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Morpho-Histological Analysis of Direct Shoot Organogenesis Induced in Flower Buds Cultures of <i>Allium altissimum</i>

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American Journal of Plant Sciences 2014年第13期5卷 2015-2022页

作者： tatyana V. Poluboyarova tatyana I. Novikova Galina Yu. Vinogradova Elena V. Andronova Biotechnology Laboratory Central Siberian Botanical Garden of the Siberian Branch of the Russian Academy of Sciences Novosibirsk Russia Department of Embryology and Reproductive Biology Komarov Botanical Institute of the Russian Academy of Sciences St Petersburg Russia

The present work gives a detailed study of in vitro shoot organogenesis of the ornamental onion A. altissimum Regel from the buds of the middle layer of the inflorescences. The course of morphogenesis was examined by light and scanning electron microscopy. Histological observation revealed that during 3 - 5 days of culture on the BDS medium supplemented with 2.0 mg·L-1 of BA and 2.0 mg·L-1 of NAA the epidermal cells of the stamen filament in the area of its fusion with the tepal became competent and dedifferentiated. Originally the organogenesis involved several initial epidermal cells. The formation of meristematic centers was observed from day 3 to day 14. The apical shoot meristems and leaf primordia in a roller shape formed from day 14 to day 28 of culture on the same media. The further development of vegetative shoots and formation of the bulblets were observed when the explants were stimulated by triapenthenol (2.0 mg·L-1).

关键词： Allium altissimum Direct Shoot Organogenesis Regeneration Tissue Culture

Molecular pathways of liver regeneration:A comprehensive review

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World Journal of Hepatology 2021年第3期13卷 270-290页

作者： Yana V Kiseleva Sevak Z Antonyan tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov International School“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Emergency Surgical Gastroenterology N.V.Sklifosovsky Research Institute for Emergency MedicineMoscow 129010Russia Department of Human Anatomy I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119048Russia Laboratory of Minimally Invasive Surgery A.I.Evdokimov Moscow State University of Medicine and DentistryMoscow 127473Russia Pathology Department A.V.Vishnevsky National Medical Research Center of Surgery of the Russian Ministry of HealthcareMoscow 117997Russia

The liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70%of its *** knowledge of this phenomenon dates back to Greek mythology(the story of Prometheus),many aspects of liver regeneration are still not understood.A variety of different factors,including inflammatory cytokines,growth factors,and bile acids,promote liver regeneration and control the final size of the organ during typical regeneration,which is performed by mature hepatocytes,and during alternative regeneration,which is performed by recently identified resident stem cells called“hepatic progenitor cells”.Hepatic progenitor cells drive liver regeneration when hepatocytes are unable to restore the liver mass,such as in cases of chronic injury or excessive acute *** liver maintenance,the body mass ratio is essential for homeostasis because the liver has numerous functions;therefore,a greater understanding of this process will lead to better control of liver injuries,improved transplantation of small grafts and the discovery of new methods for the treatment of liver *** current review sheds light on the key molecular pathways and cells involved in typical and progenitor-dependent liver mass regeneration after various acute or chronic *** studies and a better understanding of liver regeneration will lead to the development of new therapeutic methods for liver diseases.

关键词： Liver regeneration Molecular pathways Hepatic progenitor cells Cytokines Micro ribonucleic acid Partial hepatectomy

Molecular mechanisms of Wnt secretion and signaling

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Molecular mechanisms of Wnt secretion and signaling

Linear Problems of Optimal Control of Fuzzy Maps

2012全国发育生物学大会

作者： tatyana Y.Belenkaya Division of Developmental Biology Cincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Secreted Wnt proteins play essential roles in many biological processes including growth,patterning,tissue and energy homeostasis,and maintenance of somatic stem *** of the Wnt pathway contributes to human diseases such as *** development,Wnt acts as a morphogen and activates the expression of its target genes in a concentration-dependent *** lab has been focused on the question of how Wnt morphogen gradient and its signaling activities are regulated during development using Drosophila model *** studies have demonstrated that heparan sulfate proteoglycans play essential roles in regulating Wingless(Wg,the Drosophila Wnt-1) gradient and its signaling *** have shown that retromer complex is essential for Wg *** have further characterized essential lipid-modification sites in Wg protein,which are required Wg signaling and *** RNAi screens,we have recently identified several other genes essential for Wg secretion and *** genes include a Snx3 essential for retromer-mediated Wg secretion,a nuclear factor required for Wg downstream signaling activity.I will present our latest studies in my presentation.

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Intelligent Information Management 2009年第3期1卷 139-144页

作者： Andrej V. PLOTNIKOV tatyana A. KOMLEVA 不详

In the present paper, we show the some properties of the fuzzy R-solution of the control linear fuzzy differential inclusions and research the optimal time problems for it.

关键词： fuzzy differential inclusions control problems

Russian Universities and Global Ratings

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Russian Universities and Global Ratings

Biological Evaluation of a Novel 2’-Fluoro Derivative 5-Azacytidine as a Potent DNA Methyltransferase Inhibitor

作者： Boris Zemtsov tatyana Suzdaleva National Research University N.E.Bauman Moscow State Technical University (BMSTU)

The paper covers high school reform in Russia. It considers the problem of university ranking. The world rating systems' influence and their application in the assessment of higher education in Russia are analyzed. The discussion goes into complicated questions of indexing and synthesis between our country's tradition and modern practices used worldwide. The authors make a point on the importance of the correlation between the international scientometrics and the features of Russian higher education in order to successfully integrate the latter into the highly competitive environment of the world-leading centers for science and education.

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Pharmacology & Pharmacy 2024年第11期15卷 388-402页

作者： Elena Kalinichenko tatyana Bozhok Roman Zilberman Alesya Panibrat Institute of Bioorganic Chemistry National Academy of Sciences of Belarus Minsk Belarus

Background: DNA methyltransferases (DNMTs) are key epigenetic regulatory enzymes involved in the expression of many genes and are considered as an attractive target for cancer treatment, especially hematological malignancies. Therefore, promising DNMT inhibitors characterized by low toxicity, target activity and high selectivity are crucial for the development of new cancer therapy and research on the inhibitory mechanism. We had previously demonstrated that the novel 2’-fluoro-2’-deoxy-arabinofuranosyl 5-azacytosine nucleoside (2’F-araAC) showed high antiproliferative activity in vitro and increased hydrolytic stability compared to the known agents like azacitidine and decitabine. Objective: The objective of the present study was to investigate the effect of novel 2’F-araAC as potent anti-leukemia agent and DNMTs inhibitor on nuclear extract of the HCT-116 human colorectal cell line and P388 and L1210 mouse leukemia cell lines. Methods: The DNMTs activity was evaluated using the fluorometric DNMT Activity Quantification Kit (Abcam) and were reported as the percentage of control. Nuclear proteins were extracted from HCT-116 cell line using the Nuclear Extraction Kit (Abcam). To explore the mechanism of anti-leukemic activity of 2’F-araAC, cell cycle and apoptosis analyses were performed on P388 and L1210 cell lines. Results: It has been shown that the DNMTs activity was significantly reduced at 1 and 10 µM of 2’F-araAC compared to controls. Moreover, 2’F-araAC can induce G2/M cell cycle arrest and apoptosis in P388 and L1210 mouse leukemia cell lines as shown by flow cytometry method. Apoptosis was 54.53% and 43.35% for 2’F-araAC vs. 2.88% and 5.25% for the control P388 and L1210 cell lines, respectively. Conclusions: Thus, our study presents a new and promising compound to further develop new epigenetic regulators to be used as antitumor agents.

关键词： Drug Discovery Decitabine 2’-Fluorodeoxy-Arabino Analog DNA Methyltransferase Enzyme Inhibition Cell Cycle Apoptosis

Comparison of the Analgesic Activity of Antiparkinsonian Aminoadamantane Derivatives Amantadine and Hemantane

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Advances in Parkinson's Disease 2016年第3期5卷 50-60页

作者： Elena Ivanova Inga Kapitsa Elena Valdman tatyana Voronina Laboratory of Psychopharmacology Zakusov Institute of Pharmacology Moscow Russia

The efficacy of some aminoadamantane derivatives used as neurodegeneration treatments is due to their ability to block NMDA receptors. But this mechanism of pharmacological action can also produce analgesic activity. Analgesic properties of two aminoadamantanes, amantadine (20 mg/kg) and hemantane (20 mg/kg), which were uncompetitive NMDA receptor antagonists, were assessed in rodent models of pain induced by different pain stimuli (tail-flick test, acetic twitches test in mice and formalin test in rats). Additionally, the anti-inflammatory properties of hemantane and amantadine were evaluated in mice with acetic peritonitis and in rats with hind paw edema induced by formalin injection. The results of our study demonstrate that the analgesic activity of the 1-aminoadamantane amantadine differs from the 2-aminoadamantane hemantane. The analgesic activity of amantadine administered intraperitoneally was more pronounced in the case of acute thermal pain in mice compared to hemantane, and only amantadine had a significant analgesic effect on the acute early phase of formalin pain in rats induced by the effect of the algogen on the primary sensory afferents. Hemantane was more effective than amantadine for relieving pain produced by inflammation owing to its pronounced anti-inflammatory activity: only hemantane decreased the amount of acetic twitches in mice that received drugs orally and was effective in the tonic phase of formalin pain in rats.

关键词： NMDA Receptor Antagonists Tail-Flick Test Acetic Twitches Formalin Test Exudative Inflammation

Inpatient management of iron deficiency anemia in pediatric patients with inflammatory bowel disease: A single center experience

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World Journal of Clinical Pediatrics 2024年第1期13卷 107-117页

作者： Krishanth Manokaran Jonathan Spaan Giulio Cataldo Christopher Lyons Paul D Mitchell tatyana Sare LoriA Zimmerman Paul A Rufo Center for Inflammatory Bowel Disease Boston Children's HospitalBostonMA 02115United States Institutional Centers for Clinical and Translational Research Boston Children's HospitalBostonMA 02115United States

BACKGROUND Screening for iron deficiency anemia(IDA)is important in managing pediatric patients with inflammatory bowel disease(IBD).Concerns related to adverse reactions may contribute to a reluctance to prescribe intravenous(IV)iron to treat IDA in this *** To track the efficacy and safety of IV iron therapy in treating IDA in pediatric IBD patients admitted to our *** A longitudinal observational cohort study was performed on 236 consecutive pediatric patients admitted to our tertiary IBD care center between September 2017 and December 2019.92 patients met study criteria for IDA,of which 57 received IV iron,17 received oral iron,and 18 were discharged prior to receiving iron *** Patients treated with IV iron during their hospitalization experienced a significant increase of 1.9(±0.2)g/dL in mean(±SE)hemoglobin(Hb)concentration by the first ambulatory follow-up,compared to patients who received oral iron 0.8(±0.3)g/dL or no iron 0.8(±0.3)g/dL(P=0.03).One out of 57(1.8%)patients that received IV iron therapy experienced an adverse *** Our findings demonstrate that treatment with IV iron therapy is safe and efficacious in improving Hb and iron levels in pediatric patients with IDA and active IBD.

关键词： Iron deficiency anemia Pediatric inflammatory bowel disease Intravenous iron therapy Inflammatory bowel disease

ESTIMATION OF POLARIZATION MODE DISPERSION （ PMD ） VALUE IN OPTICAL FIBRE DURING LIGHTNING STROKES

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ESTIMATION OF POLARIZATION MODE DISPERSION （ PMD ） VALUE I...