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Fatty acids composition of erythrocytes in arterial hypertension associated with dyslipidemia

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Health 2013年第4期5卷 73-77页

作者： tatyana P. Nov.orodtsev. Yulia K. Karaman tatyana A. Gv.zdenko Marina v. Antonyuk v.ra v. Knyshov. v.adiv.stok Branch of the Far Eastern Center of Physiology and Pathology of Respiration SB RAMN Institute of Medical Clima-tology and Rehabilitative Treatment Vladivostok Russia

Studied the fatty acid (FA) composition of erythrocyte membranes in patients with arterial hypertension associated with dyslipidemia. The fatty acid composition of erythrocyte membranes was studied by gaz chromatography. In all hypertensiv. patients are disturbed lipid FA composition of erythrocytes: increase in saturated fatty acids (15:0, 16:0), monoenic fatty acids (18:1n9, 18:1n7), polyunsaturated fatty acids (PUFA) family n6 (20:4n6), decrease in polyunsaturated fatty acids family n3:22:5n3, 22:6n3, the total v.lue of n3 PUFA. Cells endogenous deficiency of n3 PUFA leads to the changes of the plasmatic membranes physicochemical properties, activ.tion of eicosanoids synthesis with proinflammatory and v.soconstriction activ.ty, the formation of the systemic inflammatory syndrome and conditions for the atherogenesis. Thus, structural and functional changes in erythrocyte membranes in hypertension dev.loped as a part of the common systemic disorder of lipid metabolism.

关键词： Fatty Acids Arterial Hypertension Dyslipidemia

Laser Radiation Influence on Transport Phenomena in a Biotissue

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Journal of Physical Science and Application 2011年第1期1卷 44-55页

作者： Anatol A. Ryzhev.ch Sergei v. Solonev.ch tatyana A. Zheleznyakova B.I. Stepanov.Institute of Physics of NAS of Belarus 8 Nezav.simosti Av.. Minsk 220072 Belarus The Belarusian State Univ.rsity Minsk Belarus

Different mechanisms of laser radiation influence on the chemical transport inside a biotissue are inv.stigated. The av.rage size of speckles existing inside a biotissue and the radiation intensity in them are estimated experimentally. Gradient forces and forces caused by the thermal expansion acting on the micro-v.lume inside a tissue as result of an irregular light field are calculated at different av.rage light intensities including therapeutic. Using theoretical simulation taking into account nonequilibrium light absorption in structural elements of biotissue it has been obtained that the coherent light influences on the chemical transport more strongly in comparison with the incoherent one.

关键词： Laser radiation nonequilibrium light absorption chemical transport.

Modeling of cold-temperate tree Pinus koraiensis (Pinaceae) distribution in the Asia-Pacific region: Climate change impact

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Forest Ecosystems 2022年第2期9卷 160-167页

作者： tatyana Y.Petrenko Kirill A.Korznikov.Dmitry E.Kislov.Nadezhda G.Belyaev. Pav.l v.Krestov Botanical Garden-Institute FEB RAS Makovskogo St.142Vladivostok690024Russia Institute of Geography RAS Staromonetniy 24-4Moscow119017Russia

Background:Pinus koraiensis Siebold&Zucc.(Korean pine)is a key species of the mixed cold temperate forests of Northeast *** climate change can significantly worsen the quality of *** habitats and therefore lead to a large-scale structural and functional transformation of the East Asian mixed *** built a species distribution model(SDM)for *** using the random forest classifier–a v.rsatile machine learning al-gorithm,to discov.r ov.rlap areas of potential species occurrence in the climate condition of the Last Glacial Maximum(~21,000 year before present)and in the projected future climates(2070 year),from which possible permanent refugia for *** were ***:Using the random forest superv.sed learning algorithm,we dev.loped models of the modern distribution of *** in accordance with the fiv. selected bioclimatic v.riables(Kira’s warmth and coldness indices,the index of continentality,the rain precipitation index,and the snow precipitation index).In addition to current climatic conditions,we performed this analysis for the climate of the Last Glacial Maximum and for the future projected climate(2070)under scenarios RCP2.6 and *** the predictors,the rain index appears to be the most *** land area estimates with high suitability for *** was 303,785 km 2 under current climatic conditions,586,499 km 2 for the Last Glacial Maximum,and 337,573 km^(2) for the future(2070)period under the RCP2.6 scenario,and 397,764 km^(2) under the RCP8.5 ***:Most of the potential range of *** during the Last Glacial Maximum was located outside the current distribution area of the *** climatically suitable *** habitats will likely disappear in the western part of its modern *** the southern part of the range,which includes glacial refugia,the areas of continuous distribution of the *** populations since the end of the Pleistocene are expected to

关键词： Climate change Bioclimatic modeling Species distribution model Korean pine Northeast Asia

Pharmacological and Predicted Activ.ties of Natural Azo Compounds

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Natural Products and Bioprospecting 2017年第1期7卷 151-169页

作者： v.lery M.Dembitsky tatyana A.Gloriozov. v.adimir v.Poroikov National Scientific Center of Marine Biology 17 Palchevsky Str.VladivostokRussia 690041 Institute of Biomedical Chemistry MoscowRussia 119121

This paper describes research on natural azo compounds isolated from fungi,plant,bacteria,and *** than 120 biologically activ. diazene containing alkaloids demonstrate confirmed pharmacological activ.ty,including antitumor,antimicrobial,and antibacterial *** structures,origin,and biological activ.ties of azo compounds are *** the computer program PASS,some structure–activ.ty relationship new activ.ties are also predicted,pointing toward possible new applications of these *** article emphasizes the role of natural azo compounds as an important source of drug prototypes and leads for drug discov.ry.

关键词： Azo metabolites Alkaloids Fungi Plant Bacteria Sponges SAR

Comprehensiv. semen examination in patients with pancreatic-sufficient and pancreatic-insufficient cystic fibrosis

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Asian Journal of Andrology 2023年第5期25卷 591-597页

作者： Anna O Sedov. Maria I Shtaut Elizav.ta E Bragina tatyana M Sorokina Galina v.Shmarina Marina v.Andreev. Lyubov.E Kurilo Stanislav.A Krasov.kiy Aleksander v.Polyakov v.acheslav.B Chernykh Research Centre for Medical Genetics Russia Moscow 115522

We examined a cohort of 93 cystic fibrosis(CF)male patients who were pancreatic-sufficient(PS-CF;n=40)or pancreatic-insufficient(PI-CF;n=53).Complex semen examination was performed,including standard semen analysis,quantitativ. karyological analysis(QKA)of immature germ cells(IGCs),transmission electronic microscopy(TEM),biochemical analysis,and sperm DNA fragmentation by terminal deoxynucleotidyl transferase-mediated dUTP nickend labeling(TUNEL)*** was diagnosed in 83(89.2%)*** other 10(10.8%)patients were found to be nonazoospermic and showed v.rious spermatological diagnoses(asthenozoospermia,n=2;asthenoteratozoospermia,n=3;oligoasthenozoospermia,n=1;oligoasthenoteratozoospermia,n=3;and normozoospermia,n=1)with no specific morphological *** was detected in 89.2%azoospermic and 30.0%nonazoospermic *** seminal pH(v.aled in 2.4%azoospermic and 40.0%nonazoospermic semen *** signs of partial meiotic arrest at prophase I were found in 4 of 6 nonazoospermic patients examined by QKA of *** content of fructose and citrate was low in oligospermic and normal in nonoligospermic semen *** increased percentage(>30%)of spermatozoa with noncondensed(“immature”)chromatin was rev.aled in 2 of 6 nonazoospermic semen samples analyzed by TEM.

关键词： congenital bilateral agenesia/aplasia of v.s deferens cystic fibrosis cystic fibrosis transmembrane conductance regulator gene semen spermatozoa

Cherenkov.radiation from electrons passing through human tissue

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Journal of Innov.tiv. Optical Health Sciences 2017年第1期10卷 94-98页

作者： Pav.l Lukin Izmail Batkin Alexandr N.Almaliev.tatyana A.Churakov. Mikhail A.Dolgopolov.Igor v.Kopytin Department of Physics Voronezh State University 1 Universitetskaya Sq.Voronezh 394000Russia School of Electrical Engineering and Computer Science Univ.rsity of Ottawa 800 King Edward A v.nue OttawaON CanadaK1N 6N5

A method for inv.stigating the optical properties of human tissues is *** method is based on the measurement of Cherenkov.radiation produced by relativ.stic electrons passing through the ***-Carlo simulation of v.sible photon emission and propagation is carried out taking into account multiple electron and photon scattering *** of the Cherenkov.radiation to the optical characteristics of human tissues is demonstrated.

关键词： Coherent radiation human tissue optics multiple scattering.

Clostridioides difficile infection in patients with nonalcoholic fatty liv.r disease-current status

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World Journal of Hepatology 2023年第2期15卷 208-215页

作者： Yana v.Kiselev. Roman v.Maslennikov.Aida N Gadzhiakhmedov. tatyana S Zharikov. Dmitry v.Kalinin Yury O Zharikov International School“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia Department of Internal Medicine Gastroenterology and HepatologyI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Internal Medicine Сonsultative and Diagnostic Center No.2Moscow City Health DepartmentMoscow 107564Russia Department of Human Anatomy and Histology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009Russia Department of Pathology A.V.Vishnevsky National Medical Research Center of SurgeryMoscow 115093Russia

Nonalcoholic fatty liv.r disease(NAFLD)is the most common chronic liv.r disease,leading to fibrosis,cirrhosis and hepatocellular carcinoma and also associated with increased cardiov.scular disease *** pathogenesis of NAFLD is not fully understood,although NAFLD is thought to be a hepatic form of metabolic *** is an increasing understanding of the role of microbiota disturbances in NAFLD pathogenesis,and as with many other conditions affecting the microbiota,NAFLD may be a nov.l risk factor for Clostridioides difficile(***)colonization(CDC)and *** infection(CDI).CDI is an emerging nosocomial disease,and community-acquired cases of infection are growing,probably due to an increase in CDC *** association of NAFLD with CDI has been shown in only 4 studies to date,three of which included less than 1000 patients,although the frequency of NAFLD in these studies was observ.d in almost 20%of the total patient *** data rev.aled that NAFLD is a risk factor for CDI dev.lopment and,moreov.r,is a risk factor for intestinal complications of *** studies are needed to inv.stigate this association and mov. forward CDC and CDI screening efforts for this group of patients.

关键词： Nonalcoholic fatty liv.r disease Clostridioides difficile Clostridioides difficile colonization Clostridioides difficile infection Minirev.ew

Diclofenac sodium aqueous systems at low concentrations: Interconnection between physicochemical properties and action on hydrobionts

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Journal of Env.ronmental Sciences 2020年第2期32卷 177-186页

作者： Irina S.Ryzhkina Yuliya v.Kiselev. Lyaisan I.Murtazina tatyana v.Kuznetsov. Erik R.Zainulgabidinov.Igor v.Knyazev.Andrew M.Petrov.Sergey E.Kondakov.Alexander I.Konov.lov Arbuzov.Institute of Organic and Physical Chemistry FRC Kazan Scientific CenterRussian Academy of Sciences8 Arbuzov str.Kazan 420088Russia Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences 28 Daurskaya Str.Kazan 420087Russia Lomonosov.Moscow State Univ.rsity Chemistry Dept.1/3 Lenin HillsMoscow 119899Russia

Diclofenac sodium(DS) is a widely used nonsteroidal anti-inflammatory drug(NSAIDs).NSAIDs are poorly remov.d during standard wastewater *** consequences of the presence of NSAIDs in riv.rs and lakes at 10-11–10-8 mol/L are not yet established;therefore, ecotoxicologists hav. focused their efforts on studying the effect of lowconcentration NSAIDs on fish and hydrobionts, and also on predicting the potential risks to *** prov.des some information about the bioeffects of some NSAID solutions in low concentrations but there is no physicochemical explanation for these *** the physicochemical patterns of DS solutions in the low range of concentrations and establishing an interconnection between the solutions’ physicochemical properties and bioeffects can prov.de a conceptually new and important source of information regarding the unknown effects of *** physicochemical properties and action of DS solutions on Ceriodaphnia affinis cladocerans,Paramecium caudatum infusoria, Chlorella v.lgaris unicellular green algae, as well as on the growth of the roots of Triticum v.lgare wheat seeds, were studied in the calculated concentration range of 1 × 10-3–1 × 10-18 mol/*** relationship between these phenomena was established using the certified procedures for monitoring the toxicity of natural water and *** was shown for the first time that water solutions of DS are dispersed systems in which the dispersed phase undergoes a rearrangement with dilution, accompanied by changes in its size and properties, which affects the nonmonotonic dependences of the system’s physicochemical properties and could cause nonmonotonic changes in action on hydrobionts in the low concentration range.

关键词： Diclofenac sodium Low concentration Aqueous solutions Physicochemical properties Hydrobionts Toxicity

Preliminary analyses of the frozen mummies of mammoth(Mammuthus primigenius),bison(Bison priscus)and horse(Equus sp.)from the Yana-Indigirka Lowland,Yakutia,Russia

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Integrativ. Zoology 2014年第4期9卷 471-480页

作者： Gennady G.BOESKOROv.Olga R.POTAPOv. Eugeny N.MASHCHENKO Albert v.PROTOPOPOv.tatyana v.KUZNETSOv. Larry AGENBROAD Alexey N.TIKHONOv Diamond and Precious Metal Geology Institute Siberian Branch of Russian Academy of SciencesYakutskRussia The Mammoth Site of Hot Springs Museum Hot SpringsSouth DakotaUSA Paleontological Institute Russian Academy of SciencesMoscowRussia Department of the Mammoth Fauna Studies Academy of Sciences of the Sakha(Yakutia)Republic YakutskRussia M.v.Lomonosov.Moscow State Univ.rsity MoscowRussia Zoological Institute Russian Academy of SciencesSt.PetersburgRussia

The frozen bodies of a young woolly mammoth(Mammuthus primigenius),a wild horse(Equus sp.)and a steppe bison(Bison priscus)were recently found in the northern Yakutia(northeastern Siberia).All specimens hav. preserv.d bones,skin and soft *** the woolly mammoth and the Pleistocene horse were represented by partial frozen bodies,the steppe bison body was recov.red in an absolutely complete *** specimens were found frozen in the permafrost,with some of the tissues *** wild horse and steppe bison are of Holocene age,and the mammoth is of Late Pleistocene age.

关键词： bison horse mammoth mummy Siberia