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Low bone mineral density and the severity of cholestasis in biliary atresia

World Journal of Hepatology 2017年第16期9卷 746-751页

作者： Krittapak Homchan tawatchai chaiwatanarat Wanvisa Udomsinprasert Voranush Chongsrisawat Yong Poovorawan Sittisak Honsawek Center of Excellence in Clinical Virology Department of PediatricsFaculty of MedicineChulalongkorn UniversityKing Chulalongkorn Memorial HospitalThai Red Cross Society Department of Radiology Faculty of MedicineChulalongkorn University Department of Biochemistry Faculty of MedicineChulalongkorn University

AIM To investigate the prevalence of osteopenia and osteoporosis in postoperative biliary atresia(BA) children and the association of bone mineral density(BMD) and biochemical parameters in post Kasai BA subjects. METHODS A total of 70 patients with post Kasai BA were enrolled in this prospective study. The patients were classified into two groups according to their jaundice status. BMD of the lumbar spine was analyzed using dual energyX-ray *** The prevalence of low bone mass(osteopenia and osteoporosis) in BA patients were 51.4%(36 out of 70). Ten patients(35.7%) in the jaundice group and 8 patients(19.0%) in the non-jaundice group had osteopenia. Sixteen patients(57.1%) in the jaundice group and 2 patients(4.8%) in the no jaundice group had osteoporosis. In addition, lumbar spine BMD Z-score was substantially lower in the jaundice BA patients compared with non-jaundice patients. BA subjects with persistent jaundice had significantly lower serum 25-hydroxyvitamin D than those without jaundice. Further analysis revealed that lumbar spine BMD was correlated with age(r = 0.774, P < 0.001), serum albumin(r = 0.333, P = 0.005), total bilirubin(r =-0.476, P < 0.001), aspartate aminotransferase(r =-0.583, P < 0.001), alanine aminotransferase(r =-0.428, P < 0.001), and alkaline phosphatase(r =-0.456, P < 0.001).CONCLUSION Low BMD was associated with biochemical parameters reflecting the severity of cholestasis in post Kasai BA patients.

关键词： Bone mineral density Jaundice Biliary atresia Cholestasis Severity

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Controlled synthesis of magnetic carbon nanoparticles via glycerol/ferrocene co-pyrolysis with magnetic induction

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Particuology 2018年第2期16卷 9-16页

作者： Konrat Kerdnawee Noriaki Sano Hajime Tamon tawatchai Charinpanitkul Center of Excellence in Particle Technology Department of Chemical Engineering Faculty of Engineering Chulalongkorn University Bangkok Thailand Department of Chemical Engineering Graduate School of Engineering Kyoto University Kyoto Japan

We performed a controlled synthesis of magnetic carbon nanoparticles （M-CNPs） via co-pyrolysis of glycerol and ferrocene with magnetic induction. The morphology of the synthesized M-CNPs was confirmed by transmission electron microscopy, and thermogravimetric analysis was used to analyze the carbon and Fe contents. M-CNPs that responded to magnetic stimulation were also examined with an AC-magnetic susceptibility analyzer. Our investigations on the influence of synthesis temperature in the range 700-1000℃ suggested that for an initial glycerol to ferrocene weight ratio of 3：1 and a temperature of 800 ℃ gave the highest yield of M-CNPs. Comparing the synthesis with and without magnetic induction, the controlled synthesis under the influence of magnetic induction shows promise as a method for producing high quality M-CNPs in high yields.

关键词： Carbon nanoparticle Glycerol Co-pyrolysis Magnetic induction

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Dispersion of multi-walled carbon nanotubes in poly(p-phenylene) thin films and their electrical characteristics

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Particuology 2009年第5期7卷 403-407页

作者： Adi Ilcham Amornwong Srisurichan Apinan Soottitantawat tawatchai Charinpanitkul Center of Excellence in Particle Technology Department of Chemical EngineeringFaculty of EngineeringChulalongkorn UniversityBangkokThailand

Dispersion of multi-walled carbon nanotubes in poly（p-phenylene） composite exposed to toluene was experimentally investigated. 3 mg of multi-walled carbon nanotubes with nominal size of 20 nm was compounded with 30 mg of poly（p-phenylene） with the presence of terpineol as binding initiator. To investigate an optimal condition for homogenizing all constituents, ultrasonication with an output power of 750W was employed with compounding time of 3, 10, 20 and 30 min. With FTIR analyses, it could be confirmed that homogeneous composite of multi-walled carbon nanotubes and poly（p-phenylene） could be prepared. SEM analyses were also conducted to examine the dispersion of multi-walled carbon nanotubes in the polymer matrix. Then intrinsic electrical resistance of the composites after being exposed to toluene was also investigated. It was found that the composite film prepared with ultrasonication for 20 min could provide sufficiently sensitive response with respect to varied concentration of toluene.

关键词： Dispersion Carbon nanotube Poly(p-phenylene) Composite Electrical resistance

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Interdisciplinary researches for potential developments of drugs and natural products

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Asian Pacific Journal of Tropical Biomedicine 2017年第4期7卷 378-384页

作者： Arunrat Chaveerach Runglawan Sudmoon tawatchai Tanee Department of Biology Faculty of ScienceKhon Kaen University Genetics and Environmental Toxicology Research Group Khon Kaen University Faculty of Law Khon Kaen University Faculty of Environment and Resource Studies Mahasarakham University

Developments of drugs or natural products from plants are possibly made, simple to use and lower cost than modern *** development processes can be started with studying local wisdom and literature reviews to choose the plants which have long been used in diverse areas, such as foods, traditional medicine, fragrances and *** those data will be associated with scientific researches, namely plant collection and identification, phytochemical screening by gas chromatography-mass spectrometry,pharmacological study/review for their functions, and finally safety and efficiency tests in *** safety testing, in vitro cell toxicity by cell viability assessment and in vitro testing of DNA breaks by the comet assay in human peripheral blood mononuclear cells can be *** active chemicals and functions containing plants were chosen with safety and efficacy for human uses, then, the potential medicinal natural products will be *** on these procedures, the producing cost will be cheaper and the products can be evaluated for their clinical ***, the best and lowest-priced medicines and natural products can be distributed worldwide.

关键词： Cell viability Comet assay Drug development GC–MS

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Two new species of Curcuma (Zingiberaceae) used as cobra-bite antidotes

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植物分类学报 2008年第1期46卷 80-88页

作者： Arunrat CHAVEERACH Runglawan SUDMOON tawatchai TANEE Piya MOKKAMUL Nison SATTAYASAI Jintana SATTAYASAI Faculty of Science Khon Kaen University Khon Kaen 40002 Thailand Faculty of Environment and Resource Studies Mahasarakham University Mahasarakham 44000 Thailand Faculty of Medicine Khon Kaen University Khon Kaen 40002 Thailand

Two new species of Curcuma, C. sattayasaii A. Chaveerach ＆ R. Sudmoon and C. zedoaroides A. Chaveerach ＆ T. Tanee with rhizomes traditionally used for many decades as cobra-bite antidotes are described and illustrated. Curcuma sattayasaii is similar to C. longa L., but differs in rhizome horizontally branching on ground; coma bracts pinkish-white or pinkish-pale green; corolla pale yellow with orange tip; labellum pale orange with an orange central band; anther crest very short, broadly ovate, wider than long. Curcuma zedoaroides is similar to C. zedoaria （Christm.） Roscoe, but differs in rhizome branching pattern; the protruding secondary rhizomes curved down; blades oblong to oblong-lanceolate; peduncle glabrous; fertile and coma bracts glabrous; corolla lobes pale yellow to white, lateral lobe ovate, dorsal lobe broadly ovate. The new taxa have been found in a village of Khon Kaen Province, Northeastern Thailand.

关键词： Curcuma Curcuma sattayasaii A. Chaveerach & R. Sudmoon Curcuma zedoaroides A. Chaveerach & T. Tanee cobra-bite antidote new species Khon Kaen Thailand

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Mediastinal small cell carcinoma with liver and bone marrow metastasis, mimicking lymphoma

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World Journal of Clinical Cases 2015年第10期3卷 915-919页

作者： Napaporn Nawarawong tawatchai Pongpruttipan Pitulak Aswakul Varayu Prachayakul Siriraj GI Endoscopy Center Division of GastroenterologyDepartment of Internal MedicineSiriraj HospitalMahidol University Division of Hematopathology Department of PathologyFaculty of MedicineSiriraj HospitalMahidol University Liver and Digestive Institute Samitivej Sukhumvit Hospital

Primary mediastinal neuroendocrine tumors are a rare malignancy that accounts for < 10% of all mediastinal tumors. The case presented here involves a 52-yearold man who had been suffering for 3 mo from chronic cough, anorexia and substantial weight loss, as well as 2 wk of jaundice prior to his admission. A computed tomography scan showed a 4.3 cm × 6.6 cm mediastinal mass with multiple liver nodules scattered along both hepatic lobes. Endoscopic ultrasound showed a large heterogeneous hypoechoic mass at the mediastinum with multiple target-like nodules in the liver. Fine-needle aspiration specimens revealed numerous, small, round cells with hyperchromatic nuclei, scarce cytoplasm, and frequent mitotic features. Immunohistochemical study revealed positive results for AE1/AE3, CD56 and chromogranin A, with negative findings for synaptophysin, CK20, vimentin, CK8/18 and CD45. The patient was subsequently diagnosed with a poorly differentiated neuroendocrine carcinoma, small cell type. A bone marrow biopsy also revealed extensive involvement by the carcinoma.

关键词： Bone marrow metastasis Liver metastasis Lymphoma Mediastinal mass Neuroendocrine tumor

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Piper protrusum(Piperaceae),a new species from southern Thailand based on morphological and molecular evidence

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Journal of Systematics and Evolution 2011年第5期49卷 468-475页

作者： Runglawan SUDMOON tawatchai TANEE Arunrat CHAVEERACH Department of Biology Faculty of ScienceKhon Kaen University Faculty of Environment and Resource Studies Mahasarakham University

Piper protrusum Chaveer.& Tanee,*** described and *** dominantly comprises three branching types with three different types of leaf blades,bases,and *** critical distinguishing character is the protruded receptacle having a bract and nine *** plants have been discovered in areas of Southern Thailand since 2004 without reproductive *** investigated sites were revisited several times,and an individual with flowers was finally found in July *** analysis of the new species and five similar species is carried out based on DNA *** genetic distances between the new species and five similar species range from 0.25 to 0.35,supporting new species *** data conform to morphological data in validating that it is a new ***,its DNA barcodes have been provided for further identification in case the morphological data is *** sequence data have been submitted to the GenBank database under accession numbers GU980898(rpoB gene),GU980899(rpoC1 gene),and GU980900(psbA-trnH region).

关键词： DNA fingerprint new species Piperaceae Piper protrusum Thailand.

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Three new species of Piperaceae from Thailand

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植物分类学报 2006年第4期44卷 447-453页

作者： CHAVEERACH Arunrat SUDMOON Runglawan TANEE tawatchai MOKKAMUL Piya Department of Biology Faculty of Science Khon Kaen University Khon Kaen 40002 Thailand Department of Biochemistry Faculty of Science Khon Kaen University Khon Kaen 40002 Thailand

Three new species of Piperaceae, Piper dominantinervium A. Chaveerach & P. Mokkamul, P. pilobracteatum A. Chaveerach & R. Sudmoon from southern Thailand, and P. phuwuaense A. Chaveerach & T. Tanee from northeastern Thailand, are described and illustrated. P. phuwuaense is considered rare and endemic to Phu Wua Wildlife Sanctuary. Morphological differences between the new species and related taxa are discussed.

关键词：泰国新种双子叶植物黄花胡椒麻根胡椒科胡椒属

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Geochemical Characteristics and New Eruption Ages of Ruby-Related Basalts from Southeast Kenya

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Journal of Earth Science 2014年第5期25卷 799-821页

作者： tawatchai Chualaowanich Chakkaphan Sutthirat Visut Pisuttha-Arnond Christoph Hauzenberger Chinghua Lo Tongyi Lee Punya Charusiri Department of Geology Chulalongkorn University Patumwan Department of Mineral Resources Rama VI Rd. Ratchathewi Department of Earth Sciences Karlz-Fan University of Graz Department of Geoscience National Taiwan University Department of Earth Science National Taiwan Normal University

Two ruby-related basaltic fields were recently discovered in the southeast region of Kenya, exposed in the Nguu and Ngulai Hills vicinities. These fields host abundant deep-seated xenoliths, including corundum-bearing granulites. The basalts are alkaline affinity having compositions from foidrite to basanite. The Ngulai basalts have a wider range of SiO2（38.2 wt.%-44.8 wt.%） covering those of the Nguu basalts（38.7 wt.%-42.3 wt.%）. This overlapping behavior also holds for other major oxides and trace elements, e.g., Al2O3, Na2 O, K2 O, Cr, Ni, Rb and Ga. The overall OIB-like incompatible patterns with strong K depletion and slight spike of Ti enrichment signatures imply low degrees of partial melting of the upper mantle region source induced under a mantle plume-related process. The K-depletion signature indicates a residual K-bearing phase still retained in the source domain. Chondrite-normalized REE patterns exhibiting strong LREE enrichment without Eu anomalies suggest that plagioclase fractionation is insignificant. New 40Ar/39 Ar ages indicate eruption events occurred during the Pleistocene times, which are around 2 Ma for the Ngulai basalts and 0.9 to 1.6 Ma for the Nguu basalts. Clinopyroxene-basalt thermobarometric calculations yield the equilibrium P-T ranges of -8-29 kbar and 1 200-1 450 ℃.

关键词： ruby-related Cenozoic basalt Ar/Ar age corundum-bearing xenolith Kenya Nguu,Ngulai.

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Adsorption and Ozonation Kinetic Model for Phenolic Wastewater Treatment

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Chinese Journal of Chemical Engineering 2011年第1期19卷 76-82页

作者： Wongsarivej Pratarn TongpremPornsiri Swasdisevi Thanit Charinpanitkul tawatchai Tanthapanichakoon Wiwut National Nanotechnology Center Thailand Science Park Klong Luang Pathumthani 12120 Thailand School of Energy Environment and Materials King Mongkut's University of Technology Thonburi 126 Pracha uztid Rd.Bangkok 1040 Thailand Center of Excellence in Particle Technology Faculty of Engineering Chulalongkorn University Payathai Rd.Wangmai Pathumwan Bangkok 10330 Thailand

A three phase fluidized bed reactor was used to investigate the combined effect of adsorption and oxidation for phenolic wastewater *** solutions containing 10 mg·L 1of phenol and ozone were continuously fed co-currently as upward flow into the reactor at constant flow rate of 2 and 1 L·min 1,*** phenolic treatment results in seven cases were compared：（a）O3 only,（b）fresh granular activated carbon（GAC）,（c） 1st reused GAC,（d）2nd reused GAC,（e）fresh GAC enhanced with O3,（f）1st reused GAC enhanced with O3,and （g）2nd reused GAC enhanced with *** phenolic wastewater was re-circulated through the reactor and its concentration was measured with respect to *** experimental results revealed that the phenolic degradation using GAC enhanced with O3 provided the best *** effect of adsorption by activated carbon was stronger than the effect of oxidation by *** GAC could adsorb phenol better than reused *** cases of adsorption on GAC followed the Langmuir isotherm and displayed pseudo second order adsorption ***,a differential equation for the fluidized bed reactor model was used to describe the phenol concentration with respect to time for GAC enhanced with *** calculated results agree reasonably well with the experimental results.

关键词： adsorption ozonation kinetic model phenol wastewater

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