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New insights into the therapeutic approaches for the treatment of tauopathies

Neural Regeneration Research 2024年第5期19卷 1020-1026页

作者： Himanshi Singh Asmita Das Mohammad Moshahid Khan tayebeh pourmotabbed Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Department of Biotechnology Delhi Technological UniversityShahbad DaulatpurDelhiIndia Department of Neurology College of MedicineUniversity of Tennessee Health Science CenterMemphisTNUSA Neuroscience Institute University of Tennessee Health Science CenterMemphisTNUSA Center for Muscle Metabolism and NeuropathologyDivision of Regenerative and Rehabilitation Sciences and Department of Physical TherapyCollege of Health ProfessionsUniversity of Tennessee Health Science CenterMemphisTNUSA

Tauopathies are a group of neurological disorders,including Alzheimer’s disease and frontotemporal dementia,which involve progressive neurodegeneration,cognitive deficits,and aberrant tau protein *** development of tauopathies cannot currently be stopped or slowed down by treatment *** the significant contribution of tau burden in primary tauopathies and the strong association between pathogenic tau accumulation and cognitive deficits,there has been a lot of interest in creating therapies that can alleviate tau pathology and render neuroprotective ***,small molecules,immunotherapies,and gene therapy have been used to reduce the pathological tau burden and prevent neurodegeneration in animal models of ***,the major pitfall of the current therapeutic approach is the difficulty of drugs and gene-targeting modalities to cross the blood-brain barrier and their unintended side *** this review,the current therapeutic strategies used for tauopathies including the use of oligonucleotide-based gene therapy approaches that have shown a promising result for the treatment of tauopathies and Alzheimer’s disease in preclinical animal models,have been discussed.

关键词： dementia gene therapies immunotherapy neurodegeneration oligonucleotides tau tauopathies therapies

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Correlation between critical thinking and emotional intelligence:a national crosssectional study on operating room nursing students in Iran

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Frontiers of Nursing 2024年第1期11卷 99-104页

作者： Armin Fereidouni Esmaeil Teymoori tayebeh Bahmani Hamid Reza Sabet Zahra Maleki Mina Gharibi Department of Operating Room Technology Community Based Psychiatric Care Research CenterSchool of Nursing and MidwiferyShiraz University of Medical SciencesShirazIran Department of Operating Room Technology School of Paramedical SciencesAJA University of Medical SciencesTehranIran Department of Operating Room School of Allied Medical ScienceFasa University of Medical SciencesFasaIran Clinical Education Research Center Shiraz University of Medical SciencesShirazIran Medical Journalism Department School of Paramedical SciencesShiraz University of Medical SciencesShirazIran Department of Epidemiology Student Research CommitteeShiraz University of Medical SciencesShirazIran

Objective:According to the World Federation of Medical Education,critical thinking should be part of the training of medical and paramedical *** can improve the quality of care of patients after surgery by having or acquiring this skill in health ***,Emotional intelligence is introduced as an impor tant and effective factor on the professional performance and mental health of healthcare ***,the present study was designed and implemented to determine the relationship between emotional intelligence and critical thinking among operating room nursing students of medical sciences universities in ***:This cross-sectional study was done on 420 operating room students in 10 top medical sciences universities of Iran in *** sampling method in this research was multistage *** data collection instruments included demographic characteristics,Rickett's critical thinking,and Bradberry-Greaves'emotional intelligence *** receiving the ethics code,data collection was done for 2 *** data analysis,descriptive and inferential analyses including independent t-tests,analysis of variance,and Pearson correlation were *** collected data were analyzed by SPSS 18(IBM Corporation,Armonk,New York,United States).P-value<0.05 was considered ***:The mean age of the students participating in this study was 23.02±3.70 years,with women constituting 67.4%of *** results of data analysis indicated that the mean total score of critical thinking and emotional intelligence was 124.10±37.52 and 114.12±43.63,respectively.A direct significant correlation between critical thinking and emotional intelligence(r=0.459,P-value<0.001)and a significant relationship between gender and emotional intelligence(P-value=0.028)were ***:Based on the present study results,educational managers in the Ministry of Health are suggested to consider suitable educational programs for improving critical think

关键词： critical thinking emotional intelligence operating room students operating room nurses

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Investigation on the ballistic performance of the aluminum matrix composite armor with ceramic balls reinforcement under high velocity impact

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Defence Technology(防务技术) 2023年第11期29卷 134-152页

作者： Ali Ansari tayebeh Akbari Masoomeh Rahimi Pishbijari School of Mechanical Engineering Iran University of Science and TechnologyTehranIran Faculty of Materials and Manufacturing Technologies Malek Ashtar University of TechnologyTehranIran Islamic Azad University of Parand Branch TehranIran

In this research, the ballistic behavior of the ceramic-reinforced aluminum matrix composite plates is investigated to provide an optimal design for protecting against 7.62 mm bullet at the speed of 800 m/s experimentally and numerically. The target materials are Al5083 alloy as the metal matrix and alumina ceramic balls as the reinforcement. To simulate a 3D numerical model, ABAQUS FE code has been *** validation the numerical model by experiments, the effect of ceramic ball weight percentage include 15%, 30% and 45% and the target thickness 20, 25 and 30 mm is considered on the ballistic results like the kinetic energy, residual velocity and depth of penetration. Finally, it was found that the specimen with 25 mm thickness and 30% alumina is optimum based on existing ballistic protection criteria.

关键词： Ballistic Ceramic-reinforced Aluminum matrix Simulation Experiment

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Polythiophene encapsulated inside(13, 0) CNT: A nano-hybrid system

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Chinese Physics B 2014年第6期23卷 422-425页

作者： tayebeh Movlarooy Department of Physics University of Shahrood

We present a first-principles calculation on the electronic and optical properties of a hybrid nanotube system consisting of a （13, 0） single-walled carbon nanotube encapsulated by polythiophene. This hybrid-system represents a complete new type of matter and is known as the peapod system. We analyze bow the polythiophene changes the electronic and optical properties of the nanotube. In particular, we examine new features in the dielectric function due to the transitions between the states of the polymer and the nanotube. The electronic structure of the combined system appears to be a simple superposition of the individual constituents. The density functional theory calculations demonstrate van der Waals interaction as the bonding mechanism between the tube and the encapsulated molecule.

关键词： electronic structure peapod density functional theory polythiophene

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Critical involvement of circular RNAs in virus-associated cancers

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Genes & Diseases 2023年第6期10卷 2296-2305页

作者： Arghavan Zebardast tayebeh Latifi Moein shirzad Golnaz Goodarzi Saeed Ebrahimi Fana Sadra Samavarchi Tehrani Yousef Yahyapour Department of Virology School of Public HealthTehran University of Medical SciencesTehran ***Iran Cellular and Molecular Biology Research Center Health Research InstituteBabol University of Medical SciencesBabol 47176Iran Department of Clinical Biochemistry School of MedicineTehran University of Medical SciencesTehran ***Iran Student Scientific Research Center Tehran University of Medical SciencesTehran ***Iran Infectious Diseases and Tropical Medicine Research Center Health Research InstituteBabol University of Medical SciencesBabol 47176Iran

Virus-related cancer is cancer where viral infection leads to the malignant transformation of the host's infected cells. Seven viruses (e.g., human papillomavirus (HPV), Epstein–Barr virus (EBV), Kaposi's sarcoma herpesvirus (KSHV), Hepatitis B virus (HBV), Hepatitis C virus (HCV), Human T-lymphotropic virus (HTLV), and Merkel cell polyomavirus (MCV)) that infect humans have been identified as an oncogene and have been associated with several human malignancies. Recently, growing attention has been attracted to exploring the pathogenesis of virus-related cancers. One of the most mysterious molecules involved in carcinogenesis and progression of virus-related cancers is circular RNAs (circRNA). These emerging non-coding RNAs (ncRNAs), due to the absence of 5′ and 3′ ends, have high stability than linear RNAs and are found in some species across the eukaryotic organisms. Compelling evidence has revealed that viruses also encode a repertoire of circRNAs, as well as dysregulation of these viral circRNAs play a critical role in the pathogenesis and progression of different types of virus-related cancers. Therefore, understanding the exact role and function of the virally encoded circRNAs with virus-associated cancers will open a new road for increasing our knowledge about the RNA world. Hence, in this review, we will focus on emerging roles of virus-encoded circRNAs in multiple cancers, including cervical cancer, gastric cancer, Merkel cell carcinoma, nasopharyngeal carcinoma, Kaposi cancer, and liver cancer.

关键词： Cancer Circular RNA Neoplasms Oncogenes Viruses

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Preparation of CO2 selective composite membranes using Pebax/CuBTC/PEG-ran-PPG ternary system

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Journal of Energy Chemistry 2017年第3期26卷 530-539页

作者： tayebeh Khosravi Mohammadreza Omidkhah Faculty of Chemical Engineering Tarbiat Modares UniversityP.O.Box 14115-143TehranIran

Three phase PebaxMH 1657/PEG-ran-PPG/CuBTC（polymer/liquid/solid） was successfully deposited as a selective layer on a porous Polysulfone（PSF） support. In fact, the beneficial properties of PEG（high selectivity） with those of PPG（high permeability, amorphous） have been combined with superior properties of mixed matrix membrane（MMMs）. The membranes were characterized by DSC, TGA and SEM, while CuBTC was characterized by COand CHadsorption test. Statistically based experimental design（central composite design, CCD） was applied to analyze and optimize the effect of PEG-ran-PPG（10–50 wt%） and CuBTC（0–20 wt%） mass contents on the COpermeance and CO/CHideal selectivity. Based on the regression coefficients of the obtained models, the COpermeance was notably influenced by PEG-ran-PPG,while CuBTC has the most significant effect on the CO/CHideal selectivity. Under the optimum conditions（PEG-ran-PPG: 32.76 wt% and CuBTC: 20 wt%）, nearly 620% increase in the COpermeance and43% enhancement in the CO/CHideal selectivity was observed compared to the neat Pebax. The effect of pressure（3, 9 and 15 bar） on the pure and mixed gas separation performance of the composite membranes was also investigated. The high solubility of COin the membranes resulted in the enhancement of COpermeability with increase in gas pressure.

关键词： CO2 separation Pebax Composite membrane CuBTC PEG-ran-PPG

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Maximum mass of a hot neutron star with a quark core

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Research in Astronomy and Astrophysics 2011年第4期11卷 471-481页

作者： tayebeh Yazdizadeh Gholam Hossein Bordbar Islamic Azad University Bafgh Branch Department of Physics Shiraz University Research Institute for Astronomy and Astrophysics of Maragha

We have considered a hot neutron star with a quark core, a mixed phase of quark-hadron matter, and a hadronic matter crust and have determined the equation of state of the hadronic phase and the quark phase. We have then found the equation of state of the mixed phase under the Gibbs conditions. Finally, we have computed the structure of a hot neutron star with a quark core and compared our results with those of the neutron star without a quark core. For the quark matter calculations, we have used the MIT bag model in which the total energy of the system is considered as the kinetic energy of the particles plus a bag constant. For the hadronic matter calculations, we have used the lowest order constrained variational formalism. Our calculations show that the results for the maximum gravitational mass of a hot neutron star with a quark core are substantially different from those of a neutron star without the quark core.

关键词： dense matter -- equation of state -- stars fundamental parameters(masses, radii, temperatures)

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Novel in silico EST-SSR markers and bioinformatic approaches to detect genetic variation among peach(Prunus persica L.)germplasm

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Journal of Forestry Research 2020年第4期31卷 1359-1370页

作者： Mehrana Koohi Dehkordi tayebeh Beigzadeh Karim Sorkheh Department of Agronomy Faculty of AgriculturePayame-Noor UniversityP.O.Box 19395-3697TehranIran Department of Agronomy and Plant Breeding Faculty of AgricultureShahid Chamran University of AhvazP.O.Box 61355/144AhvazIran

Because there are thousands of peach cultivars,cultivar classification is a critical step before starting a breeding *** molecular markers such as simple sequence repeats(SSRs)can be *** this study,67 polymorphic primers produced 302 *** values for SI index(1.903)suggested higher genetic variability in the genotype under *** values for observed alleles(Na),expected heterozygosity(He),effective alleles(Ne),Nei’s information index(h),and polymorphic information content(PIC)were 4.5,0.83,5.45,0.83,and 0.81,*** dendrogram constructed based on Jaccard’s similarity coefficients outlined four distinct clusters in the entire *** addition,an analysis of molecular variance(AMOVA)showed that70.68%of the total variation was due to within-population variation,while 29.32%was due to variation among *** to this research,all primers were successfully used for the peach *** EST-SSR markers should be useful in peach breeding programs and other research.

关键词： Expressed sequenced tags(EST) Simple sequence repeats(SSR) Prunus persica L. Genetic diversityl

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Graphene oxide based carbon composite as adsorbent for Hg removal:Preparation, characterization, kinetics and isotherm studies

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Chinese Journal of Chemical Engineering 2017年第9期25卷 1170-1175页

作者： tayebeh Esfandiyari Navid Nasirizadeh Mohammad Dehghani Mohammad Hassan Ehrampoosh Department of Environmental Health Engineering Shaheed Sadoughi University of Medical Sciences Young Researchers and Elite Club Yazd Branch Islamic Azad University

The presence of Hg in the aqueous media is known to cause severe health issues in both humans and *** technologies and especially adsorbents have been applied for its removal. In this study, a graphene oxide–carbon composite(GO–CC) as a new adsorbent was prepared by sol gel procedure and characterized using field emission scanning electron microscopy, BET and EDX. The effects of different variables including solution p H, contact time, adsorbent dose and GO ratio in adsorbent matrix on the removal capacity of Hg were studied. The isotherm data correlated well with the Langmuir isotherm model. Further analysis recommended that the Hg^(2+) adsorption process is governed by the intra-particle and external mass transfer, in which the film diffusion was the rate restrictive step. The presented composite has maximum absorption capacity, q_(max) of 68.8 mg·g^(-1), which is comparable with carbon based adsorbent reported in the previous publications.

关键词： Adsorbent Mercury removal Sol gel Carbon composite

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Central composite design for optimization and formulation of desulphurization of iron ore concentrate using atmospheric leaching process

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Journal of Iron and Steel Research(International) 2018年第1期25卷 57-64页

作者： Ali Mostafavi Hassan Rezvanipour Dariush Afzali tayebeh Shamspur Amir Hajizadehomran Department of Chemistry Shahid Bahonar Universityof Kerman Kerman 84156-83111 Iran Gol-e-Gohar Iron Ore Mining and Industrial Company Sirjan Km 50 of Shiraz road 111/78185 Kerman Iran Department of Environment Institute of Science and HighTechnology and Environmental Sciences GraduateUniversity of Advanced Technology Kerman 76311-33131Iran

Owing to the negative effects of sulphur in iron ore on steelmaking process and environment, a tank leaching process was performed in atmospheric conditions to remove the sulphur from the iron ore concentrate and simultaneously to transform sulphide minerals into useful by-products. To achieve desirable sulphur removal rate and efficiency, central composite design was adopted as a response surface methodology for the optimization and evaluation of the process. A full-quadratic polynomial equation between the sulphur removal and the studied parameters was established to assess the behaviour of sulphur removal as a function of the factors and to predict the results in various conditions. The optimum conditions were obtained based on the variance tests and response surface plots, from which the optimized ranges for each factor resulting in the best response （corresponding to the highest percentage of desulphurization） could be then achieved. The results show that most desirable conditions are atmospheric leaching in 1.39 mol/dm3 nitric acid and 0.88 mol/dm3 sulphuric acid for 47 h. The designed process under the optimized desulphurization conditions was applied to a real iron ore concentrate. More than 75% of the total sulphur was removed via the leaching process. In addition to the desulphurization, the conversion of sulphide-bearing minerals into useful by-products, extraction of valuable metals, and executing the process under atmospheric conditions are the other advantages of the proposed method.

关键词： Desulphurization Iron ore concentrate Sulphide mineral leaching Central composite design Atmosphericleaching process

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