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Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4(ITIH4)in Autoimmune Cholestatic Liver Diseases

Journal of Clinical and Translational Hepatology 2022年第5期10卷 796-802页

作者： tea lund laursen Lars Bossen Rasmus Pihl Anne Troldborg Thomas Damgaard Sandahl Annette Gudmann Hansen Trine Folserass Mette Vesterhus Henning Grønbæk Steffen Thiel Department of Hepatology and Gastroenterology Aarhus University HospitalAarhusDenmark Department of Biomedi-cine Aarhus UniversityAarhusDenmark Department of Rheumatology Aarhus University HospitalAarhusDenmark Department of Clinical Medicine Aarhus UniversityAarhusDenmark Norwegian PSC Research Center Department of Transplantation MedicineDivision of SurgeryInflammatory Diseases and TransplantationOslo University Hospital Rik-shospitaletOsloNorway Haraldsplass Deaconess Hospital BergenNorway Department of Clinical Science University of BergenBergenNorway

Background and Aims:There is an unmet need for new bi-omarkers to improve diagnostics and prognostics in primary biliary cholangitis(PBC)and primary sclerosing cholangitis(PSC).Inter-α-inhibitor heavy chain 4(ITIH4)is an abun-dant,liver-produced protein,and its synthesis may be al-tered in liver *** investigated whether ITIH4 plas-ma concentrations were affected in PBC and PSC ***:We developed an immunoassay specific for ITIH4 and determined ITIH4 plasma concentrations in 66 PBC,126 PSC,92 autoimmune hepatitis(AIH),67 chronic hepatitis C(CHC),33 alcoholic hepatitis(AH)patients and 138 healthy controls(HCs).Hepatic ITIH4 expression was investigated by immunohistochemistry in ***:The mean plas-ma concentration of ITIH4 was almost doubled in PBC[409μg/mL(95%CI:388-431)]and 35%higher in PSC[308μg/mL,(95%CI:296-319)]compared with HCs[226μg/mL(95%CI:221-231);p<0.001].In PBC patients,ITIH4 correlated with IgM(rho=0.49,p<0.001).Responders to ursodeoxycholic acid treatment(UDCA)had lower levels of ITIH4 than incomplete responders[395μg/mL(95%CI:364-425)]vs.460μg/mL(95%CI:421-498);p=0.02].Four weeks of UDCA treatment had no effect(p=0.19).In-creased ITIH4 immunohistochemical staining was seen in a liver biopsy from a PBC ***4 levels in AIH[224μg/mL(95%CI:208-241)]and HCs were similar(p=0.8).ITIH4 levels were lower in AH[199μg/mL(95%CI:175-223)]and CHC[202μg/mL(192-212)]patients than in HCs(p<0.05).Conclusions:The plasma concentration of ITIH4 was highly elevated in patients with PBC and PSC,suggesting that ITIH4 should be further investigated as a biomarker in cholestatic liver disease.

关键词： Primary biliary cholangitis Primary sclerosing cholangitis Autoim-mune hepatitis Ursodeoxycholic acid treatment Alcoholic hepatitis Chronic viral hepatitis

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Western Tethyan Epeiric Ramp Setting in the Early Triassic： An Example from the Central Dinarides (Croatia)

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Journal of Earth Science 2018年第4期29卷 806-823页

作者： Dunja Aljinovic Micha Horacek Leopold Krystyn Sylvain Richoz tea Kolar-Jurkovsek Duje Smircic Bogdan Jurkovsek University of Zagreb Faculty of Mining Geology and Petroleum Engineering Pierottijeva 6 Zagreb 10000 Croatia BLT Wieselburg HBLFA Francisco-Josephinum Rottenhauserstr. 1 Wieselburg 3250 Austria Institute of Paleontology Vienna University A lthanstrafle 14 Vienna 1090 Austria lund University Lithosphere and Biosphere science Solvegatan 12 Lund 22362 Sweden Geological Survey of Slovenia Dimiceva Ulica 14 Ljubljana 1000 Slovenia

In the central part of the External Dinarides in Plavno, Croatia, near Knin, a remarkably thick （927.5 m） Early Triassic depositional sequence was investigated. The Plavno sequence starts in the EarlyGriesbachian and ends with a continuous transition into the Anisian strata. A complete 13C isotope curve has been achieved and combined with conodonts, bivalves and ammonoids to establish and correlate stage and substage boundaries. The 613C curve is consistent with former studies. It displays a general increase from the Griesbachian to a prominent maximum beyond the ＋8%0 amplitude around the Dienerian-Smithian boundary （DSB）, followed by a steep and continuous decline to low, negative values in the Smithian. Around the Smithian-Spathian boundary （SSB） a steep rise to a second maximum occurred. It is followed by a saw-tooth shaped decline in the Spathian and a similar increase to a peak at the Spathian-Anisian boundary （SAB）. Sedimentologically, the Plavno sequence is interpreted as having been deposited on an extensive epeiric ramp under long-term transgressive conditions, sharing depositional characteristics of both the epeiric platform and the carbonate ramp. The entire Plavno sequence was deposited above the storm-wave base and was storm influenced. Three informal members are differentiated： 1） the dolostone member （Early Griesbachian）; 2） the silicielastic member （red-coloured shale, siltstone, sandstone with oolitic/bioclastie grainstone intercalations）, which can be further divided into lower, middle and upper intervals （Late Griesbachian, Dienerian and Smithian）; and 3） the mudstone member （grey lime mudstones, marls and calcisiltites with common ammonoids and gastropods- Spathian）. The Plavno sequence is compared with other western Tethyan sections. Observed differences stem from local controls on deposition in the overall shallow marine environment.

关键词： Early Triassic Dinarides epeiric ramp 6Z3C isotope curve litho- and biostratigraphy.

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