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Molecular pathways of liver regeneration:A comprehensive review

World Journal of Hepatology 2021年第3期13卷 270-290页

作者： Yana V Kiseleva sevak Z Antonyan tatyana s zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov International school“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Emergency surgical Gastroenterology N.V.Sklifosovsky Research Institute for Emergency MedicineMoscow 129010Russia Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119048Russia Laboratory of Minimally Invasive surgery A.I.Evdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Pathology Department A.V.Vishnevsky National Medical Research Center of Surgery of the Russian Ministry of HealthcareMoscow 117997Russia

The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its *** knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute *** liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver *** current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic *** studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases.

关键词： Liver regeneration Molecular pathways Hepatic progenitor cells Cytokines Micro ribonucleic acid Partial hepatectomy

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Clostridioides difficile infection in patients with nonalcoholic fatty liver disease-current status

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World Journal of Hepatology 2023年第2期15卷 208-215页

作者： Yana V Kiseleva Roman V Maslennikov Aida N Gadzhiakhmedova tatyana s zharikova Dmitry V Kalinin Yury O Zharikov International school“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia Department of Internal Medicine Gastroenterology and HepatologyI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Internal Medicine Сonsultative and Diagnostic Center No.2Moscow City Health DepartmentMoscow 107564Russia Department of Human Anatomy and Histology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009Russia Department of Pathology A.V.Vishnevsky National Medical Research Center of SurgeryMoscow 115093Russia

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease,leading to fibrosis,cirrhosis and hepatocellular carcinoma and also associated with increased cardiovascular disease *** pathogenesis of NAFLD is not fully understood,although NAFLD is thought to be a hepatic form of metabolic *** is an increasing understanding of the role of microbiota disturbances in NAFLD pathogenesis,and as with many other conditions affecting the microbiota,NAFLD may be a novel risk factor for Clostridioides difficile(***)colonization(CDC)and *** infection(CDI).CDI is an emerging nosocomial disease,and community-acquired cases of infection are growing,probably due to an increase in CDC *** association of NAFLD with CDI has been shown in only 4 studies to date,three of which included less than 1000 patients,although the frequency of NAFLD in these studies was observed in almost 20%of the total patient *** data revealed that NAFLD is a risk factor for CDI development and,moreover,is a risk factor for intestinal complications of *** studies are needed to investigate this association and move forward CDC and CDI screening efforts for this group of patients.

关键词： Nonalcoholic fatty liver disease Clostridioides difficile Clostridioides difficile colonization Clostridioides difficile infection Minireview

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Identifying sex-specific injury predictors as a key factor in maintaining optimal physical activity levels

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World Journal of Orthopedics 2023年第3期14卷 146-154页

作者： Maria V sankova Vladimir N Nikolenko Marine V Oganesyan Andjela D Vovkogon Aida N Gadzhiakhmedova tatyana s zharikova Yury O Zharikov Department of Human Anatomy and Histology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009Russia Department of Normal and Topographic Anatomy Lomonosov Moscow State UniversityMoscow 119991Russia European Osteopathic Clinical Center of the Moscow Branch of the“Medical Academy of Osteopathic Education” Saint Petersburg 199106Russia Institute of Clinical Medicine I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia

BACKGROUND Optimal physical activity is known to reduce cardiovascular,respiratory and endocrine system diseases and,as a consequence,improve quality of *** important risk factor for reinjuries during normal exercise is the initial connective tissue *** variety of clinical dysplastic manifestations significantly complicate the timely diagnosis of this *** To establish pathognomonic sex-specific dysplasia phenotypes that indicate a particular sensitivity to physical *** The study involved 117 participants with recurrent musculoskeletal injuries that occurred during normal *** were 67 women(57.26%)and 50 men(42.74%),which made it possible to compare the presence of the identified signs between sexes.A validated questionnaire was used to screen their connective tissue *** Ranking the most commonly revealed dysplasia signs depending on their clinical significance made it possible to establish pathognomonic sex-specific phenotypes that indicated a particular susceptibility to *** programs of optimal physical activity are necessary for men with chest deformities,flat-valgus feet,dolichostenomelia,arachnodactylia,hemorrhoids,abdominal muscle diastasis and recurrent *** women,special sensitivity to physical exertion was associated with a combination of signs such as asthenic body,joint hypermobility,overly soft auricles,thin hyperelastic skin,atrophic striae,telangiectasias and varicose *** particular importance were universal signs such as gothic palate,scoliosis,kyphosis,leg deformities,temporomandibular joint crunching,and moderate to high *** Participants’connective tissue condition should be considered when designing optimal physical activity *** the established sex-specific dysplasia phenotypes will allow timely optimization of training loads,thus reducing the risk of injury.

关键词： Injury risk Physical activity Connective tissue condition sex-specific dysplasia phenotypes Clinical dysplastic manifestations

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Risk modeling of femoral neck fracture based on geometric parameters of the proximal epiphysis

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World Journal of Orthopedics 2022年第8期13卷 733-743页

作者： Anna D shitova Olga N Kovaleva Anna V Olsufieva Inchekhanum A Gadzhimuradova Dmitry D Zubkov Mikhail O Kniazev tatyana s zharikova Yury O Zharikov International school“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991MoscowRussia Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009MoscowRussia Department of Biomedical Disciplines of the Faculty of Medicine Nonstate Educational Private Institution of Higher Education"Moscow Financial and Industrial University“Synergy”Moscow 125190MoscowRussia Institute of Clinical Medicine I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991MoscowRussia

BACKGROUND Fractures of the proximal femur epiphysis are problematic for state health care because they are associated with severe medical and social problems and high morbidity and mortality *** To model the potential risk of hip fracture via femur geometric *** seventy educational cadaveric femurs from people aged 14 to 80 years,10 X-ray images from the records of the Human Anatomy Department and 10 X-ray images from the Department of Traumatology,Orthopedics and Disaster surgery of sechenov University,were *** parameters of the fractured bone were measured using images captured with a Canon d60 *** projection values of the proximal epiphysis of the cadaveric femurs and geometric parameters of the bones shown in the X-ray images were measured with Autodesk software(AutoCAD 2018).Analysis of the video frames showing bone rotation reveal that the greater trochanter can be inscribed in a parallelepiped,where one of the faces is parallel to the plane of view in the frontal standard projection and is *** angle of bone rotation obtained by turning the cube corresponded to the angle measured with the second *** reliable method of calculating the rotation of the bone relative to the anterior projection was employed in subsequent *** geometric parameters of the femur were measured using X-ray images according to the proposed *** The geometric parameters of 70 femurs were analyzed,and correlation coefficients were *** measurement results were compared with those reported by other *** potential influence of femur geometry on force distribution in the proximal epiphysis of the femur was described,and a 2-dimensional model of the femur epiphysis associated with minimal neck fracture risk was *** assessment of the geometric parameters of the femoral epiphysis indicated the greatest risk of a varus fracture of the neck if the angle of the minimal resistance zone(AMRZ)

关键词： Fracture Proximal epiphysis of femur Risk Traumatology Hip neck Risk assessment scale

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structure and heterogeneity of habitat determine diet of predators despite prey abundance:similar response in Long-eared,short-eared Owls and Common Kestrels

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Avian Research 2023年第1期14卷 54-61页

作者： tatyana Kovinka Alexander sharikov tatyana Massalskaya sergey Volkov Zoology and Ecology Department Moscow State Pedagogical UniversityKibalchicha Str.6-3129164MoscowRussid severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscow119071Russia

According to one of the theses of optimal foraging theory,main prey species abundance in the hunting area is the main factor determining the diet and habitat choices of birds of *** other factors can also be *** habitat structure influences the predators’diets as *** this study we examined the influence of habitat structure on diet compositions of three species of birds:Long-eared Owl(Asio otus),short-eared Owl(***)and Common Kestrel(Falco tinnunculus).The study was carried out from 2007 to 2019 in a 48 km2area of the Crane’s Homeland Reserve,Moscow Region,*** habitat structures of model species’hunting territories(ratio of different types of landscape elements)were classified in module"semi-Automatic Classification Plugin"based on the QGIs.A boosted regression tree analysis identified that the share of the main prey species in the diet is primarily determined by the landscape structure of hunting *** largest share of Common Vole(Microtus arvalis)in birds’diet was determined by the shrubs area(15%of hunting area),the meadow area(75%),the habitat heterogeneity(70%)and the arable land area(5%).The same predictors determined the largest share of Root Vole(Microtus oeconomus):the shrubs area 25%,the meadow area 70%,and the arable land area 3%.The annual mean abundance of prey species did not determine their importance in the diet of birds of ***,the main prey abundance in the hunting area is not a determining factor for the formation of diet composition of birds of prey.

关键词： Birds of prey diet Boosted regresion tnee Habitat strnocture efiect Prey sbundance

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A word about the teacher

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Research in Astronomy and Astrophysics 2019年第3期19卷 35-46页

作者： Galina N.Dryomova Olga V.Eretnova tatyana s.Polushina Russian Federal Nuclear Centre named after academician E.I.Zababakhin Chelyabinsk state University Ural Federal University named after the First President of Russia B.N.Yeltsin

This is a memorial report on the biography and scientific heritage of M.A. svechnikov — an outstanding scientist and teacher, the founder of the Ural school of close binary stars and the author of the classification ... 详细信息

关键词： catalogs photometric-spectroscopic-stars eclipsing variables classification scheme-close binary stars

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Mathematical modeling of nanodispersed hardening of FCC materials

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Acta Metallurgica sinica(English Letters) 2018年第12期31卷 1297-1304页

作者： Oleg Matvienko Olga Daneyko tatyana Kovalevskaya National Research Tomsk state University TomskRussia 634050 Tomsk state University of Architecture and Building TomskRussia 634003

The plastic deformation of the pipe made of Cu-based alloy hardened by incoherent nanoparticles and subjected to theuniform internal pressure was investigated. The limits of elastic and plastic resistance are determined. The insignificantexcess in the limit of the elastic resistance enables the plastic deformation in the most part of the pipe wall. The densities ofshear-forming dislocations and prismatic dislocation loops are higher in alloys strengthened with coarse particles than inalloys strengthened with fine particles. At small distances between the strengthening particles, this effect is the mostpronounced.

关键词： Deformation Dislocation Dispersion-strengthening - Nanoparticles Hardening stress strain Elastic-plastic deformation Pipe

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Irrigation erosion of irrigated soils in the foothills of southern Kazakhstan

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Journal of Arid Land 2013年第2期5卷 166-171页

作者： Abdulla s sAPAROV Enadiy K МIRZAKEEV tatyana M sHARYPOVA Galymzhan A sAPAROV Jilili ABUDUWAILI Kazakh Research Institute of soil science and Agrochemistry named after Uspanov Almaty 050060 Kazakhstan state Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geography Chinese Academy of SciencesUrumqi 830011 China

Abstract： This paper presented the results from the study of irrigation erosion of irrigated lands in southern Ka- zakhstan. The main purpose of the work is the conservation of the fertility of irrigated soils, and then the soils of the upper, middle and lower sections of the slopes at the experimental site were studied. Based on field investigations, authors studied the water resistance of aggregates of gray-brown soils and light gray soils before and after irrigation and qualitative indicators of changes in physical and chemical properties of structured soils in irrigation were de- termined by conventional methods of soil research. The results indicated that the changes in the physical properties of soils by using polymeric compounds created a fundamentally new opportunity to control water erosion of soils.

关键词： irrigation erosion furrow irrigation structure-forming polymers deformation of furrows permissible water speed aggregate water stability

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Growth rate of CO_(2) hydrate film on water-oil and water-gaseous CO_(2) interface

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Chinese Journal of Chemical Engineering 2023年第4期56卷 266-272页

作者： tatyana P.Adamova sergey s.skiba Andrey Yu.Manakov sergey Y.Misyura Kutateladze Institute of Thermophysics sB RAs Lavrentiev Ave.1Novosibirsk 630090Russian Federation

It is known that injection of carbon dioxide into the petroleum reservoir(CO_(2) flooding) is one of the effective methods for enhanced oil recovery. CO_(2) flooding may be complicated by formation of CO_(2) hydrate plugs. It makes topical investigation of CO_(2) hydrate formation in the system gaseous CO_(2)-oil-water. In this work, the growth rates of carbon dioxide hydrate films at the water-oil as well as the water-gas interface are studied in the pressure range of 2.30-3.04 MPa and at temperatures between -5.4 and 5.0℃. It is found that the growth rate for the water-oil interface is 3.5 times lower than that for the water-gas interface with carbon dioxide. It is hypothesised that the observed decrease in the growth rate is related to the mechanical resistance of the oil components adsorbed on the interface to the growth of the hydrate film. The growth rate of the film has been shown to depend on the experimental procedure,most likely due to the different initial concentrations of carbon dioxide in the aqueous solutions.

关键词： Gas hydrate Oil Carbon dioxide Growth rate Hydrate film

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Local inflammatory response to gastroesophageal reflux:Association of gene expression of inflammatory cytokines with esophageal multichannel intraluminal impedance-pH data

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World Journal of Clinical Cases 2022年第26期10卷 9254-9263页

作者： sergey Morozov tatyana sentsova Department of Gastroenterology Hepatology and NutritionFederal Research Center of NutritionBiotechnology and Food SafetyMoscow 115446Russia Department of Hospital Pediatrics No.2 Russian National Research Medical University named after N.I.PirogovMoscow 117997Russia

BACKGROUND Gene expression of inflammatory cytokines may take part in the pathophysiology of different forms of gastroesophageal reflux disease(GERD).AIM To explore gene expression of inflammatory cytokines in esophageal mucosa in patients with erosive esophagitis(EE)and non-erosive forms of GERD(NERD)and its association with data of esophageal multichannel intraluminal impedancepH(MII-pH)*** This was a single-center prospective *** mucosa samples were taken from the lower part of the esophagus during *** of interleukin(IL)-1β,IL-10,IL-18,tumor necrosis factorα(TNFA),toll-like receptor 4(TLR4),GATA binding protein 3(GATA3),differentiation cluster 68(CD68)andβ-2 microglobulin genes in esophageal mucosa was assessed with ImmunoQuantex ***-pH measurements were performed on all the *** of GERD was confirmed by the results of the MII-pH *** on the endoscopy,patients were allocated to the groups of EE and *** control group consisted of non-symptomatic subjects with normal endoscopy and MII-pH *** used nonparametric statistics to compare the differences between the *** of expression of the mentioned genes with the results of the MII-pH data was assessed with spearman’s rank *** Data from 60 patients with GERD and 10 subjects of the control group were available for the *** expression of IL-18(5.89±0.4 vs 5.28±1.1,P=0.04)and GATA3(2.92±0.86 vs 2.23±0.96,P=0.03)was found in the EE group compared to *** of IL-1β,IL-18,TNFA,and TLR4 was lower(Psure correlated with the expression of IL-1β(spearman’s rank r=0.29),IL-18(r=0.31),TNFA(r=0.35),GATA3(r=0.34),TLR4(r=0.29),and CD68(r=0.37).Mean esophagealрНcorrelated inversely with the expression of IL-18,TNFA,GATA3,TLR4,and *** association of gene expression with the number of gastroesophageal refluxes was ***

关键词： Gastroesophageal reflux disease Gene expression Cytokines Erosive esophagitis Non-erosive gastroesophageal reflux disease Esophageal multichannel intraluminal impedance-pH Gastroesophageal reflux

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