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Nrf2 as a potential target for the treatment of epilepsy

Neural Regeneration Research 2024年第9期19卷 1865-1866页

作者： Prince Kumar Singh tawf.eq shekh-ahmad Institute for Drug Research School of PharmacyFaculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael

Epilepsy is a prevalent chronic brain disorder that is characterized by a persistent predisposition to recurrently generate epileptic seizures and is often associated with cognitive and psychological *** affects approximately 65 million individuals,including both males and females of all ages worldwide,and poses a significant burden on patients,their families,and the health system(Vezzani et al.,2019).

关键词： epilepsy Nrf2

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Stress intensity factors under combined bending and torsion moments

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第1期13卷 1-8页

作者： Al Emran ISMAIL ahmad Kamal ARIFFIN Shahrum ABDULLAH Mariyam Jameelah GHAZALI Mohammed ABDULRAZZAQ Ruslizam DAUD Faculty of Mechanical & Manufacturing Engineering Universiti Tun Hussein Onn Malaysia Faculty of Engineering & Built Environment Universiti Kebangsaan Malaysia School of Mechatronic Engineering Universiti Malaysia Perlis

This paper discusses stress intensity factor （SIF） calculations for surface cracks in round bars subjected to combined torsion and bending loadings. Different crack aspect ratios, a/b, ranging from 0.0 to 1.2 and relative crack depths, a/D, ranging from 0.1 to 0.6 were considered. Since the loading was non-symmetrical for torsion loadings, a whole finite element model was constructed. Then, the individual and combined bending and torsion loadings were remotely applied to the model. The equivalent SIF method, F＊eq, was then used explicitly to combine the individual SIFs from the bending and torsion loadings. A comparison was then carried out with the combined SIF, F＊FE, obtained using the finite element analysis （FEA） under similar loadings. It was found that the equivalent SIF method successfully predicted the combined SIF for Mode I. However, discrepancies between the results determined from the different approaches occurred when Fm was involved. It was also noted that the predicted F＊ EE using FEA was higher than the F＊eq predicted through the equivalent SIF method due to the difference in crack face interactions.

关键词： Stress intensity factor (SIF) Combined loadings Finite element analysis (FEA) Surface cracks Round solid bars

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Determining the Effect of Deprivation on Quality of Life after Total and Unicompartmental Knee Arthroplasty

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Open Journal of Orthopedics 2015年第6期5卷 140-150页

作者： Abid Malik Mudussar Abrar ahmad Justin Peter Cobb Department of Orthopaedics Charing Cross Hospital London UK

Determining the effect of deprivation on quality of life after total and unicompartmental knee arthroplasty Quality of life (QoL) following joint replacement is now a national priority, with every patient being assessed using the Oxford Knee Score. The current literature is conflicted as to whether deprivation has any effect on outcome after knee surgery. The type of surgery is another variable that may determine outcome. We set out to investigate which of these factors was a more powerful predictor of outcome. A prospective trial began where, 68 patients were telephoned, (30 TKA’s and 38 UKA’s). Each were asked a series of questions comprising the Oxford Knee Score (post operation), Imperial Knee Score (post operation), EuroQol-5D (pre and post operation) and individual deprivation questions. This was compared with the deprivation status using Townsend scores. A comparison of total and unicompartmental outcomes were also analysed including cost-effectiveness. No correlation was found between outcome and Townsend scores (p eq-5D (p < 0.05) and the Imperial Knee Score (p < 0.09). This was not reflected in the Oxford Knee Score. UKA’s were also found to be more cost-effective than TKA’s. Deprivation has no major effect on the outcome of knee surgery in London. A clear difference in efficacy exists between TKA’s and UKA’s. Sensitivity of scores needs to be addressed.

关键词： Deprivation Arthroplasty Quality of Life Unicompartmental

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