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Icariin plus curcumol enhances autophagy through the mTOR pathway and promotes cathepsin B-mediated pyroptosis of prostate cancer cells

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 55-64页

作者： Xu-Yun Wang wen-Jing Xu Bo-Nan Li Tian-Song Sun wen Sheng Department of Andrology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Dermatology The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha410021China School of Integrated Chinese and Western Medicine Hunan University of Chinese MedicineChangsha410208China Andrology Laboratory Hunan University of Chinese MedicineChangsha410208China School of Rehabilitation Medicine and Health Care Hunan University of MedicineHuaihua418000China School of Traditional Chinese Medicine Hunan University of MedicineHuaihua418000China

Objective:To examine the effect of icariin plus curcumol on prostate cancer cells PC3 and elucidate the underlying ***:We employed the Cell Counting Kit 8 assay and colony formation assay to assess cell viability and *** expression was analyzed using monodansylcadaverine *** and Western blot analyses were used to evaluate protein expressions related to autophagy,pyroptosis,and the mTOR *** damage was examined using the lactate dehydrogenase ***,cathepsin B and NLRP3 were detected by ***:Icariin plus curcumol led to a decrease in PC3 cell proliferation and an enhancement of *** levels of LC3-Ⅱ/LC3-Ⅰand beclin-1 were increased,while the levels of p62 and mTOR were decreased after treatment with icariin plus *** changes were reversed upon overexpression of ***,3-methyladenine resulted in a decrease in inflammatory cytokines,pyroptosis-related protein levels,and lactate dehydrogenase concentration,compared to the icariin plus curcumol *** cathepsin B reversed the regulatory effects of icariin plus ***:Icariin plus curcumol demonstrates great potential as a therapeutic agent for castration-resistant prostate cancer by enhancing autophagy via the mTOR pathway and promoting pyroptosis mediated by cathepsin *** findings provide valuable insights into the molecular mechanisms underlying the therapeutic potential of icariin and curcumol for prostate cancer treatment.

关键词： Icariin Curcumol Autophagy mTOR Cathepsin B Pyroptosis Prostate cancer

ASYMPTOTIC THEORY FOR THE CIRCUIT ENVELOPE ANALYSIS

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Journal of Computational Mathematics 2024年第4期42卷 955-978页

作者： Chunxiong Zheng Xianwei wen Jinyu Zhang Zhenya Zhou College of Mathematics and Systems Science Xinjiang UniversityUrumqi 830046China Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Empyrean Software Empyrean Technology Co.Ltd.Beijing 100102China

Asymptotic theory for the circuit envelope analysis is developed in this paper.A typical feature of circuit envelope analysis is the existence of two significantly distinct timescales:one is the fast timescale of carrier wave,and the other is the slow timescale of modulation *** first perform pro forma asymptotic analysis for both the driven and autonomous *** resorting to the Floquet theory of periodic operators,we make a rigorous justification for first-order asymptotic *** turns out that these asymptotic results are valid at least on the slow *** speed up the computation of asymptotic approximations,we propose a periodization technique,which renders the possibility of utilizing the NUFFT *** experiments are presented,and the results validate the theoretical findings.

关键词： Asymptotic analysis Circuit envelope analysis Floquet theory Singularly perturbed problem

Diabetes remission and nonalcoholic fatty pancreas disease

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World Journal of Diabetes 2024年第7期15卷 1390-1393页

作者： wen-Jun Wu Department of Endocrinology Jinshan Branch of Shanghai Sixth People’s HospitalShanghai 201500China

This editorial focuses on the relationship between nonalcoholic fatty pancreas disease(NAFPD)and the development and remission of type 2 diabetes(T2D).NAFPD is characterized by intrapancreatic fatty deposition associated with obesity and not associated with alcohol abuse,viral infections,and other *** fat deposition in the pancreas is associated with the development of T2D,and the underlying mechanism is lipotoxicβ-cell ***,the results on the relationship between intrapancreatic fat deposition(IPFD)andβ-cell function are *** of the therapeutic approach,weight loss improves IPFD,glycemia,andβ-cell *** imaging is valuable for clinically monitoring and evaluating the management of T2D.

关键词： Diabetes remission Type 2 diabetes Pancreatic fat content βcell function Weight loss

Ferromagnetism and insulating behavior with a logarithmic temperature dependence of resistivity in Pb_(10-x)Cux(PO_(4))_(6)O

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 106-111页

作者： Yuhang Zhang Cong Liu Xiyu Zhu Hai-Hu wen Center for Superconducting Physics and Materials National Laboratory of Solid State Microstructures and Department of PhysicsNational Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

Recent claim of discovering above-room-temperature superconductivity(Tc≈400 K)at ambient pressure in copper doped apatite Pb10(PO_(4))_(6)O has stimulated world-wide enthusiasm and impulse of motion.A lot of follow-up works have been carried out with controversial *** check whether superconductivity is really present or absent in the material,we need samples which should have a rather pure phase of Pb_(10-x)Cux(PO_(4))_(6)*** we report the characterization results from the Pb_(10-x)Cux(PO_(4))_(6)O with a fraction of about 97 wt.%inferred from the fitting to the X-ray diffraction pattern,if assuming Cu2S as the only *** resistivity measurements show that it is a semiconductor characterized roughly by a ln(1/T)temperature dependence in wide temperature region without trace of *** measurements show that it has a general ferromagnetic signal with a weak superparamagnetic *** grains of the sample show clear interactions with a Nb Fe B *** detected Cu concentration is much lower than the expected nominal *** results show the absence of metallicity and superconductivity in Pb_(10-x)Cux(PO_(4))_(6)O at ambient pressure,and suggest the presence of strong correlation effect.

关键词： superconductivity Pb10(PO4)6O ferromagnetic correlation effect

Quantitative characterization of fusion state of virgin and aged asphalt using nano-ferrous ferric oxide tracer

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 467-480页

作者： Qiang Li Song Liu Huameng wen Zhou Zhou College of Civil Engineering Nanjing Forestry UniversityNanjing 210037China School of Transportation Southeast UniversityNanjing 211189China

The exact evaluation of the fusion rate of virgin and aged asphalt is essential to optimize the performance of the recycled asphalt *** fusion rate index was developed by tracing the distribution of tracer asphalt,which contains nano-ferrous ferric oxide(nano-Fe_(3)O_(4))*** fusion simulation tests were performed on three types of asphalt to obtain different fusion states,and fatigue tests were performed to evaluate the influence of the fusion rate on the fatigue life of the recycled *** was found that the tracer asphalt containing 4%nano-Fe_(3)O_(4)shows the optimal trace effect,and the developed fusion rate index can quantitatively characterize the influence of different factors on the fusion state of the recycled *** fusion state is closely related to the fatigue performance of recycled asphalt,and the fusion rate index can fairly evaluate its fatigue *** relationship between the fusion rate and the fatigue life of recycled asphalt depends on the factors that cause the fusion rate *** the influence of the amount of rejuvenator,the fatigue life of recycled asphalt grows exponentially with increasing fusion rate due to enhancement of molecular motion as well as a supplement of lightweight *** the influence of heat preservation treatment,fatigue life increases linearly with increasing fusion *** proposed fusion rate index can be utilized to quantitatively characterize the fusion state of virgin and aged asphalt,thus providing a simple way to guide the practical application of recycled asphalt.

关键词： Recycled asphalt Rejuvenator Tracing technique Fusion rate Fatigue

Fixed-Time Gradient Flows for Solving Constrained Optimization: A Unified Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第8期11卷 1849-1864页

作者： Xinli Shi Xiangping Xu Guanghui wen Jinde Cao School of Cyber Science and Engineering Southeast UniversityNanjing 210096China School of Mathematics Southeast UniversityNanjing 210096China

The accelerated method in solving optimization problems has always been an absorbing *** on the fixedtime(FxT)stability of nonlinear dynamical systems,we provide a unified approach for designing FxT gradient flows(FxTGFs).First,a general class of nonlinear functions in designing FxTGFs is provided.A unified method for designing first-order FxTGFs is shown under Polyak-Łjasiewicz inequality assumption,a weaker condition than strong *** there exist both bounded and vanishing disturbances in the gradient flow,a specific class of nonsmooth robust FxTGFs with disturbance rejection is *** the strict convexity assumption,Newton-based FxTGFs is given and further extended to solve time-varying ***,the proposed FxTGFs are further used for solving equation-constrained ***,an FxT proximal gradient flow with a wide range of parameters is provided for solving nonsmooth composite *** show the effectiveness of various FxTGFs,the static regret analyses for several typical FxTGFs are also provided in ***,the proposed FxTGFs are applied to solve two network problems,i.e.,the network consensus problem and solving a system linear equations,respectively,from the perspective of ***,by choosing component-wisely sign-preserving functions,these problems can be solved in a distributed way,which extends the existing *** accelerated convergence and robustness of the proposed FxTGFs are validated in several numerical examples stemming from practical applications.

关键词： Consensus constrained optimization disturbance rejection linear equations fixed-time gradient flow(FxTGF).

Does Green Food Certification promote agri-food export quality?Evidence from China

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Journal of Integrative Agriculture 2024年第3期23卷 1061-1074页

作者： Ping Wei Hongman Liu Chaokai Xu Shibin wen College of Economics and Management China Agricultural UniversityBeijing 100083China School of Public Affairs Zhejiang UniversityHangzhou 310058China

The construction of a food certification system plays a vital role in upgrading export quality, which previous studies have largely overlooked. We match China's industry-level data of Green Food Certification with its HS6-digit export data of agri-food products to quantify the impact of Green Food Certification on export quality. We identify the significant and positive effect of Green Food Certification on export quality. The 2SLS estimation based on instrumental variables and a range of robustness checks confirm the validity and robustness of the benchmark conclusions. Further analysis discloses that Green Food Certification improves export quality by raising agricultural production efficiency and brand premiums. Heterogeneity analysis shows that the effect of Green Food Certification varies across regions, notably improving the quality of agri-food products exported to developed regions and regions with high levels of import supervision. Furthermore, among various product types, Green Food Certification significantly improves the export quality of primary products and products vulnerable to non-tariff measures. The above findings could guide the future development of agri-food quality certification systems, potentially leading to a transformation and promotion of the agri-food trade.

关键词： Green Food Certification agri-food products green transformation export quality food labeling

Deformation mechanism and hydrocarbon significance of Eocene organic-rich fine-grained soft sediments in the Leijia Region,Liaohe Depression

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Frontiers of Earth Science 2024年第1期18卷 83-97页

作者： Yijie wen Jianguo ZHANG Shu TAO Chenyu CAI School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Key Laboratory of Strategy Evaluation for Shale Gas(Ministry of Land Resources) China University of Geosciences(Beijing)Beijing 100083China School of Foreign Languages China University of Geosciences(Beijing)Beijing 100083China

The deformation structure of soft sediments has always been a research hotspot,which is of great significance for analyzing the tectonic and sedimentary evolution background of a basin,as well as the physical properties of *** studies have reported that a large number of soft sediment deformation structures are developed in the western part of Liaohe *** this study,through core observation and thin section identification,various types of deformation structures are identified in the core samples which are collected from the upper Es4 in the Leijia region,western sag of Liaohe depression,such as liquefied dikes,liquefied breccia,convoluted laminae,annular bedding,synsedimentary faults,vein structures,*** on the characteristics of core structure,single well profile and continuous well profile,combined with the regional background,this study clarifies that the deformation structure of soft sediments in the study area is mainly caused by seismic *** is found that the permeability and porosity of deformation layers in the study area are higher than those of the undeformation layers,which proves that the deformation structure of soft sediments has a good effect on improving the physical properties of reservoirs.

关键词： soft sediment deformation structure Liaohe depression organic-rich fine-grained soft sediments hydrocarbon significance

Structure engineering of cathode host materials for Li-S batteries

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Rare Metals 2024年第4期43卷 1370-1389页

作者： Jia-Jun Long Hua Yu wen-Bo Liu School of New Energy and Materials Southwest Petroleum UniversityChengdu610500China School of Mechanical Engineering Sichuan UniversityChengdu610065China

Although lithium-sulfur batteries are one of the favorable candidates for next-generation energy storage devices,a few key challenges that have not been addressed have limited its *** challenges include lithium dendrite growth in the anode side,volume change of the active material,poor electrical conductivity,dissolution and migration of poly sulfides,and slow rate of solid-state reactions in the cathode *** the electrochemical performance of lithium-sulfur batteries is greatly affected by the design of the cathode host material,it has also been widely discussed in addressing the abovementioned *** this paper,three design ideas of cathode host materials in terms of microstructure,crystal structure and electronic structure are introduced and ***,the current progress of these three structural design strategies and their effects on the electrochemical performance of lithium-sulfur batteries are discussed in ***,future directions in the structural design of cathode materials for lithium-sulfur batteries are discussed and further perspectives are provided.

关键词： Lithium-sulfur batteries Structure engineering Cathode Host materials