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Gastrointestinal tumors in transplantation: Two case reports and review of literature

World Journal of Gastroenterology 2022年第34期28卷 5076-5085页

作者： Romain Stammler Dany Anglicheau Bruno Landi tchao meatchi Emilia Ragot Eric Thervet Helene Lazareth Department of Nephrology Georges Pompidou European HospitalParis 75015France Department of Renal Transplantation Necker-Enfants Malades InstituteFrench National Institutes of Health and Medical Research U1151Paris 75015France Universite Paris Cite Assistance Publique des Hôpitaux de ParisParis 75001France Department of Gastroenterology and Digestive Oncology Georges Pompidou European HospitalParis 75015France Department of Pathology Georges Pompidou European HospitalParis 75015France Department of Digestive Surgery Georges Pompidou European HospitalParis 75015France

BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal *** most of them harbor a KIT mutation(75%),selective kinase inhibitors are the therapeutic option and show a sustained objective response among patients with metastatic or unresectable GISTs.A wellknown higher risk of neoplasm has been described among renal transplant recipients(RTRs).Nevertheless,only few cases of GIST onset among transplant patients have been reported in the *** SUMMARY Here,we describe 2 cases of gastric GIST occurring during the follow-up of *** also review the existing literature concerning GIST occurrence in transplant *** total and in association with our 2 cases,16 patients have been *** median age was 59.5 years and 69%were *** a median tumor size of 45 mm,no patient displayed metastatic dissemination at *** from transplantation to diagnosis was highly variable between 5 mo and 21 *** data mostly revealed high risk of progression(43%).Death increased to 29%during *** treatment was systematically performed when the tumor was operable(94%).The use of adjuvant therapy was uncommon(19%).CONCLUSION GISTs represent rare but potentially severe malignant complication among transplant patients.

关键词： Gastrointestinal stromal tumors Imatinib mesylate Transplantation Kidney transplantation Proto-oncogene protein c-KIT Case report

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