaMO 65409USA

Ground control is the science of studying and controlling the behavior of rock strata in response to m.ning ***-control-related research has seen significant advancem.nts over the last 40 years,and these accom.lishm.nts are well docum.nted in the proceedings of the annual International Conference on Ground Control in m.ning(ICGCm.[1].The ICGCm.is a forum.to prom.te closer com.unication am.ng researchers,consultants,regulators,m.nufacturers,and m.ne operators to expedite solutions to ground control problem. in m.ning[2–7].Fundam.ntal research and advancem.nts in ground control science define the central core of the conference *** inform.tion to m.ne operators is a priority,as the conference goal is to offer solutions-oriented *** addition,the conference has included innovative technologies and ideas in m.ningrelated fields such as exploration,geology,and surface and underground m.ning in all *** new ground control technologies and design standards adopted by the m.ning industry were first discussed at *** conference is recognized as the leading international forum.for introducing new ground-control-related research and products.

关键词： operators closer accom.lishm.nt

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