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Local inflammatory response to gastroesophageal reflux:Association of gene expression of inflammatory cytokines with esophageal multichannel intraluminal impedance-pH data

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World Journal of Clinical Cases 2022年第26期10卷 9254-9263页

作者： sergey Morozov tatyana sentsova Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Hospital Pediatrics No.2 Russian National Research Medical University named after N.I.PirogovMoscow 117997Russia

BACKGROUND Gene expression of inflammatory cytokines may take part in the pathophysiology of different forms of gastroesophageal reflux disease(GERD).AIM To explore gene expression of inflammatory cytokines in esophageal mucosa in patients with erosive esophagitis(EE)and non-erosive forms of GERD(NERD)and its association with data of esophageal multichannel intraluminal impedancepH(MII-pH)*** This was a single-center prospective *** mucosa samples were taken from the lower part of the esophagus during *** of interleukin(IL)-1β,IL-10,IL-18,tumor necrosis factorα(TNFA),toll-like receptor 4(TLR4),GATA binding protein 3(GATA3),differentiation cluster 68(CD68)andβ-2 microglobulin genes in esophageal mucosa was assessed with ImmunoQuantex ***-pH measurements were performed on all the *** of GERD was confirmed by the results of the MII-pH *** on the endoscopy,patients were allocated to the groups of EE and *** control group consisted of non-symptomatic subjects with normal endoscopy and MII-pH *** used nonparametric statistics to compare the differences between the *** of expression of the mentioned genes with the results of the MII-pH data was assessed with spearman’s rank *** Data from 60 patients with GERD and 10 subjects of the control group were available for the *** expression of IL-18(5.89±0.4 vs 5.28±1.1,P=0.04)and GATA3(2.92±0.86 vs 2.23±0.96,P=0.03)was found in the EE group compared to *** of IL-1β,IL-18,TNFA,and TLR4 was lower(Psure correlated with the expression of IL-1β(spearman’s rank r=0.29),IL-18(r=0.31),TNFA(r=0.35),GATA3(r=0.34),TLR4(r=0.29),and CD68(r=0.37).Mean esophagealрНcorrelated inversely with the expression of IL-18,TNFA,GATA3,TLR4,and *** association of gene expression with the number of gastroesophageal refluxes was ***

关键词： Gastroesophageal reflux disease Gene expression Cytokines Erosive esophagitis Non-erosive gastroesophageal reflux disease Esophageal multichannel intraluminal impedance-pH Gastroesophageal reflux

Growth rate of CO_(2) hydrate film on water-oil and water-gaseous CO_(2) interface

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Chinese Journal of Chemical Engineering 2023年第4期56卷 266-272页

作者： tatyana P.Adamova sergey s.skiba Andrey Yu.Manakov sergey Y.Misyura Kutateladze Institute of Thermophysics sB RAs Lavrentiev Ave.1Novosibirsk 630090Russian Federation

It is known that injection of carbon dioxide into the petroleum reservoir(CO_(2) flooding) is one of the effective methods for enhanced oil recovery. CO_(2) flooding may be complicated by formation of CO_(2) hydrate plugs. It makes topical investigation of CO_(2) hydrate formation in the system gaseous CO_(2)-oil-water. In this work, the growth rates of carbon dioxide hydrate films at the water-oil as well as the water-gas interface are studied in the pressure range of 2.30-3.04 MPa and at temperatures between -5.4 and 5.0℃. It is found that the growth rate for the water-oil interface is 3.5 times lower than that for the water-gas interface with carbon dioxide. It is hypothesised that the observed decrease in the growth rate is related to the mechanical resistance of the oil components adsorbed on the interface to the growth of the hydrate film. The growth rate of the film has been shown to depend on the experimental procedure,most likely due to the different initial concentrations of carbon dioxide in the aqueous solutions.

关键词： Gas hydrate Oil Carbon dioxide Growth rate Hydrate film

Mid-Miocene thermal impact on the lithosphere by sub-lithospheric convective mantle material:Transition from high-to moderate-Mg magmatism beneath Vitim Plateau,siberia

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Geoscience Frontiers 2017年第4期8卷 753-774页

作者： Irina Chuvashova sergei Rasskazov tatyana Yasnygina Institute of the Earth's Crust Siberian Branch of RAS Irkutsk state University

High-Mg lavas are characteristic of the mid-Miocene volcanism in Inner *** the Vitim Plateau,small volume high-Mg volcanics erupted at 16-14 *** were followed with voluminous moderate-Mg lavas at 14-13 *** the former unit,we have recorded a sequence of（1） initial basaltic melts,contaminated by crustal material,（2） uncontaminated high-Mg basanites and basalts of transitional（K-Na-K） compositions,and（3） picrobasalts and basalts of K series;in the latter unit a sequence of（1） initial basalts and basaltic andesites of transitional（Na-K-Na） compositions and（2） basalts and trachybasalts of K-Na *** pressure estimation,we infer that the high-Mg melts were derived from the sublithospheric mantle as deep as 150 km,unlike the moderate-Mg melts that were produced at the shallow *** 14-13 Ma rock sequence shows that initial melts equilibrated in a garnet-free mantle source with subsequently reduced degree of melting garnet-bearing *** melting of relatively depleted lithospheric material,evidenced by mantle xenoliths,was involved in melting,*** suggest that the studied transition from high-to moderate-Mg magmatism was due to the mid-Miocene thermal impact on the lithosphere by hot sub-lithospheric mantle material from the Transbaikalian low-velocity（melting） domain that had a potential temperature as high as 1510℃.This thermal impact triggered rifting in the lithosphere of the Baikal Rift Zone.

关键词： Volcanism Geodynamics Cenozoic Asia Asthenosphere Lithosphere

Fundamentals of Presbyopia: visual processing and binocularity in its transformation

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Eye and Vision 2018年第1期5卷 1-10页

作者： Olga I.Rozanova Andrey G.shchuko tatyana s.Mischenko Irkutsk branch of s.Fyodorov Eye Microsurgery Federal state Institution IrkutskRussian Federation Irkutsk state Medical University IrkutskRussian Federation

Background:The accommodation has considerable interactions with the pupil response,vergence response and *** transformation of visual reception processing and the changes of the binocular cooperation during the presbyopia development are still poorly ***,the regularities of visual system violation in the presbyopia formation need to be *** study aims to reveal the transformation of visual reception processing and to determine the role of disturbances in binocular interactions in presbyopia ***:This study included 60 people with emmetropic refraction,uncorrected distance visual acuity 1.0 or higher(decimal scale),normal color perception,without concomitant *** first group consisted of 30 people(from 18 to 27 years old)without presbyopia,the second cohort comprised 30 patients(from 45 to 55 years old)with *** eyeball anatomy and optics were evaluated using ultrasound biomicroscopy,aberrometry,and *** functional state of the visual system was investigated under monocular and binocular *** registration of the disparate fusional reflex limits was performed by the original technic using a diploptic device which facilitated investigation of the binocular interaction under natural conditions without the accommodation response,but with the different vergence *** disparate fusional reflex was analyzed using the proximal and distal fusion borders,and the convergence and divergence fusion *** calculation of the area of binocularity field was performed in ***:The presbyopia formation is characterized by a change in an intraocular anatomy,optics,visual processing,and *** processes of binocular interaction inhibition make a significant contribution to the misalignment of the visual *** modification of the proximal,distal and convergence fusion borders was *** was revealed that 87%of the presbyopic patients had binocularity sh

关键词： Presbyopia Binocularity Visual processing Visual reception

Considerations for hematopoietic stem cell transplantation in primary immunodeficiency disorders

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World Journal of Transplantation 2019年第3期9卷 48-57页

作者： tatyana Gavrilova Division of Allergy and Immunology Montefiore Medical Center

Primary immunodeficiency disorders (PIDs) result from inborn errors in *** to infections and oftentimes severe autoimmunity pose life-threatening risks to patients with these *** cell transplant (HCT) remains the only curative option for *** combined immunodeficiency disorders (sCID) most commonly present at the time of birth and typically require emergent HCT in the first few weeks of *** poses an unusual challenge for *** source and conditioning regimen often impact the outcome of immune reconstitution after HCT in *** use of matched or unmatched, as well as related versus unrelated donor has resulted in variable outcomes for different subsets of ***, there is significant variability in the success of engraftment even for a single patient’s lymphocyte *** certain cell lines do well without a conditioning regimen, others will not reconstitute unless conditioning is *** decision to proceed with a conditioning regimen in an already immunocompromised host is further complicated by the fact that alkylating agents should be avoided in radiosensitive *** manuscript reviews some of the unique elements of HCT in PIDs and evidence-based approaches to transplant in patients with these rare and challenging disorders.

关键词： Primary immunodeficiency disorders Hematopoietic stem cell transplant Autoimmunity Conditioning regimens Engraftment

strengthening long-term embankments maintained on permafrost soils

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Research in Cold and Arid Regions 2017年第3期9卷 317-320页

作者： Evgeny s.Ashpiz tatyana s.Vavrinyuk Moscow state University of Railway Engineering of Emperor Nicholas II The group of companies "MIAKOM"

An analysis of the reasons for the displacements of long-term embankments maintained on permafrost soils indicates that they mainly occur due to plastic deformations in the layer of seasonal freezing and thawing;therefore,the reconstruction of permafrost is not effective in this *** is proposed to strengthen these embankments with the help of using jet technology for cementation of the top layer of the *** approach is considered through the example of the deforming embankment on 6,278 km of the Turinskaya-Karymskaya section of the Trans-siberian Railway.

关键词： embankment permafrost roadbeds temperature forecast stress-strain state jet technology

Report of the restudy of the defined global stratotype of the base of the silurian system

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Episodes 2008年第3期31卷 315-318页

作者： Jiayu Rong Michael Melchin s. Henry Williams tatyana N. Koren Jacques Verniers sKL Nanjing Institute of Geology and Palaeontology Chinese Academy of Sciences 210008 Nanjing PRC Department of Geology St. Francis Xavier University Antigonish NS B2G 2W5 Canada Petro-Canada Oil and Gas 150 - 6th Avenue SW Calgary AB T2P 3E3 Canada All Russian Geological Research Insfitute-VsEGEI Sredny pr. 74 199026 St. Petersburg Russia Research Unit Palaeontology Ghent University Krijgslaan 281/S 8 2000 Ghent Belgium

The Global stratotype section and Point （GssP） for the base of the silurian system was defined in 1985. since that time, a number of researchers have suggested that this section has serious deficiencies for use as a GssP. As a result, in 2000, the subcommission on silurian stratigraphy （sss） proposed undertaking a formal restu@ of this GssP, which was subsequently approved by the International Commission of stratigraphy （ICs）. The result of this restudy was the formal proposal that the current GssP, at 1.6 m above the base of the Birkhill shale, at Dob＇s Linn, scotland, should be maintained as the same locality and stratigraphic level, but the bios- tratigraphical definition of the boundary should be revised. The previously defined, basal silurian grapto- lite zone, the Parakidograptus acuminatus Zone, should be subdivided into a lower Akidograptus ascensus Zone and a higher E acuminatus Zone. The base of the A. ascensus Zone, marked by the first appearance of A. ascensus, should be regarded as the biostratigraphic mark for the base of the silurian. This proposal has now been formally approved by the sss and ICs, and ratified by International Union of Geological sciences. This is the first GssP to undergo formal restudy and redefini- tion, and the proposal also included a recommended procedure for restudy of GssPs.

关键词：全球层形志留纪地质学研究项目

structure-activity relationship in water-gas shift reaction over gold catalysts supported on Y-doped ceria

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Journal of Rare Earths 2019年第4期37卷 383-392页

作者： tatyana Tabakova Lyuba Ilieva Ivan Ivanov Maela Manzoli Rodolfo Zanella Petya Petrova Zbigniew Kaszkur Institute of Catalysis Bulgarian Academy of Sciences Department of Drug science and Technology & Centre for Nanostructured Interfaces and surfaces University of Turin Centro de Ciencias Aplicadas y Desarrollo Tecnologico Universidad Nacional Autonoma de Mexico Institute of Physical Chemistry PAS

The utilization of pure hydrogen as an energy source in fuel cells gave rise to renewed interest in developing active and stable water-gas shift catalysts. Gold catalysts have proven to be very efficient for water-gas shift reaction at low temperature. The aim of the present study was to investigate the effect of:(i) different preparation methods(impregnation and coprecipitation) to obtain a modified ceria support,and(ii) the amount of Y_2 O_3(1.0 wt%, 2.5 wt%, 5.0 wt% and 7.5 wt%) as dopant on the water-gas shift activity of Au/CeO_2 catalysts. An extended characterization by means of s_(BET), XRD, HRTEM/HAADF, FTIR,H_2-TPR and CO-TPR measurements in combination with careful evaluation of the catalyst behavior allowed to shed light on the parameters governing the water-gas shift activity. The catalysts show very high activity(>90% CO conversion) in the temperature range 180-220 ℃,with a slightly better performance of the gold catalysts on supports prepared by impregnation. The decreased activity with increasing Y_2 O_3 concentration is related to the hindering of oxygen mobility due to ordering of surface oxygen vacancies in vicinity of segregated Y^(3+). The effect of catalyst pre-treatments and the stability of the best performing samples were examined as well.

关键词： Gold catalyst Water gas shift reaction Doped ceria Yttrium Hydrogen production Rare earths

Monitoring cellular metabolism of 3T3 upon wild type E. coli infection by mapping NADH with FLIM

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Chinese Optics Letters 2010年第10期8卷 931-933页

作者： tatyana Buryakina Pin-Tzu su Vladimir Gukassyan Wan-Jr syu Fu-Jen Kao Institute of Biophotonics National Yang-Ming University Institute of Microbiology and Immunology National Yang-Ming University Department of Photonics National Sun Yat-Sen University

Fluorescence lifetime imaging microscopy （FLIM） has gained popularity as a sensitive technique to monitor the functional/conformational states of reduced nicotinamide adenine dinucleotide （NADH）, one of the main compounds of oxidative phosphorylation. In this letter, we apply the technique to characterize the metabolic changes in mouse embryonic fibroblast 3T3 cells upon bacterial infection. A gradual shortening of the decaying time constants in both the short and the long lifetime components of NADH＇s autofluorescence is detected. The ratio of the short and the long lifetime components＇ relative contributions, however, shows a rapid increase, indicating the rise of cellular metabolic activity over the course of infection.

关键词： Amides Cell culture Phosphorylation Tissue